Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Six patients with acute nonlymphocytic leukemia ( ANLL ) , four with acute lymphocytic leukemia ( ALL ) , two with chronic myelogenous leukemia ( CML ) , and two with myelodysplastic syndrome ( MDS ) . ^^^ Among these patients , six with ANLL , two with ALL , one with CML and one with MDS were alive in complete remission 8 to 58 months post BMT . ^^^ Four patients died of relapse ( one with ALL , and one with MDS ) , and chronic GVHD ( one with ALL and one with CML ) . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
The karyotypes of 98 patients between the ages of 8 and 81 years with acute lymphoblastic leukemia ( ALL ) , acute myeloid leukemia ( AML ) , myelodysplastic syndromes ( MDS ) , and chronic myeloid leukemia ( CML ) are presented . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
However , cytogenetically unrelated clones have been reported in some disorders including one case of acute leukemia ( AL ) , one of acute lymphoblastic leukemia ( ALL ) , one of acute myeloblastic leukemia ( AMMoL ) , and five of myelodysplastic syndromes ( MDS ) . ^^^ One patient we report and 5 from the literature had two unrelated clones with trisomy 8 and deletion of the long arm of chromosome 5 ( 5q ) ; all had MDS . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Thirty seven patients with de novo acute myeloblastic leukaemia ( AML ) were compared to 26 patients with AML that had developed after a myelodysplastic phase ( MDS AML ) , and 17 cases of acute lymphoblastic leukaemia ( ALL ) . ^^^ The mean G score was decreased in MDS AML ( 178 + / 67 . 9 ) , and in de novo AML ( 212 + / 65 . 1 ) , but not in ALL ( 275 + / 24 . 3 ) . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Patients ( n = 320 ) with either acute undifferentiated leukemia ( AUL ) , AML , MDS or acute lymphoblastic leukemia ( ALL ) were screened for rearrangement of the genes involved in this translocation . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Significant frequency differences between geographic areas were found for the aberrations +8 , 1 ( 17q ) , +19 , and an additional Ph 1 chromosome in chronic myeloid leukemia ( CML ) ; 5 , 5q , and +8 in acute nonlymphocytic leukemia ( ANLL ) ; t ( 8 ; 21 ) in ANLL M 2 ; t ( 15 ; 17 ) in ANLL M 3 ; 5q and 7 in myelodysplastic syndromes ( MDS ) ; t ( 9 ; 22 ) and +21 in acute lymphocytic leukemia ( ALL ) ; t ( 14 ; 18 ) in follicular lymphoma ; 8 and 22 / 22q in meningioma ; and structural abnormalities of 12q in pleomorphic adenoma of the salivary glands ( PAS ) . ^^^ No geographic incidence variation was detected for 7 and +21 in ANLL ; +8 in MDS ; 6q and +8 in ALL ; +12 in chronic lymphocytic leukemia ; 6q in non Hodgkin ' s lymphoma ( NHL ) ; t ( 8 ; 14 ) in Burkitt ' s lymphoma ; t ( 11 ; 22 ) in Ewing ' s sarcoma ; 1 ( 12p ) in germ cell tumors ; 1p in neuroblastoma ; structural abnormalities of 3q , 8q , and 9p in PAS ; or 3p in renal cell carcinoma . ^^^ No significant correlations were found regarding the incidence of 5q in ANLL and MDS , 6q in ALL and NHL , 7 in ANLL and MDS , +8 in ANLL and CML , +8 in ANLL and MDS , +8 in ALL and ANLL , or +21 in ALL and ANLL . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
By applying the immunocytochemical assay we have demonstrated that in myeloproliferative diseases ( AML , ALL , MDS , CGL ) , in single cases , in smear preparations from the peripheral blood and bone marrow the cells with MDR positive phenotype can be detected in the material obtained from patients before therapy , and without clinically and anamnestically known exposure to cytotoxic or immunosuppressive drugs . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Chromosomal studies were performed on 114 blood samples and 117 bone marrow samples , taken systematically over a period of 4 months after bone marrow transplantation ( BMT ) in 42 children grafted for acute lymphoblastic leukaemia ( ALL ) ( n = 20 ) , acute myeloid leukaemia ( AML ) ( n = 16 ) , non Hodgkin ' s lymphoma ( NHL ) ( n = 2 ) and myelodysplastic syndrome ( MDS ) ( n = 4 ) . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
We studied the activity of serum adenosine deaminase ( ADA ) and its isozyme in 36 leukemic patients ( 16 ANLL , 11 ALL , and 9 CML ) and 8 MDS . ^^^ The appearance rate of abnormally high ADA value were 81 . 24 % for ANLL , 100 % for ALL , 77 . 8 % for CML and 37 . 5 % for MDS . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Mean age of the patients was 65 years , and the hematologic diseases were CML , AML , ALL , MDS and malignant lymphoma . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Cytogenetic anomalies are common in MDS , and multiple and complicated abnormalities develop in nearly all patients with progressing disease . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
In patient characteristics , eleven of 32 patients with ANLL ( 34 . 4 % ) , one of ten patients with ALL ( 10 % ) , four of nine patients with CML BC ( 44 . 4 % ) , six of seven patients with AA ( 85 . 7 % ) , two of four patients with MDS ( 50 % ) , and one of seven patients with other types ( 14 . 3 % ) , who had random donor transfusion , developed HLA Ab . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
A total of 1652 attempts at cytogenetic analysis with banding technique were performed in 240 patients with acute nonlymphocytic leukaemia ( ANLL ) , 177 with chronic myeloid leukaemia ( CML ) , 157 with myelodysplasia ( MDS ) , 82 with myeloproliferative disorders ( MPD ) , 114 with acute lymphoblastic leukaemia ( ALL ) , 42 with non Hodgkin lymphoma or other lymphoproliferative disorders ( NHL + LPD ) , and 120 patients with benign disorders . ^^^ Success rate was 73 74 . 4 % in ALL , MPD , and NHL + LPD , versus 87 94 % in ANLL , MDS , CML , and benign disorders . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Using a probe specific for erb B oncogene , which encodes a truncated form of the EGF receptor , we examined RNA and DNA derived from bone marrow and peripheral blood mononuclear cells from three patients with myelodysplastic syndromes ( MDS ) and one with acute lymphocytic leukemia ( ALL ) , all bearing an abnormal clone in their bone marrow with a similar unbalanced 1 ; 7 translocation . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
We measured the levels of adenosine deaminase ( ADA ) and immunosuppressive acid protein ( IAP ) in 10 patients with acute myeloid leukemia ( AML ) , 5 with acute lymphoblastic leukemia ( ALL ) , 8 with chronic myeloid leukemia ( CML ) , 7 with myelodysplastic syndrome ( MDS ) , 5 with malignant lymphoma ( ML ) , 3 with multiple myeloma ( MM ) and one with adult T cell leukemia . ^^^ On admission , the level of IAP was abnormally high in all cases of AML and ALL 50 % of CML cases , 71 . 4 % of MDS cases , 60 % of ML cases and none of MM cases . ^^^ ADA was elevated in all cases of ALL , 77 . 8 % of AML and CML cases , 57 . 1 % of MDS cases , 60 % of ML cases and 33 . 3 % of MM cases . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
By applying the immunocytochemical assay , we have demonstrated that in myeloproliferative diseases ( AML , ALL , MDS , CGL ) in single cases in smear preparations from the peripheral blood as well as from the bone marrow P glycoprotein positive cells , respectively , cells with mdr positive phenotype can be detected in the material obtained from patients before therapy and without clinically and anamnestically known exposure to cytotoxic or immunosuppressive drugs . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
From 1979 to 1988 , 82 allogeneic and 2 syngeneic bone marrow transplants ( BMT ) were performed in 78 patients ( age range 13 49 years ) with the following diagnoses : acute myelogenous leukemia ( AML ) ( 21 patients ) ; acute lymphoblastic leukemia ( ALL ) ( 15 patients ) ; chronic myelocytic leukemia in chronic , accelerated , or blastic phase ( CML CP , AP or BC ) ( 25 patients ) ; myelodysplastic syndrome ( MDS ) ( 1 patient ) ; multiple myeloma ( MM ) ( 1 patient ) ; Hodgkin ' s disease ( HD ) ( 1 patient ) ; diffuse poorly differentiated lymphoma ( DPDL ) ( 1 patient ) ; aplastic anemia ( AA ) ( 13 patients ) . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Table 3 shows that most patients with AML , MDS and ALL can be placed into one of three major prognostic categories . ^^^ When chromosome analysis is combined with a cytological study in AML and MDS and with a cytological and immunophenotypic study in ALL , the clinical value of such analysis is further enhanced . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
This study shows the progression of a myelodysplastic syndrome ( MDS ) to pre B acute lymphoblastic leukaemia ( ALL ) with an unusual phenotype . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
The change from a chronic MDS to an acute leukaemia of mixed ( myeloid and null ALL ) type suggests either transformation of a pre existing abnormal clone or de novo appearance of two separate leukaemic clones . . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Furthermore , the resemblance between de novo and secondary 5q MDS and ANLL is striking ; clinically , as well as cytogenetically , they are indistinguishable , suggesting that all de novo cases may be due to environmental ( chemical ) carcinogens . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Because of this restricted distribution of TdT , biochemical and immunofluorescence techniques have been employed to determine the distribution of TdT phenotypes in human leukemias and lymphomas , showing high levels of TdT in approximately 95 % of acute lymphoblastic leukemia ( ALL ) and lymphoblastic lymphoma ( LBL ) , approximately 50 % of patients with acute undifferentiated leukemia ( AUL ) , approximately 10 of patients with acute nonlymphoblastic leukemia ( ANLL ) , and approximately 30 % of patients with chronic myeloid leukemia ( CML ) and other myeloproliferative ( MPS ) or myelodysplastic ( MDS ) syndromes in blast crisis . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
This cytogenetic deletion mapping revealed that the most commonly lost chromosomes were Y and 7 in acute myeloid leukemia ( AML ) , myelodysplastic syndromes ( MDS ) , and chronic myeloproliferative disorders ( MPD ) ; 10 , Y , 7 , 20 , and 21 in acute lymphocytic leukemia ( ALL ) ; 10 , Y , and 17 in chronic lymphoproliferative disorders ( LPD ) ; and 10 and Y in non Hodgkin ' s lymphoma ( NHL ) . ^^^ Chromosome segments / bands lost due to unbalanced structural abnormalities in at least 5 % of the cases were 5q13 33 , 7q22 36 , 9q13 31 , 11q23 25 , 12p12 13 , 17p11 13 , and 20q11 13 in AML ; 5q13 35 and 20q11 13 in MDS ; 5q22 23 , 7q22 , 13q12 22 , 17p11 13 , and 20q11 13 in MPD ; 6q15 27 , 9p11 24 , 12p12 13 , and 19p13 in ALL ; 6q16 27 , 11q21 25 , 13q13 14 , and 14q32 in LPD ; and 6q21 27 , 11q13 25 , and 14q24 32 in NHL . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
The numbers of cases of leukemia and other related haematological disorders were as follows : 16 acute myeloid leukemia ( AML ) ; 8 myelodysplastic syndrome ( MDS ) ; 1 acute lymphatic leukemia ( ALL ) ; 3 chronic myeloid leukemia ( CML ) ; 4 non Hodgkin ' s lymphoma ( NHL ) ; 2 multiple myeloma ( MM ) ; 2 myelofibrosis ( MF ) ; 2 chronic lymphatic leukemia ( CLL ) . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Expression of the DCC gene was reduced or absent in 10 of 39 ( 26 % ) patients with acute myelogenous leukemia ( AML ) , three of 14 ( 29 % ) patients with acute lymphocytic leukemia ( ALL ) , seven of 33 ( 21 % ) patients with chronic myelogenous leukemia ( CML ) , three of 39 ( 8 % ) patients with myelodysplastic syndromes ( MDS ) , and five of nine ( 56 % ) patients with overt leukemia progressed from MDS . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
In this report , we describe the results of unrelated donor bone marrow transplants ( BMT ) in 50 children with leukemia ( 25 acute lymphoblastic leukemia [ ALL ] , 3 acute myeloid leukemia [ AML ] , 3 juvenile chronic myelogenous leukemia [ JCML ] , 10 chronic myeloid leukemia [ CML ] ) or myelodysplastic syndrome ( MDS ; 9 ) . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
PATIENTS AND METHODS : Major leukemic subtypes , acute lymphoblastic leukemia ( ALL ) , acute nonlymphoblastic leukemia ( ANLL ) , myelodysplastic syndromes ( MDS ) , and transient abnormal myelopoiesis ( TAM ) are evaluated in the context of patient age and treatment responsiveness . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Occasionally , the other subtypes of myelodysplastic syndrome ( MDS ) ( refractory anemia , refractory anemia with ringed sideroblasts , refractory anemia with excess blasts , refractory anemia with excess blasts in transformation ) have been noted to transform into acute lymphoblastic leukemia ( ALL ) . ^^^ We now report a case of CMML that transformed into ALL and we review the literature of 13 other cases of MDS with ALL transformation . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
We analyzed p16INK4A and p15INK4B genes in 178 cases of primary leukemias including 81 cases of chronic lymphocytic leukemia ( CLL ) , seven of hairy cell leukemia ( HCL ) , seven of chronic myelogenous leukemia ( CML ) , 43 of acute myelogenous leukemia ( AML ) , 27 of acute lymphoblastic leukemia ( ALL ) , and 13 of myelodysplastic syndrome ( MDS ) by Southern blot analyses . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
We looked for MDM 2 gene amplification and over expression by Southern and Northern blot analysis in 135 and 66 cases of haematological malignancies , including ALL , AML , CML in chronic phase , CLL , MDS , PLL , non Hodgkin ' s lymphoma ( NHL ) and myeloma . ^^^ An over expression of MDM 2 RNA was seen in 9 / 66 ( 14 % ) patients tested , including 3 / 9 ALL , 3 / 24 AML , 2 / 4 myelomas , 1 / 1 PLL , but 0 / 2 CML , 0 / 2 NHL and 0 / 21 MDS . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
We observed a significant proliferative response to exogenous IL 1 beta in leukemic cells from 27 / 66 patients with de novo AML , 1 / 29 patients with ALL , 2 / 3 patients with AUL , 8 / 12 patients with AML arising from MDS , 4 / 7 patients with myeloid crisis of CML , and 0 / 4 patients with lymphoid crisis of CML . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Of the 15 patients in our group , 11 with chronic , myelocytic leukemia ( CML ) , 3 with Ph negative acute lymphocytic leukemia ( ALL ) , one with myelodysplastic syndrome ( MDS ) . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Between March 1983 and December 1992 , we performed 178 allogeneic BMTs for patients with hematopoietic stem cell disorders : 48 acute myelogenous leukemia ( AML ) , 27 acute lymphoblastic leukemia ( ALL ) , 40 chronic myelogenous leukemia ( CML ) , 55 severe aplastic anemia ( SAA ) , 6 myelodysplastic syndrome ( MDS ) , 1 non Hodgkin ' s lymphoma and 1 hybrid leukemia . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Mobility shifts suggesting sequence alteration were observed in 5 cases ( 22 % ) in exon 1 and 2 of the N ras gene by PCR SSCP . 3 cases ( 1 MDS , 1 MDS overt AML and 1 ALL ) were detected to contain missense point mutations . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Using this technique , in our series of 560 patients with preleukemia and leukemia , we consistently provided the banding quality that allowed all chromosomes of the karyotype to be identified in 96 % of myelodysplastic syndromes ( MDS ) 91 % of acute lymphocytic leukemia ( ALL ) , and 94 % of acute myeloid leukemia ( AML ) cases , and we also identified cytogenetically abnormal clones in 70 % of AML patients . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
