Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: P11308 and Q01543	Pubmed	SVM Score :0.82815555
Among the latter , we show that Fli 1 , Ets 2 , Er 81 and Pu 1 physically interact with Erg . 0.82815555^^^
Interacting proteins: P11308 and Q01543	Pubmed	SVM Score :0.0
The ERGB gene shows extensive amino acid identity to the human ERG and the mouse Fli 1 genes . ^^^
Interacting proteins: P11308 and Q01543	Pubmed	SVM Score :0.0
A genomic clone , isolated from a phage library prepared from the DNA of the sea urchin Lytechinus variegatus , was shown by sequence analysis to be a homolog of the ets family genes , ERG and Fli 1 . ^^^ The first 84 amino acids are homologous with all members of the ets gene family , while the remainder of the sequence is only homologous with the human ERG and murine Fli 1 genes . ^^^
Interacting proteins: P11308 and Q01543	Pubmed	SVM Score :0.0
Several genes related to the ets oncogene ( c ets 1 , ets 2 , erg , elk 1 , elk 2 , PU . 1 / Spi 1 , E 74 and Fli 1 ) have been described . ^^^
Interacting proteins: P11308 and Q01543	Pubmed	SVM Score :0.0
Ewing tumours ( ET ) , including Ewing ' s sarcoma and peripheral primitive neuroectodermal tumour , are well characterised at the molecular level by a unique chromosomal rearrangement which fuses the EWS gene to one of two closely related ETS proto oncogenes , FLI 1 or ERG . ^^^ We have analysed tumour derived material from 30 ET patients with well documented clinical course ( 18 with localised and 12 with metastatic disease at diagnosis ) for the presence of EWS / FLI 1 or EWS / ERG RNA . ^^^
Interacting proteins: P11308 and Q01543	Pubmed	SVM Score :0.0
The breakpoints have been cloned and were shown to fuse the EWS gene on chromosome 22 to one of two closely related ETS proto oncogenes , FLI 1 or ERG , which reside on chromosomes 2 and 21 , respectively . ^^^
Interacting proteins: P11308 and Q01543	Pubmed	SVM Score :0.0
Nucleotide sequence analysis revealed that the human Fli 1 gene codes for a 452 residue protein the predicted amino sequence of which shows 80 % homology to the human erg 2 protein previously described . ^^^ This 3 ' ets homology domain , which is mainly responsible for DNA binding activity , is seen in all the ets family members ; however , the 5 ' ets homology region is conserved in only five genes , Fli 1 , c ets 1 , ets 2 , GABP alpha , and erg , suggesting a common biological function which is shared among these genes . ^^^
Interacting proteins: P11308 and Q01543	Pubmed	SVM Score :0.0
EWS erg and EWS Fli 1 fusion transcripts in Ewing ' s sarcoma and primitive neuroectodermal tumors with variant translocations . ^^^
Interacting proteins: P11308 and Q01543	Pubmed	SVM Score :0.0
In these tumors , the EWS is fused to genes encoding transcriptional activators / repressors , like Fli 1 or erg or ATF 1 or wt 1 . ^^^
Interacting proteins: P11308 and Q01543	Pubmed	SVM Score :0.0
Identical EWS nucleotide sequences found in the EWS / FLI 1 fusion transcripts are fused to portions of ERG encoding an ETS DNA binding domain resulting in expression of a hybrid EWS / ERG protein . ^^^
Interacting proteins: P11308 and Q01543	Pubmed	SVM Score :0.0
The 5 ' half of the EWS gene has recently been described to be fused to the 3 ' regions of genes encoding the DNA binding domain of several transcriptional regulators , including ATF 1 , FLI 1 , and ERG , in several human tumors . ^^^
Interacting proteins: P11308 and Q01543	Pubmed	SVM Score :0.0
EWS FLI 1 and EWS ERG chimeric mRNAs in Ewing ' s sarcoma and primitive neuroectodermal tumor . ^^^ In these translocations , the amino terminal portion of the EWS gene located in 22q12 fuses to the carboxyl terminal portion of the FLI 1 gene located in 11q24 or the ERG gene located in 21q22 , which belong to the ets oncogene superfamily of transcription activators . ^^^ We detected 2 types of EWS ERG chimeric mRNA in 2 ES cell lines and 1 PNET tumor sample in addition to 4 types of EWS FLI 1 chimeric mRNA in 11 ESs ( 4 cell lines and 7 tumor samples ) and 4 PNETs ( 2 cell lines and 2 tumor samples ) . ^^^
Interacting proteins: P11308 and Q01543	Pubmed	SVM Score :0.0
Recently , Ewing ' s tumours have been shown to carry specific hybrid transcripts resulting from the fusion of the EWS gene with FLI 1 or ERG genes . ^^^ EWS / FLI 1 and EWS / ERG transcripts being observed in eight and two cases respectively . ^^^
Interacting proteins: P11308 and Q01543	Pubmed	SVM Score :0.0
These rearrangements fuse the EWS gene on chromosome 22q12 to either the FLI 1 or ERG genes , both members of the ETS family of transcription factors . ^^^ Identical EWS nucleotide sequences found in the majority of EWS FLI 1 and EWS ERG chimeric transcripts are fused to a portion of ETV 1 encoding an ETS domain with sequence specific DNA binding activity . ^^^
Interacting proteins: P11308 and Q01543	Pubmed	SVM Score :0.0
As a result of acquired chromosome rearrangement , the N terminal portion of the EWS protein is fused to the DNA binding domain of either FLI 1 or ERG in the Ewing family of tumors and to the DNA binding domain of ATF 1 in malignant melanoma of soft parts . ^^^
Interacting proteins: P11308 and Q01543	Pubmed	SVM Score :0.0
