| Interacting proteins: P11308 and P50549 |
Pubmed |
SVM Score :0.0 |
| Identical EWS nucleotide sequences found in the majority of EWS FLI 1 and EWS ERG chimeric transcripts are fused to a portion of ETV 1 encoding an ETS domain with sequence specific DNA binding activity . ^^^ |
|
| Interacting proteins: P11308 and P50549 |
Pubmed |
SVM Score :0.0 |
| The EWS gene is fused in Ewing sarcoma like tumors by a chromosomal translocation to one of the four ETS family genes : FLI 1 , ERG , ETV 1 , and E1AF . ^^^ |
|
| Interacting proteins: P11308 and P50549 |
Pubmed |
SVM Score :0.0 |
| In Ewing tumors EWS can be fused to four different members of the ETS family , namely FLI 1 , ERG , ETV 1 and E1AF . ^^^ |
|
| Interacting proteins: P11308 and P50549 |
Pubmed |
SVM Score :0.0 |
| EWS FLI 1 , EWS ERG , and EWS ETV 1 oncoproteins of Ewing tumor family all suppress transcription of transforming growth factor beta type 2 receptor gene . ^^^ Ewing sarcoma specific chromosomal translocations fuse the EWS gene to a subset of ets transcription factor family members , most commonly the FLI 1 gene and less frequently ERG , ETV 1 , E1A F , or FEV . ^^^ Here , we also examined effects of EWS ETV 1 and EWS ERG on expression of the TGF beta RII gene . ^^^ We show that relative to the control , NIH 3T3 cell lines stably transfected with the EWS FLI 1 , EWS ERG , or EWS ETV 1 gene fusion express reduced levels of TGF beta RII mRNA and protein , and that these cell lines have reduced TGF beta sensitivity . ^^^ Cotransfection of these fusion genes and the TGF beta RII promoter suppresses TGF beta RII promoter activity and also FLI 1 , ERG , or ETV 1 induced promoter activity . ^^^ |
|
| Interacting proteins: P11308 and P50549 |
Pubmed |
SVM Score :0.0 |
| Ewing sarcoma family of tumors share recurrent translocations that fuse EWS from 22q12 to five different members of transcription factors namely FLI 1 , ERG , ETV 1 , E1AF and FEV . ^^^ |
|
| Interacting proteins: P11308 and P50549 |
Pubmed |
SVM Score :0.0 |
| Similarly , the variant t ( 21 ; 22 ) , t ( 7 ; 22 ) , t ( 17 ; 22 ) , and t ( 2 ; 22 ) rearrangements also form chimeric genes between regions of EWS and the ETS gene family ( ERG , ETV 1 , E1AF , and FEV ) . ^^^ |
|
| Interacting proteins: P11308 and P50549 |
Pubmed |
SVM Score :0.0 |
| Other reciprocal translocations resulting in formation of chimeric genes between EWS and ETS family genes ( ERG , ETV 1 , E1AF , and FEV ) are t ( 21 ; 22 ) , t ( 7 ; 22 ) , t ( 17 ; 22 ) , and t ( 2 ; 22 ) , respectively . ^^^ Different chimeric genes , EWS ERG and EWS ETV 1 , were detected in the other two ES samples . ^^^ |
|
| Interacting proteins: P11308 and P50549 |
Pubmed |
SVM Score :0.0 |
| In many human cancers , the N terminal portion of hTAF ( 2 ) 68 , EWS , or TLS is fused to the DNA binding domain of one of several transcription factors including Fli 1 , ERG , ETV 1 , E1AF , WT 1 , ATF 1 , CHOP , or TEC . ^^^ |
|
| Interacting proteins: P11308 and P50549 |
Pubmed |
SVM Score :0.0 |
| Two ETS transcription factors , ERG and ETV 1 , were identified as outliers in prostate cancer . ^^^ We identified recurrent gene fusions of the 5 ' untranslated region of TMPRSS 2 to ERG or ETV 1 in prostate cancer tissues with outlier expression . ^^^ By using fluorescence in situ hybridization , we demonstrated that 23 of 29 prostate cancer samples harbor rearrangements in ERG or ETV 1 . ^^^ |
|
| Interacting proteins: P11308 and P50549 |
Pubmed |
SVM Score :0.0 |
| These rearrangements generate an active fusion gene between the EWS gene and either the human FLI 1 gene or other members of the ETS gene family : the ERG gene localized in band 21q22 . 2 , the ETV 1 gene localized in band 7p22 , or the E1AF gene localized in band 17q12 . ^^^ |
|
| Interacting proteins: P11308 and P50549 |
Pubmed |
SVM Score :0.0 |
| Subsequently , a series of cellular Ets genes were isolated ( Ets 1 , Ets 2 , Erg , Elk 1 , Sap 1 , PEA 3 , PU . 1 , Fli 1 , Pok / Yan , Etv 1 etc . ) . ^^^ |
|
| Interacting proteins: P11308 and P50549 |
Pubmed |
SVM Score :0.0 |
| Among the latter , we show that Fli 1 , Ets 2 , Er 81 and Pu 1 physically interact with Erg . ^^^ |
|
| Interacting proteins: P11308 and P50549 |
Pubmed |
SVM Score :0.0 |
| Here we show that those Ets family proteins that participate in Ewing ' s sarcoma , including Fli 1 , ERG , and ETV 1 , cooperatively bind these tandem elements with Fos Jun while other Ets family members do not . ^^^ |
|
| Interacting proteins: P11308 and P50549 |
Pubmed |
SVM Score :0.0 |
| Recently , using a novel bioinformatic approach , we identified recurrent gene fusions between TMPRSS 2 and the ETS family members ERG or ETV 1 in the majority of prostate cancers . ^^^ |
|
| Interacting proteins: P11308 and P50549 |
Pubmed |
SVM Score :0.0 |
| In a minority of cases , the EWS gene is fused to another member of the ETS gene ( ERG , ETV 1 , E1AF , and FEV ) . ^^^ |
|
| Interacting proteins: P11308 and P50549 |
Pubmed |
SVM Score :0.0 |
| Chromosomal translocation results in transcriptional activation of truncated ETS transcription factors ERG and ETV 1 , the first candidates for dominant oncogenes for prostate cancer . ^^^ |
|
| Interacting proteins: P11308 and P50549 |
Pubmed |
SVM Score :0.0 |
| Finally , the recent discovery of chromosomal translocations resulting in the upregulation of one of at least 3 ETS genes ( ERG , ETV 1 , ETV 4 ) may lead to novel agents for the treatment of this disease . . ^^^ |
|
| Interacting proteins: P11308 and P50549 |
Pubmed |
SVM Score :0.0 |
| NA |
|