| Interacting proteins: P08620 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08620 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08620 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08620 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08620 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08620 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08620 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08620 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08620 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08620 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08620 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08620 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08620 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08620 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08620 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08620 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08620 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08620 and P11362 |
Pubmed |
SVM Score :0.64578271 |
| Here we demonstrate using a cell free system that , at low concentrations of heparin , FGF 4 binds only to FGFR 2 , while much higher heparin levels are required for binding to FGFR 1 . 0.64578271^^^ |
|
| Interacting proteins: P08620 and P11362 |
Pubmed |
SVM Score :0.0 |
| MM 14 cells express FGFR 1 and are repressed from differentiation by FGF 1 , FGF 2 , and FGF 4 but not FGF 7 . ^^^ |
|
| Interacting proteins: P08620 and P11362 |
Pubmed |
SVM Score :0.0 |
| Furthermore , truncated FGFR 2 is significantly more efficient at producing reversion than FGFR 1 , indicating that FGF 4 preferentially utilizes the FGFR 2 signalling pathway . ^^^ |
|
| Interacting proteins: P08620 and P11362 |
Pubmed |
SVM Score :0.0 |
| To investigate the roles of FGF signaling in the regulation of myogenesis both in the somite and the limb bud , mosaic chicken embryos were generated that consist of somitic cells carrying transgenes expressing one of the following : FGF 1 , FGF 4 , the FGF receptor type 1 ( FGFR 1 ) or its dominant negative mutant ( delta FGFR 1 ) . ^^^ |
|
| Interacting proteins: P08620 and P11362 |
Pubmed |
SVM Score :0.0 |
| FGF 1 and FGF 2 competed efficiently with ( 125 ) 1 FGF 2 for binding to FGFR 1 and FGFR 1L , whereas FGF 4 was less efficient . ^^^ |
|
| Interacting proteins: P08620 and P11362 |
Pubmed |
SVM Score :0.0 |
| While FGF 4 binds and activates the IIIc splice forms of FGFR 1 to 3 at comparable levels , it shows little activity towards the IIIb splice forms of FGFR 1 to 3 as well as towards FGFR 4 . ^^^ Mutation of several key residues in FGF 4 , observed to interact with FGFR 1 or with heparin in the model , produced ligands with reduced receptor binding and concomitant low mitogenic potential . ^^^ |
|
| Interacting proteins: P08620 and P11362 |
Pubmed |
SVM Score :0.0 |
| All cases of embryonal carcinoma ( 14 cases ) , yolk sac tumor ( 3 cases ) , and choriocarcinoma ( 3 cases ) showed positive immunostaining for FGF 8 , FGF 4 , and FGFR 1 . ^^^ In contrast , out of 13 cases of seminoma , immunostaining was negative for FGF 8 , FGF 4 , and FGFR 1 in 8 cases ( 61 . 5 % ) , 6 cases ( 46 . 1 % ) , and 7 cases ( 53 . 8 % ) , respectively . ^^^ In addition , the Ki 67 labeling index showed extremely high mitogenic activity in embryonal carcinoma , yolk sac tumor , and choriocarcinoma , which are precisely the carcinomas with the highest expressions of FGF 8 , FGF 4 , and FGFR 1 . ^^^ Taken together , these findings confirm the involvement of FGF 8 , FGF 4 , and FGFR 1 in highly proliferative conditions of nonseminomatous germ cell tumors . . ^^^ |
|
| Interacting proteins: P08620 and P11362 |
Pubmed |
SVM Score :0.0 |
| The 1p34 locus containing MYCL 1 , 2p24 ( MYCN ) , 7p12 ( EGFR ) , and 12q14 ( MDM 2 ) were amplified in one of the 32 cases ( 3 % ) , and the 17q12 locus ( ERBB 2 ) and 8p11 ( FGFR 1 ) in two of the 32 cases ( 6 % ) , while only the 11q13 locus ( Cyclin D 1 , FGF 4 , and EMS 1 ) was frequently amplified ( 28 % , 9 / 32 ) , demonstrating this locus to be a major target in ESCCs . ^^^ |
|
| Interacting proteins: P08620 and P11362 |
Pubmed |
SVM Score :0.0 |
| In situ hybridization revealed that , on days 3 and 7 , FGF 4 , and FGFR subtypes 1 and 2 ( FGFR 1 and FGFR 2 ) were expressed in mesenchymal cells and chondrocytes , and in the area of alkaline phosphatase ( ALP ) expression . ^^^ On day 10 , FGF 4 was not detected , whereas the expression of FGFR 1 and FGFR 2 was detectable in the area of alkaline phosphatase ( ALP ) expression . ^^^ |
|
| Interacting proteins: P08620 and P11362 |
Pubmed |
SVM Score :0.0 |
| Frequently gained BAC clone encoded genes were TIM 1 , PDGFR beta , REC Q 4 , VAV 2 , FGF 4 , KLK 2 , PNUTL 1 , GDNF , FLG , EXT 1 , WISP 1 , HER 2 , and SOX 18 . ^^^ |
|
| Interacting proteins: P08620 and P11362 |
Pubmed |
SVM Score :0.0 |
| Studies of receptor binding showed that K 140 had higher affinity than wt K FGF for two of the four members of FGF receptor ' s family , specifically for FGFR 1 ( flg ) and FGFR 2 ( bek ) . ^^^ |
|