Greater than 95 % of pPNETs carry t ( 11 ; 22 ) or t ( 21 ; 22 ) chromosomal translocations which fuse the EWS gene from chromosome 22q12 in frame with either FLI 1 from chromosome 11q24 or ERG from chromosome 21q22 . ^^^
Interacting proteins: P11308 and Q01543	Pubmed	SVM Score :0.0
In 20 of 22 ET , a gene rearrangement was identified which resulted in the substitution of the effector domain of one of the closely related DNA binding oncogenes , FLI 1 or ERG , by the transactivating domain of a new gene , EWS . ^^^
Interacting proteins: P11308 and Q01543	Pubmed	SVM Score :0.0
In Ewing ' s sarcomas and related peripheral primitive neuroectodermal tumors , a t ( 11 ; 22 ) translocation or a ( 21 , 22 ) rearrangement is associated with hybrid transcripts of the EWS gene with the FLI 1 or ERG gene . ^^^
Interacting proteins: P11308 and Q01543	Pubmed	SVM Score :0.0
In Ewing tumors EWS can be fused to four different members of the ETS family , namely FLI 1 , ERG , ETV 1 and E1AF . ^^^ FEV encodes a 238 amino acid protein which contains an ETS DNA binding domain closely related to that of FLI 1 and ERG . ^^^ However , the N terminal portion of FEV is only 42 amino acids long which suggests that FEV is lacking important transcription regulatory domains contained in FLI 1 and ERG N terminal parts . ^^^
Interacting proteins: P11308 and Q01543	Pubmed	SVM Score :0.0
The Ewing family of tumors is recurrently characterized at the molecular level by the presence of a fusion transcript between the EWS gene on chromosome 22 and either the FLI 1 or ERG genes , 2 closely related members of the Ets family of transcription factors . ^^^
Interacting proteins: P11308 and Q01543	Pubmed	SVM Score :0.0
The present analysis of 89 Ewing ' s sarcomas and related tumours show that in addition to the expected EWS FLI 1 fusion , the EWS gene can be fused to ERG , a transcription factor closely related to FLI 1 but located on chromosome 21 . ^^^ All 13 different fusion proteins that were evidenced contained the N terminal domain of EWS and the Ets domain of FLI 1 or ERG suggesting that oncogenic conversion is achieved by the linking of the two domains with no marked constraint on the connecting peptide . . ^^^
Interacting proteins: P11308 and Q01543	Pubmed	SVM Score :0.0
We have previously isolated and characterized the human Fli 1 gene and have found it to be highly homologous ( 80 % ) to the human erg 2 gene . ^^^ It appears that Fli 1 and erg proteins fall into the category of ets proteins that recognize limited ets target sequences , unlike c ets 1 , ets 2 and Elk 1 . ^^^
Interacting proteins: P11308 and Q01543	Pubmed	SVM Score :0.0
PURPOSE : Because of the high heterogeneity of EWS gene fusions with FLI 1 and ERG genes due to variable chromosomal breakpoint locations in Ewing tumors ( ET ) ( 14 different chimeric transcripts identified so far ) , we evaluated the clinical impact of the expression of diverse fusion transcripts in ET patients . ^^^
Interacting proteins: P11308 and Q01543	Pubmed	SVM Score :0.0
The breakpoints have been cloned and shown to fuse the Ewing sarcoma gene to one of two closely related ETS proto oncogens , FLI 1 or ERG , which reside on chromosomes 11 and 21 , respectively . ^^^
Interacting proteins: P11308 and Q01543	Pubmed	SVM Score :0.0
Among primitive neuroectodermal tumors , Ewing tumors are characterized by a gene rearrangement recombining the 5 ' EWS gene portion with one of two ETS related proto oncogenes , FLI 1 or ERG , in roughly 90 and 10 % of cases , respectively . ^^^
Interacting proteins: P11308 and Q01543	Pubmed	SVM Score :0.0
The EWS gene is fused in Ewing sarcoma like tumors by a chromosomal translocation to one of the four ETS family genes : FLI 1 , ERG , ETV 1 , and E1AF . ^^^ The orientation of EWS and FLI 1 on chromosomes 22 and 11 , respectively , is 5 ' centromeric and 3 ' telomeric , whereas that of ERG on chromosome 21 is the reverse . ^^^
Interacting proteins: P11308 and Q01543	Pubmed	SVM Score :0.0
Inhibition of apoptosis by normal and aberrant Fli 1 and erg proteins involved in human solid tumors and leukemias . ^^^ Two ets family members , namely erg and Fli 1 are fused with two EWS family members namely EWS and TLS / FUS as a result of chromosome translocation in human solid tumors and leukemias . ^^^ EWS erg and EWS Fli 1 , which are involved in greater than 95 % of Ewing family of tumors , were shown to function as transcriptional activators . ^^^ Expression of these fusion proteins ( EWS erg and EWS Fli 1 ) are shown to be essential for maintaining the oncogenic and tumorigenic properties of tumor cells . ^^^ Therefore , we have studied the role of normal ( Fli 1 and erg ) and aberrant fusion proteins ( EWS erg , EWS Fli 1 and TLS / FUS erg ) in apoptosis . ^^^
Interacting proteins: P11308 and Q01543	Pubmed	SVM Score :0.0
These molecular cytogenetic methods allowed us ( 1 ) to precisely localize the genomic breakpoints within EWSR 1 and EWSR 2 and to identify the chromosome carrying the fusion gene ; ( 2 ) to determine the nature of events generating the fusion genes ; ( 3 ) to demonstrate that some variant translocations represent masked complex translocations ; and ( 4 ) to show that the generation of an EWS / ERG fusion gene can not be obtained through a simple balanced translocation . . ^^^ These rearrangements generate an active fusion gene between the EWS gene and either the human FLI 1 gene or other members of the ETS gene family : the ERG gene localized in band 21q22 . 2 , the ETV 1 gene localized in band 7p22 , or the E1AF gene localized in band 17q12 . ^^^
