| Interacting proteins: P19447 and P11274 |
Pubmed |
SVM Score :0.0 |
| The previously uncharacterized CDC 24 homology domain of BCR , which is missing in the P 185 BCR ABL oncogene of Philadelphia chromosome ( Ph 1 ) positive acute lymphocytic leukemia but is retained in P 210 BCR ABL of chronic myelogeneous leukemia , was found to bind to the xeroderma pigmentosum group B protein ( XPB ) . ^^^ The binding appeared to be required for XPB to be tyrosine phosphorylated by BCR ABL . ^^^ |
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| Interacting proteins: P19447 and P11274 |
Pubmed |
SVM Score :0.0 |
| We have previously shown that P 210 BCR ABL binds to the xeroderma pigmentosum group B protein ( XPB ) through the portion of BCR that is homologous to the catalytic domain of GDP GTP exchangers such as yeast CDC 24 and Dbl . ^^^ In the baculovirus overexpression system which facilitates binding of coexpressed proteins , we now show that XPB binds to the intact BCR protein efficiently but not to CDC 24 or Dbl , suggesting specificity of this interaction . ^^^ The binding of endogenous BCR and XPB proteins was also detected in Hela cells , and this was inhibited by a blocking peptide . ^^^ GST XPB ( 203 782 ) was localized predominantly in the cytoplasm and bound to BCR but not to p 62 , one of the other components in TFIIH . ^^^ GST XPB ( 1 782 ) was largely in the nucleus and bound to p 62 and BCR . ^^^ |
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