| Interacting proteins: P11362 and P29353 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11362 and P29353 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11362 and P29353 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11362 and P29353 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11362 and P29353 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11362 and P29353 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11362 and P29353 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11362 and P29353 |
Pubmed |
SVM Score :0.0 |
| The activated FGFR 1 couples to Ras through two adaptor proteins , FRS 2 and Shc . ^^^ |
|
| Interacting proteins: P11362 and P29353 |
Pubmed |
SVM Score :0.0 |
| Furthermore , FGFR 4 induced only a weak tyrosyl phosphorylation of phospholipase C gamma and no detectable tyrosyl phosphorylation of the SHC adaptor proteins in contrast to FGFR 1 . ^^^ |
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| Interacting proteins: P11362 and P29353 |
Pubmed |
SVM Score :0.0 |
| The activated fibroblast growth factor receptor 1 ( FGFR 1 ) expressed in L 6 myoblasts did not bind Grb 2 directly , but indirectly , through the small adaptor protein Shc , which was tyrosine phosphorylated in response to fibroblast growth factor 2 ( FGF 2 ) stimulation . ^^^ A FGFR 1 mutant in which Tyr 766 , a known autophosphorylation site , was changed to Phe , mediated less efficient tyrosine phosphorylation of Shc . ^^^ FGF 2 stimulation of mutant FGFR 1 expressing cells still allowed formation of complexes containing Shc , Grb 2 , and the nucleotide exchange factor Sos and mediation of a mitogenic signal . ^^^ |
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| Interacting proteins: P11362 and P29353 |
Pubmed |
SVM Score :0.0 |
| FGFR 4 activation also fails to elicit detectable signals characteristic of the FGFR 1 response : tyrosine phosphorylation of SHC and extracellular signal related kinase ( ERK ) proteins and induction of fos and tis 11 RNA expression . ^^^ Activation of FGFR 1 in transfected L 6 myoblasts induced far stronger phosphorylation of phospholipase C gamma , SHC , and ERK proteins than could activation of FGFR 4 in L 6 cells , and only FGFR 1 activation induced tyrosine phosphorylation of a characteristic 80 kD protein . ^^^ |
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| Interacting proteins: P11362 and P29353 |
Pubmed |
SVM Score :0.0 |
| Interestingly , both the wild type and a mutant FGFR 1 ( FGFR 1 4F ) are able to phosphorylate Shc and an unidentified Grb 2 associated phosphoprotein of 90 kDa ( pp 90 ) . ^^^ Binding of the Grb2 / Sos complex to phosphorylated Shc and pp 90 may therefore be the key link between FGFR 1 and the Ras signaling pathway , mito genesis , and neuronal differentiation . . ^^^ |
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| Interacting proteins: P11362 and P29353 |
Pubmed |
SVM Score :0.0 |
| Instead , there was a strong constitutive association of FGFR 1 with the adaptor proteins Shc and Grb 2 and the Ras guanine nucleotide exchange factor Sos . ^^^ Thus , in cells transformed by 5 Src , tyrosine phosphorylation of FGFR 1 results not in the expected association with PLC gamma and p 90 , but rather in the recruitment of the Ras activating Shc / Grb2 / Sos complex . ^^^ |
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| Interacting proteins: P11362 and P29353 |
Pubmed |
SVM Score :0.0 |
| Wild type FGFR 1 , FGFR 1 3F , and FGFR 1 4F similarly bind to a 90 kDa tyrosine phosphorylated protein and activate Shc , extracellular signal regulated kinase ( ERK ) 2 , and JunD after stimulation with FGF 2 . ^^^ |
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| Interacting proteins: P11362 and P29353 |
Pubmed |
SVM Score :0.0 |
| These results indicate that FGFR 1 , 3 , and 4 ( 1 ) are capable of signaling in a similar fashion ; ( 2 ) primarily use FRS 2 and , perhaps , PLCgamma ; and ( 3 ) do not utilize Shc . ^^^ |
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| Interacting proteins: P11362 and P29353 |
Pubmed |
SVM Score :0.0 |
| It also prevented the increase in protein tyrosine phosphorylation induced by bFGF , including phosphorylation of FGFR 1 , FGFR 2 , phospholipase C gamma ( PLC gamma ) , and Shc as well as the recruitment of the Grb2 / Sos signaling complex . ^^^ |
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| Interacting proteins: P11362 and P29353 |
Pubmed |
SVM Score :0.0 |
| METHODS : Sections of postnatal 5 day old and adult rat , and aged human retina , and cell cultures prepared from selected cell populations of young rat retina , were immunolabeled with specific antisera to FGFR ( FGFR 1 , 2 , 3 , and 4 ) or candidate signaling molecules [ phospholipase Cg 1 ( PLCg 1 ) , son of sevenless 1 and 2 ( SOS 1 , SOS 2 ) , extracellular signal regulated kinase 1 and 2 ( ERK1 / 2 ) , protein tyrosine phosphatase ( SH PTP 2 ) and SH 2 containing protein ( Shc ) ] , and with multiple retinal cell type specific antibodies . ^^^ |
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| Interacting proteins: P11362 and P29353 |
Pubmed |
SVM Score :0.0 |
| In vitro , TAKA 1 cells stably transfected with FGFR 1 IIIc exhibited increased basal growth ; enhanced basal tyrosine phosphorylation of FGFR substrate 2 ( FRS 2 ) , Shc , and phospholipase Cgamma ; and increased activation of mitogen activated protein kinase ( MAPK ) . ^^^ |
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| Interacting proteins: P11362 and P29353 |
Pubmed |
SVM Score :0.0 |
| Using bovine retinal capillary endothelial cells ( BRCEC ) , we investigated the effects of short term hypoxia on DNA synthesis , phosphotyrosine induction , changes in the expression of basic fibroblast growth factor receptor ( bFGFR ) , protein kinase C ( PKC alpha ) , heat shock protein 70 ( HSP 70 ) , and SH 2 containing protein ( SHC ) . ^^^ |
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| Interacting proteins: P11362 and P29353 |
Pubmed |
SVM Score :0.0 |
| Angiogenic growth factors and their receptors , such as basic fibroblast growth factor ( bFGF ) and Flg , vascular endothelial growth factor ( VEGF ) and Flk 1 , platelet derived growth factor ( PDGF ) B chain and PDGF beta receptor , and five intracellular signal proteins ( phosphatidylinositol 3 kinase [ PI3K ] , phospholipase C gamma [ PLC gamma ] , C Src , SHC , and mitogen activated protein kinase [ MAPK ] ) were examined by Western blot analysis . ^^^ |
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