Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
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Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.88029179
This coupled with the observations that MIP 1 alpha can induce expression of TGF beta suggests to us that the complex interactions between MIP 1 alpha and MIP 1 beta and the direct TGF beta isoforms ( beta 1 , beta 2 , and beta 3 ) act to ensure minimized MIP 1 alpha beta expression and maximized TGF beta expression . 0.88029179^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.5660213
Hypothalamic interaction between macrophage inflammatory protein 1 alpha ( MIP 1 alpha ) and MIP 1 beta in rats : a new level for fever control . 1 . 0.5660213^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
LD 78 is a small secreted protein that has a sequence similar to a number of other polypeptides , including murine macrophage inflammatory protein 1 alpha ( MIP 1 alpha ) , interleukin 8 ( IL 8 ) , Act 2 , monocyte chemoattractant protein 1 ( MCP 1 ) , and others . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The human macrophage inflammatory proteins 1 alpha and beta ( MIP 1 alpha and beta ) , which are also known as LD 78 and ACT 2 , respectively , are distinct but highly related members of the chemoattractant cytokine ( chemokine ) family . rMIP 1 alpha and beta labeled with 125I specifically bind to human peripheral blood monocytes , the monocytic cell line THP 1 , peripheral blood T cells , and the YT cell line . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
CCl 4 is metabolized by liver endoplasmic reticulum in the presence of NADPH to a highly reactive product , probably CCl 3 ; this activation of CCl 4 results in covalent binding of CCl 3 and lipid peroxidation . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Our results suggest that the initial toxicity of CCl 4 for the Ca2+ pump results from the metabolism of CCl 4 to the CCl 3 . radical . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Isolated rat liver mitochondria incubated under hypoxic conditions with succinate and ADP were found able to activate CCl 4 to a free radical species identified as trichloromethyl free radical ( CCl 3 ) by e . s . r . spectroscopy coupled with the spin trapping technique . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
CCl 4 metabolism was measured as ( 1 ) covalent binding of [ 14C ] CCl 4 to membrane protein , ( 2 ) electron spin resonance spin trapping of CCl 3 . radicals and ( 3 ) CCl 4 induced lipid peroxidation . ^^^ We conclude that damage to the hepatocyte plasma membrane during CCl 4 intoxication is not due to a significant local activation of CCl 4 to CCl 3 . within that membrane . . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
These data support the hypothesis that ethanol induces a cytochrome P 450 isozyme that is highly active in the metabolism of CCl 4 to the CCl 3 radical . 4 . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
As expected , alpha tocopherol inhibits CCl 4 dependent microsomal lipid peroxidation and , at a very high concentration , will inhibit the covalent binding of CCl 3 to microsomal protein by up to 50 % . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
These data indicate that pretreatment with DMPG may reduce the hepatic concentration of the toxic CCl 3 . free radicals in CCl 4 poisoned rats . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Activation of carbon tetrachloride , measured as covalent binding of [ 14C ] CCl 4 , spin trapping of CCl 3 and CCl 4 stimulated lipid peroxidation , was much lower in liver microsomes from CPP treated rats . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
CCl 4 exerts its toxicity through its metabolites , including the free radicals CCl 3 . and CCl ( 3 ) 00 . . ^^^ Oxygen strongly inhibits the hepatic cytochrome P 450 mediated formation of CCl 3 . from CCl 4 and promotes the conversion of CCl 3 . to CCl ( 3 ) 00 . . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The results suggest that ethanol extract of Aucuba japonica protects CCl 4 hepatotoxicity at a site in the chain events leading to necrosis but not the activation step of CCl 4 to 10 CCl 3 and 10 C 1 free radicals . . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
CCl 3 by an NADPH anaerobic liver microsomal activation of CCl 4 , covalently binds to heme and heme degradation products from CO binding particles . 14C from CCl 4 covalently binds to heme and heme degradation products from liver CL binding particles from rats treated with 14CCl4 . ^^^ CCl 3 to heme and protein moieties of P 450 and CCl 4 induced P 450 destruction is discussed . . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Evidence for in vivo covalent binding of CCl 3 derived from CCl 4 to cholesterol of rat liver . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Only 3 incorporated in their structure CCl 3 or CCl 2 portions of the CCl 4 molecule and , consequently , most of the adducts formed would be missed during regular procedures most toxicologists use to determine CCl 4 . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The well known metabolism of CCl 4 to trichloromethyl radicals in rat liver microsomal dispersions has been reinvestigated with the goal to determine the repeatability and reproducibility of the EPR signal intensity of the EPR spectrum of the CCl 3 adduct of PBN . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Consistently , in DHEA pretreated microsomes the protein covalent binding of the trichloromethyl radical ( CCl 3 degrees ) , is similar to that of not supplemented microsomes treated with CCl 4 . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The lag period for CCl 4 induced release of calcium was associated with the time required to deplete alpha tocopherol from the microsomal membranes ; however , lipid peroxidation was not observed at these levels of CCl 4 , and the lag period for CCl 4 induced release of calcium was shorter under anaerobic than aerobic conditions , suggesting a possible role for CCl 3 in the mechanism of activation . ^^^ Production of CCl 3 was observed by ESR spin trapping experiments with PBN ; PBN prevented the CCl 4 induced calcium release , presumably by interacting with CCl 3 and other reactive species . ^^^ The CCl 4 induced calcium release was blocked by ruthenium red , a specific inhibitor of the ryanodine receptor ; ruthenium red did not block CCl 4 metabolism to CCl 3 . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The electron spin resonance ( ESR ) study gave the signal of the PBN CCl 3 adduct in the liver of the rats which were pretreated with PBN , confirming that CCl 4 was metabolized into CCl 3 . radicals with cytochrome P 450 enzyme and indicating that PBN could trap them . ^^^ The blood biochemical assay supported the trapping of the CCl 3 . radicals ; the pretreatment of rats with PBN inhibited the increase in the GOT and GPT values upon exposure to CCl 4 . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Since chemokine receptors CXCR 3 and CCR 5 are preferentially expressed on Th 1 cells , we tested the expression and regulation of several chemokines , including those that signal through CXCR 3 ( interferon gamma inducible protein of 10 kDa , IP 10 , CXCL 10 ; and monokine induced by interferon gamma , Mig , CXCL 9 ) and CCR 5 ( macrophage inflammatory protein ( Mip ) 1 alpha , CCL 3 ; and Mip 1 beta , CCL 4 ) in RA synovial fluids , synovial tissues , and blood . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The most active chemokines for resting Th ( IL 10 ) , in terms of calcium mobilization and in vitro migration , were in order of potency : CCL 2 ( monocyte chemoattractant protein 1 , CCR 2 ligand ) , CCL 4 ( macrophage inflammatory protein 1beta , CCR 5 ligand ) , CCL 3 ( macrophage inflammatory protein 1alpha , CCR1 / 5 ligand ) , CCL 17 ( thymus and activation regulated chemokine , CCR 4 ligand ) , CCL 1 ( 1 309 , CCR 8 ligand ) , CXCL 12 ( stromal derived factor 1 , CXCR 4 ) , and CCL 11 ( eotaxin , CCR 3 ligand ) . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
