| In vitro studies showed that nonautocrine cells behave like epithelial parental cells , whereas autocrine cells have a mesenchymal phenotype correlated with the overexpression of urokinase plasminogen activator receptor ( uPAR ) , the internalization of E cadherin , and the redistribution of beta catenin from the cell surface to the cytoplasm and nucleus . uPAR was defined as an early target , whereas E cadherin and the leukocyte common antigen related protein tyrosine phosphatase ( LAR PTP ) were later targets of FGF signaling , with FGFR 1 activation more efficient than FGFR 2 at modulating these targets . ^^^ |