| Interacting proteins: P51692 and P10276 |
Pubmed |
SVM Score :0.0 |
| To determine the molecular mechanisms of myeloid leukemogenesis and maturation arrest in STAT5b RARalpha ( + ) APL and its unresponsiveness to ATRA , we examined the effect of STAT5b RARalpha on the activity of myeloid transcription factors including RARalpha / retinoid 10 receptor ( RXR ) alpha , STAT 3 , and STAT 5 as well as its molecular interactions with the nuclear receptor corepressor , SMRT , and nuclear receptor coactivator , TRAM 1 . ^^^ |
|
| Interacting proteins: P51692 and P10276 |
Pubmed |
SVM Score :0.0 |
| The Stat 5 RARalpha fusion protein represses transcription and differentiation through interaction with a corepressor complex . ^^^ Recently , the human Stat 5 gene was found to be translocated to the RARalpha gene in a patient with acute promyelocytic leukemia indicating that Stat 5 might also play a role in cellular transformation . ^^^ We investigated the mechanism by which Stat 5 might exert this function and studied the biochemical and cellular functions of fusion proteins comprising Stat 5 and RARalpha . ^^^ The expression of Stat 5 RARalpha causes the transcriptional repression of gene transcription , a process that requires the coiled coil domain of Stat 5 ( amino acid positions 133 333 ) . ^^^ Oligomerization of this domain in the Stat 5 RARalpha fusion protein leads to stable binding of the corepressor SMRT independent of all trans retinoic acid ( ATRA ) stimulation and is accompanied by an impaired response to differentiation signals in hematopoietic cells . ^^^ |
|
| Interacting proteins: P51692 and P10276 |
Pubmed |
SVM Score :0.0 |
| Significant down regulation of expression in patients was detected in genes CDK 4 inhibitor A , PURA , notch 1 in mononuclears ; STAT 2 , STAT 5 , RAR alpha , MCL 1 , junB , caspase 4 in granulocytes ; CDK 6 , GADD 153 , ERBB 3 , cadherin 5 in both fractions . ^^^ |
|
| Interacting proteins: P51692 and P10276 |
Pubmed |
SVM Score :0.0 |
| Constitutively active Stat 5 constructs enhance both the transcriptional activity of RARs in EML cells and the commitment of these cells to granulocyte / monocyte progenitors , whereas dominant negative Stat 5 constructs inhibit this IL 3 induced enhancement of RAR transcriptional activity . ^^^ Thus , Stat 5 is an important mediator of the IL 3 induced enhancement of RAR transcriptional activity that accompanies the commitment of immature EML cells to the granulocyte / monocyte lineage . ^^^ |
|
| Interacting proteins: P51692 and P10276 |
Pubmed |
SVM Score :0.0 |
| The activity of three transactivators of the Ntcp promoter : hepatocyte nuclear factor 1 alpha ( HNF 1 alpha ) , nuclear receptor heterodimer retinoid 10 receptor : retinoid acid receptor ( RXR : RAR ) and signal transducer and activator of transcription 5 ( Stat 5 ) was assessed using gel electrophoretic mobility shift assays . ^^^ |
|
| Interacting proteins: P51692 and P10276 |
Pubmed |
SVM Score :0.0 |
| We report on the molecular characterization of a RARA gene re arrangement in a patient with APL L and demonstrate that the signal transducer and activator of transcription STAT5b gene is fused with RARA . ^^^ In this study , we identified STAT5b as a new gene fused to RARA in leukaemia ; this is the first human tumour bearing a structurally abnormal STAT gene . . ^^^ The signal transducer and activator of transcription STAT5b gene is a new partner of retinoic acid receptor alpha in acute promyelocytic like leukaemia . ^^^ |
|
| Interacting proteins: P51692 and P10276 |
Pubmed |
SVM Score :0.0 |
| RARalpha fuses to the PML gene in the vast majority of APL cases , and in a few cases to the PLZF , NPM , NuMA and Stat5b genes , respectively , leading to the generation of RARalpha 10 : and 10 : RARalpha fusion genes . ^^^ |
|
| Interacting proteins: P51692 and P10276 |
Pubmed |
SVM Score :0.0 |
| RARalpha fuses to the PML gene in the vast majority of APL cases , and in a few cases to the PLZF , NPM , NuMA and STAT5b genes . ^^^ |
|
| Interacting proteins: P51692 and P10276 |
Pubmed |
SVM Score :0.0 |
| In other cases of t ( 15 ; 17 ) negative APL , various chromosomal rearrangements involving 17q21 have been documented leading to fusion of RARalpha to alternative partners , namely PLZF , NPM , NuMA and STAT5b . ^^^ |
|
| Interacting proteins: P51692 and P10276 |
Pubmed |
SVM Score :0.0 |
| The RAR alpha gene fuses to variable partners ( PML , PLZF , NPM , NuMA and STAT5B : 10 genes ) leading to the expression of APL specific fusion proteins with identical RAR alpha moieties . ^^^ |
|
| Interacting proteins: P51692 and P10276 |
Pubmed |
SVM Score :0.0 |
| As a consequence of the translocation , RARalpha variably fuses to the PML , PLZF , NPM , NuMA , and Stat5b genes ( 10 genes ) , respectively , leading to the generation of RARalpha 10 and 10 RARalpha fusion genes . ^^^ |
|
| Interacting proteins: P51692 and P10276 |
Pubmed |
SVM Score :0.0 |
| RARalpha variably fuses to PML , PLZF , NPM , NuMA , and Stat5B genes ( 10 genes / proteins ) . ^^^ |
|
| Interacting proteins: P51692 and P10276 |
Pubmed |
SVM Score :0.0 |
| RARalpha fuses to the PML gene in the vast majority of APL cases , and in a few cases to the PLZF , NPM , NuMA and STAT5b genes respectively . ^^^ |
|
| Interacting proteins: P51692 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51692 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51692 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51692 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|