Interacting proteins: P11308 and Q01543	Pubmed	SVM Score :0.0
Subsequently , a series of cellular Ets genes were isolated ( Ets 1 , Ets 2 , Erg , Elk 1 , Sap 1 , PEA 3 , PU . 1 , Fli 1 , Pok / Yan , Etv 1 etc . ) . ^^^
Interacting proteins: P11308 and Q01543	Pubmed	SVM Score :0.0
The 7 . 3 MoAb appears to be specific for FLI 1 because it does not react with ERG , the ETS family member most closely related to FLI 1 . ^^^
Interacting proteins: P11308 and Q01543	Pubmed	SVM Score :0.0
Molecular diagnosis of Ewing tumors : improved detection of EWS FLI 1 and EWS ERG chimeric transcripts and rapid determination of exon combinations . ^^^ Most Ewing tumors ( ET ) , including Ewing sarcomas , peripheral primitive neuroectodermal tumors ( PNET ) , and Askin ' s tumors , can be defined according to the specific chromosomal translocations t ( 11 ; 22 ) ( q 24 ; q 12 ) ( EWS FLI 1 ) or t ( 21 ; 22 ) ( q 21 ; q 12 ) ( EWS ERG ) . ^^^ Because of variable chromosomal breakpoint locations , however , the EWS gene fusions with FLI 1 and ERG genes are highly heterogenous , resulting in different sizes of the amplification products . ^^^
Interacting proteins: P11308 and Q01543	Pubmed	SVM Score :0.0
In more than 95 % of patients , the Ewing family of tumors ( ET ) has chimeric transcripts caused by fusion of the EWS gene to either FLI 1 or ERG . ^^^ The presence of specific EWS FLI 1 or EWS ERG transcripts in peripheral blood ( PB ) samples of patients being treated for ET was prospectively evaluated , and these data were correlated to their clinical status . ^^^
Interacting proteins: P11308 and Q01543	Pubmed	SVM Score :0.0
The Ewing ' s sarcoma ( ES ) family of tumors , including peripheral neuroectodermal tumor ( PNET ) , is defined genetically by specific chromosomal translocations resulting in fusion of the EWS gene with a member of the ETS family of transcription factors , either FLI 1 ( 90 95 % ) or ERG ( 5 10 % ) . ^^^ A second level of molecular genetic heterogeneity stems from the variation in the location of the translocation breakpoints , resulting in the inclusion of different combinations of exons from EWS and FLI 1 ( or ERG ) in the fusion products . ^^^ In a group of 86 ES / PNET with defined EWS ETS fusions ( 45 EWS FLI 1 type 1 , 27 EWS FLI 1 non type 1 , 14 EWS ERG ) , we assessed proliferation rate by immunostaining for Ki 67 using MIB 1 antibody ( n = 85 ) , apoptosis by TUNEL assay ( n = 66 ) , and IGF 1R expression by immunostaining with antibody 1H7 ( n = 78 ) . ^^^ Comparing EWS FLI 1 to EWS ERG cases , Ki 67 proliferative index was higher in the latter ( P = 0 . 01 , Mann Whitney test ; P = 0 . 02 , Fisher ' s exact test ) , but there was no significant difference in IGF 1R . ^^^
Interacting proteins: P11308 and Q01543	Pubmed	SVM Score :0.0
A comparison with Fli 1 , the most closely Erg related gene , revealed that both gene expressions partially overlap , suggesting that they may contribute to related functions in these tissues . ^^^
Interacting proteins: P11308 and Q01543	Pubmed	SVM Score :0.0
EWS FLI 1 , EWS ERG , and EWS ETV 1 oncoproteins of Ewing tumor family all suppress transcription of transforming growth factor beta type 2 receptor gene . ^^^ Ewing sarcoma specific chromosomal translocations fuse the EWS gene to a subset of ets transcription factor family members , most commonly the FLI 1 gene and less frequently ERG , ETV 1 , E1A F , or FEV . ^^^ We show that relative to the control , NIH 3T3 cell lines stably transfected with the EWS FLI 1 , EWS ERG , or EWS ETV 1 gene fusion express reduced levels of TGF beta RII mRNA and protein , and that these cell lines have reduced TGF beta sensitivity . ^^^ Cotransfection of these fusion genes and the TGF beta RII promoter suppresses TGF beta RII promoter activity and also FLI 1 , ERG , or ETV 1 induced promoter activity . ^^^ These results indicate that transcriptional repression of TGF beta RII is an important target of the EWS FLI 1 , EWS ERG , or EWS ETV 1 oncogene , and that EWS ets fusion proteins may function as dominant negative forms of ets transcription factors . . ^^^
Interacting proteins: P11308 and Q01543	Pubmed	SVM Score :0.0
Synergistic binding was observed in EMSA between AP 1 on the one hand , FLI 1 , ERG , and ETS 1 protein on the other . ^^^ The presence of regulatory sequences for transcription factors such as ETS 1 , FLI 1 , or ERG , whose activity is associated with cell proliferation , endothelial cell differentiation , and matrix metalloproteinase transduction , may be an indication of the important role that HO 1 may play in coronary collateral circulation , tumor growth , angiogenesis , and hemoglobin induced endothelial cell injuries . . ^^^
Interacting proteins: P11308 and Q01543	Pubmed	SVM Score :0.0
These populations were monitored for mRNA expression of the Erg , Ets 1 , Ets 2 , Fli 1 , Tel , Elf 1 , GABPalpha , PU . 1 and Spi B genes . ^^^
Interacting proteins: P11308 and Q01543	Pubmed	SVM Score :0.0
The Ewing family of tumors is characterized by recurrent reciprocal translocations that generate chimeric proteins , either EWS FLI 1 or EWS ERG . ^^^
