| Interacting proteins: P51451 and P11274 |
Pubmed |
SVM Score :0.0 |
| The BCR associates with two classes of tyrosine kinase : Src family kinase ( Lyn , Fyn , Blk or Lck ) and Syk kinase . ^^^ |
|
| Interacting proteins: P51451 and P11274 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51451 and P11274 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51451 and P11274 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51451 and P11274 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51451 and P11274 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51451 and P11274 |
Pubmed |
SVM Score :0.0 |
| The BCR associates with two classes of tyrosine kinase : Src family kinase ( Src protein tyrosine kinase [ PTK ] ; Lyn , Fyn , Blk , or Lck ) and Syk kinase . ^^^ |
|
| Interacting proteins: P51451 and P11274 |
Pubmed |
SVM Score :0.0 |
| Several tyrosine kinases have been shown to be associated with the BCR , including the src family members Lyn , Fyn , Blk , and Lck and the non src kinase Syk . ^^^ |
|
| Interacting proteins: P51451 and P11274 |
Pubmed |
SVM Score :0.0 |
| In B cells , two classes of protein tyrosine kinases ( PTKs ) , the Src family of PTKs ( Lyn , Fyn , Lck , and Blk ) and non Src family of PTKs ( Syk ) , are known to be involved in signal transduction induced by the stimulation of the B cell antigen receptor ( BCR ) . ^^^ |
|
| Interacting proteins: P51451 and P11274 |
Pubmed |
SVM Score :0.0 |
| As phosphorylation on tyrosine residues of Lyn , Fyn , and Blk protein tyrosine kinases occurred upon BCR stimulation , these PTKs may be candidates being involved in an induction of not only tyrosine phosphorylation of substrates but also p 21ras activation . ^^^ |
|
| Interacting proteins: P51451 and P11274 |
Pubmed |
SVM Score :0.0 |
| In an in vitro assay using recombinant cytoplasmic tails of the different FcgammaRII isoforms as well as tyrosine exchange mutants , we show that each of the BCR associated PTKs ( Lyn , Blk , Fyn , and Syk ) shows different phosphorylation patterns with regard to the different FcgammaR isoforms and point mutants . ^^^ |
|
| Interacting proteins: P51451 and P11274 |
Pubmed |
SVM Score :0.0 |
| Several protein tyrosine kinases are activated rapidly following engagement of the BCR / preBCR complexes , including members of the Src family ( Lyn and Blk ) , the Syk / ZAP70 family ( Syk ) , and the Tec family ( Btk ) . ^^^ |
|
| Interacting proteins: P51451 and P11274 |
Pubmed |
SVM Score :0.0 |
| Here the Src related kinase Blk is shown to effect functions associated with the pre BCR . ^^^ In mice lacking a functional pre BCR , active Blk supported maturation beyond the pro B cell stage , suppressed VH to DJH rearrangement , relieved selection for productive heavy chain rearrangement , and stimulated kappa rearrangement . ^^^ Thus , sustained activation of Blk induces responses normally associated with the pre BCR . . ^^^ |
|