While secreted alkaline phosphatase ( SEAP ) tagged chemokines SLC ( CCL 21 ) , TARC ( CCL 17 ) , and RANTES ( CCL 5 ) bound to mast cells and the extracellular matrix ( ECM ) in RA synovium under physiologic salt conditions , MCP 1 ( CCL 2 ) , MIP 1 alpha ( CCL 3 ) , MIP 1 beta ( CCL 4 ) , and fractalkine ( FKN , CX3CL1 ) fusion proteins did not detectably bind . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
In this well characterized model of free radical initiated damage , liver metabolism of CCl 4 to CCl 3 . causes lipid peroxidation , F ring isoprostane formation , and pathologic leukocyte activation . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The effect is not unique to CCL 5 , as other CCR 5 ligands such as CCL 3 ( MIP 1alpha ) and CCL 4 ( MIP 1beta ) also trigger TIL cell death , nor is it limited to melanoma cells , as it also operates in activated primary T lymphocytes . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Pathogenicity was associated with T cell production of the macrophage attracting chemokines CCL 3 and CCL 4 . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The results showed that aqueous CCl 4 was dissociated into CCl 3 and Cl radicals by 248 nm laser , and CHCl 3 was dissociated into CHCl 2 and Cl radicals after adding C6H6 . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
CD 30 cross linking also induced the release of CCL 5 and CCL 3 and the up regulation of membrane binding capacity for CCL 3 and CCL 4 and decreased proliferative activity . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Cytolytic activity of NK cells is augmented by CCL 2 , CCL 3 , CCL 4 , CCL 5 , CCL 10 , and CXC3L1 . ^^^ Activated NK cells produce XCL 1 , CCL 1 , CCL 3 , CCL 4 , CCL 5 , CCL 22 , and CXCL 8 . ^^^ Furthermore , CCL 3 , CCL 4 , and CCL 5 produced by NK cells can inhibit in vitro replication of HIV . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Supernatant fluid from CSF was analysed for four beta ( CCL 2 , CCL 3 , CCL 4 , CCL 5 ) and two alpha ( CXCL 9 , CXCL 10 ) chemokines by enzyme linked immunosorbent assay ( ELISA ) . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
MIP 1alpha ( CCL 3 ) and eotaxin ( CCL 11 ) induced a significant and only partially overlapping intracellular calcium flux in antigen elicited and peripheral blood eosinophils , and MCP 1 ( CCL 2 ) , MDC ( CCL 22 ) , MIP 1beta ( CCL 4 ) , and TCA 3 ( CCL 1 ) did not . ^^^ Peripheral blood eosinophils migrated toward MIP 1alpha ( CCL 3 ) and eotaxin ( CCL 11 ) but not MCP 1 ( CCL 2 ) , MDC ( CCL 22 ) , MIP 1beta ( CCL 4 ) , and TCA 3 ( CCL 1 ) . ^^^ Antigen elicited eosinophils migrated toward MIP 1alpha ( CCL 3 ) and eotaxin ( CCL 11 ) , but also migrated in response to MIP 1beta ( CCL 4 ) and TCA 3 ( CCL 1 ) , suggesting the up regulation of additional chemokine receptors on antigen elicited eosinophils . ^^^ MIP 1alpha ( CCL 3 ) and eotaxin ( CCL 11 ) induced a significant and only partially overlapping intracellular calcium flux in antigen elicited and peripheral blood eosinophils , and MCP 1 ( CCL 2 ) , MDC ( CCL 22 ) , MIP 1beta ( CCL 4 ) , and TCA 3 ( CCL 1 ) did not . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
We also determined that CCR 5 binding chemokines MIP 1alpha ( CCL 3 ) , CCL 4 , and RANTES ( CCL 5 ) , specifically by signaling through CCR 5 , could affect all progenitor B cell populations through a novel mechanism involving heterologous desensitization of CXCR 4 . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Here , using real time PCR we have shown that CCL 3 L1 and a novel CCL 4 isoform ( termed CCL 4 L1 ) can vary from 1 6 copies per diploid genome ( pdg ) in Caucasians and are occasionally completely absent . ^^^ The other isoforms ( CCL 3 and CCL 4 ) remain at two copies per dpg . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Nef expression by immature human and macaque DCs triggered IL 6 , IL 12 , TNF alpha , CXCL 8 , CCL 3 , and CCL 4 release , but without up regulating costimulatory and other molecules characteristic of mature DCs . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
After stimulation via high affinity Fcepsilon receptor 1 ( FcepsilonRI ) , the transcriptional levels of several CC chemokines were markedly increased , and 1 309 ( CCL 1 ) , macrophage inflammatory protein 1alpha ( MIP 1alpha ) ( CCL 3 ) and MIP 1beta ( CCL 4 ) were found among the 10 most increased human and mouse transcripts from approximately 12 000 genes ( including some expressed sequence tags ) . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Recombinant CbpA up regulated expression of messenger RNA of CXCL 8 and CCL 2 but not of XCL 1 , CXCL 10 , CCL 1 , CCL 3 , CCL 4 , or CCL 5 in A 549 cells and induced increased secretion of CXCL 8 , CCL 2 , CXCL 1 , and CXCL 5 in a dose and time dependent manner . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
OBJECTIVE : Interleukin 1 receptor antagonist ( IL 1Ra ) and also mononuclear cell attractant chemokines CCL 3 , CCL 4 and CCL 5 have been implicated in the immunopathogenesis of primary Sjgren syndrome ( pSS ) . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Cultured , activated human T cells expressed the chemokines lymphotactin ( XCL 1 ) , RANTES , macrophage inflammatory protein 1 alpha ( MIP 1 alpha ; CCL 3 ) and MIP 1 beta ( CCL 4 ) , but no appreciable Gro alpha . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
In contrast , the proinflammatory chemokine CCL 3 was secreted mostly by P DCs , whereas CCL 4 and CXC chemokine ligand 8 were produced by both subsets . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