Interacting proteins: P11308 and Q01543	Pubmed	SVM Score :0.0
Molecular modeling studies have revealed that the spatial structure of ETS domain of Nd Ets and Nd Erg was conserved , in comparison to the murine Ets 1 and human Fli 1 proteins , respectively . . ^^^
Interacting proteins: P11308 and Q01543	Pubmed	SVM Score :0.0
Ewing sarcoma ( ES ) and peripheral primitive neuroectodermal tumors ( PNETs ) are associated with a chromosomal translocation resulting in a fusion of the amino terminus of EWS with the DNA binding domain of an ETS transcription factor ( most commonly FLI 1 or ERG ) . ^^^
Interacting proteins: P11308 and Q01543	Pubmed	SVM Score :0.0
All of the fusion genes reported to date in Ewing ' s tumors juxtapose the EWS gene at 22q12 to an ETS related gene , the most common of which are FLI 1 at 11q24 and ERG at 21q22 . ^^^
Interacting proteins: P11308 and Q01543	Pubmed	SVM Score :0.0
Ewing sarcoma family of tumors share recurrent translocations that fuse EWS from 22q12 to five different members of transcription factors namely FLI 1 , ERG , ETV 1 , E1AF and FEV . ^^^
Interacting proteins: P11308 and Q01543	Pubmed	SVM Score :0.0
The primary genetic alteration in ES / PNET , the fusion of the EWS gene with FLI 1 or ERG , is diagnostically highly specific for these tumors , and molecular variation in the structure of the EWS FLI 1 fusion gene also is of prognostic significance . ^^^
Interacting proteins: P11308 and Q01543	Pubmed	SVM Score :0.0
BACKGROUND : The primary genetic alteration in > 95 % of Ewing sarcomas ( ES ) is a specific fusion of EWS with FLI 1 or ERG . ^^^
Interacting proteins: P11308 and Q01543	Pubmed	SVM Score :0.0
This group of tumors is defined by the consistent presence of chromosomal translocations resulting in gene fusions between EWS gene and a member of the ETS family of transcription factors , mainly FLI 1 and ERG . ^^^
Interacting proteins: P11308 and Q01543	Pubmed	SVM Score :0.0
It expresses specific chimeric genes ( EWS FLI 1 , EWS ERG , EWS ETV 1 , and EWS E1AF ) , the 3 ' portions of which are all members of the ETS family . ^^^ ETS related proteins , such as FLI 1 , ERG , and E1AF , transactivate the promoters of matrix metalloproteinase ( MMP ) genes , which play important roles in the processes of invasion and metastasis . ^^^
Interacting proteins: P11308 and Q01543	Pubmed	SVM Score :0.0
These reciprocal functional interactions extended to other nuclear receptors such as thyroid hormone and retinoic acid receptors , as well as to Fli 1 , an ERG related ETS factor . ^^^
Interacting proteins: P11308 and Q01543	Pubmed	SVM Score :0.0
In contrast to Tel and Yan , which self associate to form insoluble polymers , we also show that the isolated PNT domains from Ets 1 , Ets 2 , Erg , Fli 1 , GABPalpha , and Pnt P 2 are monomeric in solution . ^^^
Interacting proteins: P11308 and Q01543	Pubmed	SVM Score :0.0
In ES / PNET , the EWS gene is juxtaposed to the FLI 1 gene in 85 % of cases and to the ERG gene in another 7 % of cases ; the EWS gene is juxtaposed to the WTI gene in DSRCT . ^^^
Interacting proteins: P11308 and Q01543	Pubmed	SVM Score :0.0
The FLI 1 transcription factor is a member of the ETS gene family , most closely related to ERG . ^^^ FLI 1 phosphorylation is not stimulated by phorbal 12 myristate 13 acetate ( PMA ) , a protein kinase C activator , and in this it differs from ERG protein phosphorylation . ^^^ Our data suggest that although the FLI 1 and ERG genes are highly homologous , their distinct properties may contribute to their different roles in gene regulation . . ^^^
Interacting proteins: P11308 and Q01543	Pubmed	SVM Score :0.0
This article addresses the problem by considering the tissue distribution of FLI 1 and ERG expression and by reviewing evidence for combinatorial control of EWS ets activity . . ^^^
Interacting proteins: P11308 and Q01543	Pubmed	SVM Score :0.0
Endoglin expression in the endothelium is regulated by Fli 1 , Erg , and Elf 1 acting on the promoter and a 8 kb enhancer . ^^^ Subsequent molecular analysis demonstrated that both the 8 enhancer and the promoter depend on conserved Ets sites , which were bound in endothelial cells in vivo by Fli 1 , Erg , and Elf 1 . ^^^
Interacting proteins: P11308 and Q01543	Pubmed	SVM Score :0.0
Here we show that those Ets family proteins that participate in Ewing ' s sarcoma , including Fli 1 , ERG , and ETV 1 , cooperatively bind these tandem elements with Fos Jun while other Ets family members do not . ^^^
Interacting proteins: P11308 and Q01543	Pubmed	SVM Score :0.0
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Interacting proteins: P11308 and Q01543	Pubmed	SVM Score :0.0
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Interacting proteins: P11308 and Q01543	Pubmed	SVM Score :0.0
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Interacting proteins: P11308 and Q01543	Pubmed	SVM Score :0.0
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Interacting proteins: P11308 and Q01543	Pubmed	SVM Score :0.0
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Interacting proteins: P11308 and Q01543	Pubmed	SVM Score :0.0
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Interacting proteins: P11308 and Q01543	Pubmed	SVM Score :0.0
