| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| Cloning of the amplified products led to the identification of five true receptors , thyroid hormone receptor alpha ( THR alpha ) , retinoic acid receptor alpha , retinoic acid receptor gamma , retinoid 10 receptor alpha , and retinoid 10 receptor gamma , as well as four orphan receptors , apolipoprotein AI regulatory protein ( ARP 1 ) , chicken ovalbumin upstream promoter transcription factor 1 ( COUP TF 1 ) , estrogen related receptor 2 , and testis receptor 4 ( TR 4 ) . ^^^ |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| The levels of the retinoid receptors , retinoic acid receptor alpha and retinoid 10 receptor gamma , were up regulated in response to fenretinide , suggestive of ligand induced receptor up regulation . ^^^ |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| Reverse transcriptase PCR demonstrated strong expression of transcripts for mouse RA receptors ( RARalpha , RARgamma , and RXRalpha ) , with lower levels of expression of RARbeta , RXRbeta , and RXRgamma in neonatal SVs . ^^^ |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| TGF beta 1 transcriptionally stimulated the expression of RARalpha , RARgamma , and RXRalpha genes , but did not do so for RARbeta , RXRbeta , and RXRgamma genes . ^^^ |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| By reverse transcriptase polymerase chain reaction ( PCR ) , we found that peripheral blood B lymphocytes expressed RARalpha , RARgamma , and RXRalpha , but not RARbeta , RXRbeta , or RXRgamma . ^^^ |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| RPMI 8226 cells were shown to express mRNAs for all the retinoid receptors subtypes , ie , RARalpha , RARbeta , RARgamma , RXRalpha , RXRbeta , and RXRgamma . ^^^ |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| The expression patterns of the three mouse retinoic acid ( RA ) receptor gene isotypes ( RARalpha , RARbeta , and RARgamma ) and retinoid 10 receptor gene isotypes ( RXRalpha , RXRbeta , and RXRgamma ) have been investigated by in situ hybridization analysis of their RNA transcripts in the inner ear of mouse fetuses at 18 . 5 days of gestation . ^^^ |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| Retinoid receptors RARalpha , RARgamma , and RXRalpha are expressed in both the precardiac endoderm and mesoderm in the normal and the vitamin A deficient quail embryo , while the expression of RXRgamma is restricted to precardiac endoderm . ^^^ |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| In marked contrast , RXRalpha af 2 ( o ) / RXRbeta / and RXRalpha af 2 ( o ) / RXRbeta / / RXRgamma / compound mutants display a large array of malformations , which nearly recapitulate the full spectrum of the defects that characterize the fetal vitamin A deficiency ( VAD ) syndrome and were previously found in RAR single and compound mutants , as well as in RXRalpha / RAR ( alpha , beta or gamma ) compound mutants . ^^^ |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| RARalpha is found in cortex and hippocampus and RARbeta and RXRgamma are both highly expressed in the dopamine innervated areas caudate / putamen , nucleus accumbens and olfactory tubercle . ^^^ |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| The effects of retinoids are mediated by nuclear receptors , i . e . , the retinoic acid receptors ( RARalpha , RARbeta , and RARgamma ) and the retinoid 10 receptors ( RXRalpha , RXRbeta , and RXRgamma ) . ^^^ |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| Results indicate that RARalpha , RXRalpha , and RXRgamma are initially expressed throughout the cochlear duct . ^^^ |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| Inceasing the hydrophobicity around the rings with analogues ethyl 4 ( N , 4 , 4 , 7 tetramethyl 1 , 2 , 3 , 4 tetrahydroquinolin 6 oyloxy ) benzoate ( 2 ) [ 7 methyl group added ] and ethyl 4 ( 4 , 4 dimethyl N isopropyl 1 , 2 , 3 , 4 tetrahydroquinolin 6 oyloxy ) benzoate ( 3 ) [ NCH ( CH ( 3 ) ) ( 2 ) group at C 4 ] increased the potency and specificity for RARalpha , RARbeta , and RXRalpha , compared to 1 , but had little effect on RXRbeta and RXRgamma activation . ^^^ |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| The reverse transcriptase polymerase chain reaction ( RT PCR ) was used to amplify cDNA fragments encoding RARalpha , RARbeta , RARgamma , RXRalpha , RXRbeta , and RXRgamma from human retinal RNA . ^^^ |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemical results revealed the expression of RARalpha , RARbeta , RXRalpha , and RXRgamma proteins in somatic and germ cells throughout postnatal development . ^^^ Interestingly , RARalpha and RXRalpha had a similar subcellular localization pattern in Sertoli cells throughout postnatal testis development , while RARalpha and RXRgamma were both present in the nucleus of spermatocytes and elongating spermatids . ^^^ These results suggest that RARalpha may potentially dimerize with RXRalpha in Sertoli cells and with RXRgamma in germ cells . ^^^ |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| During brown adipocyte differentiation RXRalpha and RXRgamma mRNA expression is induced in parallel with UCP 1 mRNA , whereas the mRNA for the three RAR subtypes , alpha , beta and gamma , decreases . ^^^ |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| RESULTS : RARalpha , RARgamma , RXRalpha , and RXRgamma mRNAs were detected in most normal and cancerous prostates . ^^^ |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| The vitamin A nuclear receptors compromise six members , three all trans retinoic acid receptors ( RARalpha , RARbeta , RARgamma ) and three 9 cis retinoic acid receptors ( RXRalpha , RXRbeta , RXRgamma ) ( Mangelsdorf et al . 