| Interacting proteins: P23468 and P10586 |
Pubmed |
SVM Score :0.0 |
| Purification and characterization of the catalytic domains of the human receptor linked protein tyrosine phosphatases HPTP beta , leukocyte common antigen ( LCA ) , and leukocyte common antigen related molecule ( LAR ) . ^^^ Human HPTP beta , leukocyte common antigen ( LCA ) , and leukocyte common antigen related molecule ( LAR ) are transmembrane receptor like proteins whose cytoplasmic regions contain either one ( HPTP beta ) or two ( LCA and LAR ) domains that are homologous to protein tyrosine phosphatases ( PTPases ) . ^^^ The cytoplasmic regions of HPTP beta , LCA , and LAR were expressed in Escherichia coli and purified to greater than 90 % purity . ^^^ |
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| Interacting proteins: P23468 and P10586 |
Pubmed |
SVM Score :0.0 |
| HPTP delta is very similar to leukocyte common antigen related molecule ( LAR ) , in both the extracellular and cytoplasmic regions . ^^^ |
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| Interacting proteins: P23468 and P10586 |
Pubmed |
SVM Score :0.0 |
| Substrate specificities of catalytic fragments of protein tyrosine phosphatases ( HPTP beta , LAR , and CD 45 ) toward phosphotyrosylpeptide substrates and thiophosphotyrosylated peptides as inhibitors . ^^^ HPTP beta shows distinctions from the related LAR PTPase and T cell CD 45 PTPase domains : it recognizes phosphotyrosyl peptides of 9 11 residues from lck , src , and PLC gamma with Km values of 2 , 4 , and 1 microM , some 40 200 fold lower than the other two PTPases . ^^^ |
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| Interacting proteins: P23468 and P10586 |
Pubmed |
SVM Score :0.0 |
| We describe the cloning and characterization of human PTP sigma ( HPTP sigma ) and compare the structure , alternative splicing , tissue distribution , and PTPase activity of LAR , HPTP delta , and HPTP sigma , as well their ability to associate with the intracellular coiled coil LAR interacting protein LIP . 1 . ^^^ Multiple isoforms of LAR , HPTP delta , and HPTP sigma appear to be generated by tissue specific alternative splicing of up to four mini exon segments that encode peptides of 4 16 aa located in both the extracellular and intracellular regions . ^^^ Northern blot analysis indicates that LAR and HPTP sigma are broadly distributed whereas HPTP delta expression is largely restricted to brain , as is the short HPTP sigma isoform containing only four fibronectin type 3 like domains . ^^^ LAR , HPTP delta , and HPTP sigma exhibit similar in vitro PTPase activities and all three interact with LIP . 1 , which has been postulated to recruit LAR to focal adhesions . ^^^ |
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| Interacting proteins: P23468 and P10586 |
Pubmed |
SVM Score :0.0 |
| Northern blot analysis of various tissues revealed the presence of a truncated LAR mRNA lacking the cytoplasmic tyrosine phosphatase domains and indicated that this LAR mutation is not accompanied by obvious changes in the expression levels of one of the LAR like receptor tyrosine phosphatases PTPdelta or PTPsigma . ^^^ |
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| Interacting proteins: P23468 and P10586 |
Pubmed |
SVM Score :0.0 |
| The mRNA levels for receptor like protein tyrosine phosphatases ( PTPases ) , PTPalpha , PTPdelta , PTPgamma and LAR , were evaluated by Northern blot analysis in two types of chemically induced rat primary hepatomas . ^^^ |
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| Interacting proteins: P23468 and P10586 |
Pubmed |
SVM Score :0.0 |
| Twenty one PTPs were identified , including nine cytosolic PTPs ( TcPTP , P19PTP , PTP1B , PTPMEG , PTP1C , SYP , PTPH 1 , PTPL 1 , and PTPD 1 ) , nine transmembrane PTPs ( PTPdelta , PTPgamma , PTPkappa , DEP 1 , IA 2 , LAR , PTPalpha , PTPNE 3 , and PTPepsilon ) , and three new PTPs PTPmu like PTPkappa like , and IA 2beta . ^^^ |
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| Interacting proteins: P23468 and P10586 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P23468 and P10586 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P23468 and P10586 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P23468 and P10586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P23468 and P10586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P23468 and P10586 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P23468 and P10586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P23468 and P10586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P23468 and P10586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P23468 and P10586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P23468 and P10586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P23468 and P10586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P23468 and P10586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P23468 and P10586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P23468 and P10586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P23468 and P10586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P23468 and P10586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P23468 and P10586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P23468 and P10586 |
Pubmed |
SVM Score :0.0 |
| NA |
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