By contrast , in all MDS cases , lymphoid blast cells coexisted with another myeloid component ( hybrid leukemias ) and showed an early B phenotype . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
One hundred and twenty eight patients with acute myeloid leukemia ( AML ) , acute lymphoid leukemia ( ALL ) , myelodysplastic syndromes ( MDS ) , or chronic lymphocytic leukemia ( CLL ) were studied by both methods . ^^^ Immunocytochemistry showed detectable levels of intracellular p 53 in 19 cases ( including 2 / 19 AML , 2 / 21 ALL , 11 / 48 MDS , 4 / 40 CLL ) . ^^^ Staining by p 53 antibodies was restricted to the nucleus of blasts in AML , ALL , and MDS , and of lymphocytes in CLL . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Their diagnoses were as follows : chronic myeloid leukemia ( CML ) in 13 , acute myeloid leukemia ( AML ) in seven , acute lymphocytic leukemia ( ALL ) in six , myelodysplastic syndrome ( MDS ) in two , aplastic anemia ( AA ) in two , and Fanconi anemia ( FA ) in one . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Patients with acute myelogenous leukemia ( AML ; N = 30 ) , chronic myelogenous leukemia ( CML ; N = 27 ) , acute lymphoblastic leukemia ( ALL ; N = 12 ) , myelodysplastic syndromes ( MDS ; N = 8 ) , lymphomas ( N = 8 ) , and aplastic anemia ( N = 7 ) were treated with a variety of myeloablative preparative regimens . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Chromosome band 11q23 is frequently involved in acute myeloid leukemia ( AML ) and acute lymphoblastic leukemia ( ALL ) de novo , as well as in myelodysplastic syndromes ( MDS ) and lymphoma . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
We examined 191 patients ( 85 acute myeloid leukemia [ AML ] , 48 acute lymphocytic leukemia [ ALL ] , 32 chronic myeloid leukemia [ CML ] , 17 SAA , and nine myelodysplastic syndrome [ MDS ] ) who were in hematologic remission 6 months to 13 years after either curative chemotherapy ( n = 69 ) or allogeneic bone marrow transplantation ( BMT ) ( n = 122 ) by culturing their precursor cells from bone marrow ( BM ) ( n = 548 ) and peripheral blood ( PB ) ( n = 529 ) in methylcellulose . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Main indications for unrelated BMT were CML ( 115 ) , AML ( 32 ) , ALL ( 24 ) , SAA ( 19 ) , MDS ( 10 ) . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
The incidence at diagnosis was acute lymphoblastic leukemia ( ALL ) 2 . 2 % , acute myeloid leukemia ( AML ) 2 . 4 % , and myelodysplastic syndrome ( MDS ) 3 . 4 % . ^^^ The incidence in relapse and refractory disease was ALL 8 . 9 % , AML 3 . 3 % , and MDS 6 . 3 % . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Forty two children , mean age 6 . 4 years ( range 9 months to 15 years ) , received an allogeneic BMT for : acute lymphoblastic leukaemia ( ALL ) , n = 17 ; acute myeloid leukaemia ( AML ) , n = 5 ; biphenotypic leukaemia , n = 1 ; myelodysplastic syndrome ( MDS ) , n = 5 ; chronic granulocytic leukaemia ( CGL ) , n = 1 ; severe aplastic anaemia ( SAA ) , n = 7 ; familial erythrophagocytic lymphohistiocytosis ( FEL ) , n = 2 ; beta thalassaemia major ( beta thal ) , n = 1 ; and juvenile chronic myeloid leukaemia ( JCML ) , n = 3 . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
In fresh samples from AML , ALL , CLL , NHL , myeloma and MDS , no betagal positive cells were seen 48h and 72h after infection , except in one case of myeloma and one case of CLL ( where 10 % and 2 % of betagal positive cells were seen after infection , respectively ) . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
One hundred thirty five patients with chronic myeloid leukemia ( CML ) ( N = 84 ) , acute myeloid leukemia ( AML ) ( N = 23 ) , acute lymphoblastic leukemia ( ALL ) ( N = 22 ) , myelodysplastic syndrome ( MDS ) ( N = 5 ) , and polycythemia vera with osteomyelofibrosis ( PCV ) ( N = 1 ) were treated with transfusions of donor lymphocytes . ^^^ Lymphocyte transfusions were also given to 18 patients with ALL , AML , MDS , and transformed phase CML who were in remission after chemotherapy . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
We describe a patient with Philadelphia chromosome ( Ph 1 ) positive acute lymphoblastic leukaemia ( ALL ) who developed it 2 . 5 years after being diagnosed with myelodysplastic syndrome ( MDS ) . ^^^ These findings indicate that this ALL arose from the MDS clone through multiple cytogenetic evolutions , the final event of which was the acquisition of p 190 BCR ABL type Ph1 . . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
From the adult leukemia database at MD Anderson Cancer Center , nine patients with ALL following myelodysplastic syndrome ( MDS ) ( n=6 ) , smoldering leukemia ( n=1 ) , or cytopenias with dysplastic features ( n=2 ) were identified . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Consecutive bone marrow samples were studied from cases of AML ( 30 cases ) , myelodysplastic syndromes ( MDS ) ( 4 cases ) , myeloproliferative disorders in blast crisis ( MPD BC ) ( 6 cases ) , and ALL ( 5 cases ) . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Clinical studies have indicated that HHT is effective in treating acute myeloid leukemia ( AML ) , chronic myeloid leukemia ( CML ) and myelodysplastic syndrome ( MDS ) , but not acute lymphoblastic leukemia ( ALL ) and solid tumors . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
There were 58 APL samples ( 23 patients : 10 samples obtained with disease activity , 43 samples in complete remission ( CR ) and 5 PBSC samples ) and 6 control samples , of non APL hematological neoplasms ( 3 other AML , 1 CML , 1 ALL , and 1 MDS ) . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
A total of 404 samples were evaluated with banding techniques ; 66 patients had myeloproliferative syndromes ( MPS ) ; 64 , chronic myeloid leukaemia ( CML ) ; 50 , acute nonlymphocytic leukaemia ( ANLL ) ; 40 , myelodysplastic syndromes ( MDS ) ; 39 , lymphoproliferative disorders ( LPD ) ; 37 , acute lymphocytic leukaemia ( ALL ) ; 31 with non Hodgkin lymphomas ; and 57 patients had benign disorders . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Samples of peripheral blood were taken from 11 patients ( blood group A , B and O ) , suffering from acute myeloblastic leukemia ( AML ) , acute lymphoblastic leukemia ( ALL ) , myelodysplastic syndrome ( MDS ) , before and after chemotherapy , compared to normal control samples . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
The other 22 were high risk patients : six were transplanted for ALL in third remission ( CR 3 ) , two for AML in CR 2 , two for myelodysplastic syndrome ( MDS ) and 12 for acute leukemia in relapse . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
The diagnoses at relapse were : CML in chronic phase ( CP ) ( two patients ) , CML in accelerated phase ( AP ) ( four patients ) , AML ( four patients ) , MDS ( one patient ) , ALL ( four patients ) and relapse of Hodgkin ' s disease ( one patient ) . ^^^ Six patients obtained complete remission ( CR ) , one with CML in CP , three with CML in AP , one MDS and one ALL . ^^^ Four patients developed marrow hypoplasia after DLI ( three CR and one PR ) and two patients ( ALL with CR and MDS with CR ) were hypoplastic at relapse and marrow hypoplasia continued after DLI . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Patients were diagnosed with Ewing ' s sarcoma ( 1 ) , ALL ( 4 ) , AML ( 3 ) , CML ( 2 ) , Wiskott Aldrich Syndrome ( WAS ; 1 ) , MDS ( 1 ) and SAA ( 2 ) . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Diagnoses included 29 ANLL , 27 ALL , six CML and four MDS . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Among all referred cases , the rates of detection of cytogenetically abnormal clones were 95 % for chronic myelogenous leukemia ( CML ) , 54 % for acute lymphoblastic leukemia ( ALL ) , 51 % for acute myeloid leukemia ( ANLL ) , and 43 % for myelodysplastic syndrome ( MDS ) . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Ten acute myeloid leukemias ( AML ) , two myelodysplastic syndromes ( MDS ) , one Philadelphia chromosome positive chronic myeloid leukemia ( CML ) , three acute lymphoblastic leukemias ( ALL ) , one chronic lymphoproliferative disorder ( CLD ) , and three non Hodgkin ' s lymphomas ( NHL ) with abnormalities leading to 3p deletions were identified , constituting 2 . 9 % of AML , 0 . 7 % of MDS , 1 . 0 % of CML with changes in addition to t ( 9 ; 22 ) , 1 . 5 % of ALL , 4 . 2 % of CLD , and 1 . 1 % of NHL with cytogenetic abnormalities analyzed at our Department . ^^^ Among 19042 karyotypically aberrant published cases , 1 . 2 % of 6260 AML , 1 . 3 % of 2285 MDS , 0 . 8 % of 840 chronic myeloproliferative disorders ( CMD ) , 0 . 7 % of 1894 CML with additional aberrations to t ( 9 ; 22 ) , 0 . 6 % of 3589 ALL 2 . 4 % of 1602 CLD , 4 . 5 % of 178 Hodgkin disease ( HD ) , and 3 . 1 % of 2394 NHL displayed partial loss of 3p ( 0 . 6 4 . 5 % ; P < 0 . 001 ) ; the majority occurring together with other abnormalities . ^^^ The frequencies of 3p loss did not differ significantly among the MDS , ALL , and CLD morphologic subgroups , between B and T cell ALL , CLD , and NHL , among low , intermediate , and high grade NHL , or between therapy related MDS and de novo MDS , whereas the incidence of 3p deletions was higher in treatment associated AML ( P < 0 . 001 ) than in de novo AML and varied among the AML FAB groups ( P < 0 . 001 ) . ^^^ The most frequently deleted chromosome bands were 3p25 in AML , 3p26 in MDS , 3p14 in CMD , 3p25 , 3p23 , and 3p21 in CML , 3p26 and 3p25 in ALL , 3p26 and 3p25 in CLD , 3p26 in HD , and 3p26 in NHL . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
In this study , we examined a large number of patients to clarify the distribution and frequency of a recently described FLT 3 tandem duplication among hematopoietic malignancies , including 112 acute myelocytic leukemia ( AML ) , 55 acute lymphoblastic leukemia ( ALL ) , 37 myelodysplastic syndrome ( MDS ) , 20 chronic myelogenous leukemia ( CML ) , 30 non Hodgkin ' s lymphoma ( NHL ) , 14 adult T cell leukemia , 15 chronic lymphocytic leukemia ( CLL ) and 38 multiple myeloma ( MM ) . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
A quantitative analysis of expression levels of GM CSF receptors was performed by flow cytometry in different disease categories , ie AML ( n = 72 ) , ALL ( n = 18 ) , and MDS ( n = 12 ) , as well as 12 healthy volunteers , using three different unconjugated GM CSF / R monoclonal antibodies ( McAbs ) ( HGM CSFR ( CD 116 ) , M5D12 , 4B5F5 ) , and appropriate standards . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
The results showed that the expression of the HSP 27 gene was enhanced in 4 cases of acute lymphoid leukemia ( ALL ) , 7 cases of acute nonlymphoid leukemia ( ANLL ) and 2 cases of myelodysplastic syndrome ( MDS ) as compared with that of the normal blood cells , yet there was no significant difference in the HSP 27 expression between the ALL and ANLL cells . ^^^ The expression of HSP 70 in all the 5 ALL and ANLL patients was much lower than that of the normal subjects , except 1 case of ALL and 1 case of MDS , in which the expression was obviously enhanced . ^^^ All the cases including 11 ANLL , 5 ALL and 1 MDS had higher HSP 90 alpha expression than the normal subjects . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Within a prospective study we analyzed hematopoietic chimerism in serial peripheral blood samples taken from 55 patients with acute leukemias ( ALL 21 , AML 20 , MDS 14 ) with a median age of 13 . 5 years at very short time intervals following allogeneic bone marrow transplantation ( allo BMT ) . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
The diagnosis was acute myeloid leukemia ( AML ) in 10 patients , two each with chronic myeloid leukemia ( CML ) , acute lymphoblastic leukemia ( ALL ) , chronic lymphocytic leukemia ( CLL ) and myelodysplastic syndrome ( MDS ) and the remaining three with malignant lymphoma ( ML ) . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
To explore the feasibility and potential advantages of PBSC in allogeneic transplantation , we grafted 24 patients ( age 16 57 , median 37 ) with different hematologic diseases ( ALL = 10 , AML = 5 , MM = 4 , NHL = 2 , CML = 1 , MDS = 1 , AA = 1 ) , 23 HLA identical to their siblings and 1 partially matched . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
This chromosome abnormality is known to occur predominantly in acute myeloid leukemia ( AML ) FAB type M5a and less often in AML M 4 ; in this series it was also found to occur , uncommonly , in other AML FAB types , in childhood acute lymphoblastic leukemia ( ALL ) ( nine cases ) , in relatively young patients with myelodysplastic syndrome ( MDS ) ( five cases ) , acute biphenotypic leukemia ( two cases ) , and acute undifferentiated leukemia ( one case ) . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Twenty seven patients had acute lymphoblastic leukemia ( ALL ) , 16 had acute myeloid leukemia ( AML ) , one had acute biphenotypic leukemia , one had acute undifferentiated leukemia and 12 had myelodysplastic syndrome ( MDS ) . ^^^ MDS patients were all adult , median age of 69 years , median WBC of 3 10 10 ( 9 ) / l , and 7 / 12 had refractory anemia . ^^^ The clinical outcome depended on diagnosis : children with ALL had a better prognosis ( 4 / 16 relapsed , one died ) than AML patients ; all adults and children with AML and 5 / 12 MDS patients died . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
In total of 137 cases , each positivity of telomerase activity was MDS = 17 / 51 , overt leukemia from MDS = 6 / 15 , AML = 17 / 21 , ALL = 4 / 6 , CML CP ( chronic phase ) = 0 / 10 , CML BC ( blastic crisis ) = 4 / 4 , MPD ( myeloproliferative disease ) BC = 3 / 3 , CLL = 1 / 10 , MM ( multiple myeloma ) = 0 / 6 , aplastic anemia = 3 / 5 , essential thrombocytosis = 0 / 3 , and polycythemia vera = 1 / 3 . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
These abnormalities have been found to be associated with AML , MDS , ALL , and NHL as well . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
In addition to well known anomalies , some unusual abnormalities were found , such as t ( 17 ; 22 ) , trisomy 9 combined with t ( 14 ; 17 ) , ( 2 ; 7 ) and Philadelphia chromosome in CML ; t ( 1 ; 12 ) , t ( 11 ; 22 ) , t ( 9 ; 17 ) , and t ( 12 ; 21 ) in AML ; trisomy 11 in MDS ; t ( 2 ; 9 ) and complex t ( 8 ; 8 ; 13 ; 14 ) in ALL . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Sixteen patients with malignant disease ( AML 10 , ALL 3 , CML 2 , MDS 1 ) and two with non malignant disease ( SCID 1 , osteopetrosis 1 ) underwent non T cell depleted allo BMT . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Two hundred and sixty five ( 265 ) allogeneic marrow transplants ( AlloTX ) ( related , unrelated ) were carried out in chronic myeloid leukemia ( CML , 30 % ) , AML ( 23 % ) , acute lymphoid leukemia ( ALL , 14 % ) , myelodysplastic syndrome ( MDS , 9 % ) , severe aplastic anemia ( SAA , 8 % ) , and other diseases ( 14 % ) . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Subsequently we analyzed the cells obtained from 48 patients with hematological malignancies , which consisted of 6 samples from patients with ALL , 30 from AML , 2 from CML BC , 3 from B cell lymphoma and one from each acute mixed leukemia ( AMixL ) , adult T cell leukemia ( ATL ) , T cell large granular lymphocytic leukemia ( T LGL leukemia ) , chronic lymphocytic leukemia ( CLL ) , myelodysplastic syndrome ( MDS ) RAEB in T , multiple myeloma ( MM ) or T cell lymphoma . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Among 290 BMT procedures : 74 AML , 78 ALL , 34 CML , 6 SAA , 3 MDS , 42 HD , 35 NHL , 11 MM , and 7 solid tumours ( breast or testis cancer ) Allogeneic BMT was performed in 76 patients and ABMT / APBCT in 214 patients . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Seven patients with acute leukemia ( n = 5 ALL , n = 1 AML ) or lymphoma ( n = 1 ) received primary allogeneic PBPC transplantation , four patients received a second allotransplantation for graft failure ( n = 1 AML , n = 1 sickle cell anemia ) or disease recurrence ( n = 1 ALL , n = 1 MDS ) . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Among hematopoietic malignancies , the highest frequencies of p15del and p16del were seen in acute lymphoblastic leukemia ( ALL ) ( > 30 % ) with striking rates in T ALL ( > 50 % ) , but also high rates in B cell precursor ( BCP ) ALL ( > 20 % ) ; the rates of deletions in chronic lymphoid leukemia ( CLL ) , multiple myeloma , acute and chronic myeloid leukemia ( AML and CML ) , and myelodysplastic syndromes ( MDS ) were rather low , only some B cell and T cell lymphomas showed increased frequencies . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