1995 ) . ^^^ |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| The biological actions of retinoic acid ( RA ) are mediated by retinoic acid receptors ( RARalpha , RARbeta , and RARgamma ) and retinoid 10 receptors ( RXRalpha , RXRbeta , and RXRgamma ) . ^^^ |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| Messenger RNA expression of retinoic acid receptors ( RARalpha , RARbeta and RARgamma ) and retinoid 10 receptors ( RXRalpha , RXRbeta and RXRgamma ) was examined using reverse transcription polymerase chain reaction in 42 papillary thyroid carcinomas ( PTCs ) . ^^^ |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| At the 4 / 5 somite stage of HH 8 , when retinoid signaling is initiated in the avian embryo , mRNAs of all receptors are present , with very strong and ubiquitous expression patterns for RARalpha , RARalpha 2 , RARgamma , RARgamma 2 , and RXRalpha , a persistent expression of RARgamma in the neural tissues , a strong expression of RARbeta 2 in lateral plate mesoderm and somites , and an anterior expression of RXRgamma . ^^^ |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| Retinoids are natural and synthetic compounds related to retinoic acid that act through interaction with two basic types of nuclear receptors : retinoic acid receptors ( RAR alpha , RARbeta and RARgamma ) and retinoid 10 receptors ( RXRalpha , RXRbeta and RXRgamma ) as retinoid inducible transcription factors . ^^^ |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| The RA treated HL 60 cells used here expressed all RA receptor ( RAR ) and retinoid 10 receptor ( RXR ) subtypes ( as detected by Northern analysis ) except RXRgamma . ^^^ |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| In Y 79 cells , PEDF treatment increased the expression levels of RARalpha and RXRgamma receptors and in the A RPE 19 cells it resulted in a decrease in expression of the RARbeta and RXRbeta receptors . ^^^ |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| Gene expression in tumor tissues was detected with the following frequencies : RARalpha 100 % , RARbeta 94 % , RARgamma 94 % , RXRalpha 100 % , RXRbeta 100 % and RXRgamma 92 % . ^^^ Levels of mRNA expression in tumor tissues compared with matching normal appearing tissue were equal or reduced with the following frequencies : RARalpha 76 . 1 % , RARbeta 59 . 1 % , RARgamma 39 . 8 % , RXRalpha 67 . 1 % , RXRbeta 54 . 5 % and RXRgamma 88 . 6 % , and were significantly associated with any one other subtype . ^^^ |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| After a SD to LD switch , gene expression changes of CRABP 2 , RAR , H3R , and VGF occurred relatively rapidly toward LD control levels , ahead of body weight recovery and testicular recrudescence , whereas CRBP 1 responded less robustly and rxrgamma did not respond at the mRNA level . ^^^ In this brain nucleus in photorefractory animals , the CRABP 2 , RAR , H3R , and VGF mRNA returned toward LD levels , whereas CRBP 1 and rxrgamma remained at the reduced SD level . ^^^ |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| The present paper shows that proliferating PCC 7 cells primarily express RXRalpha and RARalpha , lower levels of RXRbeta , and barely detectable amounts of RARbeta , RARgamma , and RXRgamma . ^^^ |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| However , for fetal and neonatal samples , there were positive correlations between gestational age and mRNA expression for RARalpha ( r = 0 . 665 ; P = 0 . 001 ) , RXRalpha ( r = 0 . 444 ; P = 0 . 050 ) , and RXRgamma ( r = 0 . 464 ; P = 0 . 039 ) . ^^^ |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| We also show that RARalpha and RXRbeta are confined to Sertoli cells , whereas RARgamma is expressed in spermatogonia and RARbeta , RXRalpha , and RXRgamma are colocalized in step 7 8 spermatids . ^^^ |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| In the nonlesioned spinal cord , immunoreactivity for RARalpha , RXRalpha , RXRbeta and RXRgamma was localized in the cytosol of neurons , that of RXRalpha and RXRbeta in astrocytes and that of RARalpha , RXRalpha and RXRgamma in some oligodendrocytes . ^^^ |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48443 and P10276 |
Pubmed |
SVM Score :0.0 |
| NA |
|