| Interacting proteins: P51813 and P11309 |
Pubmed |
SVM Score :0.0 |
| Here , we present the evidence that two cytoplasmic kinases Pim 1 and Etk are involved in this process . ^^^ Furthermore , we showed that IL 6 downstream tyrosine kinase Etk can induce tyrosine phosphorylation of Pim 1 which is correlated with its kinase activity . ^^^ Interestingly , Etk can also be activated by Pim 1 when they are coexpressed in prostate cancer cells , suggesting a possible positive feedback loop between Etk and Pim 1 . ^^^ It appears that both Pim 1 and Etk are required for IL 6 induced activation of androgen receptor mediated transcription in prostate cancer cells because overexpression of the kinase deficient form of either Pim 1 or Etk dramatically blocks the IL 6 effect . ^^^ Taken together , our data suggest a synergism of Ser / Thr kinase Pim 1 and tyrosine kinase Etk in IL 6 signaling and provide new insights into ligand independent activation of androgen receptor in prostate cancer cells . . ^^^ |
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| Interacting proteins: P51813 and P11309 |
Pubmed |
SVM Score :0.0 |
| The 44 kDa Pim 1 kinase directly interacts with tyrosine kinase Etk / BMX and protects human prostate cancer cells from apoptosis induced by chemotherapeutic drugs . ^^^ The 44 kDa Pim 1 contains the proline rich motif at the N terminus and directly binds to the SH 3 domain of tyrosine kinase Etk . ^^^ |
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| Interacting proteins: P51813 and P11309 |
Pubmed |
SVM Score :0.0 |
| NA |
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