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Interacting proteins: P11308 and Q01543	Pubmed	SVM Score :0.0
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Interacting proteins: Q01543 and P11308	Pubmed	SVM Score :0.82815555
Among the latter , we show that Fli 1 , Ets 2 , Er 81 and Pu 1 physically interact with Erg . 0.82815555^^^
Interacting proteins: Q01543 and P11308	Pubmed	SVM Score :0.0
These molecular cytogenetic methods allowed us ( 1 ) to precisely localize the genomic breakpoints within EWSR 1 and EWSR 2 and to identify the chromosome carrying the fusion gene ; ( 2 ) to determine the nature of events generating the fusion genes ; ( 3 ) to demonstrate that some variant translocations represent masked complex translocations ; and ( 4 ) to show that the generation of an EWS / ERG fusion gene can not be obtained through a simple balanced translocation . . ^^^
Interacting proteins: Q01543 and P11308	Pubmed	SVM Score :0.0
A genomic clone , isolated from a phage library prepared from the DNA of the sea urchin Lytechinus variegatus , was shown by sequence analysis to be a homolog of the ets family genes , ERG and Fli 1 . ^^^ The first 84 amino acids are homologous with all members of the ets gene family , while the remainder of the sequence is only homologous with the human ERG and murine Fli 1 genes . ^^^
Interacting proteins: Q01543 and P11308	Pubmed	SVM Score :0.0
Several genes related to the ets oncogene ( c ets 1 , ets 2 , erg , elk 1 , elk 2 , PU . 1 / Spi 1 , E 74 and Fli 1 ) have been described . ^^^
Interacting proteins: Q01543 and P11308	Pubmed	SVM Score :0.0
Ewing tumours ( ET ) , including Ewing ' s sarcoma and peripheral primitive neuroectodermal tumour , are well characterised at the molecular level by a unique chromosomal rearrangement which fuses the EWS gene to one of two closely related ETS proto oncogenes , FLI 1 or ERG . ^^^ We have analysed tumour derived material from 30 ET patients with well documented clinical course ( 18 with localised and 12 with metastatic disease at diagnosis ) for the presence of EWS / FLI 1 or EWS / ERG RNA . ^^^
Interacting proteins: Q01543 and P11308	Pubmed	SVM Score :0.0
The breakpoints have been cloned and were shown to fuse the EWS gene on chromosome 22 to one of two closely related ETS proto oncogenes , FLI 1 or ERG , which reside on chromosomes 2 and 21 , respectively . ^^^
Interacting proteins: Q01543 and P11308	Pubmed	SVM Score :0.0
EWS FLI 1 and EWS ERG chimeric mRNAs in Ewing ' s sarcoma and primitive neuroectodermal tumor . ^^^ In these translocations , the amino terminal portion of the EWS gene located in 22q12 fuses to the carboxyl terminal portion of the FLI 1 gene located in 11q24 or the ERG gene located in 21q22 , which belong to the ets oncogene superfamily of transcription activators . ^^^ We detected 2 types of EWS ERG chimeric mRNA in 2 ES cell lines and 1 PNET tumor sample in addition to 4 types of EWS FLI 1 chimeric mRNA in 11 ESs ( 4 cell lines and 7 tumor samples ) and 4 PNETs ( 2 cell lines and 2 tumor samples ) . ^^^
Interacting proteins: Q01543 and P11308	Pubmed	SVM Score :0.0
Recently , Ewing ' s tumours have been shown to carry specific hybrid transcripts resulting from the fusion of the EWS gene with FLI 1 or ERG genes . ^^^ EWS / FLI 1 and EWS / ERG transcripts being observed in eight and two cases respectively . ^^^
Interacting proteins: Q01543 and P11308	Pubmed	SVM Score :0.0
Nucleotide sequence analysis revealed that the human Fli 1 gene codes for a 452 residue protein the predicted amino sequence of which shows 80 % homology to the human erg 2 protein previously described . ^^^ This 3 ' ets homology domain , which is mainly responsible for DNA binding activity , is seen in all the ets family members ; however , the 5 ' ets homology region is conserved in only five genes , Fli 1 , c ets 1 , ets 2 , GABP alpha , and erg , suggesting a common biological function which is shared among these genes . ^^^
Interacting proteins: Q01543 and P11308	Pubmed	SVM Score :0.0
The ERGB gene shows extensive amino acid identity to the human ERG and the mouse Fli 1 genes . ^^^
Interacting proteins: Q01543 and P11308	Pubmed	SVM Score :0.0
As a result of acquired chromosome rearrangement , the N terminal portion of the EWS protein is fused to the DNA binding domain of either FLI 1 or ERG in the Ewing family of tumors and to the DNA binding domain of ATF 1 in malignant melanoma of soft parts . ^^^
Interacting proteins: Q01543 and P11308	Pubmed	SVM Score :0.0
Greater than 95 % of pPNETs carry t ( 11 ; 22 ) or t ( 21 ; 22 ) chromosomal translocations which fuse the EWS gene from chromosome 22q12 in frame with either FLI 1 from chromosome 11q24 or ERG from chromosome 21q22 . ^^^
Interacting proteins: Q01543 and P11308	Pubmed	SVM Score :0.0
In 20 of 22 ET , a gene rearrangement was identified which resulted in the substitution of the effector domain of one of the closely related DNA binding oncogenes , FLI 1 or ERG , by the transactivating domain of a new gene , EWS . ^^^
Interacting proteins: Q01543 and P11308	Pubmed	SVM Score :0.0
In Ewing ' s sarcomas and related peripheral primitive neuroectodermal tumors , a t ( 11 ; 22 ) translocation or a ( 21 , 22 ) rearrangement is associated with hybrid transcripts of the EWS gene with the FLI 1 or ERG gene . ^^^