High levels of CCL 3 and CCL 4 were produced within 8 h after infection , which is likely to account for the observed CCR 5 down modulation on Mtb infected DC . ^^^ Mtb induced expression of CCL 3 , CCL 4 , CXCL 9 , and CXCL 10 was involved in the stimulation of NK and T cell migration . ^^^ This indicates that IFN alpha beta may modulate the immune response through the expression of CXCL 10 , which along with CXCL 9 , CCL 3 , and CCL 4 participates in the recruitment and selective homing of activated / effector cells , which are known to accumulate at the site of Mtb infection and take part in the formation of the granulomas . . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Here , we show that IL 7 induced a dose dependent production of CCL 3 ( MIP 1alpha ) , CCL 4 ( MIP 1beta ) , and CCL 5 ( RANTES ) in peripheral blood mononuclear cells ( PBMC ) , ex vivo tonsil lymphoid tissue of HIV ( ) individuals , and PBMC from HIV ( + ) individuals , suggesting that IL 7 may regulate beta chemokine production in vivo . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Moreover , significant increases in the mRNA expression of chemokines CCL 2 ( monocyte chemoattractant protein 1 ) , CCL 11 ( eotaxin 1 ) , CCL 3 ( macrophage inflammatory protein 1alpha ) , and CCL 4 ( macrophage inflammatory protein 1beta ) were found . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Here we report that purified Cath D , as well as culture supernatants from the human breast carcinoma cell lines MCF 7 and T47D , selectively degrade macrophage inflammatory protein ( MIP ) 1 alpha ( CCL 3 ) , MIP 1 beta ( CCL 4 ) , and SLC ( CCL 21 ) . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Moreover , the forskolin mediated increases in intracellular cAMP concentrations were inhibited by the ligands for CCR 1 , CCL 3 , CCL 4 , and CCL 5 , suggesting that the expressed CCR 1 was functional . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
MCP 1 ( CCL 2 ) , MIP 1 alpha ( CCL 3 ) , and MIP 1 beta ( CCL 4 ) were up regulated within 2 days after M . corti infection . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
We investigated the effect of maslinic acid ( a triterpene derivative obtained from olive pomace ) , on the susceptibility of plasma or hepatocyte membranes to lipid peroxidation ( LPO ) , induced respectively by the hydroxyl radical ( OH * ) generated by Fe2+ / H2O2 ex vivo and by the system Fe3+ / ascorbate in vitro ; moreover , three groups of animals used in the plasma study were pretreated with CCl 4 ( to generate CCl 3 * ) . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
In addition , the relative roles of the chemokines that bind CXCR 3 ( CXCL 9 , CXCL 10 , CXCL 11 ) and CCR 5 ( CCL 3 , CCL 4 , CCL 5 ) in this process are unknown . ^^^ In vivo , T lymphocytes were recruited in large numbers with rapid kinetics to skin sites injected with CXCL 10 and CCL 5 and less to CCL 3 , CCL 4 , CXCL 9 , and CXCL 11 . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Prostaglandin E 2 inhibits production of the inflammatory chemokines CCL 3 and CCL 4 in dendritic cells . ^^^ In this study we report that exogenous PGE 2 inhibits CCL 3 ( MIP 1alpha ) and CCL 4 ( MIP 1beta ) expression and release from dendritic cells stimulated with either lipopolysaccharide ( LPS ) , a TLR 4 ligand , or peptidoglycan , a TLR 2 ligand . ^^^ Intraperitoneal administration of PGE 2 together with LPS results in a reduction in the levels of CCL 3 and CCL 4 released in the peritoneal fluid , a reduction in the number of dendritic cells accumulating in the peritoneal cavity , and a reduction in CCL 3 amount per cell in the peritoneal cell population . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Real time quantitative PCR analysis of infiltrating leukocytes revealed a marked elevation of steady state mRNA levels of IL 1beta and TNFalpha and the chemokines KC , MIP 2 , CXCL 9 , CXCL 10 , CXCL 11 , CCL 2 , CCL 3 , and CCL 4 at 6 h postchallenge , which diminished over time . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
CCR 2 and CCR 5 interact primarily with the human CC family ligands CCL 2 ( formerly called monocyte chemoattractant protein ; MCP 1 ) , CCL 3 and CCL 4 ( macrophage inflammatory protein 1 alpha and 1 beta ; MIP 1 alpha / beta ) , and their main function is to recruit leukocytes from circulation into the tissues , thus playing an important role in human inflammatory disorders . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The chemokine receptor , CCR 5 , is a G protein coupled receptor responsible for some of the effects of the chemokines CCL 3 , CCL 4 and CCL 5 . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The focus of TGFbeta inhibition is observed to be directed in genes involved in chemotaxis ( IL 15 , CXCL 1 , CXCL 2 , CCL 3 , CCL 4 , CCL 5 , CCL 9 ) , chemokine receptors ( CCR 5 , CCR 9 ) , LIF receptor , and FPR 2 , and on genes mediating cell migration ( MMP 9 , MMP 13 , MacMARCKS , endothelin receptor B , Ena / VASP , Gas 7 ) , apoptosis ( FAS , TNF , TNF receptor , caspase 1 and 11 ) , and host response to infection ( toll like receptor 6 , Mx 1 , and MARCO ) . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
We show that VIP inhibited the function of chemokine receptors on monocytes and CD 4 ( + ) T lymphocytes , with impaired chemotaxis and calcium flux in response to the cognate chemokine ligands CXCL 12 , CCL 3 , CCL 4 , and CCL 5 . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Protection from T1D elicited by IGF I / IGFBP 3 was mediated by up regulated CCL 4 and down regulated CCL 3 gene expression in pancreatic draining lymph nodes , activation of the phosphatidylinositol 3 kinase and Akt / protein kinase B signaling pathway of beta cells , reduced beta cell apoptosis , and stimulation of beta cell replication . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Main results were : NK cell lytic activities against both the NK susceptible K 562 cell line and the NK resistant Daudi cell line were significantly augmented in EU IDUs compared with either controls or seroconverters before or after seroconversion ; NK cells producing the cytokines IFN gamma and TNF alpha and the beta chemokines CCL 3 , CCL 4 , and CCL 5 were also increased in the EU IDUs , either after in vitro activation or without stimulation . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
One anti CXCR 4 factor is macrophage derived chemokine ( chemokine ligand 22 , CCL 22 ) , and anti CCR 5 factors include macrophage inflammatory protein 1 alpha ( CCL 3 ) , macrophage inflammatory protein 1 beta ( CCL 4 ) , and RANTES ( regulated upon activation of normal T cells expressed and secreted ) ( CCL 5 ) . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
RNase protection assay revealed that in addition to CCL 2 ( monocyte chemoattractant protein 1 ) , CCL 3 ( macrophage inflammatory protein 1alpha ( MIP 1alpha ) ) , CCL 4 ( MIP 1beta ) , CCL 5 ( RANTES ) , CXCL 2 ( MIP 2 ) , and CXCL 10 ( inducing protein 10 ) , XCL 1 ( lymphotactin / single C motif 1alpha / activation induced , T cell derived and chemokine related cytokine ) was identified to be up regulated by Tat expression . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Up regulation of mRNA for CCL 4 , CCL 3 , CCL 5 , CCL 2 , and CXC chemokine ligand ( CXCL ) 10 in herpes simplex virus stimulated PDC was detected by RNAse protection assays . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Accordingly , EBV immortalized B cells secreted these chemokines , especially CCL 3 , CCL 4 , and CCL 22 , in large quantities . ^^^ However , the concomitant production of CCL 3 , CCL 4 , and CCL 5 by EBV infected B cells may eventually attract Th 1 cells and cytotoxic T cells , leading to elimination of EBV infected B cells at latency 3 and to selection of those with limited expression of latent genes . . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
All beads elicited comparable levels of CXCL 9 , CXL 10 , CCL 2 , CCL 17 , and CCL 22 mRNA , but PPD beads caused biased CXCL 2 CXCL5 , CCL 3 , and CCL 4 expression whereas both pathogen Ags induced CCL 7 . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
