| Interacting proteins: P43626 and P10321 |
Pubmed |
SVM Score :0.0 |
| Cross linking of the p 58 NK receptor , involved in the recognition of HLA C alleles , delivers a negative signal that prevents target cell lysis . ^^^ |
|
| Interacting proteins: P43626 and P10321 |
Pubmed |
SVM Score :0.0 |
| Much attention has been focused on the NK cell receptors CD158a ( EB 6 ) and CD158b ( GI 183 ) , which recognize two alternative epitopes on the HLA Cw locus . ^^^ |
|
| Interacting proteins: P43626 and P10321 |
Pubmed |
SVM Score :0.0 |
| Expression of HLA C specific natural killer cell receptors ( CD158a and CD158b ) on peripheral blood mononuclear cells after allogeneic bone marrow transplantation . ^^^ |
|
| Interacting proteins: P43626 and P10321 |
Pubmed |
SVM Score :0.0 |
| The expression rates of CD158a , CD158b and CD 94 on T cells and NK cell were detected by flow cytometry and donor / recipient HLA Cw was analyzed using PCR after peripheral blood stem cell transplantation ( PBSCT ) and umbilical cord blood transplantation ( UCBT ) . ^^^ |
|
| Interacting proteins: P43626 and P10321 |
Pubmed |
SVM Score :0.0 |
| RESULTS : When the interaction between NK cell inhibitory receptors ( i . e . , CD158a , CD158b , and CD159a ) and MHC class 1 molecules ( i . e . , HLA C and HLA E ) on HIV infected autologous T cells was blocked , a drastic increase in killing of anti gp 120 coated HIV infected cells by NK cells was observed . ^^^ |
|
| Interacting proteins: P43626 and P10321 |
Pubmed |
SVM Score :0.0 |
| One soluble KIR2D , derived from an inhibitory receptor with a long cytoplasmic tail ( KIR2DL1 ) , bound to HLA C allotypes containing asparagine 77 and lysine 80 in the heavy chain , as expected , since these allotypes inhibit lysis by NK cells expressing KIR2DL1 . ^^^ Mutagenesis of amino acid 44 in KIR2DL1 and KIR2DL2 suggested this residue controls the affinity of KIR for the 77 / 80 motif of HLA C molecules . ^^^ |
|
| Interacting proteins: P43626 and P10321 |
Pubmed |
SVM Score :0.0 |
| Furthermore , the covalently linked KIR2DL1 dimer binds more tightly to HLA Cw 4 than the wild type monomer , suggesting the occurrence of a second binding event that increases the overall affinity of KIR dimer for HLA C . . ^^^ |
|
| Interacting proteins: P43626 and P10321 |
Pubmed |
SVM Score :0.0 |
| The possible role of carbohydrate in the interaction of HLA C with a human inhibitory natural Killer cell Immunoglobulin like Receptor with two Ig domains , KIR2DL1 , was investigated . ^^^ |
|
| Interacting proteins: P43626 and P10321 |
Pubmed |
SVM Score :0.0 |
| In addition , the HLA Cw specificities that are major ligands for killer cell immunoglobulin like ( inhibitory ) receptors ( KIRs ) , particularly KIR2DL1 ( Cw 2 , Cw 4 , and CW 5 ) and KIR2DL2 ( Cw 1 , Cw 3 , and Cw 7 ) , were found more frequently among patients with TB , which suggests a possible inhibition of natural killer cell activity against the infected target cells . ^^^ |
|
| Interacting proteins: P43626 and P10321 |
Pubmed |
SVM Score :0.0 |
| Because of the known association of human leucocyte antigen ( HLA ) Cw * 06 with psoriasis , the study concentrated on the five KIR genes that have HLA C as their recognized ligand ( i . e . , KIR2DL1 , 2DL2 , 2DL3 , 2DS1 , and 2DS2 ) . ^^^ |
|
| Interacting proteins: P43626 and P10321 |
Pubmed |
SVM Score :0.0 |
| Furthermore , when subjects were classified according to KIR3DL1 / 3DS1 / HLA B and KIR2DL1 / HLA C combinations , an increasing trend toward susceptibility was observed as combinations became more inhibitory . ^^^ |
|
| Interacting proteins: P43626 and P10321 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43626 and P10321 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43626 and P10321 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43626 and P10321 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43626 and P10321 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43626 and P10321 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43626 and P10321 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43626 and P10321 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43626 and P10321 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43626 and P10321 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43626 and P10321 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43626 and P10321 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43626 and P10321 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43626 and P10321 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43626 and P10321 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43626 and P10321 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43626 and P10321 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43626 and P10321 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43626 and P10321 |
Pubmed |
SVM Score :0.0 |
| NA |
|