Interacting proteins: Q01543 and P11308	Pubmed	SVM Score :0.0
EWS erg and EWS Fli 1 fusion transcripts in Ewing ' s sarcoma and primitive neuroectodermal tumors with variant translocations . ^^^
Interacting proteins: Q01543 and P11308	Pubmed	SVM Score :0.0
In these tumors , the EWS is fused to genes encoding transcriptional activators / repressors , like Fli 1 or erg or ATF 1 or wt 1 . ^^^
Interacting proteins: Q01543 and P11308	Pubmed	SVM Score :0.0
These rearrangements fuse the EWS gene on chromosome 22q12 to either the FLI 1 or ERG genes , both members of the ETS family of transcription factors . ^^^ Identical EWS nucleotide sequences found in the majority of EWS FLI 1 and EWS ERG chimeric transcripts are fused to a portion of ETV 1 encoding an ETS domain with sequence specific DNA binding activity . ^^^
Interacting proteins: Q01543 and P11308	Pubmed	SVM Score :0.0
Identical EWS nucleotide sequences found in the EWS / FLI 1 fusion transcripts are fused to portions of ERG encoding an ETS DNA binding domain resulting in expression of a hybrid EWS / ERG protein . ^^^
Interacting proteins: Q01543 and P11308	Pubmed	SVM Score :0.0
The 5 ' half of the EWS gene has recently been described to be fused to the 3 ' regions of genes encoding the DNA binding domain of several transcriptional regulators , including ATF 1 , FLI 1 , and ERG , in several human tumors . ^^^
Interacting proteins: Q01543 and P11308	Pubmed	SVM Score :0.0
The Ewing family of tumors is recurrently characterized at the molecular level by the presence of a fusion transcript between the EWS gene on chromosome 22 and either the FLI 1 or ERG genes , 2 closely related members of the Ets family of transcription factors . ^^^
Interacting proteins: Q01543 and P11308	Pubmed	SVM Score :0.0
The present analysis of 89 Ewing ' s sarcomas and related tumours show that in addition to the expected EWS FLI 1 fusion , the EWS gene can be fused to ERG , a transcription factor closely related to FLI 1 but located on chromosome 21 . ^^^ All 13 different fusion proteins that were evidenced contained the N terminal domain of EWS and the Ets domain of FLI 1 or ERG suggesting that oncogenic conversion is achieved by the linking of the two domains with no marked constraint on the connecting peptide . . ^^^
Interacting proteins: Q01543 and P11308	Pubmed	SVM Score :0.0
We have previously isolated and characterized the human Fli 1 gene and have found it to be highly homologous ( 80 % ) to the human erg 2 gene . ^^^ It appears that Fli 1 and erg proteins fall into the category of ets proteins that recognize limited ets target sequences , unlike c ets 1 , ets 2 and Elk 1 . ^^^
Interacting proteins: Q01543 and P11308	Pubmed	SVM Score :0.0
PURPOSE : Because of the high heterogeneity of EWS gene fusions with FLI 1 and ERG genes due to variable chromosomal breakpoint locations in Ewing tumors ( ET ) ( 14 different chimeric transcripts identified so far ) , we evaluated the clinical impact of the expression of diverse fusion transcripts in ET patients . ^^^
Interacting proteins: Q01543 and P11308	Pubmed	SVM Score :0.0
The breakpoints have been cloned and shown to fuse the Ewing sarcoma gene to one of two closely related ETS proto oncogens , FLI 1 or ERG , which reside on chromosomes 11 and 21 , respectively . ^^^
Interacting proteins: Q01543 and P11308	Pubmed	SVM Score :0.0
Among primitive neuroectodermal tumors , Ewing tumors are characterized by a gene rearrangement recombining the 5 ' EWS gene portion with one of two ETS related proto oncogenes , FLI 1 or ERG , in roughly 90 and 10 % of cases , respectively . ^^^
Interacting proteins: Q01543 and P11308	Pubmed	SVM Score :0.0
The EWS gene is fused in Ewing sarcoma like tumors by a chromosomal translocation to one of the four ETS family genes : FLI 1 , ERG , ETV 1 , and E1AF . ^^^ The orientation of EWS and FLI 1 on chromosomes 22 and 11 , respectively , is 5 ' centromeric and 3 ' telomeric , whereas that of ERG on chromosome 21 is the reverse . ^^^
Interacting proteins: Q01543 and P11308	Pubmed	SVM Score :0.0
In Ewing tumors EWS can be fused to four different members of the ETS family , namely FLI 1 , ERG , ETV 1 and E1AF . ^^^ FEV encodes a 238 amino acid protein which contains an ETS DNA binding domain closely related to that of FLI 1 and ERG . ^^^ However , the N terminal portion of FEV is only 42 amino acids long which suggests that FEV is lacking important transcription regulatory domains contained in FLI 1 and ERG N terminal parts . ^^^
Interacting proteins: Q01543 and P11308	Pubmed	SVM Score :0.0
Inhibition of apoptosis by normal and aberrant Fli 1 and erg proteins involved in human solid tumors and leukemias . ^^^ Two ets family members , namely erg and Fli 1 are fused with two EWS family members namely EWS and TLS / FUS as a result of chromosome translocation in human solid tumors and leukemias . ^^^ EWS erg and EWS Fli 1 , which are involved in greater than 95 % of Ewing family of tumors , were shown to function as transcriptional activators . ^^^ Expression of these fusion proteins ( EWS erg and EWS Fli 1 ) are shown to be essential for maintaining the oncogenic and tumorigenic properties of tumor cells . ^^^ Therefore , we have studied the role of normal ( Fli 1 and erg ) and aberrant fusion proteins ( EWS erg , EWS Fli 1 and TLS / FUS erg ) in apoptosis . ^^^