OBJECTIVES : To investigate the production of dynamic alpha and beta chemokines represented by interleukin 8 ( IL 8 ) as alpha chemokine and CCL 2 ( monocyte chemoattractant protein 1 , CCR 2 ligand ) , CCL 4 ( macrophage inflammatory protein 1beta , CCR 5 ligand ) , CCL 3 ( macrophage inflammatory protein 1alpha , CCR1 / 5 ligand ) , ( CCL 5 , regulated upon activation , normal T cell expressed and secreted ( RANTES , CCR 5 ligand ) as beta chemokines by the human intestinal cell line INT 407 stimulated with factors produced by living Campylobacter jejuni ( C . jejuni ) and those present within sonicated and filtrated bacteria . ^^^ RESULTS : Living bacteria induced increased numbers of IL 8 , CCL 4 and CCL 2 but not CCL 3 or CCL 5 producing cells . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Four of these genes comprise two closely related paralogous pairs : CCL 3 CCL3L1 and CCL 4 CCL4L1 . ^^^ One BAC clone ( AC131056 . 5 ) on the contig with substantial internal sequence duplication contains two complete copies of CCL3L1 and CCL4L1 and one truncated copy of CCL3L1 , while a partially overlapping clone ( AC003976 . 1 ) contains one copy each of CCL 3 and CCL 4 . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
RESULTS : Serum and vaginal fluid IgG and IgA antibodies , IL 2 and IFN gamma producing cells , and macrophage inflammatory protein ( MIP ) 1beta and MIP 1alpha ( CCL 4 and CCL 3 ) were significantly raised in immunized macaques ( P = 0 . 01 0 . 05 ) . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Three CC chemokines MIP 1alpha ( CCL 3 ) , MIP 1beta ( CCL 4 ) , and RANTES ( CCL 5 ) are natural ligands for the human immunodeficiency virus 1 ( HIV 1 ) coreceptor CCR 5 . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
In particular , the interaction between chemokines CCL 3 ( MIP 1alpha ) , CCL 4 ( MIP 1beta ) and CCL 5 ( RANTES ) and their receptor , CC chemokine receptor 5 ( CCR 5 ) , may be critical in regulating T cell functions by mediating recruitment , polarization , activation and differentiation of antiviral type 1 cytokine secreting T helper and cytotoxic T cells . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
This was associated with reduced renal expression of CC chemokines CCL 2 , CCL 3 , CCL 4 , and CCL 5 and the chemokine receptors CCR 1 , CCR 2 , and CCR 5 . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
These proteins termed CCL 3 ( MIP 1alpha ) , CCL 4 ( MIP 1beta ) , CCL9 / 10 ( MIP 1delta ) , and CCL 15 ( MIP 1gamma ) according to the revised nomenclature for chemokines are produced by many cells , particularly macrophages , dendritic cells , and lymphocytes . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Here , we investigated whether reduced GRK 2 expression changes the chemotactic response of T cells to the chemokines CCL 3 , CCL 4 , and CCL 5 . ^^^ In conclusion , a 50 % decrease in T cell GRK 2 expression results in increased responsiveness to CCL 3 , CCL 4 , and CCL 5 , suggesting that the 50 % reduction in lymphocyte GRK 2 level as observed during inflammation can have functional consequences for the response of these cells to chemokines . . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The authors now show that the interaction of human microglia , the resident phagocytes of the brain , with Tat leads to dramatic increases in the secretion of the chemokines CCL 2 , CXCL 8 , CXCL 10 , CCL 3 , CCL 4 , and CCL 5 . ^^^ Tat induced expression of CCL 2 and CCL 4 was mediated by the activation of the extracellular regulated kinase ( ERK ) 1 / 2 mitogen activated protein kinase ( MAPK ) pathway and the phosphatidylinositol 3 kinase ( PI3K ) pathway , whereas the induction of CXCL 8 and CCL 3 was mediated only by the p 38 MAPK pathway . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
M . tuberculosis infection causes an increase in the expression of beta chemokines CCL 3 , CCL 4 , and CCL 5 , and their receptor CCR 5 , in the lungs . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NK cells not only react to , but also produce IFN gamma , TNF alpha , GM CSF , CCL 3 , CCL 4 , and CCL 5 , enabling them to recruit various immune cells to sites of immune response . . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
We described previously the inhibitory effect of PGE ( 2 ) on the expression and release of the inflammatory chemokines CCL 3 and CCL 4 from activated dendritic cells . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
AMD 3451 dose dependently inhibited the intracellular Ca ( 2+ ) signaling induced by the CXCR 4 ligand CXCL 12 in T lymphocytic cells and in CXCR 4 transfected cells , as well as the Ca ( 2+ ) flux induced by the CCR 5 ligands CCL 5 , CCL 3 , and CCL 4 in CCR 5 transfected cells . ^^^ In freshly isolated monocytes , AMD 3451 inhibited the Ca ( 2+ ) flux induced by CXCL 12 and CCL 4 but not that induced by CCL 2 , CCL 3 , CCL 5 , and CCL 7 . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
CCL 3 and CCL 4 triggered migration of GM CSF primed neutrophils was inhibited by the CCR 5 antagonist TAK 779 . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
We here investigated wether genes encoding the interleukins IL 1beta , IL 6 and IL 8 , and the chemokines CCL 2 , CCL 3 , CCL3L1 and CCL 4 are useful markers for sensitization testing in CD34+ progenitor derived dendritic cells ( CD 34 DC ) . ^^^ After 24 h , consistent upregulatory effects of all sensitizing compounds on transcript expression of CCL 2 , CCL 3 and CCL 4 were observed , whereas SDS ( and BC ) had no effect . ^^^ Our findings suggest that the CCL 2 , CCL 3 and CCL 4 genes may be selective end point markers in the CD 34 DC model to discern chemical sensitizers from irritants . . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
New insights into TH 2 cell dominance are presented in reports dealing with a range of chemokines , including CCL 3 ( MIP 1alpha ) , CCL 4 ( MIP 1beta ) , CCL 5 ( RANTES ) , CXCL 9 ( Mig ) , and CXCL 10 ( IP 10 ) . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Expression of the beta chemokines CCL 3 , CCL 4 , CCL 5 and their receptors in idiopathic inflammatory myopathies . ^^^ The expression of CCL 3 ( MIP 1alpha ) , CCL 4 ( MIP 1beta ) , CCL 5 ( RANTES ) and their main receptors ( CCR 1 and CCR 5 ) was studied by semi quantitative reverse transcriptase polymerase chain reaction ( RT PCR ) and immunohistochemistry in a series of 16 IIM and five controls ( four normal muscles and one tonsil ) . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
We investigated the role played by chemokine receptor 5 ( CCR 5 ) in the influx of T cells to the cardiac tissue of T . cruzi infected mice . mRNA and protein for the CCR 5 ligands CCL 3 , CCL 4 , and CCL 5 were detected in the hearts of infected mice in association with CD4+ and CD8+ T cells . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The potential energies associated with fragmentation of the carbon tetrachloride anion radical ( CCl 4 ) into a trichloromethyl radical ( CCl 3 ) and a chloride ion ( Cl ) were explored as a function of the carbon chlorine bond distance during cleavage . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
