| Interacting proteins: Q9Y6Q9 and P10276 |
Pubmed |
SVM Score :0.58513165 |
| SMRT was released from STAT5b RARalpha / SMRT complexes by ATRA at 10 ( 6 ) M , whereas TRAM 1 became associated with STAT5b RARalpha at 10 ( 7 ) M . 0.58513165^^^ |
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| Interacting proteins: Q9Y6Q9 and P10276 |
Pubmed |
SVM Score :0.52598288 |
| In GST pull down experiments , NuMA RARalpha formed a complex with the corepressor SMRT , was released from the NuMA RARalpha / SMRT complexes by all trans retinoic acid ( ATRA ) at 10 ( 7 ) 10 ( 6 ) M and became associated with the coactivator TRAM 1 at 10 ( 8 ) M ATRA . 0.52598288^^^ |
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| Interacting proteins: Q9Y6Q9 and P10276 |
Pubmed |
SVM Score :1.0468917 |
| In this report , we demonstrate that RAR selective ligands have distinct quantitative activation properties which are reflected by their abilities to promote interaction of DNA bound human RXRalpha ( hRXRalpha ) hRARalpha heterodimers with the nuclear receptor coactivator ( NCoA ) SRC 1 in vitro . 1.0468917^^^ |
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| Interacting proteins: Q9Y6Q9 and P10276 |
Pubmed |
SVM Score :0.0 |
| Transient transfection assays in mammalian cells indicate that GCN 5 cooperates with p / CIP as a coactivator of RAR alpha dependent transcription . ^^^ |
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| Interacting proteins: Q9Y6Q9 and P10276 |
Pubmed |
SVM Score :0.0 |
| METHODS : Multiprobe ribonuclease protection assay and real time reverse transcriptase polymerase chain reaction were used to quantitate mRNA levels of steroid receptors , vitamin D receptor ( VDR ) , retinoic acid receptors ( RAR ) , and cofactors AIB 1 ( amplified in breast cancer 1 ) , CBP ( cyclic adenosine monophosphate response element binding protein ) , pCAF ( p300 / CBP associated factor ) , TIF 2 ( transcription intermediary factor 2 ) , N CoR ( nuclear receptor corepressor ) , and SMRT ( silencing mediator of repressed transcription ) . ^^^ |
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| Interacting proteins: Q9Y6Q9 and P10276 |
Pubmed |
SVM Score :0.0 |
| RAR coactivators ACTR , SRC 1 , and transcriptional intermediary factor 2 ( TIF 2 ) stimulated human ( h ) SP B promoter activity in a dose dependent fashion in pulmonary adenocarcinoma H 441 cells . ^^^ |
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| Interacting proteins: Q9Y6Q9 and P10276 |
Pubmed |
SVM Score :0.0 |
| Here we show that the receptor associated coactivator 3 ( RAC 3 ) uses two separate LXXLL motifs to bind RAR and RXR . ^^^ The mutation of the coactivator binding pockets of RAR and RXR abolishes RAC 3 binding . ^^^ Although the coactivator pocket of RXR is essential for the function of the RXR homodimer , it has a minor role for the recruitment of RAC 3 and trans activation by the RXR / RAR heterodimer . ^^^ Consistently , deletion of the activation helix of RXR enhances binding of RAC 3 to the heterodimer , and mutation of the coactivator pocket of RXR had little effect on RXR / RAR activity . ^^^ |
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| Interacting proteins: Q9Y6Q9 and P10276 |
Pubmed |
SVM Score :0.0 |
| SRC 3 phosphorylation and degradation occur only within the context of RARalpha complexes , suggesting that the RAR isotype defines a phosphorylation code through dictating the accessibility of the coactivator to p38MAPK . ^^^ P38MAPK dependent phosphorylation and degradation of SRC 3 / AIB1 and RARalpha mediated transcription . ^^^ Here we show that during RA dependent activation of the RARalpha isotype , the p 160 coactivator pCIP / ACTR / AIB 1 / RAC 3 / TRAM 1 / SRC 3 is phosphorylated by p38MAPK . ^^^ SRC 3 phosphorylation has been correlated to an initial facilitation of RARalpha target genes activation , via the control of the dynamics of the interactions of the coactivator with RARalpha . ^^^ We propose a model in which RARalpha transcriptional activity is regulated by SRC 3 through coordinated events that are fine tuned by RA and p38MAPK . . ^^^ |
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| Interacting proteins: Q9Y6Q9 and P10276 |
Pubmed |
SVM Score :0.0 |
| In contrast to RAR , which prevents the binding of RXR ligands and recruits the nuclear receptor corepressor N CoR , PPAR permits the binding of SRC 1 in response to both RXR and PPAR ligands . ^^^ |
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| Interacting proteins: Q9Y6Q9 and P10276 |
Pubmed |
SVM Score :0.0 |
| Several nuclear receptor coactivators ( CBP , F SRC 1 , SRC 1 , and RIP 140 ) that interact with other steroid receptors were tested as potential mediators of the N and C terminal interaction of rAR using the mammalian two hybrid system . ^^^ |
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| Interacting proteins: Q9Y6Q9 and P10276 |
Pubmed |
SVM Score :0.0 |
| Recruitment of an LXXLL motif of SRC 1 to RAR in response to ligand displaces the RXR AF 2 domain , allowing RXR ligands to bind and promote the binding of a second LXXLL motif from the same SRC 1 molecule . ^^^ |