Interacting proteins: Q01543 and P11308	Pubmed	SVM Score :0.0
Subsequently , a series of cellular Ets genes were isolated ( Ets 1 , Ets 2 , Erg , Elk 1 , Sap 1 , PEA 3 , PU . 1 , Fli 1 , Pok / Yan , Etv 1 etc . ) . ^^^
Interacting proteins: Q01543 and P11308	Pubmed	SVM Score :0.0
The 7 . 3 MoAb appears to be specific for FLI 1 because it does not react with ERG , the ETS family member most closely related to FLI 1 . ^^^
Interacting proteins: Q01543 and P11308	Pubmed	SVM Score :0.0
Molecular diagnosis of Ewing tumors : improved detection of EWS FLI 1 and EWS ERG chimeric transcripts and rapid determination of exon combinations . ^^^ Most Ewing tumors ( ET ) , including Ewing sarcomas , peripheral primitive neuroectodermal tumors ( PNET ) , and Askin ' s tumors , can be defined according to the specific chromosomal translocations t ( 11 ; 22 ) ( q 24 ; q 12 ) ( EWS FLI 1 ) or t ( 21 ; 22 ) ( q 21 ; q 12 ) ( EWS ERG ) . ^^^ Because of variable chromosomal breakpoint locations , however , the EWS gene fusions with FLI 1 and ERG genes are highly heterogenous , resulting in different sizes of the amplification products . ^^^
Interacting proteins: Q01543 and P11308	Pubmed	SVM Score :0.0
In more than 95 % of patients , the Ewing family of tumors ( ET ) has chimeric transcripts caused by fusion of the EWS gene to either FLI 1 or ERG . ^^^ The presence of specific EWS FLI 1 or EWS ERG transcripts in peripheral blood ( PB ) samples of patients being treated for ET was prospectively evaluated , and these data were correlated to their clinical status . ^^^
Interacting proteins: Q01543 and P11308	Pubmed	SVM Score :0.0
Synergistic binding was observed in EMSA between AP 1 on the one hand , FLI 1 , ERG , and ETS 1 protein on the other . ^^^ The presence of regulatory sequences for transcription factors such as ETS 1 , FLI 1 , or ERG , whose activity is associated with cell proliferation , endothelial cell differentiation , and matrix metalloproteinase transduction , may be an indication of the important role that HO 1 may play in coronary collateral circulation , tumor growth , angiogenesis , and hemoglobin induced endothelial cell injuries . . ^^^
Interacting proteins: Q01543 and P11308	Pubmed	SVM Score :0.0
These populations were monitored for mRNA expression of the Erg , Ets 1 , Ets 2 , Fli 1 , Tel , Elf 1 , GABPalpha , PU . 1 and Spi B genes . ^^^
Interacting proteins: Q01543 and P11308	Pubmed	SVM Score :0.0
The Ewing family of tumors is characterized by recurrent reciprocal translocations that generate chimeric proteins , either EWS FLI 1 or EWS ERG . ^^^
Interacting proteins: Q01543 and P11308	Pubmed	SVM Score :0.0
The Ewing ' s sarcoma ( ES ) family of tumors , including peripheral neuroectodermal tumor ( PNET ) , is defined genetically by specific chromosomal translocations resulting in fusion of the EWS gene with a member of the ETS family of transcription factors , either FLI 1 ( 90 95 % ) or ERG ( 5 10 % ) . ^^^ A second level of molecular genetic heterogeneity stems from the variation in the location of the translocation breakpoints , resulting in the inclusion of different combinations of exons from EWS and FLI 1 ( or ERG ) in the fusion products . ^^^ In a group of 86 ES / PNET with defined EWS ETS fusions ( 45 EWS FLI 1 type 1 , 27 EWS FLI 1 non type 1 , 14 EWS ERG ) , we assessed proliferation rate by immunostaining for Ki 67 using MIB 1 antibody ( n = 85 ) , apoptosis by TUNEL assay ( n = 66 ) , and IGF 1R expression by immunostaining with antibody 1H7 ( n = 78 ) . ^^^ Comparing EWS FLI 1 to EWS ERG cases , Ki 67 proliferative index was higher in the latter ( P = 0 . 01 , Mann Whitney test ; P = 0 . 02 , Fisher ' s exact test ) , but there was no significant difference in IGF 1R . ^^^
Interacting proteins: Q01543 and P11308	Pubmed	SVM Score :0.0
A comparison with Fli 1 , the most closely Erg related gene , revealed that both gene expressions partially overlap , suggesting that they may contribute to related functions in these tissues . ^^^
Interacting proteins: Q01543 and P11308	Pubmed	SVM Score :0.0
EWS FLI 1 , EWS ERG , and EWS ETV 1 oncoproteins of Ewing tumor family all suppress transcription of transforming growth factor beta type 2 receptor gene . ^^^ Ewing sarcoma specific chromosomal translocations fuse the EWS gene to a subset of ets transcription factor family members , most commonly the FLI 1 gene and less frequently ERG , ETV 1 , E1A F , or FEV . ^^^ We show that relative to the control , NIH 3T3 cell lines stably transfected with the EWS FLI 1 , EWS ERG , or EWS ETV 1 gene fusion express reduced levels of TGF beta RII mRNA and protein , and that these cell lines have reduced TGF beta sensitivity . ^^^ Cotransfection of these fusion genes and the TGF beta RII promoter suppresses TGF beta RII promoter activity and also FLI 1 , ERG , or ETV 1 induced promoter activity . ^^^ These results indicate that transcriptional repression of TGF beta RII is an important target of the EWS FLI 1 , EWS ERG , or EWS ETV 1 oncogene , and that EWS ets fusion proteins may function as dominant negative forms of ets transcription factors . . ^^^
Interacting proteins: Q01543 and P11308	Pubmed	SVM Score :0.0
