| Interacting proteins: P11308 and P15036 |
Pubmed |
SVM Score :0.53333725 |
| Both the N terminal region , comprising the transactivation domain , and the C terminal region of ETS 2 associated with ERG and , interestingly , the interaction of ERG through the transactivation domain of ETS 2 was DNA independent . 0.53333725^^^ |
|
| Interacting proteins: P11308 and P15036 |
Pubmed |
SVM Score :0.0 |
| This 3 ' ets homology domain , which is mainly responsible for DNA binding activity , is seen in all the ets family members ; however , the 5 ' ets homology region is conserved in only five genes , Fli 1 , c ets 1 , ets 2 , GABP alpha , and erg , suggesting a common biological function which is shared among these genes . ^^^ |
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| Interacting proteins: P11308 and P15036 |
Pubmed |
SVM Score :0.0 |
| This antibody recognizes ets 1 , ets 2 , erg , and other related proteins . ^^^ |
|
| Interacting proteins: P11308 and P15036 |
Pubmed |
SVM Score :0.0 |
| The ets 1 gene belongs to the ets gene family ( ets 1 , ets 2 , erg , and elk ) and is homologous to the 5 ets oncogene found in the avian leukemia virus E 26 . ^^^ |
|
| Interacting proteins: P11308 and P15036 |
Pubmed |
SVM Score :0.0 |
| The human ETS 2 gene is a member of the ets gene family ( ETS 1 , ETS 2 , ERG , ELK 1 and ELK 2 ) with amino acid similarity to the 5 ets oncogene of the avian leukemia virus , E 26 . ^^^ |
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| Interacting proteins: P11308 and P15036 |
Pubmed |
SVM Score :0.0 |
| A minimum of five duplication events of ets primordial genes were evident , namely ( 1 ) a duplication that separates primitive ets genes ( Drosophila precursor of 74E , mouse PU . 1 and human ELK 1 ) from the ets 1 , ets 2 , erg ancestor ; ( 2 ) and ( 3 ) two duplications that established separate ets , erg and elg / GABP alpha lineages which occurred prior to invertebrate vertebrate divergence ; ( 4 ) divergence of ets 1 and ets 2 gene family also associated with vertebrate invertebrate divergence ; ( 5 ) duplication of ets 1 and ets 2 in Xenopus laevis to produce two ets 1 genes and two ets 2 genes during genomic tetraploidation in the recent ancestry of this species . . ^^^ |
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| Interacting proteins: P11308 and P15036 |
Pubmed |
SVM Score :0.0 |
| Protooncogenes ETS 2 and ERG have been mapped to this chromosome band . . ^^^ |
|
| Interacting proteins: P11308 and P15036 |
Pubmed |
SVM Score :0.0 |
| Several genes related to the ets oncogene ( c ets 1 , ets 2 , erg , elk 1 , elk 2 , PU . 1 / Spi 1 , E 74 and Fli 1 ) have been described . ^^^ We have expressed erg 1 and erg 2 proteins in Escherichia coli and have used these recombinant proteins to show that they bind to DNA in a sequence specific manner . erg proteins exhibited different sequence specificity and affinity for the oligonucleotides recognized by c ets 1 , ets 2 , some of PU . 1 / Spi 1 and elk 1 , suggesting that the DNA binding specificities of erg and other members may overlap but are not necessarily identical . ^^^ |
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| Interacting proteins: P11308 and P15036 |
Pubmed |
SVM Score :0.0 |
| The human ETS 2 and ERG genes are members of the ETS gene family , with sequence homology to the viral ets gene of the avian erythroblastosis retrovirus , E 26 . ^^^ It is known that ERG and ETS 2 gene translocations occur in certain specific leukemias associated with defined chromosome rearrangements [ e . g . , t ( 8 ; 21 ) ] . ^^^ |
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| Interacting proteins: P11308 and P15036 |
Pubmed |
SVM Score :0.0 |
| When the information from the linkage map is combined with that from molecular studies , it is apparent that ( a ) the t ( 8 ; 21 ) breakpoint does not affect the ETS 2 gene structure or the structure of the other four loci proximal to ETS 2 : D21S55 , D21S57 , D21S17 , and ERG , and ETS related gene ; and ( b ) the actual DNA sequence involved in the t ( 8 ; 21 ) must reside in a 3 cM genetic region between the D21S58 and the D21S55 / D21S57 loci , and remains to be identified . . ^^^ |
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| Interacting proteins: P11308 and P15036 |