DESIGN AND METHODS : The CD 117 antigen expression ( clone 95C3 ) was determined by flow cytometry in a series of 135 patients with acute leukemia at diagnosis consecutively observed during the years 1995 1997 : 82 AML ( including 51 cases of de novo AML , 22 cases of AML following myelodysplastic syndromes ( MDS ) , 9 cases of myeloid blastic crisis of chronic myeloid leukemia ( BC CML ) and 53 ALL . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Patients in the study had c / pre B acute lymphoblastic leukemia ( ALL ) ( nine children and three adults ) , T ALL ( three adults ) , acute myeloid leukemia ( AML ) ( two adults ) , biphenotypic acute leukemia ( Bip L ) ( one adult ) , myelodysplasia ( MDS ) ( one adult ) and chronic myelomonocytic leukemia ( CMML ) ( one child ) . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
While most cases are of French American British ( FAB ) M 4 or FAB M 5 morphology , other FAB AML subtypes , myelodysplastic syndrome ( MDS ) , acute lymphoblastic leukemia ( ALL ) and chronic myelogenous leukemia ( CML ) occur . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
A total of 372 acute myeloid leukemias ( AML ) , 389 myelodysplastic syndromes ( MDS ) , 64 acute lymphoblastic leukemias ( ALL ) and 262 chronic myeloid leukemias ( CML ) were identified , altogether 1087 cases . ^^^ Cytogenetic abnormalities were detected in 52 % AML , 51 % MDS , 68 % ALL and 97 % CML , frequencies that did not differ significantly between the 2 time periods or referring centers . ^^^ No significant age or gender related differences in karyotypic patterns were discerned in AML , MDS , ALL or CML , whereas the karyotypic patterns varied among the FAB groups in both AML ( p= 0 . 001 ) and MDS ( p < 0 . 001 ) . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
One patient with refractory disease and nodal involvement who did not respond to the first BMT had overt expansion of the leukemia at day +36 ; one patient with Ph+ ALL and one with ANLL evolving from MDS , both with skin involvement , had blast cells in peripheral blood at day +27 and +26 , respectively . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
These results suggest that tandem duplication is involved in ALL in addition to AML , but not in childhood MDS or JCML , and that childhood AML patients with the tandem duplication have a poor prognosis . . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Of them , acute myeloid leukemia ( AML ) in 13 ( M 1 , one ; M 2 , three ; M 4 , one ; M 5 , eight ) , acute lymphoblastic leukemia ( ALL ) in one , myelodysplastic syndrome ( MDS ) in 3 , polycythemia vera ( PV ) and myelofibrosis ( MF ) , one case each . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Using a sensitive , isotopic duplex RT PCR procedure amplifying WT 1 or GATA 1 together with beta actin as the internal control in a single reaction mix , we quantitated the expression of WT 1 and GATA 1 mRNA of 16 patients with myelodysplastic syndrome ( MDS ) , 56 with acute myeloid leukemia ( AML ) and 22 with acute lymphoblastic leukemia ( ALL ) . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
The following results were obtained : ( 1 ) Nonrandom chromosome loss ( NCL ) , such as , 11 , 14 , 21 , etc , which were found in the affected members of leukemia families , were found in about 30 % sporadic ANLL , MDS and about 50 % ALL , espedislly in 100 % ( 5 / 5 ) CLL , but not found in ITP ( P < 0 . 001 ) . ^^^ These results indicated that the familial nonrandom chromosome loss were associated with leukomogenesis . ( 2 ) Because most of BM cells are hypodiploed and have the same kinds of NCL in each cases of CLL , which can develop into ALL , ANLL and also cancers , ALL BM hypo and hyper diploid and / or polyploid cells might be origin of hypodiploid cells . ( 3 ) 28 % ( 6 / 21 ) of pediatric patients with AL , MDS , or FA ( Fanconi Anemia ) have one parent , who have up to 30 % BM hypodiploid cells and similar kinds of NCL and also have the rearrangement of C erbB and abnormal proliferation of BM . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Among 2 , 243 cytogenetically investigated hematologic malignancies , 10 acute myeloid leukemias ( AML ) , 5 myelodysplastic syndromes ( MDS ) , 2 acute lymphoblastic leukemias ( ALL ) , 1 acute undifferentiated leukemia ( AUL ) , 1 atypical Philadelphia chromosome negative ( Ph ) chronic myeloid leukemia ( CML ) , 1 chronic myeloproliferative disorder ( CMD ) , and 1 chronic lymphoproliferative disorder ( CLD ) with karyotypically unrelated clones were identified , constituting 2 . 6 % of AML , 1 . 6 % of MDS , 0 . 8 % of ALL , 13 % of AUL , 9 . 1 % of Ph CML , 1 . 5 % of CMD , and 2 . 8 % of CLD with chromosomal abnormalities . ^^^ Among 17 , 733 karyotypically aberrant published cases surveyed , significant frequency differences ( P < 0 . 001 ) were discerned : 1 . 7 % of 6 , 526 AML , 3 . 4 % of 2 , 391 MDS , 0 . 4 % of 1 , 920 Ph+ CML , 2 . 9 % of 856 CMD , 0 . 9 % of 4 , 226 ALL , and 5 . 8 % of 1 , 814 CLD displayed unrelated clones . ^^^ The incidence of cytogenetic polyclonality did not differ significantly among the MDS , CMD , or ALL subgroups , between males and females , between children ( < 16 years ) and adults , or between B and T cell ALL , whereas the frequencies varied among the AML FAB types ( P < 0 . 05 ) , among the different CLD entities ( P < 0 . 001 ) , and between B and T cell CLD ( P < 0 . 001 ) . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Fifty four patients were included ( 38 + / 11 ; M / F = 33 / 21 ; CML ( n = 17 ) , AML ( n = 14 ) , ALL ( n = 15 ) ; MDS ( n = 8 ) ) . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
We have recently shown in a study of 55 patients with acute leukemias ( ALL 21 , AML 20 and MDS 14 ) , that patients who demonstrate increase amounts of autologous marrow repopulation ( increasing mixed chimerism ) have a significantly enhanced risk of relapse ( P < 0 . 0001 ) . ^^^ We describe the results of a pilot study where adoptive immunotherapy was used to treat 12 patients ( five ALL , three AML , four MDS ) who showed increasing mixed chimerism ( MC ) post transplant . ^^^ A response to immunotherapy , defined as the re establishment of complete chimerism ( CC ) and continuous complete remission ( CCR ) , was achieved in four patients ( two ALL , two AML ) following withdrawal of CsA and in a further six patients ( three ALL , three MDS ) after additional DLI . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Cytogenetic analysis revealed del ( 20 ) ( q 11 ) which were previously reported for one case each of ALL and MDS associated with cytophagocytosis by blasts , leading us to speculate a disease entity . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Twenty patients were transplanted for hematological malignancies ( ALL = 8 , AML = 6 , CML = 4 , MDS = 2 ) and four patients were transplanted for non malignant disease ( thalassemia major = 2 , Wiskott Aldrich syndrome = 1 , Kostmann ' s syndrome = 1 ) . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Observations for mutations of the Runt domain of the AML 1 gene in bone marrow cells were made in 300 patients , including 131 with acute myeloid leukemia ( AML ) , 94 with myelodysplastic syndrome ( MDS ) , 28 with blast crisis chronic myeloid leukemia ( CML ) , 3 with atypical CML , 41 with acute lymphoblastic leukemia ( ALL ) , and 3 with essential thrombocythemia ( ET ) . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Complete remission was achieved in 11 of 12 ( 91 % ) patients with relapsed chronic myelogenous leukemia ( CML ) in chronic phase , three of 11 ( 27 % ) with CML in the acute phase , eight of 21 ( 38 % ) with acute myelogenous leukemia ( AML ) , six of 23 ( 25 % ) with acute lymphoblastic leukemia ( ALL ) and five of 11 ( 45 % ) with myelodysplastic syndrome ( MDS ) . ^^^ The probability of remaining in CR at 3 years was 82 % in CML patients in the chronic phase , but 0 % in those with CML in the acute phase , 7 % in those with AML , 0 % with ALL and 33 % with MDS . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Referred to as donor leukocyte infusion ( DLI ) , this technique has been used to obtain complete remissions in relapsed acute myeloid leukemia ( AML ) , acute lymphocytic leukemia ( ALL ) , multiple myeloma , non Hodgkin ' s lymphoma , myelodysplastic syndrome ( MDS ) , and chronic myeloid leukemia ( CML ) . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Patients with ALL ( 101 ) , AML ( 21 ) , MDS ( 9 ) , underwent an HLA identical sibling BMT ( 82 ) or an HLA identical unrelated BMT ( 49 ) , receiving a conditioning regimen consisting of high dose chemotherapy in 24 patients and of F TBI combined with high dose chemotherapy in 107 patients . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
In 14 patients [ eight acute lymphoblastic leukaemia ( ALL ) , three acute myelogenous leukaemia ( AML ) and three MDS ] subfractions were analysed when increasing MC was first noted upon serial analysis of the peripheral blood . ^^^ In seven of these 14 patients ( four ALL , two AML and one MDS ) , subfractions were characterized at the time of frank haematological relapse . ^^^ Patients who relapsed before day +300 ( one ALL , two AML and one MDS ) showed recipient derived ( normal ) cells in addition to blast populations in different mononuclear subsets as well as granulocytes . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
We describe a patient who developed secondary MDS after chemotherapy for hyperdiploid ALL . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Twelve patients in the BM and 11 patients in the PBSC group were diagnosed with AMI , ; 7 / 7 , ALL ; 15 / 15 , CML ; 2 / 3 , MDS ; 1 / 1 , NHL . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Except for chronic lymphocytic leukemia ( CLL ) , vascularity was significantly higher in all leukemias and MDS compared with control bone marrows . ^^^ TNF alpha levels were significantly increased in all diseases except for AML and MDS . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
A significantly higher level of MLF 1 expression ( ratio of MLF1 / beta actin mRNA > 0 . 4 ) was readily detected in seven of 65 patients with de novo AML , three of 12 with post MDS AML and seven of 44 with MDS , but not in any patients with ALL ( n = 18 ) . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
The rate of disease free survival at three years was 57 % for patients with 1st chronic phase CML , 37 % for patients with 1st or 2nd CR ALL , 31 % for AML or MDS patients 18 years of age and 54 % for patients with inborn errors . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
We report on three cases , two with myelodysplastic syndrome ( MDS ) and one with acute lymphoblastic leukemia ( ALL ) , displaying trisomy 16 as the sole cytogenetic anomaly . ^^^ These patients had either MDS , acute myeloblastic leukemia ( AML ) , myelofibrosis , or ALL . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
The Karyotypes of 200 patients between ages of 2 and 84 years , 56 / 200 acute lymphoblastic leukemia ( ALL ) , 55 / 200 acute myeloid leukemia ( AML ) , 63 / 200 chronic myeloid leukemia ( CML ) , 20 / 200 myelodysplastic syndrome ( MDS ) , and 6 / 200 chronic lymphocytic leukemia , ( CLL ) , are analyzed . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
PATIENTS AND METHODS : Patients with refractory or relapsed acute myeloid ( AML ) or lymphocytic ( ALL ) leukemia , myelodysplastic syndromes ( MDS ) , or chronic myelogenous leukemia in blastic phase ( CML BP ) . ^^^ RESULTS : Forty two patients ( AML : 31 patients ; MDS : six patients [ five MDS + one CMML ] ; ALL : four patients ; CML BP : one patient ) were treated . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
We report two patients with therapy related myelodysplasia ( t MDS ) associated with monosomy 7 occurring in children after completion of therapy for acute lymphoblastic leukemia ( ALL ) . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Diagnoses were AML ( n = 4 ) , MDS ( n = 1 ) , ALL ( n = 3 ) , CML ( n = 3 ) and multiple myeloma ( n = 1 ) . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Complete remission ( CR ) was achieved in 11 of 12 ( 91 % ) patients with relapsed chronic myelogenous leukemia ( CML ) in the chronic phase , 3 of 11 ( 27 % ) with CML in the acute phase , 8 of 21 ( 38 % ) with acute myelogenous leukemia ( AML ) , 6 of 23 ( 25 % ) with acute lymphoblastic leukemia ( ALL ) , and 5 of 11 ( 45 % ) with myelodysplastic syndrome ( MDS ) . ^^^ The probability of remaining in CR at 3 years was 82 % in CML patients in the chronic phase , but 0 % in those with CML in the acute phase , 7 % in those with AML , 0 % with ALL , and 33 % with MDS . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
The rate of disease free survival at three years was 57 % for patients with 1st chronic phase CML , 37 % for patients with 1st or 2nd CR ALL , 31 % for AML or MDS patients < or = 18 years of age and 54 % for patients with inborn errors . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
In this leukemia phase 1 study , we investigated the toxicity profile and activity of Irofulven in patients with primary refractory or relapsed acute myeloid leukemia ( AML ) , acute lymphocytic leukemia ( ALL ) , or myelodysplastic syndromes ( MDS ) . ^^^ Twenty patients [ AML : 17 patients ; MDS : one patient ; ALL : one patient ; mixed lineage acute leukemia : one patient ] were treated . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
In that hospital the most frequent types of disorders were , in decreasing order : ANLL ( > M 1 ) , ALL , CML ( all of them showed the Ph chromosome ) and MDS . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Indication for BMT were thalassemia major 106 ( 48 % ) , CML 30 , AML 35 , ALL 10 , SAA 22 , MDS six and six for other miscellaneous disorders . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Patients with acute lymphoblastic leukemia ( ALL ) , acute myelogenous leukemia ( AML ) , chronic myelogenous leukemia ( CML ) , and myelodysplastic syndrome ( MDS ) , consecutively diagnosed from 1986 to 1999 , were enrolled . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
These results indicate that patients with ALL and balanced translocations to chromosome band 11q23 following chemotherapy with topoisomerase 2 inhibitors in the future should be included with cases of MDS or AML in calculations of risk of leukaemia . . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
These rearrangements include the commonly reported t ( 8 ; 21 ) ( q 22 ; q 22 ) or AML1 / ETO fusion in AML M 2 , the t ( 3 ; 21 ) ( q 26 ; q 22 ) or AML 1 fusion with one of three genes , MDS 1 , EAP or EVI 1 , in therapy related AML and MDS , as well as in blast crisis in CML and the t ( 12 ; 21 ) ( p 13 ; q 22 ) or TEL / AML1 fusion in B cell ALL . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
