| Interacting proteins: P07332 and P11274 |
Pubmed |
SVM Score :0.71490442 |
| In addition , Fes has been shown to associate with and phosphorylate Bcr on NH 2 terminal sequences retained within Bcr Abl . 0.71490442^^^ |
|
| Interacting proteins: P07332 and P11274 |
Pubmed |
SVM Score :0.0 |
| The presence of c fes mRNA was readily detected in both acute myeloid leukemia ( AML ) and chronic myeloid leukemia ( CML ) cells , but c fes mRNA was present in low levels or was absent in lymphoid leukemia cells . ^^^ The leukemia cells of two of five AML patients and four of four CML patients expressed more c fes mRNA than monocytes from a normal donor , with more than a threefold elevation in the cells of one CML patient . ^^^ |
|
| Interacting proteins: P07332 and P11274 |
Pubmed |
SVM Score :0.0 |
| Among the `` src family , ' ' c fes was expressed more in AML than ALL , and c abl was expressed at variable but not elevated levels in all leukemia types . c Ha ras was uniformly expressed at low levels , as in non neoplastic cells . c Ki ras transcription was detected only in T ALL ; N ras expression was barely demonstrable . ^^^ |
|
| Interacting proteins: P07332 and P11274 |
Pubmed |
SVM Score :0.0 |
| Coexpression of BCR with the cytoplasmic protein tyrosine kinase encoded by the c fes proto oncogene in Sf 9 cells resulted in stable BCR FES protein complex formation and tyrosine phosphorylation of BCR . ^^^ |
|
| Interacting proteins: P07332 and P11274 |
Pubmed |
SVM Score :0.0 |
| Previous work in our laboratory has established that BCR is a substrate for c FES , a non receptor tyrosine kinase linked to myeloid growth and differentiation . ^^^ |
|
| Interacting proteins: P07332 and P11274 |
Pubmed |
SVM Score :0.0 |
| Self peptides derived from the carboxy terminal end of the breakpoint cluster region ( bcr ) protein , as well as several differentiation stage and tissue specific self antigens characteristic of early stages of myeloid differentiation , such as c fes , c pim , granulocyte macrophage colony stimulating factor receptor alpha chain , proteinase 3 , and cathepsin G , were identified . ^^^ |
|
| Interacting proteins: P07332 and P11274 |
Pubmed |
SVM Score :0.0 |
| In the present study , we mapped the region of Bcr tyrosine phosphorylation by c Fes , the human homologue of 5 Fps , to Bcr N terminal amino acids 162 413 by using a baculovirus / Sf 9 cell co expression system . ^^^ |
|
| Interacting proteins: P07332 and P11274 |
Pubmed |
SVM Score :0.0 |
| The c Fes tyrosine kinase cooperates with the breakpoint cluster region protein ( Bcr ) to induce neurite extension in a Rac and Cdc 42 dependent manner . ^^^ |
|
| Interacting proteins: P07332 and P11274 |
Pubmed |
SVM Score :0.0 |
| Therefore , we compared c Fes expression in cells with an undifferentiated , blast phenotype ( acute myelogenous leukemia AML ) to cells with a differentiated phenotype ( chronic myelogenous leukemia CML ) . ^^^ |
|
| Interacting proteins: P07332 and P11274 |
Pubmed |
SVM Score :0.0 |
| Mutagenesis of Tyr 713 reduced both autophosphorylation of Tyr 811 and transphosphorylation of Bcr , a recently identified Fes substrate , supporting a major regulatory role for Tyr 713 . ^^^ |
|
| Interacting proteins: P07332 and P11274 |
Pubmed |
SVM Score :0.0 |
| Two MABs which recognized unrelated regions on Phl p 4 , bound three components of Fes p 4 . ^^^ |
|
| Interacting proteins: P07332 and P11274 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07332 and P11274 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07332 and P11274 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07332 and P11274 |
Pubmed |
SVM Score :0.0 |
| NA |
|