| Interacting proteins: P10586 and P56945 |
Pubmed |
SVM Score :0.0 |
| Transmembrane tyrosine phosphatase LAR induces apoptosis by dephosphorylating and destabilizing p130Cas . ^^^ RESULTS : The over expression of LAR in tissue culture cells specifically decreased the steady state protein level of p130Cas , a multifunctional signal assembly protein in signal transduction , by reducing the tyrosine phosphorylation and protein stability of p130Cas . ^^^ LAR also preferentially dephosphorylated p130Cas in vitro . ^^^ Subcellularly , LAR and p130Cas were co localized along stress fibres and at focal adhesions . ^^^ LAR over expression eliminated p130Cas from focal adhesions without affecting focal adhesion assembly . ^^^ |
|
| Interacting proteins: P10586 and P56945 |
Pubmed |
SVM Score :0.0 |
| In contrast , LAR selectively inhibited the epidermal growth factor ( EGF ) induced phosphorylation of p130CAS and the formation of the complex between p130CAS and GRB 2 but this effect did not influence the activation of MAPK by EGF . ^^^ |
|
| Interacting proteins: P10586 and P56945 |
Pubmed |
SVM Score :0.0 |
| Alternatively , dephosphorylation by calf intestinal alkaline phosphatase , PP 1 , and LAR stimulated cleavage of p130cas by caspase 3 , generating a 31 kDa fragment . ^^^ |
|
| Interacting proteins: P10586 and P56945 |
Pubmed |
SVM Score :0.0 |
| Fifty euthyroid patients ( 11 males , 39 females ; age 22 74 yr , median 50 yr ) with active TAO [ clinical activity score ( CAS ) > or =3 , NOSPECS ( no signs or symptoms ; only signs , no symptoms ; signs only ; proptosis ; eye muscle involvement ; corneal involvement ; sight visual acuity reduction ) 2a 5a ] of median duration 0 . 9 yr received either 30 mg LAR or placebo every 4 wk for 16 wk ; both groups then received 30 mg LAR for wk 16 32 and were followed up without treatment for a further 24 wk . ^^^ During wk 0 16 there was significant reduction in STI , subjective diplopia , and CAS in LAR treated patients ; STI and CAS were also reduced with placebo . ^^^ |
|
| Interacting proteins: P10586 and P56945 |
Pubmed |
SVM Score :0.0 |
| NA |
|