The diagnostic bone marrow aspirate showed trisomy 11 in five adult patients with MDS / AML as part of a complex karyotype and in two children with acute lymphoblastic leukemia ( ALL ) as part of a hyperdiploid karyotype . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Bone mineral density ( BMD ) and biochemical markers of bone metabolism were analyzed in 67 adults with ALL ( n = 27 ) , AML ( n = 14 ) , MDS ( n = 6 ) and CML ( n = 20 ) before and after allogeneic stem cell transplantation ( SCT ) . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
We analysed by immunocytochemistry the expression of p 53 , bcl 2 and ras proteins in bone marrow blasts from 59 patients with acute leukaemia ( AL ) , 36 myeloid ( AML ) and 23 lymphoid ( ALL ) , and from 22 patients with myelodysplastic syndrome ( MDS ) ; our aim was to examine if abnormalities in their expression were associated with peculiar biological and clinical findings , or with an altered apoptosis rate , as measured by TUNEL technique . ^^^ The lowest percentages of apoptotic cells were observed in ALL ( mean 1 % , p = 0 . 006 ) , whereas in MDS the apoptotic index was higher ( 16 . 7 % ) than in AML ( 8 . 6 % ) and than in the normal controls ( 10 . 8 % ) . but the difference tended to be statistically significant only for cases of refractory anaemia . ^^^ Whereas in AML and MDS the apoptotic rate was independent of the oncoprotein expression , in ALL there was a significant linear relationship between TUNEL and ras positivity ( p = 0 . 01 ) . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
METHODS : Forty nine patients , 18 with acute myeloid leukemia , ( AML ) 10 acute lymphoblastic leukemia ( ALL ) , 14 multiple myeloma ( MM ) , 6 non Hodgkin ' s lymphoma ( NHL ) and 1 myelodysplastic syndrome ( MDS RAEB t ) received APBSCT were retrospectively analyzed . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
We describe a patient with myelodysplastic syndrome ( MDS ) that transformed to Burkitt ' s acute lymphoblastic leukaemia ( ALL ) . ^^^ Chromosomal study during the ALL phase showed t ( 8 ; 22 ) ( q 24 ; q 11 ) in addition to the karyotypes determined during the MDS phase . ^^^ These findings indicate that MDS transformed to Burkitt ' s ALL through multiple cytogenetic evolutions , the final event of which seems to be overexpression of the c myc gene . . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
All were denovo MDS . ^^^ CONCLUSION : Primary MDS is seen in all age groups . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
The transformation of myelodysplasia could occur either in the same or and different FAB subtype . ( 4 ) Seven of the seventeen cases transformed to acute leukemia ( 41 . 2 % ) , 6 cases were AML and 1 was ALL . 3 of the 7 cases transformed to hypomyeloplastic leukemia and the remaining 4 transformed to hypermyeloplastic leukemia . ( 5 ) The median time from the diagnosis of RAEB to leukemia transformation , was 27 months in 7 cases with hypoplastic RAEB . ( 6 ) No relationship was found between therapeutic medicines and development of hypomyeloplastic MDS . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Diagnoses were ALL ( n= 10 ) ; AML ( n = 2 ) ; CML ( n = 2 ) ; NHL ( n = 2 ) ; MDS ( n= 1 ) ; MM ( n = 1 ) and SAA ( n = 1 ) . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Clinically , 11q23 patients had acute lymphoblastic leukemia ( ALL ) more often as their primary disease and a shorter latency from start of treatment for the primary disease to their t MDS / t AL diagnosis , except when compared with the inv ( 16 ) subgroup . ^^^ When a multivariable model was constructed , excluding patients with AL or MDS as their primary diagnosis , the relative risk of death for 11q23 patients was significantly higher than that of all five other cytogenetic subgroups . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Among them , 15 patients suffered from acute leukemia ( ALL ) ( one ph+ ALL in CR 1 , seven in CR 2 or greater , and seven in relapse , including two in relapse after the first all BMT ) , four patients suffered from chronic myelocytic leukemia ( CML ) ( in CP 2 , AP , BC , and relapse after BMT respecively ) , 6 patients suffered from myelodys plastic syndrome ( MDS ) , including one case of refractory anemia with excess of blasts ( REAB ) , one case of refractory anemia with excess of blasts in trransformation ( REAB T ) , and 4 cases of acute leukemia secondary to MDS . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
IgM and IgG WT 1 antibodies were measured by means of dot blot assay in 73 patients with hematopoietic malignancies ( 16 acute myeloid leukemia [ AML ] , 11 acute lymphoid leukemia [ ALL ] , 13 chronic myeloid leukemia [ CML ] , and 33 MDS ) and 43 healthy volunteers . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Serum nm 23 HI levels were significantly higher in patients with all of the hematological neoplasms tested ( AML , chronic myelogenous leukemia , acute lymphoblastic leukemia , ( ALL ) myelodysplastic syndrome ( MDS ) and malignant lymphomas ) than in normal controls . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Relapse of childhood ALL , AML and MDS after allogeneic stem cell transplantation can be prevented by donor lymphocyte infusion in a critical stage of increasing mixed chimerism ] . ^^^ RESULTS : Highly repetitive determination of the genetic status of 114 children with acute leukemias or MDS ( ALL : n = 41 , AML : n = 39 , MDS : n = 34 ) revealed 55 cases with CC and 43 with in MC . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Underlying diseases were leukaemia or MDS in 35 , of these ALL in 21 , hemophagocytic lymphohistiocytosis ( HLH ) in 9 , immunodeficiency or inborn error of metabolism in 5 patients . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
The patients had acute lymphoblastic leukemia ( ALL ; n = 22 ) , acute myelogenous leukemia ( AML ; n = 8 ) , myelodysplastic syndrome ( MDS ; n = 3 ) , or other diseases ( n = 7 ) . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
In addition to being aberrantly expressed in acute leukemias , activating mutations of the FLT 3 gene have been found in patients with AML , myelodysplastic syndrome ( MDS ) and more rarely , ALL . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
We compared the detection of FLT 3 ITD in DNA extracted from cells of bone marrow ( BM ) aspirations with DNA extracted from peripheral blood ( PB ) plasma in patients newly diagnosed with acute myeloid leukemia ( AML ; 85 patients ) , myelodysplastic syndrome ( MDS ; 16 patients ) , and acute lymphocytic leukemia ( ALL ; 16 patients ) . ^^^ FLT 3 ITD was detected in 18 ( 21 % ) AML samples and in one ( 6 % ) MDS sample in both cellular and plasma DNA but in none of the ALL samples . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
We identified a recurring translocation , t ( 1 ; 3 ) ( p 36 ; p 21 ) , in eight patients with various hematologic malignancies : three patients with ALL , one with chronic myelogenous leukemia ( CML ) in accelerated phase ( AP ) , two with MDS , and two with AML ( M 3 ) . ^^^ Using FISH with 13 1p35 36 cosmid probes ( tel FB 12 CA5 G 7 FD2 CB 1 ED8 FD 9 G32 AE 3 G50 AD 8 GG4 G 43 cen ) , we delineated the 1p36 breakpoint in two patients with MDS and ALL as lying between FB 12 and FD 2 ( between BAC47P3 and PAC963K15 ) , with a small deletion near the breakpoint in both cases . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
PATIENTS AND METHODS : Study participants were patients with refractory or relapsed acute myeloid ( AML ) or lymphocytic ( ALL ) leukemia , myelodysplastic syndromes ( MDS ) , or chronic myelogenous leukemia in blastic phase ( CML BP ) . ^^^ RESULTS : Forty two patients ( AML , 18 patients ; MDS , one patient ; ALL , six patients ; CML BP , 17 patients ) were treated . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Data from 118 167 HSCT ( 36 % allogeneic , 64 % autologous ) collected within the EBMT activity survey from 1990 to 2001 were used to assess trends over time , transplant rates and coefficient of variation ( CV ) of transplant rates among European countries for acute myeloid leukemia ( AML ; 18 . 5 % ) , acute lymphocytic leukemia ( ALL ; 12 % ) , chronic myeloid leukemia ( CML ; 11 . 5 % ) , myelodysplastic syndromes ( MDS ; 3 % ) , lymphoproliferative disorders ( LPS ; 36 . 3 % ) and multiple myeloma ( MM ; 18 . 7 % ) . ^^^ CVs of less than 50 % suggest consensus for allogeneic HSCT in AML , ALL , CML , MDS and NHL , for autologous HSCT in LPS and MM . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
In a phase 2 study , 62 patients with relapsed and refractory acute myeloid leukemia ( AML ; n = 31 ) , myelodysplastic syndrome ( MDS ; n = 8 ) , chronic myeloid leukemia in blastic phase ( CMLBP ; n = 11 ) , and acute lymphocytic leukemia ( ALL ; n = 12 ) received 40 mg / m2 clofarabine intravenously over 1 hour daily for 5 days , every 3 to 6 weeks . ^^^ Responses were observed in 4 of 8 patients with high risk MDS ( 50 % ) , in 7 ( 64 % ) of 11 with CML BP , and in 2 ( 17 % ) of 12 with ALL . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
This includes 110 cases of CML , 10 of ALL , 16 of AML ( M 3 ) , 2 of AML ( M 2 ) , 2 of MDS and 1 of CMML . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Comparison of the patients treated for chronic myelogenous leukemia ( CML ) , acute myelocytic leukemia ( AML ) , acute lymphocytic leukemia ( ALL ) , myelodysplastic syndromes ( MDS ) and aplastic anaemia ( AA ) revealed that mixed chimerism was practically absent in MDS and relatively long lasting in ALL and AA ( regardless to substantially different post transplantation treatment ) . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
A total of 50 patients were treated ( 44 with acute myelogenous leukemia [ AML ] / myelodysplasia [ MDS ] , 5 with chronic myelogenous leukemia [ CML ] , and 1 with acute lymphocytic leukemia [ ALL ] ) , and the drug was well tolerated at all dose levels , with myelosuppression being the major side effect . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
In the AL group ( n = 41 ) expression level of all the three subtypes was coordinately higher than that in the MDS group ( P < 0 . 01 ) , companying with a more frequency of 92 . 7 % , 97 . 6 % and 100 % . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
RESULTS : Hypermethylation of the CT gene occurred in 12 of 14 ( 85 . 7 % ) patients with acute lymphoblastic leukemia ( ALL ) , 9 of 15 ( 60 % ) acute nonlymphocytic leukemia ( ANLL ) , 8 of 10 ( 80 % ) chronic myelogenous leukemia ( CML ) , 5 of 15 ( 33 . 3 % ) malignant lymphoma ( ML ) , 2 of 5 patients with myelodysplastic syndrome ( MDS ) , 1 of 2 malignant histiocytosis ( MH ) , 1 of 3 chronic lymphocytic leukemia ( CLL ) and 1 of 9 multiple myeloma ( MM ) . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
In order to improve the definition of chromosomal breakpoints multicolor banding ( MCB ) was applied on 45 bone marrow samples from patients suffering from hematological malignancies like myelodysplastic syndrome ( MDS ) , acute myelocytic leukemia ( AML ) , chronic myelocytic leukemia ( CML ) or acute lymphoblastic leukemia ( ALL ) . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Diagnoses included AML ( n=36 ) , chronic myelogenous leukemia ( n=27 ) , NHL ( n=14 ) , ALL ( n=16 ) , MDS ( n=9 ) , aplastic anemia ( n=3 ) , and one Hodgkin ' s disease and myelofibrosis each . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Patients ( MDS 1 , NHL 1 , ALL 1 ) developed grade 2 4 GVHD at a median of 13 days ( range 9 17 ) after non myeloablative PBSCT ( HLA mismatched ) . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
However , the transformation of MDS into acute lymphoblastic leukemia ( ALL ) is extremely rare . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Nineteen cases ( 13 % ) presented as de novo ALL , two cases ( 1 % ) presented as de novo AML and three cases ( 2 % ) presented as myelodysplastic syndrome ( MDS ) . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
We studied clinical features of immunosuppressive ( cyclosporine , tacrolimus ) associated encephalopathy in bone marrow transplant patients . 378 cases of allogeneic bone marrow transplant recipients over fifteen years old of chronic and acute leukemia ( CML , ANLL , ALL ) ( n = 311 ) , myelodysplastic syndrome ( MDS ) ( n = 42 ) and severe aplastic anemia ( SAA ) ( n = 25 ) were investigated . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
In this study , various hematological malignancies , including nine cell lines and 45 clinical samples ( 32 acute myeloid leukemias ( AML ) , nine acute lymphoblastic leukemias ( ALL ) , two cases of myelodysplastic syndrome ( MDS ) , one multiple myeloma , and one chronic myelogenous leukemia in blast crisis ) , were examined to ask whether mutation of the CBP and p 300 genes could be involved in leukemogenesis . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Translocations or deletions involving the 11q23 region have been observed in acute lymphoblastic leukemia ( ALL ) , acute myelocytic leukemia ( AML ) , myelodysplastic syndrome ( MDS ) , and chronic lymphocytic leukemia ( CLL ) . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Four patients acquired CR among 7 patients with ALL after chemotherapy , but 2 out of 13 patients with AML achieved CR while 6 out of 7 patients with MDS transformed into AL . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Moreover , both positive rates and relative expression levels were significantly higher in acute myelogenous leukemia ( AML ) , acute lymphoblastic leukemia ( ALL ) , chronic myelogenous leukemia ( CML ) , and MDS groups than that in normal donor group . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
We conducted a phase 1 2 study of clofarabine plus ara C in 32 patients with relapsed acute leukemia ( 25 acute myeloid leukemia [ AML ] , 2 acute lymphoblastic leukemia [ ALL ] ) , 4 high risk myelodysplastic syndrome ( MDS ) , and 1 blast phase chronic myeloid leukemia ( CML ) . ( 1 ) Clofarabine was given as a 1 hour intravenous infusion for 5 days ( days 2 through 6 ) followed 4 hours later by ara C at 1 g / m ( 2 ) per day as a 2 hour intravenous infusion for 5 days ( days 1 through 5 ) . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
A network was therefore created to integrate the leading leukemia trial groups on chronic myeloid leukemia ( CML ) , acute myeloid leukemia ( AML ) , acute lymphatic leukemia ( ALL ) , myelodysplastic syndromes ( MDS ) and chronic myeloproliferative diseases ( CMPD ) and their interdisciplinary partners ( diagnostics , treatment research , biometry ) in cooperation with basic research and pharmaceutical industry to foster advancements in leukemia related research and health care through clinical trials , promotion of translational research , introduction of standards for diagnostics and therapy , and development of evidence based guidelines . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Diagnoses were ALL ( 8 ) , AML ( 6 ) , MDS ( 2 ) , CML ( 2 ) , large cell anaplastic lymphoma ( 1 ) and SAA ( 4 ) . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
We evaluated the feasibility of allogeneic transplantation of CliniMACS selected peripheral CD34+ cells from siblings ( four patients : AML M 4 , M 2 , CLL , MDS ) ; nonoptimal related donors ( two patients : AML M 4 , CML ) ; and unrelated donors ( two patients : CML , ALL , both without engraftment after preceding URDBMT ) . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
