| Interacting proteins: P11362 and P46108 |
Pubmed |
SVM Score :0.0 |
| Transient tyrosine phosphorylation of Crk in fibroblast growth factor 2 stimulated endothelial cells was dependent on the juxtamembrane tyrosine residue 463 in FGFR 1 , and a Crk SH 2 domain precipitated FGFR 1 via phosphorylated Tyr 463 , indicating direct complex formation between Crk and FGFR 1 . ^^^ We examined the role of Crk in FGFR 1 mediated cellular responses by use of cells expressing chimeric platelet derived growth factor receptor alpha / FGFR 1 ( alphaR / FR ) wild type and mutant Y463F receptors . ^^^ Our data indicate that Crk participates in signaling complexes downstream of FGFR 1 , which propagate mitogenic signals . . ^^^ |
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| Interacting proteins: P11362 and P46108 |
Pubmed |
SVM Score :0.0 |
| FGF 2 alone stimulated maximal phosphorylation of Src homology domain 2 tyrosine phosphatase ( SHP 2 ) and the adaptor molecule Crk , in heparan sulfate deficient Chinese hamster ovary ( CHO ) 677 cells expressing FGFR 1 . ^^^ Tyrosine residues 463 in the juxtamembrane domain and 766 in the C terminal tail in FGFR 1 are known to bind Crk and PLCgamma ( 1 ) , respectively . ^^^ |
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