| Interacting proteins: P36402 and P11274 |
Pubmed |
SVM Score :0.0 |
| The present study analyzed the expression of the following 13 TFs : AML 1 , CEBPA , E2A , ETS 1 , GATA 1 , GATA 2 , GATA 3 , IKAROS , IRF 1 , PAX 5 , PU 1 , TBET and TCF 1 in 7 malignant NK cell lines together with 5 malignant NKT cell lines , 5 T cell acute lymphoblastic leukemia ( ALL ) cell lines including 3 gamma / delta T cell receptor ( TCR ) type and 2 alpha / beta TCR type , and 3 B cell precursor ( BCP ) leukemia cell lines . ^^^ In contrast to the expression of TBET , TCF 1 was negative for all NK and NKT cell lines , being positive for 4 / 5 T and 1 / 3 BCP cell lines . ^^^ |
|
| Interacting proteins: P36402 and P11274 |
Pubmed |
SVM Score :0.0 |
| In addition , the novel gene and other key regulatory genes of the region , such IL 3 , Ril , AF5q31 and TCF 1 , were found to be deleted in an atypical CML case , thus underscoring the significance of this subregion in the leukemogenesis process . . ^^^ |
|
| Interacting proteins: P36402 and P11274 |
Pubmed |
SVM Score :0.0 |
| Bcr interferes with beta catenin Tcf 1 interaction . ^^^ We demonstrate that expressed Bcr is able to bind the transcription factor Tcf 1 to disrupt the Tcf1 / beta catenin complex . ^^^ Thus two independent mechanisms may regulate Tcf / beta catenin mediated transcription via Bcr : binding to beta catenin as we have previously shown and to Tcf 1 as shown here . . ^^^ |
|