Pubmed |
SVM Score :0.0 |
| In vitro studies have linked the up regulation of ERG expression with stromal cell independence in erythroleukemic clones and shown that the ERG related genes ETS 1 and ETS 2 have a mitogenic and transforming activity when overexpressed in NIH3T3 cells . ^^^ |
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| Interacting proteins: P11308 and P15036 |
Pubmed |
SVM Score :0.0 |
| Subsequently , a series of cellular Ets genes were isolated ( Ets 1 , Ets 2 , Erg , Elk 1 , Sap 1 , PEA 3 , PU . 1 , Fli 1 , Pok / Yan , Etv 1 etc . ) . ^^^ Ets genes also have a role in T cell development and molecular and genetic analysis of Down Syndrome patients have implicated the human Ets 2 and Erg genes in the disease . ^^^ |
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| Interacting proteins: P11308 and P15036 |
Pubmed |
SVM Score :0.0 |
| The results indicate that the promoter activity of the 60 / +19 region of the vWF gene depends on transcription factors of the Ets family of which several members like Ets 1 , Ets 2 and Erg are expressed in endothelium . ^^^ |
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| Interacting proteins: P11308 and P15036 |
Pubmed |
SVM Score :0.0 |
| Among the latter , we show that Fli 1 , Ets 2 , Er 81 and Pu 1 physically interact with Erg . ^^^ |
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| Interacting proteins: P11308 and P15036 |
Pubmed |
SVM Score :0.0 |
| These populations were monitored for mRNA expression of the Erg , Ets 1 , Ets 2 , Fli 1 , Tel , Elf 1 , GABPalpha , PU . 1 and Spi B genes . ^^^ |
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| Interacting proteins: P11308 and P15036 |
Pubmed |
SVM Score :0.0 |
| To improve the physical map of this region , we screened yeast artificial chromosome ( YAC ) libraries with ETS 2 and ERG sequences . ^^^ A 1 . 2 Mg contig , encompassing the protooncogenes ETS 2 and ERG , was identified , its restriction map established and compared to the genomic map . ^^^ ERG is distal to D21S55 and proximal to ETS 2 . ^^^ ERG and ETS 2 genes are 400 kb apart and in opposite orientations . ^^^ |
|
| Interacting proteins: P11308 and P15036 |
Pubmed |
SVM Score :0.0 |
| It appears that Fli 1 and erg proteins fall into the category of ets proteins that recognize limited ets target sequences , unlike c ets 1 , ets 2 and Elk 1 . ^^^ |
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| Interacting proteins: P11308 and P15036 |
Pubmed |
SVM Score :0.0 |
| The map order , including previously mapped reference markers , is ( cen ) D16H21S16 D16Led 1 App Sod 1 Gart Gas 4 Cbr++ + wv Pcp 4 Erg Ets 2 . ^^^ |
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| Interacting proteins: P11308 and P15036 |
Pubmed |
SVM Score :0.0 |
| Six linkage groups were defined : D21S13 D21S16 , D21S1 D21S11 , D21S65 D21S17 , ( D21S55 , ERG ) ETS 2 , BCEI D21S19 D21S42 D21S113 CBS CRYA 1 , and COL6A2 S100B . ^^^ |
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| Interacting proteins: P11308 and P15036 |
Pubmed |
SVM Score :0.0 |
| Here , we show that two members of the Ets family , Ets 2 and Erg and their combinations differentially regulate collagenase 1 and stromelysin 1 promoter activity . ^^^ In transiently transfected cells , Ets 2 activates both promoters whereas Erg induces collagenase 1 but not stromelysin 1 promoter activity . ^^^ Moreover , Erg completely inhibits stromelysin 1 promoter activation by Ets 2 . ^^^ |
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| Interacting proteins: P11308 and P15036 |
Pubmed |
SVM Score :0.0 |
| Altered expression of Erg and Ets 2 transcription factors is associated with genetic changes at 21q22 . 2 22 . 3 in immortal and cervical carcinoma cell lines . ^^^ Altered expression of the ets family transcription factors erg and ets 2 was found associated with the development of cervical carcinoma . ^^^ A clonally related pair of cervical carcinoma cell lines , C 4I and C 4II , showed differential expression of erg and ets 2 . ^^^ Pulsed field gel electrophoresis was used to analyse changes in DNA fragments related to structural changes and to construct a physical map encompassing erg and ets 2 . ^^^ Alterations in erg and ets 2 RNA expression in each of three different cell lines examined were associated with translocations . ^^^ |
