| Interacting proteins: P18433 and P10586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18433 and P10586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18433 and P10586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18433 and P10586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18433 and P10586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18433 and P10586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18433 and P10586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18433 and P10586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18433 and P10586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18433 and P10586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18433 and P10586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18433 and P10586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18433 and P10586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18433 and P10586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18433 and P10586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18433 and P10586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18433 and P10586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18433 and P10586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18433 and P10586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18433 and P10586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18433 and P10586 |
Pubmed |
SVM Score :0.0 |
| Expression of receptor protein tyrosine phosphatase alpha , sigma and LAR during development of the zebrafish embryo . ^^^ |
|
| Interacting proteins: P18433 and P10586 |
Pubmed |
SVM Score :0.0 |
| In this way , murine homologues of the human PTPases LRP , PTP beta , PTP delta , PTP epsilon and LAR were obtained . ^^^ |
|
| Interacting proteins: P18433 and P10586 |
Pubmed |
SVM Score :0.0 |
| Four of these are transmembrane PTPases : LAR , LRP , RPTP gamma , and CPTP 1 . ^^^ |
|
| Interacting proteins: P18433 and P10586 |
Pubmed |
SVM Score :0.0 |
| The expression of other phosphatases , LAR , LRP , and PTPase1B , did not change significantly . ^^^ |
|
| Interacting proteins: P18433 and P10586 |
Pubmed |
SVM Score :0.0 |
| These phosphatases include PTPalpha , LAR , CD 45 , PTPepsilon , SHP 2 , and PTP1B . ^^^ |
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| Interacting proteins: P18433 and P10586 |
Pubmed |
SVM Score :0.0 |
| Screening of a mouse brain cDNA library under low stringency conditions with a probe encompassing the intracellular ( phosphatase ) domain of the CD 45 lymphocyte antigen yielded cDNA clones coding for a 794 amino acid transmembrane protein [ hereafter referred to as receptor protein tyrosine phosphatase alpha ( R PTP alpha ) ] with an intracellular domain displaying clear homology to the catalytic domains of CD 45 and LAR ( 45 % and 53 % , respectively ) . ^^^ |
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| Interacting proteins: P18433 and P10586 |
Pubmed |
SVM Score :0.0 |
| Sequencing of 115 cDNA clones identified 10 different sequences including MPTP ( T cell PTP ) , PTP 1B , PTP P 19 , mR PTP mu , R PTP alpha , PTP NE 3 ( PTP P 1 ) , R PTP kappa and the murine homologue of human LAR . ^^^ In the regenerating liver , the levels of five PTP gene mRNAs ( MPTP , PTP P 19 , R PTP alpha , LAR homologue , and PTP RL 9 ) increased within 6 h , decreased to the normal level by 24 h , and increased again at 48 to 72 h after PH . ^^^ |
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| Interacting proteins: P18433 and P10586 |
Pubmed |
SVM Score :0.0 |
| The combinatorial library / high throughput screen protocols furnished a small molecule PTP1B inhibitor that is both potent ( K ( 1 ) = 2 . 4 nm ) and selective ( little or no activity against a panel of phosphatases including Yersinia PTPase , SHP 1 , SHP 2 , LAR , HePTP , PTPalpha , CD 45 , VHR , MKP 3 , Cdc25A , Stp 1 , and PP2C ) . ^^^ |
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| Interacting proteins: P18433 and P10586 |
Pubmed |
SVM Score :0.0 |
| Direct and indirect regulations of class 1 and 2 Cys based protein tyrosine phosphatases ( LMW PTP , PTEN , PTP PEST , SHP 2 , PTP1B , PTPalpha , PTPepsilon , DEP 1 , TC 45 , SHP 1 , HePTP and LAR ) are discussed . ^^^ |
|
| Interacting proteins: P18433 and P10586 |
Pubmed |
