| Interacting proteins: P11362 and P12830 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P11362 and P12830 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P11362 and P12830 |
Pubmed |
SVM Score :0.0 |
| Here , we demonstrate that FGFR 1 orchestrates the epithelial to mesenchymal transition and morphogenesis of mesoderm at the primitive streak by controlling Snail and E cadherin expression . ^^^ Finally , we provide evidence that the attenuation of Wnt3a signaling observed in Fgfr 1 / embryos can be rescued by lowering E cadherin levels . ^^^ |
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| Interacting proteins: P11362 and P12830 |
Pubmed |
SVM Score :0.0 |
| In vitro studies showed that nonautocrine cells behave like epithelial parental cells , whereas autocrine cells have a mesenchymal phenotype correlated with the overexpression of urokinase plasminogen activator receptor ( uPAR ) , the internalization of E cadherin , and the redistribution of beta catenin from the cell surface to the cytoplasm and nucleus . uPAR was defined as an early target , whereas E cadherin and the leukocyte common antigen related protein tyrosine phosphatase ( LAR PTP ) were later targets of FGF signaling , with FGFR 1 activation more efficient than FGFR 2 at modulating these targets . ^^^ |
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| Interacting proteins: P11362 and P12830 |
Pubmed |
SVM Score :0.0 |
| In this study , we investigated the location , trafficking , and function of FGFR 1 and E cadherin and report a novel mechanism , based on endocytic trafficking , for the coregulation of E cadherin and signaling from FGFR 1 . ^^^ FGF induces the internalization of surface FGFR 1 and surface E cadherin , followed by nuclear translocation of FGFR 1 . ^^^ The internalization of both proteins is regulated by common endocytic machinery , resulting in cointernalization of FGFR 1 and E cadherin into early endosomes . ^^^ Overexpression of E cadherin blocks both the coendocytosis of E cadherin and FGFR 1 , the nuclear translocation of FGFR 1 and FGF induced signaling to the mitogen activated protein kinase pathway . ^^^ Furthermore , stabilization of surface adhesive E cadherin , by overexpressing p120ctn , also blocks internalization and nuclear translocation of FGFR 1 . ^^^ |
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