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| Interacting proteins: Q9Y6Q9 and P10276 |
Pubmed |
SVM Score :0.0 |
| Here we demonstrate that both peroxisome proliferator activated receptor binding protein ( PBP ) and steroid receptor coactivator 1 ( SRC 1 ) are required for ligand dependent transcription of transiently transfected and chromosomally integrated reporter genes by the estrogen receptor ( ER ) and retinoic acid receptor ( RAR ) . ^^^ CFP fusions to RAR or its ligand binding domain exhibited rapid ligand dependent FRET to YFP tagged nuclear receptor interaction domains of the coactivators SRC 1 and PBP . ^^^ These findings suggest that ligand dependent transcriptional activities of the RAR and ER require concurrent or sequential recruitment of SRC 1 and PBP containing coactivator complexes . . ^^^ |
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| Interacting proteins: Q9Y6Q9 and P10276 |
Pubmed |
SVM Score :0.0 |
| This loss of cooperativity suggested a delayed acquisition of RAR full transcriptional competence because ( 1 ) cooperativity was maintained at RAR ligand subsaturating concentrations , ( 2 ) overexpression of SRC 1 led to loss of cooperativity and even to strong repression of chromosomal templates activity , and ( 3 ) loss of cooperativity was observed when additional cis acting response elements were activated . ^^^ |
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| Interacting proteins: Q9Y6Q9 and P10276 |
Pubmed |
SVM Score :0.0 |
| We however previously showed that retinoids displayed very different abilities to activate retinoid inducible reporter genes , and that these differential properties were correlated to the ability of a given ligand to promote SRC 1 recruitment by DNA bound RXR : RAR heterodimers . ^^^ |
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| Interacting proteins: Q9Y6Q9 and P10276 |
Pubmed |
SVM Score :0.0 |
| In contrast , the strength of the overall association between the heterodimer and the full length SRC 1 NID is dictated by the combinatorial action of RAR and RXR ligands , the simultaneous presence of the two receptor agonists being required for highest binding affinity . ^^^ |
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| Interacting proteins: Q9Y6Q9 and P10276 |
Pubmed |
SVM Score :0.0 |
| The aim of the study was to test the hypothesis that expression of retinoid receptors ( RARalpha , RARbeta , RARgamma ) , rexinoid receptors ( RXRalpha , RXRbeta ) , thyroid hormone receptors ( TRalpha , TRbeta ) , estrogen receptors ( ERalpha , ERbeta ) , nuclear receptor coregulators ( N CoR , SRC 1 , SMRT ) , and in addition type 1 iodothyronine 5 ' deiodinase ( 5 ' DI ) , EGFR and erb B2 / neu would be different in mammary postlactating tissue in comparison with that of nonlactating mammary gland . ^^^ Using RT PCR , we have shown that expression of RARalpha , RXRalpha , TRalpha , ERalpha , ERbeta , N CoR , SRC 1 , SMRT and EGFR in rat was significantly increased in postlactating mammary gland when compared to that of nonlactating mammary tissue . ^^^ |
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| Interacting proteins: Q9Y6Q9 and P10276 |
Pubmed |
SVM Score :0.0 |
| Overall , these results suggest that ASXL 1 is a novel coactivator of RAR that cooperates with SRC 1 and implicates it as a potential antitumor target of RA in RA resistant cancer cells . . ^^^ |
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| Interacting proteins: Q9Y6Q9 and P10276 |
Pubmed |
SVM Score :0.0 |
| SRC 1 deficient P 19 cells showed severely compromised retinoid induced responses , in agreement with the supposed role of SRC 1 as a RAR coactivator . ^^^ |
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| Interacting proteins: Q9Y6Q9 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y6Q9 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y6Q9 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y6Q9 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y6Q9 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y6Q9 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y6Q9 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y6Q9 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y6Q9 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y6Q9 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y6Q9 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y6Q9 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y6Q9 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y6Q9 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y6Q9 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y6Q9 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y6Q9 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y6Q9 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y6Q9 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y6Q9 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y6Q9 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y6Q9 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|