| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.65306123 |
| We also observed FGFR 1 associated with the nuclear fraction in FGFR 1 transfected L 6 rat myoblasts , which are known to be refractive to exogenous FGF 1 and express relatively low levels of endogenous FGFR 1 . 0.65306123^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.6313898 |
| FGFR type 4 ( FGFR 4 ) in liver parenchymal cells binds only FGF 1 , whereas FGFR 1 binds FGF 1 and FGF 2 equally . 0.6313898^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.70948917 |
| FGF 1 and FGF 2 competed efficiently with ( 125 ) 1 FGF 2 for binding to FGFR 1 and FGFR 1L , whereas FGF 4 was less efficient . 0.70948917^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| Characterization of [ 125I ] acidic fibroblast growth factor binding to the cloned human fibroblast growth factor receptor , FGF flg , on NIH 3T3 cell membranes : inhibitory effects of heparin , pertussis toxin and guanine nucleotides . ^^^ The present studies were conducted to characterize the specific binding of recombinant human [ 125I ] acidic fibroblast growth factor ( [ 125 ] aFGF ) to the cloned human fibroblast growth factor ( FGF ) receptor , flg , overexpressed on stably transfected NIH 3T3 mouse fibroblast ( NFlg 26 ) cell membranes . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| Receptor for acidic fibroblast growth factor is related to the tyrosine kinase encoded by the fms like gene ( FLG ) . ^^^ Acidic fibroblast growth factor ( aFGF ) stimulated tyrosine kinase activity of FLG in vitro and in living cells , suggesting that FLG encodes the membrane receptor for aFGF . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| We have studied the signal transduction pathways of fibroblast growth factor receptor 4 ( FGFR 4 ) and FGFR 1 , which showed virtually identical acidic fibroblast growth factor binding profiles as well as tyrosine autophosphorylation upon activation in transfected L 6 rat myoblasts and NIH3T3 mouse fibroblasts . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| In the present study , the expression of a acidic fibroblast growth factor ( aFGF ) , basic fibroblast growth factor ( bFGF ) and fibroblast growth factor receptor 1 were analyzed in 60 pancreatic cancer samples using Northern blot analysis , immunoblotting , in situ hybridization and immunohistochemical techniques . aFGF , bFGF and FGFR 1 were present in 63 % , 55 % and 52 % of the tumor samples , respectively . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| A role for locally generated and bioactive ventricular acidic fibroblast growth factor ( aFGF ) in these processes is proposed and substantiated by the following : 1 ) colocalization of aFGF peptide and fibroblast growth factor receptor ( flg ) transcripts to the developing fetal cardiomyocyte by immunohistochemistry , immunoelectron microscopy , and in situ hybridization , 2 ) continued localization of aFGF peptide and transcripts to the neonatal / mature cardiomyocyte , and 3 ) localization of flg immunoreactivity and transcripts to specific neonatal ventricular nonmuscle cell types . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| Acidic fibroblast growth factor ( FGF 1 ) and two of its receptors , FGFR 1 and FGFR 4 , were localized in cryostat sections of normal , benign and malignant human breast tissue by immunohistochemistry . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| To determine the extent to which autocrine effects of acidic fibroblast growth factor ( FGF ) 1 overexpression contribute to an increased malignant phenotype , FGF 1 transfected MCF 7 cells were retransfected with a FGF receptor ( FGFR 1 ) vector encoding a truncated dominant negative receptor to inhibit autocrine FGF signal transduction . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : To explore the expression of acidic fibroblast growth factor ( aFGF ) and its receptor FGFR 1 in ovarian epithelial cancer and observe the effects of aFGF and TPK inhibitor Genistein on intracellular PKC and ERK activity in ovarian epithelial cancer cells line CAOV 3 . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| We have previously reported the isolation of human FGFR 4 cDNA encoding a receptor for aFGF and shown that the expression patterns of FGFR 1 through FGFR 4 mRNAs are overlapping , but distinct in human fetal tissues ( Partanen et al . , 1991 ) . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| Direct binding experiments with radiolabeled acidic FGF ( aFGF ) or basic FGF ( bFGF ) , inhibition of binding with native growth factors , and Scatchard analysis of the binding data indicated that bek and flg bind either aFGF or bFGF with dissociation constants of ( 2 15 ) 10 10 ( 11 ) M . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| We report that heparin increases the binding affinity of aFGF for the two cloned and overexpressed human FGF receptors , flg and bek , by 2 3 fold . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| FDC P 1 cells expressing FGFR 1 bound aFGF and bFGF with high affinity but only in the presence of heparin . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| To identify injury responsive factors and cells , we examined the mRNAs for the following factors and some of their receptors : basic and acidic fibroblast growth factors ( bFGF , aFGF ) and FGF receptor 1 ( FGFR 1 ) ; ciliary neurotrophic factor ( CNTF ) and CNTF receptor alpha ( CNTFR alpha ) ; brain derived neurotrophic factor ( BDNF ) and its receptor trkB ; and insulin like growth factor 1 ( IGF 1 ) and IGFR 1 receptor ( IGF 1R ) . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| We report that kainic acid induced seizures lead to marked increases in mRNAs encoding basic and acidic fibroblast growth factors ( bFGF and aFGF , respectively ) and flg , one of their receptors , in the rat hippocampus . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| To investigate whether receptors for aFGF are also induced after transplantation , polymerase chain reaction , in situ hybridization , and immunohistochemistry were used to analyze expression of four receptors for aFGF ( FGFR 1 FGFR4 ) . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| We also examined the expression of mRNAs for aFGF , bFGF , KGF , FGF receptor 1 ( FGFR 1 ) and FGFR 2 in epithelial and stromal cells using Reverse Transcriptase Polymerase Chain Reaction ( RT PCR ) analysis . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| The results clearly showed that within spinal nerves aFGF and two high affinity FGF receptors , FGFR 1 and FGFR 2 , were prominently expressed in neurons , while expression in Schwann cells was undetectable . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| These findings suggest that endogenous FGFR 1 in the LHA plays an important role in FGF induced feeding suppression , while , in addition , the dissolving disulfide bond formation in aFGF fragments enhances their inhibitory effects on feeding . . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| All three growth factor / receptor systems , TGFalpha / epidermal growth factor receptor ( EGFR ) , HGF / c met and aFGF / FGF receptors ( flg and bek ) were significantly elevated at early time points when oval cells were proliferating . ^^^ These data suggest that TGFalpha and aFGF are the major growth factors involved in the progression of HCC , and that the signal of aFGF is mainly transduced by the receptor flg in HCC . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| The respective densities of muscarinic and NMDA receptors and the aFGF receptor , i . e . , FGFR 1 on the hippocampal neurons were also significantly higher in the aFGF group than in the saline group . 3 . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| Transfection of FGFR 1 into fnr PC 12 cells efficiently restored aFGF induced neurite outgrowth , whereas transfection of FGFR 3 was much less efficient . ^^^ Transfection of a chimeric receptor consisting of the extracellular domain of FGFR 3 fused to the transmembrane and intracellular domain of FGFR 1 , termed FR31b , efficiently restored aFGF induced neurite outgrowth . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| The presence of mRNA for aFGF , bFGF , and three isoforms of VEGF , as well as their receptors , FGFR 1 , FGFR 2 , Flt 1 , and KDR , in vessel outgrowths and the parent vessel , as identified by RT PCR , strongly implicated aFGF , bFGF , and VEGF as having an important role in this neovascularization response . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| The FGFR 1 ( flg ) receptor , which is recognized by aFGF and bFGF , was studied by RT PCR . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| Exogenously added acidic FGF ( aFGF ) , which generated a rapid tyrosine phosphorylation of FGFR 1 and FGFR 2 on KS cells , reversed the inhibitory effects of anti bFGF Ab . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| By comparison with the normal pancreas , acidic FGF ( aFGF ) and FGF receptor 1 ( FGFR 1 , flg ) , mRNA levels were significantly decreased in human pancreatic tissues , which were obtained approximately 8 days after onset of AP . ^^^ In regions that have undergone necrosis , there was complete loss of aFGF , bFGF , and FGFR 1 immunostaining . ^^^ In contrast , in the regenerating areas , aFGF and bFGF were readily evident in exocrine type cells , in association with a marked increase in FGFR 1 immunoreactivity . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| Furthermore , transcript levels of FGF receptor 1 ( FGFR 1 ) and 4 ( FGFR 4 ) isoforms , as well as of aFGF and bFGF were assessed by RT PCR . aFGF treated myotubes displayed increased expression of aFGF and bFGF , suggesting a paracrine effect of exogenous aFGF . ^^^ The effects of aFGF treatment on the two receptors consisted of a decrease in FGFR 1 and an increase in FGFR 4 mRNA levels in 5 day old cultures . ^^^ This led to a shift in the ratio of FGFR 1 to FGFR 4 in the FGF treated cultures which may explain the ability of satellite cells to differentiate under the influence of aFGF . . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| In an attempt to define the aFGF recognition site on fibroblast growth factor receptor 1 ( FGFR 1 ) , we developed a screening strategy for identifying FGF ligands that bind to the receptor binding region of FGF . ^^^ These sequences may thus constitute part of the aFGF binding region on FGFR 1 , and the synthesized peptide has the potential to become a therapeutic agent as an aFGF antagonist . . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| Formalin fixed , paraffin embedded normal tissues and 60 well characterized GEP endocrine tumors were immunostained using specific antibodies directed against various GEP hormones , aFGF , FGFR 1 , FGFR 2 , FGFR 3 , and FGFR 4 . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| Expression of aFGF , bFGF , and FGFR 1 in ovarian epithelial neoplasm . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| MM 14 cells express FGFR 1 and are repressed from differentiation by FGF 1 , FGF 2 , and FGF 4 but not FGF 7 . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| Tyrosine phosphorylation of a M ( r ) 150 , 000 protein resulted when MDA MB 134 cells were treated with FGF 1 or FGF 2 , implying the presence of a functional FGFR 1 . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| RT PCR analyses revealed FGF 1 , FGF 2 , FGFR 1 ( flg ) , and TGF beta 1 mRNA in all samples without evidence of modulation by FGF 1 affixation . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| Using reverse transcription PCR , Northern analysis , and immunohistochemistry , we found that some human T cells also express high affinity FGF receptor 1 ( FGFR 1 ) respond to FGF 1 . ^^^ The function of FGFR 1 receptor in Jurkat T cells is demonstrated by the production of IL 2 after stimulation with FGF 1 and anti CD 3 . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| Here we show that a lower affinity of FGFR 1 alpha for heparin parallels the lower affinity for FGF 1 . ^^^ A mutant of FGFR 1 alpha in which the sequence between Loops 1 and 2 was deleted exhibits high affinity for both FGF 1 and heparin and other properties of the FGFR 1 beta isoform , which include resistance to degradation by trypsin and display of specific antibody epitopes . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| Thus , FGF 2LA bound , with the same affinity as FGF 1 and FGF 2 , to FGFR 1 and FGFR 2 , whereas only FGF 1 and the FGF 1 loop containing mutant , FGF 2LA , bound to the keratinocyte growth factor receptor . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| A differentiated liver cell ( HepG 2 ) , which exhibits a dose dependent growth stimulatory and growth inhibitory response to heparin binding fibroblast growth factor type 1 ( FGF 1 ) , displays high and low affinity receptor phenotypes and expresses specific combinatorial splice variants alpha 1 , beta 1 , and alpha 2 of the FGF receptor ( FGF R ) gene ( flg ) . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| To investigate the roles of FGF signaling in the regulation of myogenesis both in the somite and the limb bud , mosaic chicken embryos were generated that consist of somitic cells carrying transgenes expressing one of the following : FGF 1 , FGF 4 , the FGF receptor type 1 ( FGFR 1 ) or its dominant negative mutant ( delta FGFR 1 ) . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| METHODS : Synovial tissues from patients with RA or noninflammatory arthritis were examined for the expression of FGF 1 and its receptor , FGFR 1 , by immunohistology and reverse transcriptase polymerase chain reaction . ^^^ CONCLUSION : The increased frequency of peripheral T cells that respond to FGF 1 in RA is consistent with expansion of FGFR 1 expressing T cells in the rheumatoid synovium . . