| Interacting proteins: P10586 and Q13136 |
Pubmed |
SVM Score :1.2701344 |
| Endogenous LAR was shown to bind phosphorylated liprin alpha 1 from MDA 486 cells labeled in vivo with [ 32P ] orthophosphate . 1.2701344^^^ |
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| Interacting proteins: P10586 and Q13136 |
Pubmed |
SVM Score :0.0 |
| Liprin beta 1 belongs to the family of leukocyte common antigen related ( LAR ) transmembrane tyrosine phosphatase interacting proteins that may regulate LAR protein properties via interaction with another member of the family , liprin alpha 1 . ^^^ Liprin beta 1 belongs to the family of leukocyte common antigen related ( LAR ) transmembrane tyrosine phosphatase interacting proteins that may regulate LAR protein properties via interaction with another member of the family , liprin alpha 1 . ^^^ |
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| Interacting proteins: P10586 and Q13136 |
Pubmed |
SVM Score :0.0 |
| We have identified a novel cytoplasmic 160 kDa phosphoserine protein termed LAR interacting protein 1 ( LIP . 1 ) , which binds to the LAR membrane distal D 2 protein tyrosine phosphatase domain and appears to localize LAR to focal adhesions . ^^^ Both LAR and LIP . 1 decorate the ends of focal adhesions most proximal to the cell nucleus and are excluded from the distal ends of focal adhesions , thus localizing to regions of focal adhesions presumably undergoing disassembly . ^^^ We propose that LAR and LIP . 1 may regulate the disassembly of focal adhesions and thus help orchestrate cell matrix interactions . . ^^^ |
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| Interacting proteins: P10586 and Q13136 |
Pubmed |
SVM Score :0.0 |
| The LAR / PTP delta / PTP sigma subfamily of transmembrane protein tyrosine phosphatases : multiple human LAR , PTP delta , and PTP sigma isoforms are expressed in a tissue specific manner and associate with the LAR interacting protein LIP . 1 . ^^^ We describe the cloning and characterization of human PTP sigma ( HPTP sigma ) and compare the structure , alternative splicing , tissue distribution , and PTPase activity of LAR , HPTP delta , and HPTP sigma , as well their ability to associate with the intracellular coiled coil LAR interacting protein LIP . 1 . ^^^ LAR , HPTP delta , and HPTP sigma exhibit similar in vitro PTPase activities and all three interact with LIP . 1 , which has been postulated to recruit LAR to focal adhesions . ^^^ |
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| Interacting proteins: P10586 and Q13136 |
Pubmed |
SVM Score :0.0 |
| We describe seven LAR interacting protein like genes in humans and Caenorhabditis elegans that form the liprin gene family . ^^^ Co expression studies indicate that liprin alpha 2 alters LAR cellular localization and induces LAR clustering . ^^^ |
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| Interacting proteins: P10586 and Q13136 |
Pubmed |
SVM Score :0.0 |
| Two papers in this issue of Neuron add a new dimension to our understanding of liprin and LAR RPTP function during synapse formation . present evidence that Dliprin alpha interacts with Dlar to regulate presynaptic morphogenesis of the Drosophila neuromuscular junction . demonstrate that mammalian liprin alpha 1 forms a complex with the PDZ protein GRIP and LAR in both pre and postsynaptic compartments of hippocampal neurons and is required for the clustering of the GluR 2 glutamate receptor in dendritic spines . . ^^^ |
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| Interacting proteins: P10586 and Q13136 |
Pubmed |
SVM Score :0.0 |
| Human PPFIA 1 ( also known as LIP . 1 or Liprin alpha 1 ) gene , located within CCND 1 FGF4 EMS 1 amplicon at human chromosome 11q13 . 3 , encodes KIF1A binding protein , which is implicated in trafficking of LAR subfamily PTPases and AMPA type glutamate receptors . ^^^ The region spanning SAM 1 SAM3 domains is the binding domain for LAR subfamily PTPases and PPFIBP ( Liprin beta ) family proteins . ^^^ |
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