Ewing sarcoma family of tumors share recurrent translocations that fuse EWS from 22q12 to five different members of transcription factors namely FLI 1 , ERG , ETV 1 , E1AF and FEV . ^^^
Interacting proteins: Q01543 and P11308	Pubmed	SVM Score :0.0
The primary genetic alteration in ES / PNET , the fusion of the EWS gene with FLI 1 or ERG , is diagnostically highly specific for these tumors , and molecular variation in the structure of the EWS FLI 1 fusion gene also is of prognostic significance . ^^^
Interacting proteins: Q01543 and P11308	Pubmed	SVM Score :0.0
BACKGROUND : The primary genetic alteration in > 95 % of Ewing sarcomas ( ES ) is a specific fusion of EWS with FLI 1 or ERG . ^^^
Interacting proteins: Q01543 and P11308	Pubmed	SVM Score :0.0
This group of tumors is defined by the consistent presence of chromosomal translocations resulting in gene fusions between EWS gene and a member of the ETS family of transcription factors , mainly FLI 1 and ERG . ^^^
Interacting proteins: Q01543 and P11308	Pubmed	SVM Score :0.0
It expresses specific chimeric genes ( EWS FLI 1 , EWS ERG , EWS ETV 1 , and EWS E1AF ) , the 3 ' portions of which are all members of the ETS family . ^^^ ETS related proteins , such as FLI 1 , ERG , and E1AF , transactivate the promoters of matrix metalloproteinase ( MMP ) genes , which play important roles in the processes of invasion and metastasis . ^^^
Interacting proteins: Q01543 and P11308	Pubmed	SVM Score :0.0
Molecular modeling studies have revealed that the spatial structure of ETS domain of Nd Ets and Nd Erg was conserved , in comparison to the murine Ets 1 and human Fli 1 proteins , respectively . . ^^^
Interacting proteins: Q01543 and P11308	Pubmed	SVM Score :0.0
Ewing sarcoma ( ES ) and peripheral primitive neuroectodermal tumors ( PNETs ) are associated with a chromosomal translocation resulting in a fusion of the amino terminus of EWS with the DNA binding domain of an ETS transcription factor ( most commonly FLI 1 or ERG ) . ^^^
Interacting proteins: Q01543 and P11308	Pubmed	SVM Score :0.0
All of the fusion genes reported to date in Ewing ' s tumors juxtapose the EWS gene at 22q12 to an ETS related gene , the most common of which are FLI 1 at 11q24 and ERG at 21q22 . ^^^
Interacting proteins: Q01543 and P11308	Pubmed	SVM Score :0.0
These reciprocal functional interactions extended to other nuclear receptors such as thyroid hormone and retinoic acid receptors , as well as to Fli 1 , an ERG related ETS factor . ^^^
Interacting proteins: Q01543 and P11308	Pubmed	SVM Score :0.0
In contrast to Tel and Yan , which self associate to form insoluble polymers , we also show that the isolated PNT domains from Ets 1 , Ets 2 , Erg , Fli 1 , GABPalpha , and Pnt P 2 are monomeric in solution . ^^^
Interacting proteins: Q01543 and P11308	Pubmed	SVM Score :0.0
In ES / PNET , the EWS gene is juxtaposed to the FLI 1 gene in 85 % of cases and to the ERG gene in another 7 % of cases ; the EWS gene is juxtaposed to the WTI gene in DSRCT . ^^^
Interacting proteins: Q01543 and P11308	Pubmed	SVM Score :0.0
The FLI 1 transcription factor is a member of the ETS gene family , most closely related to ERG . ^^^ FLI 1 phosphorylation is not stimulated by phorbal 12 myristate 13 acetate ( PMA ) , a protein kinase C activator , and in this it differs from ERG protein phosphorylation . ^^^ Our data suggest that although the FLI 1 and ERG genes are highly homologous , their distinct properties may contribute to their different roles in gene regulation . . ^^^
Interacting proteins: Q01543 and P11308	Pubmed	SVM Score :0.0
This article addresses the problem by considering the tissue distribution of FLI 1 and ERG expression and by reviewing evidence for combinatorial control of EWS ets activity . . ^^^
Interacting proteins: Q01543 and P11308	Pubmed	SVM Score :0.0
Endoglin expression in the endothelium is regulated by Fli 1 , Erg , and Elf 1 acting on the promoter and a 8 kb enhancer . ^^^ Subsequent molecular analysis demonstrated that both the 8 enhancer and the promoter depend on conserved Ets sites , which were bound in endothelial cells in vivo by Fli 1 , Erg , and Elf 1 . ^^^
Interacting proteins: Q01543 and P11308	Pubmed	SVM Score :0.0
Here we show that those Ets family proteins that participate in Ewing ' s sarcoma , including Fli 1 , ERG , and ETV 1 , cooperatively bind these tandem elements with Fos Jun while other Ets family members do not . ^^^
Interacting proteins: Q01543 and P11308	Pubmed	SVM Score :0.0
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Interacting proteins: Q01543 and P11308	Pubmed	SVM Score :0.0
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Interacting proteins: Q01543 and P11308	Pubmed	SVM Score :0.0
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Interacting proteins: Q01543 and P11308	Pubmed	SVM Score :0.0
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Interacting proteins: Q01543 and P11308	Pubmed	SVM Score :0.0
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Interacting proteins: Q01543 and P11308	Pubmed	SVM Score :0.0
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Interacting proteins: Q01543 and P11308	Pubmed	SVM Score :0.0
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Interacting proteins: Q01543 and P11308	Pubmed	SVM Score :0.0
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