| Interacting proteins: P10586 and P35222 |
Pubmed |
SVM Score :0.51693613 |
| Whereas physiological substrates for LAR have not been identified unequivocally , beta catenin associates with LAR and is a substrate in vitro . 0.51693613^^^ |
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| Interacting proteins: P10586 and P35222 |
Pubmed |
SVM Score :0.0 |
| We propose that changes in tyrosine phosphorylation of beta catenin mediated by TrkA and LAR PTPs control cadherin adhesive function during processes such as neurite outgrowth . . ^^^ |
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| Interacting proteins: P10586 and P35222 |
Pubmed |
SVM Score :0.0 |
| Consistent with this observation , we found direct association of plakoglobin and beta catenin with the intracellular domain of LAR in vitro . ^^^ |
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| Interacting proteins: P10586 and P35222 |
Pubmed |
SVM Score :0.0 |
| We show further that the protein tyrosine phosphatase LAR ( leukocyte common antigen related ) colocalizes with the cadherin catenin complex in epithelial cells and associates with beta catenin and plakoglobin . ^^^ Interestingly , ectopic expression of protein tyrosine phosphatase ( PTP ) LAR inhibits epithelial cell migration by preventing phosphorylation and the increase in the free pool of beta catenin ; moreover , it inhibits tumor formation in nude mice . ^^^ These data support a function for PTP LAR in the regulation of epithelial cell cell contacts at adherens junctions as well as in the control of beta catenin signaling functions . ^^^ |
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| Interacting proteins: P10586 and P35222 |
Pubmed |
SVM Score :0.0 |
| Current evidence supports a role for LAR in cadherin complexes where it associates with and dephosphorylates beta catenin , a pathway which may be critical for cadherin complex stability and cell cell association . ^^^ |
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| Interacting proteins: P10586 and P35222 |
Pubmed |
SVM Score :0.0 |
| RNA interference ( RNAi ) knockdown of LAR or dominant negative disruption of LAR function results in loss of excitatory synapses and dendritic spines , reduction of surface AMPA receptors , impairment of dendritic targeting of the cadherin beta catenin complex , and reduction in the amplitude and frequency of miniature excitatory postsynaptic currents ( mEPSCs ) . ^^^ We propose that the cadherin beta catenin complex is cotransported with AMPA receptors to synapses and dendritic spines by a mechanism that involves binding of liprin alpha to LAR RPTP and tyrosine dephosphorylation by LAR RPTP . . ^^^ |
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