There were 8 cases of acute myelogenous leukemia ( AML ) , 5 cases of acute lymphocytic leukemia ( ALL ) , 6 cases of chronic myelogenous leukemia ( CML ) and 2 cases of myelodysplastic syndrome ( MDS ) . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
In 178 patients receiving T cell depleted HLA identical sibling transplants for acute myelogenous leukemia ( AML ) , chronic myelogenous leukemia ( CML ) , acute lymphoblastic leukemia ( ALL ) , or myelodysplastic syndrome ( MDS ) , analysis of donor KIR genotype with HLA genotype demonstrated that 62 . 9 % of the patients lacked an HLA ligand for donor inhibitory KIR . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Methods Thirty three patients [ median age 42 years , range 23 55 years , diagnosis AML / myelodysplastic syndrome ( MDS ) 14 , ALL nine , CML seven and multiple myeloma ( MM ) three ] received myeloablative conditioning followed by infusion of selected CD34+ cells from matched unrelated donors ( 31 ) or HLA identical siblings ( two ) . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
METHODS : All DS patients aged < 18 years of age with a diagnosis of leukemia or myelodysplastic syndrome ( MDS ) from 1990 to 2002 were included in this retrospective study . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
METHODS : In a single center prospective cohort study , 255 patients undergoing allogeneic SCT for CML , AML , MDS , and ALL were followed for at least 5 years . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
However , neither aberrations was found in 25 patients with acute lymphoblastic leukemia ( ALL ) , 2 acute hybrid leukemia , 17 MDS and 7 chronic myeloid leukemia in blast crisis ( CML BC ) . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
We explored the clinical relevance of this phenomenon in MDS ( n = 446 ) , AML ( n = 1314 ) , and acute lymphoblastic leukemia ( ALL ) ( n = 385 ) . ^^^ Among patients with MDS or ALL , but not AML , having a higher blast percentage in PB than in BM was associated with significantly shorter survival . ^^^ Our findings suggest that MDS and ALL patients who have a higher percentage of PB blasts than BM blasts have more aggressive disease . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
We used direct sequence analysis to determine if the JAK2V617F mutation was present in acute myeloid leukemia ( AML ) , chronic myelomonocytic leukemia ( CMML ) / atypical chronic myelogenous leukemia ( aCML ) , myelodysplastic syndrome ( MDS ) , B lineage acute lymphoblastic leukemia ( ALL ) , T cell ALL , and chronic lymphocytic leukemia ( CLL ) . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Girls ( P = . 0001 ) and children diagnosed with acute myelogenous leukemia ( AML ) , chronic myelogenous leukemia ( CML ) , or myelodysplastic syndromes ( MDS ) ( compared with acute lymphoblastic leukemia [ ALL ] or non Hodgkin lymphoma [ NHL ] ; P = . 02 ) also showed more rapid growth than their counterparts . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
We retrospectively compared CSA / MTX and CSA / MMF in 93 patients ( median age 35 years , range 17 59 years , male subjects 48 , female subjects 45 ) with acute myeloid leukemia ( n=33 ) , myelodysplastic syndrome ( MDS ) ( n=3 ) , acute lymphoblastic leukemia ( ALL ) ( n=20 ) or chronic myeloid leukemia ( n=37 ) who received CSA / MMF ( n=26 ) or CSA / MTX ( n=67 ) as GVHD prophylaxis following high dose therapy and allogeneic SCT from HLA identical siblings . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
We describe the clinical , hematological and histomorphological features in children of primary myelodysplastic syndrome ( MDS ) seen at the All India Institute of Medical Sciences over three years ( Jan 2001 Jan 2004 ) . ^^^ We conclude that the latest proposed WHO classification for Pediatric MDS can be successfully applied to all cases of primary MDS . . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
In the study 13 children and 5 adults with ALL and AML or MDS , respectively , have been included . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
To analyze the frequency of CTL against PR 1 , PRAME and WT 1 after HSCT , a tetramer based analysis was performed in 97 samples taken from 35 patients ( 9 AML , 11 MDS , 2 CML , 4 ALL , 7 lymphoma and 2 renal cell carcinoma [ RCC ] ) with the HLA A 02 phenotype . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Approximately 30 % of cases of MDS eventually progress to acute myelogenous leukemia ( AML ) , while progression of MDS into acute lymphoblastic leukemia ( ALL ) is rare . ^^^ In this report , we describe a case of MDS that progressed to ALL , and review the 21 previously reported cases of MDS to ALL transformation . ^^^ We review the cancer stem cell model and its application to these disorders , and discuss the implications of the rarity of transformation of MDS to ALL for the biology of MDS and the pathogenesis of ALL . . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
GOALS : A network was therefore created to integrate the leading leukemia trial groups on chronic myeloid leukemia ( CML ) , acute myeloid leukemia ( AML ) , acute lymphatic leukemia ( ALL ) , myelodysplastic syndromes ( MDS ) and chronic myeloproliferative diseases ( CMPD ) and their interdisciplinary partners ( diagnostics , treatment research , biometry ) in cooperation with basic research and pharmaceutical industry to foster advancements in leukemiarelated research and health care through clinical trials , promotion of translational research , introduction of standards for diagnostics and therapy , and development of evidence based guidelines . ^^^ The ELN integrates 78 leading leukemia trial groups ( AML , ALL , CML , CLL , MDS , and CMPD ) , their 83 interdisciplinary partner groups ( diagnostics , treatment research , registry , guidelines ) , industry and SMEs ( small and medium sized enterprises ) across Europe to form a cooperative network for advancements in leukemia related research and health care . . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
We report a case of an elderly man who had MDS transformed into Acute Lymphoblastic Leukaemia ( ALL : L 3 ) which is a rare lymphoid transformation . . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
This study concerns a patient with minor ( m ) BCR / ABL transcript positive and Philadelphia ( Ph ) chromosome negative myelodysplastic syndrome ( MDS ) . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
We report a late appearance of the Philadelphia chromosome ( Ph ) with the p 190 BCR / ABL chimeric transcript in a 69 year old patient with acute myelogenous leukemia ( AML ) that had evolved from myelodysplastic syndrome ( MDS ) . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
A morphometric analysis of bone marrow trephine biopsies has been performed to study the frequency and planimetric characteristics of so called atypical micromegakaryocytes in chronic myeloid leukemia ( CML ) and myelodysplastic syndromes ( MDS ) . ^^^ When stringent diagnostic criteria ( diameter ranging between 10 to 15 microns , mean size about 12 microns ) were applied , this abnormal cell population comprised less than 10 % of total megakaryocytopoiesis in CML and MDS . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Cell cycle phases of bone marrow cells from 8 patients with iron deficiency anemia ( IDA ) , 8 aplastic anemia ( AA ) , 30 myelodysplastic syndrome ( MDS ) , 41 acute leukemia ( AL ) before treatment , 8 acute leukemia in relapse , 17 acute leukemia in complete remission ( CR ) , 12 chronic myelogenous leukemia ( CML ) and 4 chronic lymphocytic leukemia ( CLL ) were analysed with flow cytometry . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
RESULTS : Various types of oncohematological diseases developing 10 20 years after Chernobyl accident were registered in a group of clean up workers under study including myelodysplastic syndromes ( MDS ) , acute leukemias ( ALL and AML ) , chronic myelogenous leukemia ( CML ) and other chronic myeloproliferative diseases , chronic lymphocytic leukemia ( B CLL ) and other chronic lymphoproliferative diseases of B and T cell origin . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
The success of Bestatin therapy in MDS led us to investigate the clinical activity of Bestatin in CML . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
From these findings we conclude that ubenimex could be utilized in MDS or CML if the patient was at risk for strong chemotherapy . . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
The administration of recombinant cytokines seems to be of potential benefit in some other malignant conditions ( rIFN a in CML , recombinant colony stimulating factors [ rCSFs ] in MDS or in combination with chemotherapy in AML and advanced MDS ) . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Moreover , morphometric evaluation disclosed that micromegakaryocytes in MDS differ significantly from those in chronic myeloid leukaemia ( CML ) due to distinctive nuclear features and a disturbed nuclear : cytoplasmic ratio . ^^^ These changes generate a more pleomorphic or atypical appearance of this cell population in MDS , compared with micromegakaryocytes in CML . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
A total of 170 patients with chronic myeloid leukemia ( CML ) , 107 in chronic phase ( CP ) and 63 in blastic phase ( BP ) of the disease , 187 patients with `` de novo ' ' acute myelogenous leukemia ( AML ) and 175 patients with myelodysplastic syndrome ( MDS ) , 164 patients with primary and 11 with secondary MDS , were cytogenetically examined . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Patients with myelodysplatic syndrome ( MDS ) and chronic myelogenous leukemia ( CML ) responded to bestatin , and it is noted that cytogenetic remission was obtained in CML . ^^^ MDS and CML are thought to be a family of clonal malignant disorders in which malignant transformations occurs at the level of the pluripotent stem cell . ^^^ Bestatin may be capable of modifying the biological proliferative disequilibrium of the disease , and the therapy opens new and promising prospects in the treatment of both MDS and CML . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Leukemic blood and bone marrow cells from patients with various types of acute myeloid leukemia ( AML ) , chronic myeloid leukemia ( CML ) in chronic phase , as well as bone marrow samples from patients with myelodysplastic syndromes ( MDS ) were studied . ^^^ In the absence of exogenous EPO and in the presence of 10 % human AB serum , MGF in the presence of IL 3 and / or GM CSF induced erythroid colony formation from normal bone marrow and patients with MDS or CML , illustrating that MGF greatly diminished the EPO requirement for erythroid differentiation . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Three patients , one with Philadelphia ( Ph ) chromosome positive chronic myelocytic leukemia ( CML ) and two with primary acquired myelodysplastic syndromes ( MDS ) , have been identified to have a t ( 3 ; 21 ) ( q 26 ; q 22 ) . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Quantitative and qualitative evaluations of erythrocyte ferritin in 161 patients with RA and RAEB in MDS , AML , CML , PV , PA , HS , IDA , chronic liver disease and alcoholic liver disease were carried out . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Mean dosages of SM 108 until remission were 400 500 mg / m2 / day on CMMoL , RAEB in MDS , polycythemia vera and CML , and 600 800 mg / m2 / day on RAEB in T and AML . ^^^ Our study indicates that SM 108 is useful agent against MDS , especially CMMoL , RAEB , RAEB in T , polycythemia vera and CML . . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
MPO deficient PMN were found to occur in a minor number ( less than 4 % of the total number of PMN ) in normal humans and the incidences of an abnormal number ( greater than 4 % ) were found to be about 40 % in AML ( 1 , 2 , 3 , 4 , 8 ) , 60 % in CML ( 1 , 7 ) , 30 % in MPD other than CML ( 7 ) and 30 % in MDS ( 5 ) . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
We examined the in vitro effect of recombinant human granulocyte colony stimulating factor ( rhG CSF ) on neutrophil anomalies in 20 patients with myelodysplastic syndromes ( MDS ) and eight patients with chronic myelogenous leukemia ( CML ) . ^^^ Neutrophil alkaline phosphatase ( NAP ) activity was determined in nine MDS patients and eight CML patients by a scoring method . ^^^ NAP scores were decreased in six of the nine patients with MDS and in all of the patients with CML . ^^^ An increase in NAP scores by rhG CSF was observed even at a concentration of 1 U / mL in patients with MDS but was observed only at higher concentrations ( 1 , 000 to 10 , 000 U / mL ) in patients with CML . ^^^ Significant increases in NAP scores occurred at 12 hours ' incubation in patients with MDS , whereas the increase was more gradual in patients with CML . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Clinical investigation of interferons in the preleukemic state ( CML and MDS ) ] . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Neutrophil alkaline phosphatase activity was estimated in 194 patients ; 59 cases of chronic myeloid leukaemia ( CML ) , 42 cases of polycythaemia vera ( PV ) , 24 cases of primary myelofibrosis , 7 cases of idiopathic thrombocythaemia , 6 cases of leukaemoid reaction , 19 cases of secondary polycythaemia ( PS ) and 37 cases of the primary myelodysplastic syndrome ( MDS ) . ^^^ The MDS group , the only group besides CML that showed decreased scores , also differed significantly from the others ( p less than 0 . 001 ) . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
We studied the expression of IL 6 gene in 49 patients , including 21 chronic myelomonocytic leukemias ( CML ) , 9 other myelodysplastic syndromes ( MDS ) , 18 acute myeloid leukemias ( 11 M 2 or M 3 and 7 M 4 or M 5 ) and 1 case of acute biphenotypic lymphoid monocytic leukemia . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
AML developing after a prior history of MDS ( 5 / 17 : 29 . 4 % ) , CML BC ( 2 / 9 : 22 . 2 % ) . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
We analyzed the clinical , hematologic and genetic features of 4 patients with M 7 , and acute megakaryoblastic transformation of CML , MDS and essential thrombocythemia . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
This study included cases of myelodysplastic syndrome ( MDS ) , myeloproliferative disorder ( MPD ) , aplastic anaemia ( AA ) , idiopathic thrombocytopenic purpura ( ITP ) , chronic myelogenous leukaemia ( CML ) , and control cases free from any haematological disease . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
We analysed here the expression of c kit in myeloproliferative disorders ( MPDs ) , including chronic myelogenous leukemia ( CML ) , essential thrombocythemia ( ET ) , polycythemia vera ( PV ) , and idiopathic myelofibrosis ( IMF ) and in the myelodysplastic syndromes ( MDS ) . ^^^ There was a statistically significant increase in c kit messenger levels in CML , ET , PV , IMF , and MDS as compared with controls ( healthy volunteers ) . ^^^ Expression correlated with the phase of the disease , being highest in the blast crisis of CML and in the RAEB / RAEBt phases of MDS . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Deletions , inversions and insertions of chromosome 3q21 q 26 , as well as translocations of 3q21 with other chromosomes have been described in many cases of acute myeloid leukemia ( AML ) , acute non lymphocytic leukemia ( ANLL ) , chronic myeloid leukemia ( CML ) and myelodisplastic syndromes ( MDS ) , suggesting that this region contains several genes involved in the leukemic process . . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
