| Interacting proteins: P11274 and P55196 |
Pubmed |
SVM Score :0.0 |
| Reverse transcriptase polymerase chain reaction ( RT PCR ) using an MLL sense primer and an AF 6 antisense primer detected the MLL / AF6 fusion cDNA from three leukemia patients with the t ( 6 ; 11 ) [ two AML and one T acute lymphoblastic leukemia ( ALL ) ] and one cell line . ^^^ |
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| Interacting proteins: P11274 and P55196 |
Pubmed |
SVM Score :0.0 |
| The Bcr kinase downregulates Ras signaling by phosphorylating AF 6 and binding to its PDZ domain . ^^^ We identified Bcr as a ligand for the PDZ domain of the cell junction and Ras interacting protein AF 6 . ^^^ The Bcr kinase phosphorylates AF 6 , which subsequently allows efficient binding of Bcr to AF 6 , showing that the Bcr kinase is a regulator of the PDZ domain ligand interaction . ^^^ Bcr and AF 6 colocalize in epithelial cells at the plasma membrane . ^^^ In addition , Bcr , AF 6 , and Ras form a trimeric complex . ^^^ |
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| Interacting proteins: P11274 and P55196 |
Pubmed |
SVM Score :0.0 |
| Solution structure of AF 6 PDZ domain and its interaction with the C terminal peptides from Neurexin and Bcr . ^^^ The three dimensional models of the AF 6 PDZ Neurexin C terminal peptide complex and the AF 6 PDZ Bcr C terminal peptide complex were built up by molecular dynamics simulations . ^^^ |
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