CC chemokine ligand ( CCL ) 2 , CCL 3 and CCL 4 levels were measured in the bronchoalveolar lavage fluid ( BALF ) of 18 nonsmoker control subjects and 17 patients affected by IPF . ^^^ The BALF levels of all chemokines were significantly increased in IPF : median ( range ) CCL 3 1 . 6 ( 1 . 0 11 . 1 ) versus 1 . 2 ( 0 . 0 3 . 8 ) pg 10 mL ( 1 ) ; CCL 4 6 . 2 ( 1 . 3 96 . 0 ) versus 3 . 4 ( 0 . 3 6 . 8 ) pg 10 mL ( 1 ) ; and CCL 2 60 . 1 ( 16 . 7 251 . 3 ) versus 4 . 6 ( 0 . 5 119 . 4 ) pg 10 mL ( 1 ) . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
In the present study , we investigated the involvement of macrophage inflammatory protein 1alpha ( MIP 1alpha ) [ CC chemokine ligand 3 ( CCL 3 ) ] , MIP 1beta [ CCL 4 ] , regulated on activation , normal T expressed and secreted ( RANTES ) [ CCL 5 ] , and CC chemokine receptors ( CCRs ) on neutrophil migration in murine immune inflammation . ^^^ Herein , we show increased mRNA expression for MIP 1alpha [ CCL 3 ] , MIP 1beta [ CCL 4 ] , RANTES [ CCL 5 ] , and CCR 1 in peritoneal cells harvested from OVA challenged , immunized mice , as well as MIP 1alpha [ CCL 3 ] and RANTES [ CCL 5 ] but not MIP 1beta [ CCL 4 ] proteins in the peritoneal exudates . ^^^ OVA induced neutrophil migration response was muted in immunized MIP 1alpha [ CCL 3 ] ( / ) mice , but it was not inhibited by treatment with antibodies against RANTES [ CCL 5 ] or MIP 1beta [ CCL 4 ] . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
CCL 4 and CCL 3 were formed by duplication of a common ancestral gene , generating the SCYA 4 and SCYA 3 genes which , in turn , present a variable number of additional non allelic copies ( SCYA4L and SCYA3L1 ) . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Potential energy surface for the CCl 4 + H > CCl 3 + ClH reaction : kinetics and dynamics study . ^^^ An analytical potential energy surface for the gas phase CCl 4 + H > CCl 3 + ClH reaction was constructed with suitable functional forms to represent vibrational modes . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
From each blood sample PBMCs were separated and gene expression levels for chemokines CCL 3 , CCL 4 , CCL 5 , CXCL 10 , and their receptors CCR 1 , CCR 5 , and CXCR 3 , were determined using real time quantitative PCR . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Similar kinetics of expression were found for the chemokines CCL 5 , CCL 4 , CCL 3 and CXCL 10 and for the receptors CCR 5 and CXCR 3 , all of them linked to the Th 1 type pattern . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Secreted CCL 3 and CCL 4 were detected as a heterodimer . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Local production of TNF , IL 1beta , IFN gamma , CCL 3 ( MIP 1alpha ) , and CCL 4 ( MIP 1beta ) was reduced in IL 18 / mice , demonstrating a local proinflammatory role for IL 18 . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
With regard to chemokines , in both LC and splenic DC , type 1 IFN upregulated the production of inflammatory chemokines , such as CXCL 10 , CXCL 11 , CCL 3 , CCL 4 , and CCL 5 . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Variants of CCR 5 , which are permissive for HIV 1 infection , show distinct functional responses to CCL 3 , CCL 4 and CCL 5 . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Expression of CXCL 5 and CCL 2 was found to be independent of T cell infiltration while intragraft expression of CCL 3 , CCL 4 , CCL 5 , CXCL 9 , CXCL 10 , XCL 1 and CCL 1 was clearly T cell dependent and increased significantly with time after transplantation . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
This was associated with a significant upregulation of CD 8 ( + ) T cell derived suppressor factor , as well as the CC chemokines CCL 3 , CCL 4 and CCL 5 . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
We determined three distinct SOX markers : Cu / Zn superoxide dismutase ( Cu / Zn SOD ) , total peroxide and autoantibodies against oxidized LDL ( OxLDL Ab ) ; high sensitivity C reactive protein ( hs CRP ) ; beta chemokines : monocyte chemoattractant protein 1 ( CCL 2 ) , macrophage inflammatory proteins ( CCL 3 and CCL 4 ) and regulated upon activation , normal T cell expressed and secreted ( CCL 5 ) and the intima media thickness ( IMT ) values in CAPD patients both with and without cardiovascular disease ( CVD ) and healthy controls . ^^^ CCL 4 ( p < 0 . 01 ) and hs CRP ( p < 0 . 05 ) were increased only in patients with CVD , whereas there were no differences in the total peroxide , OxLDL Ab and CCL 3 levels between patients and controls . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
By reverse transcriptase polymerase chain reaction and enzyme linked immunosorbent assay , we show that cultured human astrocytes stimulated with interleukin 1beta and tumor necrosis factor produce CCL 2 , CCL 3 , CCL 4 , CCL 5 , CCL 20 , and CXCL 12 that act on immature DCs , but not CCL 19 and CCL 21 , 2 chemokines specific for mature DCs . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Similarly , birch dust induced a strong expression of CCL 3 , CCL 4 , and CXCL2 / 3 mRNA whereas only moderate levels of these chemokine mRNAs were detected after oak dust exposure . ^^^ TiO 2 dust induced about five fold expression of CCL 3 and CCL 4 mRNA but did not affect significantly other chemokines . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Exposure to aldrithiol 2 inactivated human immunodeficiency virus type 1 or gp 120 , but not gp 41 , triggered alpha interferon ( IFN alpha ) , CC chemokine ligand 2 ( CCL 2 ) , CCL 3 , and CCL 4 production in human plasmacytoid dendritic cells ( DCs ) but not in myeloid DCs ( M DCs ) or monocyte derived DCs from the same donors . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Similarly , all the wood dusts induced the expression of CCL 2 , CCL 3 , CCL 4 , and CXCL2 / 3 chemokines and inhibited CCL 24 expression . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
RESULTS : Alcohol inhibited IL 2 induced CC chemokine ( CCL 3 and CCL 4 ) expression by NK cells . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
In addition , the NEI treatment suppressed the mRNA expressions of CC chemokine ligand 3 ( CCL 3 ) , CCL 4 , and macrophage inflammatory protein 2 ( MIP 2 ) in neutrophils in the liver at 8 h after the CTL injection . ^^^ In support of these results , we confirmed that administration of anti CCL 3 , anti CCL 4 , and anti MIP 2 monoclonal antibodies suppressed sALT activity and leukocyte migration into the liver . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The second one occurs within 8 to 12 hours and includes CKs attracting effector memory T cells ( CXCL 8 , CCL 3 , CCL 4 , CCL 5 , CXCL 9 , CXCL 10 , and CXCL 11 ) . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Since LaCl 3 , being the most acidic phase , is not active for the destructive adsorption of CCl 4 , basic oxygen atoms , however , remain needed to stabilize the reaction intermediate CCl 3 as La O CCl3 . . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Transcriptional profiling revealed that DUSP 1 controls a significant fraction of LPS induced genes , which includes IL 6 and IL 10 as well as the chemokines CCL 3 , CCL 4 , and CXCL 2 . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
