| Interacting proteins: Q99623 and P10809 |
Pubmed |
SVM Score :0.0 |
| Three T cell clones specific for Y . enterocolitica hsp 60 were generated from 1 patient with Yersinia ReA . ^^^ |
|
| Interacting proteins: Q99623 and P10809 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99623 and P10809 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99623 and P10809 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99623 and P10809 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99623 and P10809 |
Pubmed |
SVM Score :0.0 |
| The individual antigens of the triggering bacteria still have to be defined , but hsp 65 may be of importance since this is one of the molecules recognized by synovial T cells in ReA patients . ^^^ |
|
| Interacting proteins: Q99623 and P10809 |
Pubmed |
SVM Score :0.0 |
| Bacterial hsp 60 seems to be an immunodominant T cell antigen in ReA , but there must be other relevant antigens shared by these different bacteria . ^^^ |
|
| Interacting proteins: Q99623 and P10809 |
Pubmed |
SVM Score :0.0 |
| METHODS : In 3 patients with Chlamydia induced ReA and 2 patients with Yersinia induced ReA , the SF T cell response was investigated after stimulation with the Chlamydia derived proteins major outer membrane protein ( MOMP ) and heat shock protein 60 ( Hsp 60 ) and the Yersinia derived proteins 19 kd protein and Hsp 60 . ^^^ RESULTS : In the 3 patients with Chlamydia induced ReA , the antigen specific T cell frequency ( percentage of IFNgamma CD 69 double positive CD4+ T cells ) in response to MOMP ( mean + / SD 1 . 2 + / 1 . 38 % ) and to Hsp 60 ( 1 . 21 + / 1 . 45 % ) in SF was about the same . ^^^ In the 2 patients with Yersinia induced ReA , the mean + / SD frequency was 0 . 66 + / 0 . 36 % in response to the Hsp 60 and 03 % + / 0 . 22 in response to the 19 kd protein . ^^^ Both the chlamydial Hsp 60 and MOMP are dominant T cell antigens in Chlamydia induced ReA . ^^^ |
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