The suppressive effect by TGF beta 1 was increased for growth with GM CSF , IL 3 , and SCF , and growth with G CSF was unaffected in hematologic malignancies , TGF beta 1 suppression for growth with G CSF was increased for essential thrombocythemia ( ET ) and polycythemia vera ; chronic myelogenous leukemia ( CML ) in chronic phase ; CML in accelerated phase ; CML in myeloid crisis ; myelodysplastic syndrome ( MDS ) in refractory anemia ; MDS in refractory anemia with an excess of blasts ; and acute myeloblastic leukemia ( AML ) . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
The common deletion was not detectable in 20 patients with myelodysplastic syndromes ( MDS ) , 20 patients with acute myeloid leukemia ( AML ) , and 10 patients with chronic myeloid leukemia ( CML ) . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
The t ( 3 ; 21 ) ( q 26 ; q 22 ) translocation is found usually in blastic crisis of CML and leukemias developed from MDS or hematopoietic proliferative diseases , but never in de novo acute myelocytic leukemia . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
The hematological diseases included 19 cases of myelodysplastic syndrome ( MDS ) , 18 of multiple myeloma ( MM ) , 18 of chronic myelocytic leukemia ( CML ) , 9 of aplastic anemia ( AA ) , 8 of acute myelocytic leukemia ( AML ) , 3 of chronic lymphocytic leukemia ( CLL ) , 3 of myelofibrosis , and 3 others . ^^^ Using STIR with double echo times , bone marrow showed high signal intensity ( SI ) on short TE and low SI on long TE in MDS and CML ; high SI on short and long TE in myelofibrosis and CLL ; high SI on short TE and high to moderately high SI on long TE in MM ; and low SI on short and long TE in AA . ^^^ CML and MDS were similar with low sensitivities ( 40 % , 41 % ) and high specificities ( 80 % , 78 % ) . ^^^ Differential diagnosis between CML and MDS was difficult using STIR with the double echo time method . . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
CML and MDS patients had higher TNF alpha levels than acute leukemia patients . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
EVI 1 expression was also detected in 6 ( 35 . 3 % ) of 17 MDS patients and three of six patients with chronic myeloid leukemia ( CML ) in myelomegakaryoblast crisis . ^^^ Chromosomal abnormalities at the 3q26 region , where the EVI 1 gene is located , were found in one patient with MDS and two patients with CML myelomegakaryoblast crisis who had EVI 1 expression . ^^^ In patients with post MDS AML , EVI 1 expression was not always associated with a 3q26 abnormality , whereas EVI 1 expression in CML myelomegakaryoblast crisis was often linked to a 3q26 abnormality . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Chloroma is noted in the course of the acute non lymphoblastic leukemia ( ANLL ) , chronic myeloid leukemia ( CML ) , and in myelodysplastic syndromes ( MDS ) during their transformation in the acute leukemias . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Eligible diagnosis included acute leukemia ( AL ) ( n = 15 ) , chronic myelogenous leukemia ( CML ) ( n = 4 ) , myelodysplastic syndrome ( MDS ) ( n = 3 ) , and severe aplastic anemia ( SAA ) ( n = 2 ) . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Trephine biopsies were studied from 60 patients with myelodysplasia ( MDS ) , 36 patients with chronic myelogenous leukemia ( CML ) and 18 patients with osteomyelofibrosis ( PMF ) . ^^^ HHV 6 titers were elevated in 18 % of the MDS cases , but in only one case each of CML and OMF . ^^^ Antigen expression in bone marrow cells was even more frequent : EBV EA was 76 % in MDS cases , 77 % in CML and 40 % in OMF . ^^^ HHV 6 p 41 was observed in 47 % of the MDS cases , in 54 % of the CML cases and in 20 % of the OMFs . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Based on a preliminary observation that colony stimulating factor ( CSF ) responsive myeloid progenitor cells ( CFU GM ) from a few patients with acute myeloid leukemia ( AML ) did not respond to the costimulating effects of SLF , we evaluated responsiveness of bone marrow or blood CFU GM from 26 patients with either AML , chronic myeloid leukemia ( CML ) or myelodysplastic syndrome ( MDS ) to the effects in vitro of SLF and / or granulocyte macrophage CSF ( GM CSF ) . ^^^ Nine of 13 patients with AML , 2 of 6 patients with CML and 4 of 7 patients with MDS had clonogenic cells that did not respond significantly to the costimulating effects of SLF . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
There are two groups ; one includes chronic myelogenous leukemia ( CML ) , essential thrombocythemia ( ET ) and MDS , which all have decreased chemiluminescence of neutrophils . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
GS may be diagnosed in different malignant blood diseases involving the granulocytic series , acute non lymphoblastic leukemia ( ANLL ) being the most frequent , followed by myelodysplastic syndromes ( MDS ) and chronic myeloproliferative syndromes , specially chronic myeloid leukemia ( CML ) in blastic crisis . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
In contrast , percentages of `` small ' ' megakaryocytes were significantly higher in patients with stem cell disorders ( namely , myelodisplastic syndrome and chronic granulocytic leukaemia ) , as compared to controls ( 35 . 3 % in MDS ; 22 . 9 % in CML and 10 . 6 % in controls ) . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
We evaluated engraftment of all patients with acute myelogenous leukemia ( AML ) , chronic myelogenous leukemia ( CML ) and myelodysplastic syndrome ( MDS ) receiving an unmanipulated marrow allogeneic BMT at the Detroit Medical Center from 1987 to 1992 using a busulfan , cyclophosphamide + / cytarabine preparative regimen . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
In 67 cases of newly diagnosed blood malignancies , NonT ALL , T ALL , AMLL , AML , CML , CLL , HCL , PLL , MDS , B splenic lymphoma , AUL , as well as in 9 cell lines ( U 937 , HEL , Jurkat , HL 60 , UHKT 2 , KG 1 , Raji , K 562 , REH ) , we have analysed the expression and distribution of 2 relatively incompletely studied antigenic markers from the CD nomenclature : CDw 12 and CD 17 , individually and in combination with well characterized ones . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
METHODS A retrospective review of bone marrow aspirates from 35 patients presenting consecutively with MDS and from 20 patients with each of the following : normal marrow appearance ( routine staging for non Hodgkin ' s lymphoma ) , polycythaemia rubra vera , immune thrombocytopenic purpura ( ITP ) , chronic myeloid leukaemia ( CML ) in chronic phase . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Therefore , the FAB subtype of AML including MDS and CML could be distinguished from each other on the basis of SP pattern . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
We conducted a case control study of 50 acute myeloid leukemias ( AML ) , 17 chronic myeloid leukemias ( CML ) , 19 myelodysplastic syndromes ( MDS ) , and 246 controls . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
P glycoprotein ( P gp ) expression in mononuclear bone marrow cells was analyzed in 119 patients , including 60 with chronic myelogenous leukemia ( CML ) , 48 with myelodysplastic syndromes ( MDS ) , and 11 with acute myelogenous leukemia ( AML ) . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
These findings suggest that AML / TMDS and AML / MRM are different from typical AML and are similar to MDS / AML and CML in view of their potential for disease progression from latent multiple clones . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
METHODS : Twenty four patients ( 16 relapsed or refractory acute myeloid leukemias , five blastic myelodysplastic syndromes [ MDS ] , two chemotherapy related secondary leukemias , and one blastic chronic myelogenous leukemia [ CML ] ) , including seven who had failed to respond to prior bone marrow transplantation ( BMT ) , received from 50 mCi / m2 to 210 mCi / m2 of 131I M 195 in divided doses . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Increased incidence of p 53 gene aberrations or chromosome 17p monosomy resulting from an isochromosome 17q [ 1 ( 17q ) ] has been observed with transition of chronic myelogenous leukemia ( CML ) to myeloid blast crisis ( BC ) , and in some patients with poor risk acute myeloid leukemia ( AML ) progressing from myelodysplastic syndrome ( MDS ) . ^^^ These findings question the hypothesis that p 53 gene alterations are the principal molecular event responsible for progression of CML chronic phase or MDS to 1 ( 17q ) positive CML BC or AML , respectively . . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
This therapeutic approach appears to be valuable for relapsed MDS following allo BMT as well as for chronic myelogenous leukemia ( CML ) . . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
If performed early in the disease course ( e . g . during the chronic phase of CML or first remission of acute leukemia and MDS ) allogeneic BMT cures 50 to 60 % of patients . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Of a total of 5824 patients transplanted for AML , CML or MDS by 86 teams , granulocytic sarcoma was observed in 26 patients ( 0 . 45 % occurring 4 56 months after BMT . ^^^ Granulocytic sarcoma occurred after allogeneic BMT in 20 out of 3071 patients grafted for AML ( 0 . 65 % ) , and in the CML / MDS subgroup in six out of 2753 grafted patients ( 0 . 22 % ) . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
A total of 72 patients was studied ( 29 AML , 17 MDS , 20 CML and six other myeloproliferative disorders ) . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
We investigated 23 patients for their chimerism status who underwent allogeneic transplantation using peripheral blood progenitor cells ( PBPCT ) for chronic myelogenous leukemia ( CML ) ( n = 14 ) , acute myelogenous leukemia ( AML ) ( n = 5 ) , acute lymphoblastic leukemia ( n = 1 ) , myelodysplasia ( MDS ) ( n = 1 ) , and Hodgkin ' s disease ( HD ) ( n = 2 ) . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
These data , and review of the literature , suggest that GVL induction with donor MNC infusions is less effective for patients with relapsed acute leukemia than for patients with relapsed CML ; too few patients with relapsed MDS have been treated to draw definite conclusions . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
We called this type of translocation `` segmental jumping translocation ( SJT ) . ' ' SJT of the ABL oncogene was not detected in samples from 15 patients with de novo acute myelocytic leukemia ( AML ) , 12 with myelodysplastic syndrome ( MDS ) , or 20 with chronic myelocytic leukemia ( CML ) at the chronic phase . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
In the 19 cases with deletions , we identified two distinct commonly deleted regions : one region within band 7q22 was defined by the two CML cases ; the second region encompassed a distal part of band 7q22 and the entire band 7q31 and was defined by the MDS / AML cases . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
The index group consisted of 46 children with MDS , 62 with AML , and eight with CML , which is thought to represent all myeloid leukaemias in Danish children , 1980 91 . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
We examined levels of expression and enzymatic activity of p 55 ( c fgr ) peripheral blood neutrophils of patients with myelodysplastic syndromes ( MDS ) and chronic myelogenous leukemia ( CML ) by comparison with those of normal individuals . ^^^ While neutrophils of eight normal subjects gave uniform results , the specific enzymatic activity of p 55 ( c fgr ) , a ratio of the total kinase activity versus the protein level was reduced in seven out of eight patients with MDS and all of five patients with CML . ^^^ The reduced activity of this tyrosine kinase was considered to be a biological parameter for immaturity and to reflect dysfunction of neutrophils of patients with MDS and with CML . . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
The inv ( 3 ) is a relatively frequent chromosomal rearrangement in patients with myeloid malignancies and dysmegakaryopoiesis and t ( 3 ; 12 ) ( q 26 ; p 13 ) has also been reported as a recurrent abnormality in MDS and in blast crisis of chronic myelogenous leukemia ( CML ) . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Increased EVI 1 gene expression has been detected in a number of myeloproliferative disorders including MDS , AML , blast crisis of CML , and more recently in the peripheral blood of some JMML patients . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
An enhanced expression of the mRNA for TNF alpha was observed in most of the samples from MDS patients ( 11 / 14 , 79 % ) , whereas no enhancement was observed in bone marrow samples from AML ( 0 / 6 ) , CML ( 0 / 2 ) or control cases ( 0 / 8 ) . ^^^ The expression of IFN gamma was also enhanced in some of MDS cases ( 5 / 12 , 42 % ) while AML ( 0 / 5 ) , CML ( 0 / 2 ) and control cases ( 0 / 6 ) showed very low levels of IFN gamma mRNA expression . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
When we examined the genomic DNA of G CSFR obtained from 41 patients with acute myelogenous leukemia ( AML ) , 18 with chronic myelogenous leukemia ( CML ) , 7 with myelodysplastic syndrome ( MDS ) , 2 with chronic myelomonocytic leukemia and 1 with chronic neutrophilic leukemia , we found a polymorphism in 3 patients , but no significant pathogenic mutations in any patients . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
To determine the clinical implications of soluble CD 44 ( sCD 44 ) levels in hematologic neoplasias , we developed an enzyme linked immunosobent assay for sCD 44 using two monoclonal antibodies to the standard 90 kDa form , and assessed the serum concentration of sCD 44 in normal healthy volunteers , patients with acute leukemia , myelodysplastic syndromes ( MDS ) , and those with chronic myeloid leukemia ( CML ) . ^^^ The sCD 44 levels in patients with MDS increased after they developed acute leukemia , whereas no significant difference in sCD 44 levels was observed between the chronic and the blastic phases in patients with CML . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Transfusion of donor leukocytes ( DLT ) after marrow transplantation has induced lasting remissions in the majority of patients with chronic myelogenous leukemia ( CML ) in hematological or cytogenetic relapse , some patients with acute myeloid leukemia ( AML ) , myelodysplastic syndromes ( MDS ) , transformed phase CML and multiple myeloma ( MMY ) . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
However , additional cytogenetic abnormalities , including t ( 3 ; 21 ) typically seen in therapy related myelodysplastic syndrome ( MDS ) and AML and blast crisis of CML , developed as an independent cell line following the autograft . ^^^ More than 4 years after the autograft , the patient remains in chronic phase with no evidence of accelerated phase or blast crisis of CML , but with a concurrent MDS . ^^^ We report a case of CML who developed therapy related MDS following PBSC autograft while still remaining in chronic phase . . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Fitness landscapes , which provide a unique perspective for viewing co evolving cell populations , were used to study the evolution of CML and MDS . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