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| We have previously shown that in cells irreversibly committed to DNA synthesis by FGF 1 , approximately 15 % of cell surface FGFR 1 traffics to a perinuclear locale as a structurally intact and functional tyrosine kinase ( Prudovsky , I . , Savion , N . , Zhan , X . , Friesel , R . , Xu , J . , Hou , J . , McKeehan , W . ^^^ Because ligand chase analysis demonstrated that FGFR 1beta L 6 myoblast transfectants exhibited a reduced efficiency of nuclear translocation of exogenous FGF 1 when compared with FGFR 1alpha transfectants , the intracellular trafficking of the FGFR 1alpha and FGFR 1beta isoforms was studied using an in vitro kinase assay to amplify immunoprecipitated FGFR 1 . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| The expression of FGF 1 , FGF 2 , and their receptor , FGF receptor 1 ( FGFR 1 ) , was examined in malignant salivary gland tumours and normal salivary glands , using immunohistochemical methods . ^^^ In seven cases of adenoid cystic carcinoma ( ACC ) , both duct like cells and modified myoepithelial cells were apparently immunopositive for FGF 1 , FGF 2 , and FGFR 1 . ^^^ In five cases of mucoepidermoid carcinoma ( MC ) , all three types of tumour cells including epidermoid cells , and intermediate cells expressed immunoreactive FGF 1 , FGF 2 , and FGFR 1 . ^^^ In these malignant salivary gland tumours , increased expression of FGFR 1 correlated with the intensity of both FGF 1 and FGF 2 immunoreactivity . ^^^ In contrast to malignant salivary gland tumours , eight cases of normal salivary gland showed negative immunostaining for FGF 1 , FGF 2 , and FGFR 1 while four cases were weakly immunoreactive for FGF and its receptor . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| However , the tyrosine phosphorylation of FGFR 1 substrates , Src and cortactin , is impaired in senescent HUVEC , and only the presenescent cell populations exhibit a FGF 1 dependent Src tyrosine kinase activity . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| Expression of FGF 1 and FGFR 1 in human melanoma tissues . ^^^ To determine whether FGF 1 and FGFR 1 may be involved in MM growth in vivo , we have studied the expression of the FGF 1 and FGFR 1 genes in 77 fresh MM biopsy samples , using RT PCR analysis . ^^^ Using RT PCR analysis , expression of FGF 1 and FGFR 1 was observed in 69 / 77 and 68 / 77 cases , respectively . ^^^ We conclude that FGF 1 and FGFR 1 are frequently co expressed in MM , a situation that may contribute to aberrant autocrine and paracrine pathways . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| Upregulation of acidic and basic fibroblast growth factors ( FGF 1 and 2 ) , and their cognate receptors FGFR 1 and 2 , has been demonstrated in a variety of epithelial malignancies . ^^^ In this report , the levels of FGF 1 , FGF 2 , FGF 7 mRNA and their receptors FGFR 1 and FGFR 2 , were investigated during epidermal carcinogenesis in transgenic mice expressing the early region of the ' high risk ' papillomavirus type 16 ( HPV 16 ) under control of the human keratin 14 enhancer / promoter ( K 14 HPV16 transgenic mice ) . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| FGF 1 transcripts were more abundant in newborn SMCs whereas FGF 2 and FGFR 1 mRNA expression was higher in adult SMCs . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| Prostatic stromal cells express primarily the FGFR 3 IIIc isoform and smaller amounts of FGFR 1 IIIc and FGFR 2 IIIc isoforms , which bind both FGF 1 and FGF 2 . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemical localization of fibroblast growth factor 1 ( FGF 1 ) , FGF 2 and fibroblast growth factor receptor 1 ( FGFR 1 ) in pleomorphic adenoma of the salivary glands . ^^^ In this study , fibroblast growth factor 1 ( FGF 1 ) , FGF 2 , and fibroblast growth factor receptor 1 ( FGFR 1 ) were immunohistochemically analyzed in 10 patients with pleomorphic adenoma of the salivary gland by using specific monoclonal antibodies . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| Immunoreactivity to FGF 2 , probably the best characterized member of the FGF family ( FGF 1 to FGF 10 ) and of one of its high affinity receptors , FGFR 1 , was found in autonomic neurons at embryonic day E 14 , the peak day of generation and proliferation in the common ventral motoneuron pool . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| In addition to antibody against FGF 1 , a polyclonal antiserum against the three immunoglobulin ( Ig ) like loop ectodomain of FGFR 4 and a monoclonal antibody to a 19 residue sequence in the NH 2 terminus of the NH 2 terminal Ig Loop 1 of the three loop splice variant of FGFR 1 ( FGFR1alpha ) reacts with the complex . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| By equilibrium binding human FGFR 3 IIIc preferentially bound FGF 1 with high affinity , whereas FGFR 1 IIIc bound both FGF 1 and 2 with high affinity . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| Because the effects of FGF 1 and FGF 2 are predominantly mediated through the FGF receptor 1 ( FGFR 1 ) , its expression has also been examined . ^^^ Cytoplasmic staining for FGF 1 , FGF 2 , and FGFR 1 was scored on a scale of 0 ( no staining ) to 3 ( heavy staining ) and expressed as a percentage of total cells stained . ^^^ Confocal microscopy of immunofluorescent staining for FGF 1 , FGF 2 , and FGFR 1 in sections of multinodular goiter ( n = 3 ) and normal thyroid ( n = 3 ) provided quantitation of immunostaining . ^^^ These data show that enhanced expression of FGF 1 , FGF 2 , and FGFR 1 accompany thyroid hyperplasia and are not exclusively associated with the neoplastic state . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| Binding of the intact fusion protein to FGF receptor 1 ( FGFR 1 ) on T cells was demonstrated by immunoprecipitation of the receptor bound to Fc FGF 1 and by flow cytometry showing binding of fusion protein to T cells expressing FGFR 1 . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| We demonstrate that transient exposure to FGF 1 results in a significant decrease in Fos transcript expression and a decrease in tyrosine phosphorylation of the FGFR 1 , p 42 ( mapk ) , and p 44 ( mapk ) . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| Several FGFs , including FGF 1 , 2 , 3 , 4 , 5 , 6 , and 7 , and several FGFR variants , among them the 2 immunoglobulin like form and the IIIc splice variant of FGFR 1 and the keratinocyte growth factor receptor , a splice variant of FGFR 2 , are expressed in human pancreatic cancer cell lines and are overexpressed in human pancreatic cancers or in the pancreas of chronic pancreatitis and , therefore , may play important roles in the pathobiology of these pancreatic diseases . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| In aged RPE cells , FGFR 1 was rapidly activated , and its autophosphorylation followed the kinetics of endogenous FGF 1 secretion , before the onset of apoptosis . ^^^ Treatment with neutralizing anti FGF 1 or blocking anti FGFR 1 antibodies mimics these effects . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| The localization of FGFR 1 is consistent with previous reports on the involvement of FGF 1 and FGF 2 in AD . . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| The expression and localization of fibroblast growth factor 1 ( FGF 1 ) and FGF receptor 1 ( FGFR 1 ) in human breast cancer . ^^^ In contrast to FGF 1 , Western blot analysis demonstrated the presence of FGFR 1 protein in all of the samples from breast cancer and benign tumors . ^^^ These results demonstrated that breast cancer cells not only generated FGF 1 , but also expressed FGFR 1 , and FGF 1 might play a role in the proliferation of breast cancer cells not only by paracrine but also by autocrine mechanism . . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| Here we report that in the absence of flanking sequences , isolated Ig module 2 of FGFR 1 supports the binding of FGF 1 , FGF 2 , and FGF 7 in respective order of affinity . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| Resistance was circumvented by alternatively targeting FGF 1 receptor ( Flg ) on these cells with a saporin immunotoxin . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| A dimeric ternary complex of FGFR [ correction of FGFR 1 ] , heparin and FGF 1 leads to an ' electrostatic sandwich ' model for heparin binding . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| In proliferating cultures of satellite cells , HGF , insulin like growth factor 1 ( IGF 1 ) and FGF 1 stimulated significantly ( P < 0 . 05 ) higher levels of FGFR 1 message content , relative to control conditions , and platelet derived growth factor BB ( PDGF BB ) and insulin like growth factor ( IGF 2 ) significantly ( P < 0 . 05 ) depressed FGFR 1 expression . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| The expression levels of 12 known FGF family genes ( FGF 1 to 12 ) and 4 FGFR genes ( FGFR 1 to 4 ) were also examined in seven cell lines . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| RESULTS : We detected the expression of mRNAs for FGF 1 through FGF 5 , FGF 7 through FGF 10 , and FGFR 1 through FGFR 4 ( IIIb and IIIc splice variants ) in rat metanephroi from E 14 to E 21 . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| We demonstrated the involvement of an autocrine loop involving endogenous FGF 1 in the mechanisms that govern FGF 2 induced resistance to apoptosis by showing : ( 1 ) higher levels of apoptosis in cells treated with antisense FGF 1 oligonucleotide or after neutralization of excreted FGF 1 ; ( 2 ) the long term activation of FGFR 1 and of ERK 2 , ( 3 ) the inhibition of FGFR 1 and ERK 2 activation and an increase in apoptosis if excreted FGF 1 was neutralized . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| The comparison between 5 d stimulated hypothyroid TA muscle and 5 d stimulated TA and SOL derived satellite cell cultures revealed differences in the expression of FGF 1 and FGF 2 , but similar expression levels of FGFR 1 and FGFR 4 . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| The fibroblast growth factor ( FGF ) family , with its prototype members acidic FGF ( FGF 1 ) and basic FGF ( FGF 2 ) , binds to four related receptor tyrosine kinases , termed FGFR 1 , R 2 , R 3 , and R 4 , expressed on most types of cells in tissue culture . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| To elucidate the structural determinants governing specificity in fibroblast growth factor ( FGF ) signaling , we have determined the crystal structures of FGF 1 and FGF 2 complexed with the ligand binding domains ( immunoglobulin like domains 2 [ D 2 ] and 3 [ D 3 ] ) of FGF receptor 1 ( FGFR 1 ) and FGFR 2 , respectively . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| Addition of the anti FGF receptor 1 antibody ( FGFR 1 Ab ) reverted the transformed phenotype of sp FGF 1 transfectants . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| Cross linking demonstrated that FGF 2 / HSGAGB primarily activated FGFR 1 , which in turn up regulated the activity of mitogen activated protein kinase ; in contrast , FGF 1 / HSGAGA led to the phosphorylation of equal proportions of both FGFR 1 and FGFR 2 , which in turn led to the up regulation of Src and p 125 ( FAK ) . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| Xenopus oocytes expressing fibroblast growth factor receptor 1 ( FGFR 1 ) were used as a biological model system to analyse the signal transduction pathways that are triggered by fibroblast growth factor 1 ( FGF 1 ) . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| Secreted FGF 1 induced short term activation of both FGFR 1 and ERK 2 , which were required for cell proliferation . ^^^ Secreted FGF 1 induced long term activation of FGFR 1 and ERK 2 , which was necessary to induce a constant and high level of Bcl 10 production , and to induce cell survival in FGFI cells . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemistry of FGF 1 , FGF 2 , FGFR 1 and p 53 used avidin biotin detection of the primary antibody . ^^^ These tumors expressed FGF 1 , FGF 2 , and FGFR 1 . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| We hypothesized that aberrant expression of FGFR 1 in PrECs would render them sensitive to induction of promatrilysin expression by recombinant FGF 1 . ^^^ FGF 1 increased promatrilysin expression in FGFR 1 transfected PrECs 4 fold over mock transfected cells , and this induction was inhibited by a specific FGFR 1 inhibitor , SU 5402 , and by co expression of a dominant negative FGFR 1 protein . ^^^ Our results demonstrate that aberrant FGFR 1 expression , an epigenetic phenomenon that has been associated with prostate cancer progression , allows induction of promatrilysin expression by FGF 1 in PrECs . . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| The mitogen activated protein kinase ( MAP kinase ) signalling cascade activated by fibroblast growth factors ( FGF 1 and FGF 2 ) was analysed in a model system , Xenopus oocytes , expressing fibroblast growth factor receptors ( FGFR 1 and FGFR 4 ) . ^^^ Stimulation of FGFR 1 by FGF 1 or FGF 2 and FGFR 4 by FGF 1 induced a sustained phosphorylation of extracellular signal regulated protein kinase 2 ( ERK 2 ) and meiosis reinitiation . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| RasGAP is involved in signal transduction triggered by FGF 1 in Xenopus oocytes expressing FGFR 1 . ^^^ The role of RasGAP was investigated in the model system of Xenopus oocytes expressing fibroblast growth factor receptor 1 ( FGFR 1 ) stimulated by fibroblast growth factor 1 ( FGF 1 ) . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| Heparin as low as 0 . 01 mg / mL significantly downregulated expression of TGF beta ( 1 ) and FGF 1 stimulated FGF 2 and FGFR 1 . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| In addition , both 6 O and 2 O desulfated heparin activated FGF 1 signaling via FGFR 2 IIIb , whereas neither one stimulated FGF 1 signaling via FGFR 1 or FGF 7 via FGFR 2 IIIb . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| We found that levels of mRNA for the FGFR 1 were attenuated in the mutant mice by the age of 6 months , whereas the mRNAs for FGF 1 and FGF 2 were reduced or unchanged in the brain regions tested . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| OPN mRNA induction by FGF 1 was attenuated by PD 166866 , a highly selective and potent FGFR 1 tyrosine kinase inhibitor . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| We assessed the role of fibroblast growth factors ( FGF ) in pulmonary vascular remodeling by examining the expression pattern of FGF 1 , FGF 2 , and the FGF receptor ( FGFR 1 ) in peripheral area of lung tissues from patients with COPD ( FEV ( 1 ) < or = 75 % ; n = 15 ) and without COPD ( FEV ( 1 ) > or = 85 % ; n = 13 ) . ^^^ FGF 1 and FGFR 1 were detected in vascular smooth muscle ( VSM ) , airway smooth muscle , and airway epithelial cells . ^^^ VSM cells of large ( > 200 micro m ) pulmonary vessels showed increased staining for FGF 1 ( 1 . 6 fold , P < 0 . 03 ) and FGFR 1 ( 1 . 4 fold , P < 0 . 04 ) in COPD . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| FGFR 1 signaling regulates Fgfr 1 , Fgf 1 , Fgf 3 and Bmp 7 expression and indirectly regulates Fgf 7 , Fgf 10 and Bmp 4 . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| Viral transduction of FGFR 1 , truncated FGFR 1 , or FGF 1 did not appreciably alter the proliferation of lens epithelial cells . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| FGF 1 treatment of RVEC ( R 1 alpha ) transfectants enhanced ONOO ( ) mediated cell death in a manner dependent upon FGFR 1 tyrosine kinase , MEK / Erk 1 / 2 kinase , and p 38 MAP kinase activities and independent of Src family kinase ( SFK ) activity . ^^^ FGF 1 treatment of RVEC ( R 1 beta ) transfectants inhibited the cytotoxic effects of ONOO ( ) in a manner dependent upon FGFR 1 tyrosine kinase , MEK / Erk 1 / 2 kinase , and SFK activities and independent of p 38 MAP kinase activity . ^^^ FGF 1 induced preactivation of both FGFR 1 tyrosine and Erk 1 / 2 kinases was detected in both RVEC ( R 1 alpha ) and RVEC ( R 1 beta ) transfectants . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| To resolve the discrepancies , we measured the size and molar ratio of HS in the complex and showed that both FGF 1 and FGFR 1 simultaneously interact with HS ; therefore , a model of 2 : 2 : 2 FGF1 . ^^^ Using genetic and biochemical methods , we generated HSs that were defective in FGF 1 and / or FGFR 1 binding but could form the signaling ternary complex . ^^^ Furthermore , the molar ratio of HS , FGF 1 , and FGFR 1 in the ternary complex was found to be independent of the size of HS , which indicates that the selected model can take place on the cell surface proteoglycans . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| Consistent with this , the expression patterns of FGF 1 , FGF 2 , and FGFR 1 across the myocardium persist in the absence of the epicardium . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| Co transfection of LNCaP with human MT 1 MMP reporter construct and a dominant negative FGFR 1 mutant showed that FGF 1 induced MT 1 MMP expression in LNCaP cells was completely inhibited by the mutated FGFR 1 , indicating that FGF receptor ( FGFR ) activation is necessary for induction of MT 1 MMP . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| They mimicked FGF 1 and FGF 2 for receptor binding , signal transduction , proliferation of endothelial cells and differentiation of the bladder carcinoma cell NBT 2 which expresses FGFR 2b but not FGFR 1 . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| We sought to examine FGF high and low affinity receptor ( FGFR ) expression , activation of FGFR 1 by acidic FGF ( FGF 1 ) , and proliferative effects on Y 79 cells . ^^^ Tyrosine phosphorylation of FGFR 1 induced by FGF was examined by immunoprecipitation after stimulation with FGF 1 in the presence or absence of heparin . ^^^ Retinoblastoma proliferation was monitored by radiolabeled thymidine incorporation or a vital dye based assay , after addition of FGF 1 with or without inclusion of a specific FGFR 1 neutralizing antibody or FGFR 1 antisense oligonucleotides . ^^^ The FGFR 1 was differentially phosphorylated in a time and heparin dependent manner by FGF 1 . ^^^ Proliferation of Y 79 cells induced by FGF 1 was entirely mediated by FGFR 1 , since inclusion of specific neutralizing antibodies or antisense oligonucleotides completely prevented tumor cell multiplication . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| Chronic obstructive pulmonary disease is associated with enhanced bronchial expression of FGF 1 , FGF 2 , and FGFR 1 . ^^^ In this study , the role of fibroblast growth factors ( FGF 1 and FGF 2 ) and their receptor , FGFR 1 , was assessed in bronchial airway wall remodelling in patients with COPD ( FEV 1 < 75 % ; n = 15 ) and without COPD ( FEV 1 > 85 % ; n = 16 ) . ^^^ FGF 1 and FGFR 1 were immunolocalized in bronchial epithelium , airway smooth muscle ( ASM ) , submucosal glandular epithelium , and vascular smooth muscle . ^^^ Elevated levels of FGFR 1 in ASM ( p < 0 . 005 ) and of FGF 1 ( p < 0 . 04 ) and FGFR 1 ( p < 0 . 001 ) in bronchial epithelium were observed . ^^^ Steady state mRNA levels of FGFR 1 were elevated in human ASM cells treated with either FGF 1 or FGF 2 . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| FGF 1 induced accumulation of the FGF receptor 1 ( FGFR 1 ) in astrocyte nuclei and potently stimulated nerve growth factor ( NGF ) expression and secretion . ^^^ In the degenerating spinal cord of mice carrying the ALS mutation G93A of Cu , Zn superoxide dismutase , FGF 1 was no longer localized only in the cytosol of motor neurons , while FGFR 1 accumulated in the nuclei of reactive astrocytes . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| A possible connection between the ERK 2 and JNK 1 MAP kinases transduction cascades was investigated in Xenopus oocytes expressing FGFR 1 stimulated by FGF 1 . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| After longer incubation times , FGF 1 internalized in cells expressing FGFR 1 was localized mainly to late endosomes / lysosomes , similarly to EGF . ^^^ In cells expressing FGFR 2 or FGFR 3 , sorting of FGF 1 to lysosomes was somewhat less efficient than that observed for FGFR 1 . ^^^ Furthermore , FGF 1 was more slowly degraded in cells expressing FGFR 4 than in cells expressing FGFR 1 3 and in addition , internalized FGFR 4 as such was more slowly degraded than the other receptors . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| In liver samples , the expression of FGF 1 and FGF 2 and of FGF receptors ( FGFRs ; FGFR 1 , FGFR 2 ) was significantly elevated with time after bone marrow transplantation ( BMT ) compared with other factors , and co expression of GFP and FGFs or FGFRs could be detected . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| Immunolocalization of fibroblast growth factor 1 ( FGF 1 ) , its receptor ( FGFR 1 ) , and fibroblast specific protein 1 ( FSP 1 ) in inflammatory renal disease . ^^^ We examined the expression of FGF 1 and FGF receptor ( FGFR 1 ) to determine if renal diseases with varying etiologies of inflammation , including lupus nephritis ( LN ) , acute interstitial nephritis ( AIN ) and acute rejection superimposed on chronic allograft nephropathy ( CAN ) , showed varying patterns of expression . ^^^ Double staining with CD 68 and separate immunohistochemical staining for CD 4 and CD 8 with serial sections analysis were done to identify if T lymphocytes or macrophages showed staining for FGF 1 and FGFR 1 or FSP 1 . ^^^ Infiltrating glomerular and interstitial inflammatory cells in diseased glomeruli also expressed FGF 1 and FGFR 1 . ^^^ Tubular cells expressed slightly increased FGFR 1 in renal diseases vs . normal , whereas tubules remained negative for FGF 1 in diseased kidneys . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| In the present study , we evaluated the expression of FGF 1 and FGF 2 as well as FGF receptors 1 4 ( FGFR 1 FGFR4 ) in 39 cases of Hodgkin ' s lymphoma , including all subtypes , as well as Hodgkin ' s lymphoma cell lines . ^^^ FGF 1 and FGF 2 and their receptors FGFR 2 FGFR4 , but not FGFR 1 , were found to be expressed by the malignant cells in the majority of cases . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| These exhibited a range of abilities to promote cell signalling through the FGF / FGFR tyrosine kinase signalling system , in an in vitro cell assay with combinations of FGF 1 , 2 , 3 and FGFR 1 and 3 . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| Fibroblast growth factor 1 ( FGF 1 ) can be released by motor neurons in response to damage to induce astrocyte activation by signaling through the receptor FGFR 1 . ^^^ |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05230 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|