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| Interacting proteins: P11308 and P15036 |
Pubmed |
SVM Score :0.0 |
| These BACs span the molecular markers D21S55 , ERG , ETS 2 , MX1 / 2 , collagen 18 and collagen 6 A1 / A2 . ^^^ |
|
| Interacting proteins: P11308 and P15036 |
Pubmed |
SVM Score :0.0 |
| Analysis of endothelial Ets family members showed that Ets 2 , and to a lesser extent Ets 1 , transactivate CD13 / APN promoter activity via the Ets core motif , whereas Fli , Erg , and NERF are ineffective . ^^^ |
|
| Interacting proteins: P11308 and P15036 |
Pubmed |
SVM Score :0.0 |
| Detailed mapping of the ERG ETS 2 interval of human chromosome 21 and comparison with the region of conserved synteny on mouse chromosome 16 . ^^^ We have carried out a detailed annotation of 550 kb of genomic DNA on human chromosome 21 containing the ERG and ETS 2 genes . ^^^ Comparative genomic analysis between this region and the interval of conserved synteny on mouse chromosome 16 indicated that the order and orientation of the ERG and ETS 2 genes were conserved and revealed several regions containing potential conserved noncoding sequences . ^^^ |
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| Interacting proteins: P11308 and P15036 |
Pubmed |
SVM Score :0.0 |
| Acute myeloid leukemia with complex karyotypes and abnormal chromosome 21 : Amplification discloses overexpression of APP , ETS 2 , and ERG genes . ^^^ High resolution bacterial artificial chromosome ( BAC ) array based comparative genomic hybridization disclosed amplification predominantly in the 25 to 30 megabase ( MB ) region that harbors the APP gene ( 26 . 3 MB ) and at position 38 . 7 39 . 1 MB that harbors the transcription factors ERG and ETS 2 . ^^^ Using oligonucleotide arrays , APP was by far the most overexpressed gene ( mean fold change 19 . 74 , P = 0 . 0003 ) compared to a control group of AML with normal cytogenetics ; ERG and ETS 2 also ranked among the most highly expressed chromosome 21 genes . ^^^ We hypothesize that APP and the transcription factors ERG and ETS 2 are altered by yet unknown molecular mechanisms involved in leukemogenesis . ^^^ |
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| Interacting proteins: P11308 and P15036 |
Pubmed |
SVM Score :0.0 |
| In contrast to Tel and Yan , which self associate to form insoluble polymers , we also show that the isolated PNT domains from Ets 1 , Ets 2 , Erg , Fli 1 , GABPalpha , and Pnt P 2 are monomeric in solution . ^^^ |
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| Interacting proteins: P11308 and P15036 |
Pubmed |
SVM Score :0.0 |
| The objective of this study was to investigate the role of PEA 3 in tumor progression of ovarian and breast carcinoma metastatic to effusions , and to evaluate the expression of Ets 2 and Erg in ovarian carcinoma . ^^^ Expression of Ets 2 and Erg mRNA was analyzed in 50 ovarian carcinoma effusions using the same method . ^^^ Erg and Ets 2 mRNA was expressed in 15 out of 50 ( 30 % ) and 18 out of 50 ( 36 % ) effusions , respectively , and co localized with PEA 3 ( P = 0 . 017 for Erg , P = 0 . 004 for Ets 2 ) . ^^^ In conclusion , PEA 3 is expressed at all anatomic sites in serous ovarian cancer and co localizes with Erg , Ets 2 and several metastasis associated molecules . ^^^ |
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| Interacting proteins: P11308 and P15036 |
Pubmed |
SVM Score :0.0 |
| Furthermore , both ERG and ETS 2 bind in vivo the hematopoietic enhancer of SCL / TAL1 , a key regulator of hematopoietic stem cell and megakaryocytic development . ^^^ We propose that trisomy 21 facilitates the occurrence of megakaryoblastic leukemias through a shift toward the megakaryoblastic lineage caused by the excess expression of ERG , and possibly by other chromosome 21 genes , such as RUNX 1 and ETS 2 , in hematopoietic progenitor cells , coupled with a differentiation arrest caused by the acquisition of mutations in GATA1 . . ^^^ |
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| Interacting proteins: P11308 and P15036 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11308 and P15036 |
Pubmed |
SVM Score :0.0 |
| NA |
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