We have investigated the production of these two enzymes as well as the membrane type MMP ( MT 1 MMP ) and the tissue inhibitors of metalloproteinases ( TIMPs ) TIMP 1 and TIMP 2 in the bone marrow mononuclear cells ( BM MNCs ) of patients with acute myeloid leukemia ( AML ; n = 24 ) , chronic myeloid leukemia ( CML ; n = 17 ) , myelodysplastic syndromes ( MDS ; n = 8 ) , and healthy donors ( n = 5 ) . ^^^ Quantitative Northern blot analysis in freshly isolated BM MNCs showed a relatively low constitutive expression of TIMP 1 in all samples , whereas MMP 9 gene transcription was higher in healthy donors and CML samples , than in AML and MDS . ^^^ MT 1 MMP expression was present in most samples of patients with MDS or AML but absent in those with secondary AML and CML . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
We have analyzed 21 hematologic malignancies ( 8 CML in blast crisis , 8 myelodysplastic syndromes [ MDS ] , 2 acute myeloid leukemias , 2 chronic lymphocytic leukemias , and 1 acute lymphoblastic leukemia ) with 1 ( 17q ) by fluorescence in situ hybridization ( FISH ) . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
The Ab were applied on paraffin sections of normal bm ( iliac crest , n=17 ; talus , n=1 ; phalanx , n=1 ) , myeloregenerative bm ( after chemotherapy ) , and hematologic disorders ( acute myeloid leukemia ( AML ) , n=8 ; chronic myeloid leukemia ( CML ) , n=6 ; myelodysplastic syndromes ( MDS ) , n=14 ; severe aplastic anemia ( SAA ) , n=4 ; essential thrombocythemia ( ET ) , n=2 ; idiopathic ( primary ) osteomyelo fibrosis ( IMF ) , n=1 ; polycythemia vera ( PV ) , n=1 ) . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Using an unambiguous polymerase chain reaction ( PCR ) method , we assayed nonmalignant lymphoblastoid cell lines derived from 104 patients with myeloid leukemias ; 56 had therapy related acute myeloid leukemia ( t AML ) , 30 had a primary myelodysplastic syndrome ( MDS ) , 9 had AML de novo , and 9 had chronic myelogenous leukemia ( CML ) . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Tr CML can not be distinguished from de novo CML cytogenetically , and , in contrast to tr AML and tr MDS , typical chromosomal aberrations related to tr CML have not been described . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
AIM : The expression of CD 95 ( Fas / APO 1 ) antigen was studied on bone marrow cells of 19 MDS patients , peripheral blood blast cells of 15 acute myeloid leukemia ( AML ) patients , blast cells and granulocytes of 68 patients with chronic myeloid leukemia ( CML ) 24 in chronic , 9 in accelerated phase and 35 in blastic crisis ( BC ) by indirect surface immunofluorescence assay using flow cytometry ( FACScan , Becton Dickinson , USA ) . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
The PHD distribution was : MGUS 84 cases ; NHL 57 ; MDS 33 ; CLL 26 ; CMPD 26 ; MM 21 ; HD 14 ; AL 11 ; ITP 10 ; CML 9 ; AIHA 5 ; hypoplastic anaemia 3 ; and cryoglobulinaemia 3 . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
While the megakaryocyte rich subtype of chronic myeloid leukemia ( CML ) and the 5q ( ) syndrome ( MDS ) are dominated by abnormal micromegakaryocytes , in polycythemia vera ( PV ) this cell lineage reveals a pleomorphous appearance . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
CD34+ cells from a total of 93 patients with either acute myeloid leukemia ( AML ; n = 25 ) , chronic myeloid leukemia ( CML ; n = 21 ) , chronic lymphocytic leukemia ( CLL ; n = 18 ) , polycythemia vera ( PV ; n = 16 ) , or myelodysplastic syndromes ( MDS ; n = 13 ) were analyzed before and in 19 patients after ex vivo expansion in the presence of multiple cytokines ( kit ligand , interleukin 3 , interleukin 6 , and granulocyte colony stimulating factor plus erythropoietin ) . ^^^ Compared with hematopoietic progenitor cells from normal donors ( n = 108 ) , telomerase activity ( TA ) was increased 2 to 5 fold in chronic phase ( CP ) CML , CLL , PV , and MDS . ^^^ Our results demonstrate that up regulation of telomerase is similar in CD34+ cells from CP CML , CLL , PV , and MDS patients and in normal hematopoietic cells during the first week of culture , whereas in AML and AP / BP CML , telomerase is high at baseline and down regulated during expansion culture . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Granulocytic sarcomas ( GS ) are extramedullary tumor masses of immature myeloid cells , most frequently associated with hematological disorders including acute myeloid leukemia ( AML ) , chronic myelogenous leukemia ( CML ) , and myelodysplastic syndrome ( MDS ) . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Transcripts for GM CSF , a cytokine whose production by leukemia cells is believed to play an important role in the pathogenesis of leukemia , was not detectable in 12 / 13 unprocessed AML specimens , in 12 / 12 MDS specimens , or in 7 / 7 CML specimens but once detected in many specimens after processing . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Analysis of 59 patients with acute myeloid leukaemia ( AML ) , 26 patients with myelodysplastic syndromes ( MDS ) and 10 patients with chronic myeloid leukaemia ( CML ) only revealed a polymorphic base substitution in codon 44 in one AML patient , suggesting that mutations in the MMAC1 / PTEN gene are infrequent genetic aberrations in myeloid leukaemia . . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
BACKGROUND : Patients with transformed chronic myelogenous leukemia ( CML ) and advanced myelodysplastic syndrome ( MDS ) have poor prognosis . ^^^ The aim of this study is to evaluate the feasibility of second chronic phase induction in accelerated phase ( CML AP ) or blastic crisis of CML ( CML BC ) and remission induction in advanced MDS by combining topoisomerase 1 inhibitor ( topotecan ) with topoisomerase 2 inhibitor ( mitoxantrone ) . ^^^ Eighteen patients with transformed CML ( 7 CML AP , 11 CML BC ) and 6 patients with advanced MDS were treated . ^^^ Four of 7 patients with CML AP ( 57 % ) , 2 of 4 patients with CML lymphoid blastic crisis ( LBC ) ( 50 % ) and 2 of 6 patients with advanced MDS ( 33 % ) had CR lasting more than 45 days ( 45 to 400 days ) . ^^^ CONCLUSION : The combination of topotecan mitoxantrone has shown modest activity in CML AP , CML LBC and advanced MDS with acceptable toxicities . . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
There are four major divisions : chronic myeloid leukemia ( CML ) , which is easily identified by the presence of the Philadelphia chromosome ( or its molecular equivalent ) ; the myelodysplastic syndromes ( MDS ) , which are characterized by trilineage dysplasia ; chronic myeloproliferative diseases ( CMPD ) , which include essential thrombocythemia , polycythemia vera , and agnogenic myeloid metaplasia ( AMM ) ; and atypical CMD , which includes chronic neutrophilic leukemia , chronic eosinophilic leukemia , mast cell disease , and myeloid processes that display overlapping features of MDS and CMPD ( hybrid CMD ) . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Ten patients with high risk acute myeloid leukemia ( AML ) , chronic myeloid leukemia ( CML ) , and myelodysplastic syndrome ( MDS ) relapsing early ( < 1 year , n = 8 ) or late ( > or = 1 year , n = 2 ) after allogeneic transplantation were treated with cytoreductive chemotherapy followed by unmanipulated peripheral blood stem cell transplantation ( PBSCT ) from related ( n = 3 ) and unrelated donors ( n = 7 ) . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
We examined whether IL 12 enhanced the cytotoxicity of peripheral blood mononuclear cells ( PBMNC ) and decreased leukemia cells in 30 patients with leukemia or myelodysplastic syndromes ( MDS ) : 12 acute myeloid leukemia ( AML ) ( five in complete remission ( CR ) and seven in non CR ) ; six chronic myeloid leukemia ( CML ) ; and 12 MDS ( three refractory anemia ( RA ) , eight RA with excess of blasts and one chronic myelomonocytic leukemia ) . ^^^ Following the 3 day IL 12 treatment , mean WT 1 mRNA of PBMNC was reduced from 10 ( 4 . 8 ) to 10 ( 4 . 2 ) copies / microg of total RNA in six CML patients , from 10 ( 5 . 4 ) to 10 ( 4 . 8 ) copies / microg in 12 MDS patients and from 10 ( 5 . 0 ) to 10 ( 4 . 2 ) copies / microg in five AML patients in CR , but not reduced in five of seven AML in non CR . ^^^ These results showed that IL 12 significantly enhanced PBMNC cytotoxicity and decreased the quantity of leukemia cells in PBMNC of most patients with MDS , CML and AML in CR . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Ten patients ( 7M / 3F , median age 11 ( 3 33 ) years ) with high risk leukemia ( AML in 4 , MDS in 2 , CML in 1 and T ALL in 3 ) received a hemopoietic stem cell transplant ( HSCT ) from a haploidentical father or sibling . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
METHODS : Two groups were examined : 30 normal healthy volunteers and 19 patients with primary diffuse bone marrow disease ( aplastic anemia [ n=8 ] , myelodysplastic syndrome ( MDS ) [ n=5 ] , chronic myelogenic leukemia ( CML ) [ n=4 ] , polycythemia vera [ n=2 ] ) . ^^^ However , the pattern of time intensity curves in patients with MDS , CML , and polycythemia vera was similar to that of normal volunteers . ^^^ However , there was no significant difference in the washout rate among patients with MDS , CML , polycythemia vera , and normal volunteers . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
The dual color XY , major Bcr Abl ( M Bcr Abl ) , and specific alpha satellite probes were used for sex mismatched HCT , chronic myeloid leukemia ( CML ) , and myelodysplastic syndrome ( MDS ) cases with karyotypic abnormalities before HCT , respectively . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
The lineage involvement in stem cell disorders , such as chronic myeloid leukemia ( CML ) and myelodysplastic syndrome ( MDS ) , remains unclear . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Sixty four patients had low risk diagnoses ( ALL / AML CR 1 , MDS RA / RARS , and CML CP 1 ) ; 49 patients had high risk diagnoses ( all others ) . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
We describe the cytogenetic findings of three cases with simultaneous or sequential development of a B chronic lymphocytic leukemia ( B CLL ) and either a myelodysplastic syndrome ( MDS ) in 2 cases or a chronic myeloid leukemia ( CML ) in one case . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
An allogeneic transplantation of CD 34 ( + ) selected cells from peripheral blood ( allo PBT / CD34 ( + ) ) from HLA identical sibling donors was performed in 50 adult patients with acute myeloid leukemia in first complete remission ( AML CR 1 ) ( n = 29 ) , myelodysplastic syndrome ( MDS ) ( n = 4 ) , or chronic myeloid leukemia in first chronic phase ( CML CP 1 ) ( n = 17 ) . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Basophils were obtained from patients with chronic myeloid leukemia ( CML ) , idiopathic myelofibrosis ( IMF ) , and myelodysplastic syndrome ( MDS ) , and from healthy donors . ^^^ Tryptase immunoreactive material was detected in cytoplasmic granules of basophils in CML , IMF , and MDS . ^^^ In summary , these data provide evidence that neoplastic basophils in CML , IMF , and MDS can express detectable amounts of tryptase . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Recently , a number of laboratories have cloned translocations involving the NUP 98 gene on chromosome 11p15 . 5 , from patients with acute myelogenous leukemia ( AML ) , myelodysplastic syndrome ( MDS ) , chronic myelogenous leukemia ( CML ) , and T cell acute lymphoblastic leukemia ( T ALL ) . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
METHODS : Interleukin 1 beta ( IL 1 beta ) , interleukin 2 ( IL 2 ) , interleukin 3 ( IL 3 ) , interleukin 4 ( IL 4 ) , interleukin 6 ( IL 6 ) , tumor necrosis factor alpha ( TNF alpha ) , and granulocyte macrophage colony stimulating factor ( GM CSF ) gene expressions were investigated by reverse transcription polymerase chain reaction ( RT PCR ) assay in fluorescence active cell sorter ( FACS ) sorted peripheral blood CD2+ / CD56 T cells from 12 CML patients , 10 meylodysplastic syndrome ( MDS ) patients and 7 normal individuals . ^^^ RESULTS : TNF alpha mRNA was transcribed in T cells from all of the CML , MDS and normal individuals . ^^^ IL 1 beta mRNA was transcribed in T cells from 10 CML , 9 MDS and 6 normal individuals . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Here are reported 2 novel chromosome 7p15 targets of the t ( 7 ; 11 ) ( p 15 ; p 15 ) chromosomal translocation in 2 patients with CML and myelodysplastic syndrome ( MDS ) . ^^^ Reverse transcription PCR analysis using a NUP 98 primer and a degenerate primer corresponding to the third helix of the homeodomain of HOXA demonstrated that NUP 98 was fused in frame to HOXA 11 in the patient with CML and to HOXA 13 in the patient with MDS . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Clonogenic progenitor assays showed that His TRAIL significantly reduced the number of myeloid colonies ( CFU GM ) and clusters from patients with acute myeloid leukemia ( AML ) , chronic myeloid leukemia ( CML ) , and myelodysplastic syndromes ( MDS ) . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
RESULTS : The methylation rates of P ( 15 ) ( INK4B ) were 84 % , 0 , 50 % and 75 % , respectively , for 25 cases of acute myeloid leukemia ( AML ) , 15 chronic myeloid leukemia ( CML ) , 16 myelodysplastic syndrome ( MDS ) and 12 multiple myeloma ( MM ) . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
MATERIAL AND METHODS : The study group consisted of 56 MDS patients and 73 patients at various stages of CML . 20 healthy donors and 105 patients with verified inefficient erythropoiesis ( 20 with B 12 deficiency before and after the treatment , 85 with beta thalassemia ) were the controls . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Abnormalities of chromosome 16 , including inv ( 16 ) ( p 13 ; q 22 ) , del ( 16 ) ( q 22 ) and t ( 16 ; 16 ) ( p 13 ; q 22 ) , have been reported mostly in acute myelomonocytic leukaemia ( AML ) , ( FAB M 4 Eo ) , and some in CML BC and myelodysplastic syndrome ( MDS ) cases . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
The initial prefibrotic and the overt and more advanced myelofibrotic stages of IMF / AMM show a pronounced proliferation of an abnormal megakaryo and granulopoiesis dominated by clustered atypical medium sized to giant megakaryocytes with cloud like , bulbous , and often hyperchromatic nuclei , which are not seen in allied subtypes of MPDs including chronic myeloid leukemia ( Ph ( 1+ ) CML ) and myelodysplastic syndromes ( MDS ) . ^^^ The latter allows the differentiation of true ET from reactive thrombocytosis and from thrombocythemias as an eventually presenting finding in PV , IMF / AMM , MDS , and Ph ( 1+ ) CML . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
The bone marrow and / or peripheral blood from 188 acute myeloid leukemia ( AML ) patients , 101 chronic myeloid leukemia ( CML ) , 40 MDS , and 270 normal controls were analyzed by a PCR RFLP assay to evaluate the association of the CYP3A5 polymorphisms with myeloid leukemia . ^^^ Our data showed that 15 / 188 ( 8 % ) , 8 / 101 ( 7 . 9 % ) , and 3 / 40 ( 7 . 5 % ) of the patients ( i . e . , 188 AML , 101 CML , 40 MDS ) were CYP3A5 * 1 / * 1 ; 88 / 188 ( 46 . 8 % ) , 47 / 101 ( 46 . 5 % ) , and 20 / 40 ( 50 % ) were CYP3A5 * 1 / * 3 ; and 85 / 188 ( 45 . 2 % ) , 46 / 101 ( 45 . 5 % ) , and 17 / 40 ( 42 . 5 % ) carried the CYP3A5 * 3 / * 3 genotype , respectively . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
We report a patient with Philadelphia chromosome positive ( Ph +ve ) chronic myelogenous leukemia ( CML ) , treated with hydroxyurea alone , who upon disease progression developed an additional Ph ve clone containing chromosomal abnormalities typical of myelodysplastic syndrome ( MDS ) . ^^^ We report a case of secondary Ph ve MDS / AML during blast crisis in a patient treated with hydroxyurea for CML . . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