SVM Score :0.0 |
| NSC 87877 cross inhibited Shp 1 in vitro , but it was selective for Shp 2 over other PTPs ( PTP1B , HePTP , DEP 1 , CD 45 , and LAR ) . ^^^ |
|
| Interacting proteins: P18433 and P10586 |
Pubmed |
SVM Score :0.0 |
| Since little is known about the regulation of these enzymes , we examined the effect of insulin and phorbol 12 myristate 13 acetate ( PMA ) treatment of well differentiated rat hepatoma ( Fao ) cells on the expression of mRNAs encoding three major PTPase homologs in liver : PTPase1B , an intracellular enzyme with a single conserved PTPase domain , and two tandem domain , transmembrane PTPases , known as LAR and LRP . ^^^ In contrast , treatment with insulin or PMA had no significant effect of the abundance of mRNA encoding either LAR or LRP . ^^^ |
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| Interacting proteins: P18433 and P10586 |
Pubmed |
SVM Score :0.0 |
| We evaluated the deactivation of the insulin receptor kinase by three candidate enzymes that are expressed in insulin sensitive rat tissues , including the receptor like PTPases LAR and LRP , and the intracellular enzyme , PTPase1B . ^^^ When related to the level of overall receptor dephosphorylation , LAR deactivated the receptor kinase 3 . 1 and 2 . 1 times more rapidly than either PTPase1B or LRP , respectively ( p less than 0 . 03 ) . ^^^ Relative to the rate of initial loss of 32P from receptor C terminal sites , LAR dephosphorylated the Tris phosphorylated Tyr 1150 domain 3 . 5 and 3 . 7 times more rapidly than either PTPase1B or LRP , respectively ( p less than 0 . 01 ) . ^^^ |
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| Interacting proteins: P18433 and P10586 |
Pubmed |
SVM Score :0.0 |
| To understand the significance of PTPases in physiological and pathophysiological processes in the kidney , we isolated three cDNA segments encoding PTPases ( LAR , LRP and a novel PTPase ) from rat kidney by polymerase chain reaction ( PCR ) . ^^^ |
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| Interacting proteins: P18433 and P10586 |
Pubmed |
SVM Score :0.0 |
| In order to characterize individual rat hepatic PTPases that might have specificity for autophosphorylated receptor tyrosine kinases , we isolated cDNA segments encoding three PTPases ( PTPase 1B , LAR and LRP ) that are expressed in insulin sensitive liver and skeletal muscle tissue , and evaluated their catalytic activity in vitro . ^^^ The intrinsic PTPase activities of the full length PTPase 1B protein and the cytoplasmic domains of LAR and LRP were studied by expression of recombinant cDNA constructs in the inducible bacterial vector pKK 233 2 using extracts of a host strain of Escherichia coli that lacks endogenous PTPase activity . ^^^ |
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| Interacting proteins: P18433 and P10586 |
Pubmed |
SVM Score :0.0 |
| Sequences encoding three `` receptor like ' ' transmembrane PTPases were identified and two of these ( known as LAR and LRP ) were confirmed to be expressed in muscle by subsequent cDNA library screening and Northern blot analysis . ^^^ The expression of the LAR and LRP PTPases in skeletal muscle suggests that these enzymes might have a role in the regulation of insulin action in muscle and other insulin sensitive tissues . . ^^^ |
|
| Interacting proteins: P18433 and P10586 |
Pubmed |
SVM Score :0.0 |
| Compared to the known exon intron structures of other mammalian receptor like protein tyrosine phosphatase genes , such as Ptpra ( encoding LRP ) and Ptprc ( coding for Ly 5 ) , the Ptprf gene part encoding the cytoplasmic region of mLAR contains not only smaller , but also fewer introns . ^^^ |
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| Interacting proteins: P18433 and P10586 |
Pubmed |
SVM Score :0.0 |
| Fetal rat brain expressed four known receptor like PTPs ( PTP delta , LAR , LAR PTP 2 , LRP ( PTP alpha ) ) and the non receptor phosphatase PTP1B . ^^^ |
|
| Interacting proteins: P18433 and P10586 |
Pubmed |
SVM Score :0.0 |
| In this study , we found increased mRNA levels of a non receptor type PTPase , protein tyrosine phosphatase 1B ( PTP1B ) , and receptor type PTPases , leukocyte common antigen related phosphatase ( LAR ) , and LAR related phosphatase ( LRP ) , under high glucose conditions . ^^^ In accordance with these results , LAR content was significantly increased , whereas LRP content was not increased . ^^^ |
