| Interacting proteins: O95644 and P11309 |
Pubmed |
SVM Score :0.51582049 |
| In this study we demonstrate that Pim 1 can physically interact with the NFATc 1 transcription factor and phosphorylate it in vitro on several serine residues . 0.51582049^^^ |
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| Interacting proteins: O95644 and P11309 |
Pubmed |
SVM Score :0.0 |
| Pim 1 kinase enhances NFATc activity and neuroendocrine functions in PC 12 cells . ^^^ The activity of NFATc family transcription factors is tightly regulated in T cells via signaling pathways initiated by stimulation of the T cell receptor or its downstream effectors such as the Pim 1 serine / threonine kinase . ^^^ Here , we demonstrate that NFATc dependent transcription is inducible also in NGF differentiated rat PC 12 pheochromocytoma cells treated with phorbol esthers , calcium ionophores and / or forskolin and that the Pim 1 kinase can further potentiate the effects of these agents . ^^^ |
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| Interacting proteins: O95644 and P11309 |
Pubmed |
SVM Score :0.0 |
| NA |
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