| Interacting proteins: P11274 and P08631 |
Pubmed |
SVM Score :0.83772638 |
| To elucidate some of the structural requirements and functional consequences of the association of Bcr Abl with Hck , their interaction was investigated in transiently transfected COS 7 cells . 0.83772638^^^ |
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| Interacting proteins: P11274 and P08631 |
Pubmed |
SVM Score :0.0 |
| Co immunoprecipitation experiments with hBRAG antisera detected the association of hBRAG with phosphorylated proteins in resting B cells , including the protein tyrosine kinase Hck , which is subsequently dephosphorylated upon B cell receptor ( BCR ) ligation . ^^^ |
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| Interacting proteins: P11274 and P08631 |
Pubmed |
SVM Score :0.0 |
| The interaction of the Bcr Abl tyrosine kinase with the Src kinase Hck is mediated by multiple binding domains . ^^^ We demonstrated recently that the Src kinase Hck interacts directly with Bcr Abl by a kinase independent mechanism . ^^^ Moreover , the inhibition of the Hck kinase seems to block some of the transforming effects of Bcr Abl . ^^^ To identify the binding domains mediating this interaction of Hck with Bcr Abl , we co expressed different plasmid and baculovirus vectors containing mutants or single domains of Bcr Abl and / or Hck in COS 7 and Sf 9 cells . ^^^ At least four independent binding regions for Hck were identified in Bcr Abl , one in Bcr , one in the region comprising the SH 3 and SH 2 domain of Abl , one in the SH 1 domain of Abl , and one in the C terminal domain of Abl . ^^^ |
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| Interacting proteins: P11274 and P08631 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P08631 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P08631 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P08631 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P08631 |
Pubmed |
SVM Score :0.0 |
| NA |
|