However , of six chemokines analysed , levels of CCL 3 and CCL 4 were increased ( P = 0 . 0442 and P = 0 . 0334 ) while CCL 2 was decreased ( P = 0 . 0318 ) in the multiple islet autoantibody positive group . ^^^ There was a significant correlation between the two closely related chemokines CCL 3 and CCL 4 in individuals at risk ( r = 0 . 84 , P = 0 . 00005 ) , but not in the autoantibody negative group . ^^^ The up regulation of CCL 3 and CCL 4 vs . down regulation of CCL 2 suggests opposed functions of these chemokines in the disease process . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Genes encoding cytokines and chemokines involved in host defense against A . fumigatus , including interleukin 1beta ( IL 1beta ) , IL 8 , CXCL 2 , CCL 4 , CCL 3 , and CCL 20 , as well as the opsonin long pentraxin 3 , were up regulated during the first 2 to 6 h , coinciding with an increase in phagocytosis . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Because the chemokine receptor CCR 5 and its ligands ( CCL 3 , CCL 4 , and CCL 5 ) regulate leukocyte chemotaxis and activation , we investigated the role of CCR 5 during Con A induced liver injury . ^^^ CCR 5 / mice also exhibited increased production of interleukin 4 , tumor necrosis factor alpha , CCL 3 , CCL 4 , and CCL 5 , and a prominent liver mononuclear cell infiltrate , among which many cells were CCR1+ . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Here we demonstrate that after immunization but before antigen recognition , naive CD8+ T cells in immunogen draining lymph nodes upregulate the chemokine receptor CCR 5 , permitting these cells to be attracted to sites of antigen specific dendritic cell CD4+ T cell interaction where the cognate chemokines CCL 3 and CCL 4 ( also known as MIP 1alpha and MIP 1beta ) are produced . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Immunization with this vaccine elicited serum and vaginal IgG and IgA antibodies , IFNgamma and IL 12 producing cells , and increased concentrations of CCL 3 and CCL 4 . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
One tube PCR technique for CCL 2 , CCL 3 , CCL 4 and CCL 5 applied to fine needle aspiration biopsies shows different profiles in autoimmune and non autoimmune thyroid disorders . ^^^ Moreover , even in this small group , a statistically significant increase of CCL 3 and CCL 4 was found in samples from patients with autoimmune thyroid disease as compared to those with multinodular goiter . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The consequent activation of macrophages / microglia cells was inhibited in spinal cord from PSE treated mice as determination of chemokine expressions ( CCL 2 , CCL 3 , CCL 4 , CCL 5 , CXCL 9 , and CXCL 10 ) . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
It was observed that mitogen induced production of CCL 3 and CCL 4 by cord blood mononuclear cells was increased among infants born to HIV positive compared with HIV negative mothers , and that a deficiency in production of CCL 3 was associated with increased susceptibility to intrapartum HIV 1 infection . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
We examined the signaling events activated by group IA ( GIA ) and group IB ( GIB ) sPLA ( 2 ) in human lung macrophages leading to cytokine / chemokine production . sPLA ( 2 ) induced the production of cytokines ( TNF alpha , IL 6 and IL 10 ) and chemokines ( CCL 2 , CCL 3 , CCL 4 and CXCL 8 ) , whereas no effect was observed on IL 12 , CCL 1 , CCL 5 and CCL 22 . sPLA ( 2 ) induced the phosphorylation of the MAPK p 38 and ERK1 / 2 , and inhibition of these kinases by SB 203580 and PD 98059 , respectively , reduced TNF alpha and CXCL 8 release . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
CCL 3 ( MIP 1 alpha ) , CCL 4 ( MIP 1 beta ) , and CCL 18 ( DC CK1 / PARC / AMAC 1 ) are potent chemoattractants produced by macrophages , natural killer cells , fibroblasts , mast cells , CD 4 ( + ) T cells , and CD 8 ( + ) T cells . ^^^ CCL 3 and CCL 4 are natural ligands for the primary human immunodeficiency virus type 1 ( HIV 1 ) coreceptor CCR 5 and are also known to activate and enhance the cytotoxicity of natural killer cells . ^^^ Genomic DNAs from > 3 , 000 participants enrolled in five United States based natural history cohorts with acquired immunodeficiency syndrome ( AIDS ) were genotyped for 21 single nucleotide polymorphisms ( SNPs ) in a 47 kb interval on chromosome 17q12 containing the genes CCL 3 , CCL 4 , and CCL 18 . ^^^ CCL 3 ( MIP 1 alpha ) , CCL 4 ( MIP 1 beta ) , and CCL 18 ( DC CK1 / PARC / AMAC 1 ) are potent chemoattractants produced by macrophages , natural killer cells , fibroblasts , mast cells , CD 4 ( + ) T cells , and CD 8 ( + ) T cells . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Of the plasma chemokines , only CXCL 10 was increased by IFN beta treatment ; CCL 3 , CCL 4 , CCL 5 and CXCL 9 were unaltered . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
These morphological changes were accompanied by increased secretion of CXC chemokine ligands ( CXCL ) 9 , CXCL 10 ( up to 100 fold , P < 0 . 001 ) and CXCL 8 ( up to 10 fold , P < 0 . 001 ) but not CCL 3 , CCL 4 or CCL 5 . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
We therefore examined four members of the intercrine / chemokine superfamily of cytokines ( monocyte chemotactic peptide 1 [ MCP 1 ] , RANTES , macrophage inflammatory protein 1 alpha [ MIP 1 alpha ] , and MIP 1 beta ) , which do not activate neutrophils , for their ability to affect different eosinophil effector functions . ^^^ MCP 1 , a potent monocyte chemoattractant and basophil agonist , as well as MIP 1 beta , a peptide with pronounced homology to MIP 1 alpha , did not activate the eosinophil functions tested . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Messenger RNA for TNF alpha , human MIP 1 alpha , human MIP 1 beta , and IL 8 are all induced during the development of clonal anergy in HA1 . 7 , and these levels are significantly higher than those seen during activation of the clone using an anti CD 3 antibody and IL 2 . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Macrophage inflammatory protein 1 ( MIP 1 ) , initially purified from the conditioned medium of endotoxin stimulated macrophages , is a low m . w . heparin binding protein doublet comprising two peptides , MIP 1 alpha and MIP 1 beta . ^^^ Purified preparations of the recombinantly derived MIP 1 alpha peptide alone stimulated the secretion of TNF , IL 1 alpha , and IL 6 by peritoneal macrophages , but MIP 1 beta did not . ^^^ In fact , as little as eightfold excess MIP 1 beta blocked TNF induction by MIP 1 alpha to a significant degree . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The murine macrophage inflammatory proteins 1 alpha ( MIP 1 alpha ) and MIP 1 beta are distinct but closely related cytokines . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Activated macrophages produce a number of proinflammatory cytokines including IL 6 , JE , MIP 1 alpha and MIP 1 beta . ^^^ The induction requirements for production of either IL 6 or the MIP 1 related inflammatory proteins ( MIP 1 alpha , MIP 1 beta , and JE ) have been analyzed independently using fibroblasts , monocytes , or endothelial cells . ^^^ In contrast , PGE 1 inhibits LPS induced JE , MIP 1 alpha , and MIP 1 beta mRNA expression and this inhibition is partially dependent on a cAMP mediated pathway of signal transduction . ^^^ Here we show that incubation of macrophages with either IFN gamma or PMA induces the expression of JE , MIP 1 alpha and MIP 1 beta mRNA expression . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