|
| Interacting proteins: P18433 and P10586 |
Pubmed |
SVM Score :0.0 |
| The specific activity of four candidate protein tyrosine phosphatases ( protein tyrosine phosphatase 1B ( PTP1B ) , SH 2 domain containing PTPase 2 ( SHP 2 ) , leukocyte common antigen related ( LAR ) , and leukocyte antigen related phosphatase ) ( LRP ) toward IRS 1 dephosphorylation was studied using recombinant proteins in vitro . ^^^ |
|
| Interacting proteins: P18433 and P10586 |
Pubmed |
SVM Score :0.0 |
| The mRNA levels for receptor like protein tyrosine phosphatases ( PTPases ) , PTPalpha , PTPdelta , PTPgamma and LAR , were evaluated by Northern blot analysis in two types of chemically induced rat primary hepatomas . ^^^ PTPalpha , PTPgamma and LAR did not show such a characteristic decrease . ^^^ |
|
| Interacting proteins: P18433 and P10586 |
Pubmed |
SVM Score :0.0 |
| Twenty one PTPs were identified , including nine cytosolic PTPs ( TcPTP , P19PTP , PTP1B , PTPMEG , PTP1C , SYP , PTPH 1 , PTPL 1 , and PTPD 1 ) , nine transmembrane PTPs ( PTPdelta , PTPgamma , PTPkappa , DEP 1 , IA 2 , LAR , PTPalpha , PTPNE 3 , and PTPepsilon ) , and three new PTPs PTPmu like PTPkappa like , and IA 2beta . ^^^ |
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| Interacting proteins: P18433 and P10586 |
Pubmed |
SVM Score :0.0 |
| The phosphatases LAR , PTPsigma , and PTPalpha are expressed in most neurons of E 14 and E 18 rat embryo dorsal root ganglia , while BEM 1 is expressed in a more restricted subset of these neurons . ^^^ PTPsigma mRNA was increased by 50 % after 3 days , while LAR and PTPalpha expression dropped by 50 and 20 % , respectively . ^^^ |
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| Interacting proteins: P18433 and P10586 |
Pubmed |
SVM Score :0.0 |
| Several protein tyrosine phosphatases ( PTPases ) have been implicated as regulatory agents in the insulin stimulated signal transduction pathway , including PTP1B , PTPalpha , and LAR . ^^^ Not only do the lead compounds serve as potent inhibitors of PTP1B but , in addition , several exhibit selectivities for PTP1B versus PTPalpha , LAR , and VHR that are greater than 2 orders in magnitude . . ^^^ |
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| Interacting proteins: P18433 and P10586 |
Pubmed |
SVM Score :0.0 |
| We therefore decided to undertake a detailed enzyme kinetic evaluation of various transmembrane and cytosolic PTPs ( PTPalpha , PTPbeta , PTPepsilon , CD 45 , LAR , PTP1B and SHP 1 ) , using pNPP as substrate . ^^^ |
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| Interacting proteins: P18433 and P10586 |
Pubmed |
SVM Score :0.0 |
| We therefore screened 45 suramin analogs against a panel of seven PTPs , including PTP1B , YopH , CD 45 , Cdc25A , VHR , PTPalpha , and LAR , to identify compounds with improved potency and specificity . ^^^ Two of the compounds tested , NF 504 and NF 506 , had significantly improved potency as PTP inhibitors for all phosphatases tested except for LAR and PTPalpha . ^^^ Surprisingly , we found that a significant number of these compounds activated the receptor like phosphatases , PTPalpha and LAR . ^^^ |
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| Interacting proteins: P18433 and P10586 |
Pubmed |
SVM Score :0.0 |
| We have evaluated the spatial and temporal expression patterns of three protein tyrosine phosphatases ( PTPs ) , receptor PTPalpha ( RPTPalpha ) , striatal enriched phosphatase ( STEP ) , and leucocyte common antigen related phosphatase ( LAR ) , in the retina and optic nerve ( ON ) of adult rats in which the crushed ON was either regenerating after retinal ganglion cell ( RGC ) stimulation with intravitreal peripheral nerve ( PN ) grafting or lens injury ( LI ) , or not regenerating ( no treatment ) . ^^^ |
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| Interacting proteins: P18433 and P10586 |
Pubmed |
SVM Score :0.0 |
| PTP1B was able to dephosphorylate activated JAK 2 and STAT 3 in vitro , whereas either no or a minimal effect was observed with cluster of differentiation 45 ( CD 45 ) , PTPalpha and leukocyte antigen related ( LAR ) . ^^^ |
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