| MMP 7 ( matrilysin ) rapidly cleaved TFPI to a major 35 kDa product . ^^^ MMP 7 ( matrilysin ) rapidly cleaved TFPI to a major 35 kDa product . ^^^ MMP 7 and MMP 9 cleaved TFPI at Lys ( 20 ) Leu ( 21 ) with additional COOH terminal processing . ^^^ Proteolytic cleavage by MMP 1 , MMP 7 , MMP 9 , and MMP 12 resulted in considerable loss of TFPI activity . ^^^ |