We measured the concentration of CD 33 antigen on the surface of cells in 315 bone marrow ( BM ) samples and 114 corresponding peripheral blood ( PB ) samples from patients with various leukemias ( acute myeloid leukemia [ AML ] , chronic myelogenous leukemia [ CML ] , myeloproliferative disorder [ MPD ] other than CML , myelodysplastic syndrome [ MDS ] ) and from control subjects . ^^^ The median number of CD 33 molecules per cell was highest in AML , followed by MDS , CML , and control subjects and lowest in MPD . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
PATIENTS AND METHODS : We analyzed the expression of PRV 1 in granulocytes isolated from 37 patients with ET , 37 patients with PV , 25 patients with ST , 10 patients with SE , 25 patients with secondary leukocytosis ( SL ) , five patients with chronic myelogenous leukemia ( CML ) , five patients with chronic idiopathic myelofibrosis ( IM ) , five patients with myelodysplastic syndrome ( MDS ) , and 20 normal individuals by PRV 1 specific RT PCR . ^^^ RESULTS : PRV 1 was not expressed in granulocytes isolated from normal individuals or from patients with ST , SE , CML , IM , MDS , and inflammatory / infectious SL . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Thirty one patients were acute leukemia ( AL ) ( 15 in CR ( 1 ) , 7 in CR ( 2 ) or greater , 10 in relapse including 2 relapse after allo BMT and the other one never achieved remission ) ; 12 chronic myeloid leukemia ( CML ) ( CP 5 , AP 2 , BC 4 and relapse after allo BMT 1 ) ; 7 MDS ( RAEB 1 , RAEB T 1 , AL secondary to MDS 5 ) ; Burkitt ' s lymphoma 1 . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Sandmaier , describes the current use of nonmyeloablative regimens and matched related or unrelated donors for the treatment of patients with CLL , CML , acute leukemia , MDS , lymphoma , and myeloma . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
In 20 patients with MDS , two cycles of oral R 115777 for 3 consecutive weeks followed by a 1 week rest produced an overall response rate of 30 % , consistent with 29 % reported in poor prognosis acute leukemia or blast phase chronic myelogenous leukemia ( CML ) . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
To study if older patients perform poorly relative to younger adults following myeloablative allogeneic transplants , we compared the outcomes of consecutive adults aged > or=50 years ( n=51 ) to those < 50 years ( n=262 ) who received BU , CY+ / etoposide and allogeneic transplantation for AML , CML , MDS and NHL from 1984 to 2000 . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
A regimen of busulfan and cyclophosphamide is standard therapy before transplantation of allogeneic hematopoietic stem cells in patients with chronic myelogenous leukemia ( CML ) or myelodysplastic syndrome ( MDS ) . ^^^ Enrolled were 42 patients with high risk CML ( n = 4 ) or MDS ( n = 38 ) . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
The effects of the farnesyl transferase inhibitor FTI 778 , 123 on the proliferation of normal , MDS , AML , and CML hemopoietic progenitor cells was studied . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Forty eight patients with AML ( n = 10 ) , MDS ( n = 8 ) , myelofibrosis ( n = 18 ) , atypical chronic myeloid leukemia ( CML ; n = 7 ) , chronic myelomonocytic leukemia ( CMML ; n = 3 ) , or polycythemia vera ( n = 2 ) were treated with imatinib 400 mg daily . ^^^ CONCLUSIONS : Within these small subgroups of disease types , single agent imatinib did not achieve a significant clinical response among patients with AML , MDS , atypical CML , or CMML without PDGF R fusion genes . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Ten patients , 53 ( 42 61 ) years of age with hematological malignancy ( CML in 3 , MDS in 2 , myeloma in 3 and CLL in 2 ) were included . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Subsequent studies indicated that WT 1 overexpression occurs in most cases of acute myelogenous leukemia , acute lymphoblastic leukemia , chronic myelogenous leukemia ( CML ) , and myelodysplastic syndrome ( MDS ) . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
This review summarizes results of published trials using reduced intensity conditioning ( RIC ) in patients with acute myeloid leukemia ( AML ) , myelodysplastic syndrome ( MDS ) , chronic myeloid leukemia ( CML ) , and myelofibrosis . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
DESIGN : We retrospectively evaluated 4 color flow cytometry data from more than 400 bone marrow aspirates obtained since 1998 from patients suspected of having a non CML MPD or an MDS . ^^^ These data indicate that more than 90 % of non CML MPD and MDS cases with a clonal cytogenetic abnormality will be identified as abnormal by 4 color flow cytometry , and they therefore validate the use of flow cytometry in the diagnosis of these disorders . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
The mixed CMPD / MDS disorders also show dysplastic features and variable amounts of effective hematopoiesis ; these disorders include CMML , JMML , and atypical CML . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
RESULTS : Thirty two of 38 ( 84 . 2 % ) cases with trisomy 8 , and fourteen of 17 ( 82 . 4 % ) cases with trisomy 8 as the sole chromosome aberration were myeloid disorders such as myelodysplastic syndrome ( MDS ) , acute myelocytic leukemia ( AML ) , chronic myelocytic leukemia ( CML ) . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
In total , 26 patients had acute leukaemia or MDS , 10 CML , 17 lymphoma , four myeloma and two aplastic anaemia . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Gravin was markedly down regulated in 41 of 41 patients with acute myeloid leukaemia ( AML ) , nine of 10 patients with myelodysplastic syndromes ( MDS ) and 33 of 33 patients with chronic myeloid leukaemia ( CML ) , of whom 24 were in blast crisis ( BC ) . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
We propose that SAA , APL , CML , and MDS represent different manifestations of generalized insults to the bone marrow . ^^^ In SAA , the insult to hematopoietic progenitors leads to an immune attack , while in APL , CML , and MDS , it gives rise to the malignant clones . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Recently it has also been considered as a drug of promise in hematologic malignancies such as acute myeloid leukemia ( AML ) , especially in older patients , in chronic myelogenous leukemia ( CML ) as well as myelodysplastic syndromes ( MDS ) . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
In this study , we assessed the Valpha24+ NKT cell numbers in peripheral blood ( PB ) from 30 healthy donors and 70 patients with haematopoietic malignancy including chronic myelogenous leukemia ( CML ) , malignant lymphoma ( ML ) , acute myelogenous leukemia ( AML ) and myelodysplastic syndrome ( MDS ) . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
The DNA methylation inhibitor 5 Aza 2 ' deoxycytidine ( 5 Aza CdR ) has significant therapeutic value for the treatment of patients with myelodysplastic syndrome ( MDS ) , acute myeloid leukemia ( AML ) and chronic myeloid leukemia ( CML ) . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
CONCLUSION : In some cases atypical CML is a stage of a natural course of MDS . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Taken together , gene mutations of TRAIL R 1 , TRAIL R 2 are infrequent in patients with CML and MDS . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Investigations of this agent are ongoing in a range of haematological malignancies , and studies in newly diagnosed APL , acute myeloid leukaemia ( AML ) , myelodysplastic syndromes ( MDS ) , multiple myeloma ( MM ) and chronic myelogenous leukaemia ( CML ) are reviewed here using published articles and presentations at international congresses to June 2004 . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
Diagnoses included myelodysplastic syndrome ( MDS ; n = 35 ) , chronic myeloid leukemia ( CML ; n = 8 ) , acute myeloid leukemia ( AML ; n = 6 ) , and other ( n = 3 ) . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
To investigate the correlation of C / EBPzeta transcript levels with the development of leukemia , samples from 187 patients with myelodysplastic syndrome ( MDS ) , acute myeloid leukemia ( AML ) , and chronic myeloid leukemia ( CML ) were examined for C / EBPzeta mRNA using real time quantitative PCR ( RQ PCR ) . ^^^ RQ PCR analysis demonstrated the median levels of C / EBPzeta were significantly decreased in MDS , AML , and CML patients compared with normal controls ( 1 . 40 , 0 . 96 , 2 . 60 versus 14 . 69 , P < 0 . 0001 ) . ^^^ Significant differences were also observed between patients with CML and with AML or MDS . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
We studied telomerase activity ( TA ) in mononuclear cells from peripheral blood ( PB ) and bone marrow ( BM ) from patients with myelodysplastic syndrome ( MDS ; n=24 ) , acute myeloid leukemia ( AML ; n=14 ) , chronic myeloid leukemia ( CML ; n=12 ) and 11 normal controls using a polymerase chain reaction based telomeric repeat amplification assay . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
A clinical development program with low dose decitabine in malignant diseases is focused on myelodysplastic syndrome ( MDS ) , acute myelogenous leukemia ( AML ) , and chronic myelogenous leukemia ( CML ) . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
In the present study , expression of target antigens on CD34+ / CD38 cells was analysed by multi color flow cytometry in patients with AML ( n = 18 ) , myelodysplastic syndromes ( MDS , n = 6 ) , chronic myeloid leukemia ( CML , n = 8 ) and systemic mastocytosis ( SM , n = 9 ) . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
This category consists of four subclasses , chronic myelomonocytic leukemia ( CMML ) , atypical CML ( aCML ) , juvenile chronic myelogenous leukemia and MDS / MPD unclassifiable ( MDS / MPD u ) . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
We analyzed bone marrow samples from 142 patients with Philadelphia ( Ph ) chromosome CMPD or CMPD / MDS and from 119 patients with Ph+ chronic myeloid leukemia ( CML ) using a multiplex polymerase chain reaction assay . ^^^ FLT 3 mutations occur in approximately 10 % of CMPD and CMPD / MDS but are not observed in JAK2+ CMPD or in CML . . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
In multivariate analysis the following factors were associated with increased risk of grade 2 4 aGvHD : the diagnosis of chronic myeloid leukemia ( CML ) or myelodysplastic syndrome ( MDS ) ( vs . other diagnoses ) , URD HCT ( vs . ^^^ Increased risk of grade 3 4 aGVHD was associated with : the use of prednisolone for aGvHD prophylaxis , the diagnosis of CML or MDS , and CD3+ cell dose > or =100 10 l 0 ( 6 ) / kg . ^^^
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
NA
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
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Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
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Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
NA
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
NA
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
NA
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
NA
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
NA
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
NA
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
NA
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
NA
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
NA
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
NA
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
NA
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
NA
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
NA
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
NA
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
NA
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
NA
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
NA
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
NA
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
NA
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
NA
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
NA
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
NA
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
NA
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
NA
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
NA
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
NA
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
NA
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
NA
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
NA
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
NA
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
NA
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
NA
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
NA
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
NA
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
NA
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
NA
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
NA
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
NA
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
NA
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
NA
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
NA
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
NA
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
NA
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
NA
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
NA
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
NA
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
NA
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
NA
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
NA
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
NA
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
NA
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
NA
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
NA
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
NA
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
NA
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
NA
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
NA
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
NA
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
NA
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
NA
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
NA
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
NA
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
NA
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
NA
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
NA
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
NA
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
NA
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
NA
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
NA
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
NA
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
NA
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
NA
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
NA
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
NA
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
NA
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
NA
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
NA
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
NA
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
NA
Interacting proteins: P11274 and P62258	Pubmed	SVM Score :0.0
NA