MIP 1 beta , but not MIP 2 , when added with MIP 1 alpha to cells , blocked the suppressive effects of MIP 1 alpha on both human and murine BFU E , CFU GEMM , and CFU GM colony formation . ^^^ Pulse treatment of hu bone marrow cells with MIP 1 alpha at 4 degrees C for 1 h was as effective in inhibiting colony formation as continuous exposure of cells to MIP 1 alpha , and the pulsing effect with MIP 1 alpha could not be overcome by subsequent exposure of cells to MIP 1 beta . ^^^ Also , pulse exposure of cells to MIP 1 beta blocked the activity of subsequently added MIP 1 alpha . ^^^ These results show that MIP 1 beta ' s ability to block the action of MIP 1 alpha is specific . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The presence of positionally conserved amino acid residues suggests that the mouse proteins TCA 3 , P 500 , MIP 1 alpha , MIP 1 beta , and JE are members of a single gene family . ^^^ We have used interspecies somatic cell hybrids and recombinant inbred mouse strains to show that the genes encoding TCA 3 , MIP 1 alpha , MIP 1 beta , and JE ( provisionally termed Tca 3 , Mip 1a , Mip 1b , and Sigje , respectively ) map as a cluster on the distal portion of mouse chromosome 11 near the Hox 2 gene complex . ^^^ Together , these data support the model that the cytokines TCA 3 , P 500 , MIP 1 alpha , MIP 1 beta , and JE are encoded by a single cluster of related genes . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The genomic organization of two newly described induced lymphokine genes , 464 . 1 and 744 . 1 , has been determined . 464 . 1 and 744 . 1 appear to be the human homologues of the recently cloned murine macrophage inflammatory proteins , MIP 1 alpha and MIP 1 beta , respectively . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
We have identified IL 1 , IL 3 , IL 5 , IL 6 , IFN gamma , GM CSF , JE , MIP 1 alpha , MIP 1 beta , and TCA 3 RNA in at least two of four mast cell clones . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Similar approaches can be used to investigate the biological significance of the production , by mast cells stimulated with IgE and specific antigen , of cytokines similar or identical to IL 1 , IL 3 , IL 4 , IL 5 , IL 6 , TNF alpha / cachectin , IFN gamma , GM CSF , JE , MIP 1 alpha , MIP 1 beta and TCA3 . . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Dose dependent Ca2+ fluxes were elicited upon increasing concentrations of RANTES and MIP 1 alpha whereas no response was measured upon addition of MIP 1 beta or MCP 1 . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
In the present study , the action of chemokines / intercrines on the regulation of feeding was investigated using the intracerebroventricular microinfusion of chemokine / intercrine alpha subfamily members [ interleukin 8 ( IL 8 ) ; growth related cytokine / melanoma growth stimulating activity ( GRO alpha / MGSA ) ; platelet factor 4 ( PF 4 ) ; beta thromboglobulin ( beta TG ) ; and interferon inducible protein 10 ( IP 10 ) ] and beta subfamily members [ monocyte chemotactic protein 1 / monocyte chemotactic and activating factor ( MCP 1 / MCAF ) ; regulated upon activation normal T cell expressed and presumably secreted ( RANTES ) ; macrophage inflammatory protein 1 alpha ( MIP 1 alpha ) ; and macrophage inflammatory protein 1 beta ( MIP 1 beta ) ] . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
RANTES , and , to a lesser extent , MIP 1 alpha significantly induced the production of reactive oxygen species by human eosinophils , whereas MCP 1 , MIP 1 beta , and interleukin ( IL ) 8 / NAP 1 had no significant effects . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Cultured synovial fibroblasts were found capable of expressing and producing IL 8 , GRO , monocyte chemotactic and activating factor ( MCAF ) , macrophage inflammatory protein 1 alpha ( MIP 1 alpha ) , MIP 1 beta and RANTES in response to IL 1 alpha . ^^^ The expression of IL 8 , GRO , MCAF , MIP 1 alpha , and MIP 1 beta was clearly shown to increase in freshly isolated synovial fluid mononuclear cells ( SFMC ) of RA patients , in contrast to peripheral blood mononuclear cells ( PBMC ) of RA patients and normal subjects . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
We also tested the effect of different intercrines , i . e . , IL 8 , MIP 1 alpha , MIP 1 beta , RANTES , and MCAF ( also referred to as monocyte chemotactic protein 1 ) , on human mast cell migration . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The effects of human recombinant MIP 1 alpha , MIP 1 beta , and RANTES on the chemotaxis and adhesion of T cell subsets . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The C C chemokines MIP 1 alpha , MCP 1 , and RANTES , but not MIP 1 beta , induce the chemotaxis of NK and IL 2 activated NK ( IANK ) cells , as determined in microchemotaxis assay . ^^^ Subsequently , we observed that MIP 1 alpha , MCP 1 , and RANTES , but not MIP 1 beta , enhance the binding of guanosine 5 ' O ( thiotriphosphate ) , and increase the hydrolysis of [ 32P ] GTP in IANK cell membranes . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Actions of the chemotactic cytokines MCP 1 , MCP 2 , MCP 3 , RANTES , MIP 1 alpha and MIP 1 beta on human monocytes . ^^^ The activities of six synthetic CC chemokines , MCP 1 , MCP 2 , MCP 3 , RANTES , MIP 1 alpha and MIP 1 beta on human blood monocytes were studied . ^^^ Highest numbers of migrating cells were obtained with the monocyte chemotactic proteins ( MCP ) and RANTES , somewhat lower numbers with MIP 1 alpha , and only weak migration with MIP 1 beta . ^^^ The MCP were most effective ( MCP 1 > MCP 3 > MCP 2 ) , RANTES and MIP 1 alpha showed moderate ( 1 / 3 of MCP 1 activity ) , and MIP 1 beta only minimal activity . ^^^ Marked cross desensitization was observed among MCP 1 , MCP 2 and MCP 3 on the one hand , and RANTES , MIP 1 alpha and MIP 1 beta on the other , indicating receptor sharing within these two subgroups of CC chemokines . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
When tested at 5 10 10 ( 9 ) mol / L , the decrease in histamine release by RANTES was 69 . 2 % + / 3 . 5 % , by MIP 1 alpha 48 . 8 % + / 3 . 1 % , by MIP 1 beta 42 . 9 % + / 3 . 1 % , by PF 4 56 . 5 % + / 2 . 9 % , by IL 8 41 . 2 % + / 2 . 2 , by CTAP 3 27 % + / 4 . 4 % , and by IP 10 15 . 3 % + / 2 . 6 % . ^^^ We have therefore characterized RANTES , MIP 1 alpha , MIP 1 beta , CTAP 3 , PF 4 , IL 8 , and IP 10 as inhibitors of MCAF induced histamine release . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The mRNAs encoding RANTES , MIP 1 alpha , MIP 1 beta , TCA 3 ( 1 309 ) , IP 10 , JE ( MCP 1 ) , KC ( MGSA / gro ) , and MARC ( MCP 3 ) were induced in the spinal cord 1 2 days before clinical signs were apparent . ^^^ Activated encephalitogenic T cells expressed message for RANTES , MIP 1 alpha , MIP 1 beta , and TCA 3 . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Binding of these labeled ligands could be competed by the unlabeled macrophage inflammatory proteins MIP 1 alpha and MIP 1 beta , with Kd values in the range 1 . 2 10 10 ( 9 ) to 7 . 5 10 10 ( 9 ) M . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
We have analyzed the effects of seven recombinant human ( rh ) chemokines ( MCAF , RANTES , MIP 1 alpha , MIP 1 beta , IL 8 , GRO , and IP 10 ) on the growth and function of human basophils and mast cells . ^^^ We found that MCAF , but not RANTES , MIP 1 alpha , MIP 1 beta , IL 8 , GRO , or IP 10 , causes direct and dose dependent histamine release from basophils ( MCAF , 5 micrograms / ml : 26 . 9 + / 3 . 4 % ; other chemokines : < 5 % of total histamine ) . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The rank order of beta chemokine competition for 125I human MIP 1 alpha binding was human MIP 1 alpha > mouse MIP 1 alpha approximately RANTES approximately MIP 1 beta > MCP 1 . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Rapidly purified T cells are capable of directly responding to the beta chemokines macrophage inflammatory protein 1 alpha ( MIP 1 alpha ) , MIP 1 beta , and RANTES in the absence of alpha CD 3 stimulation as previously described ( Taub , D . ^^^ Kinetic analysis of T cell activation revealed that 6 12 h of anti CD 3 stimulation was optimal to restore the ability of purified T cells to migrate in response to the chemokines MIP 1 alpha , MIP 1 beta , RANTES , and IL 8 . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Malaria specific metabolite hemozoin mediates the release of several potent endogenous pyrogens ( TNF , MIP 1 alpha , and MIP 1 beta ) in vitro , and altered thermoregulation in vivo . ^^^ We now report that purified native , as well as chemically synthesized , hemozoin crystals potently induce the release of several pyrogenic cytokines , including TNF , MIP 1 alpha , and MIP 1 beta , from murine macrophages and human peripheral blood monocytes in vitro . ^^^ As a consequence of its ability to induce pyrogenic cytokines in vitro , and thermal dysregulation in vivo , we propose that this unique parasite metabolite is an important pyrogen released by malaria parasites at schizogomy , which acts by eliciting the production of a group of potent endogenous pyrogens , which include MIP 1 alpha and MIP 1 beta , as well as TNF , in macrophages . . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
On the other hand , unlabeled MCP 3 displaced the binding of radiolabeled MIP 1 alpha , RANTES , MCP 1 and MIP 1 beta as effectively as the isologous CC chemokines . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
COS cells transiently transfected with the murine homologue of human CCR 1 bind murine MIP 1 alpha and human RANTES with Kds of 3 . 4 nM and 4 . 2 nM and murine MIP 1 beta with an EC 50 of 8 . 9 nM . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
IL 8 and the other CXC chemokines act preferentially on neutrophils , while the CC chemokines ( MCP 1 , MCP 2 , MCP 3 , RANTES , MIP 1 alpha and MIP 1 beta ) act on monocytes , but not neutrophils , and have additional activities toward basophil and eosinophil granulocytes , and T lymphocytes . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Interleukin ( IL ) 8 , another CXC chemokine , and three CC chemokines ( macrophage inhibitory protein 1 alpha [ MIP 1 alpha ] , MIP 1 beta , and C 10 ) also specifically inhibited megakaryocyte colony formation at NAP 2 equivalent doses . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Chemokine binding affinity does not predict how well the ligand will transmit a signal through the receptor : RANTES and human MIP 1 alpha induce a similar intracellular calcium flux while binding with disparate affinities , while MCP 1 and human MIP 1 beta induce calcium mobilization only at high concentrations . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
MIP 1 beta , by contrast , despite its high homology to MIP 1 alpha , was totally inactive . ^^^ Normodense human eosinophils , tested for comparison , responded in a similar fashion to RANTES and MIP 1 alpha , but were unresponsive to MCP 1 and MIP 1 beta . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The chemokine family has been organized into two subgroups with MIP 1 alpha , MIP 1 beta , macrophage chemotactic and activating factor ( MCAF ) and RANTES belonging to one subgroup , and GRO alpha , MIP 2 alpha ( GRO beta ) , MIP 2 beta ( GRO gamma ) , platelet factor 4 ( PF 4 ) , IL 8 , and neutrophil activating peptide ( NAP ) 2 belonging to the other . ^^^ In contrast , MIP 1 beta , MIP 2 beta , GRO alpha , NAP 2 , and RANTES were not suppressive nor did they synergize with MIP 1 alpha , MIP 2 alpha , PF 4 , IL 8 , or MCAF to suppress . ^^^ However , a fivefold excess of MIP 1 beta blocked the suppressive effects of MIP 1 alpha . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Preferential migration of activated CD4+ and CD8+ T cells in response to MIP 1 alpha and MIP 1 beta . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Human macrophage inflammatory protein alpha ( MIP 1 alpha ) and MIP 1 beta chemokines attract distinct populations of lymphocytes . ^^^ Here we show that two molecules in the chemokine ( for chemoattractant cytokine ) superfamily , human macrophage inflammatory protein 1 alpha ( MIP 1 alpha ) and MIP 1 beta , do not share identical attractant activities for lymphocyte subpopulations . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Recently , it has been reported that PMNs can express and secrete chemotactic cytokines or chemokines , including IL 8 , MIP 1 alpha , and MIP 1 beta . ^^^ In this article we demonstrate that PMNs treated with IFN gamma , a Th 1 derived cytokine , can inhibit early mRNA expression for MIP 1 alpha , MIP 1 beta , and IL 8 ( up to 8 hours post IFN gamma addition ) , while augmenting their production at 24 hours post IFN gamma addition . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
In contrast , the production of MIP 1 alpha and MIP 1 beta by pulmonary vascular smooth muscle cells increased when stimulated by immune associated cytokines as well as with IL 1 beta and TNF . ^^^ Human pulmonary artery endothelial cells did not generate MIP 1 alpha or MIP 1 beta in response to graded doses of any of the cytokines . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
IL 8 was as potent as RANTES , MIP 1 alpha , and MIP 1 beta in inducing T cell chemotaxis . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The closely related chemokines MIP 1 alpha , MIP 1 beta , RANTES , interleukin 8 ( IL 8 ) , and Gro alpha were inactive at concentrations as high as 300 nM . ^^^ Activation of the MIP 1 alpha / RANTES receptor also mediated inhibition of adenylyl cyclase activity but with a different pharmacological profile : MIP 1 alpha ( 110 pM , IC 50 ) , RANTES ( 140 pM ) , MIP 1 beta ( 10 nM ) , and MCP 1 ( 820 nM ) . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The responses of lymphocytes to six CC chemokines MCP 1 , MCP 2 , MCP 3 , MIP 1 alpha , MIP 1 beta , and RANTES were studied using cloned human CD4+ and CD8+ T cells . ^^^ The monocyte chemotactic proteins ( MCP 1 , MCP 2 , and MCP 3 ) showed a typically bimodal concentration dependence , and were considerably more effective than MIP 1 alpha , MIP 1 beta , or RANTES . ^^^ The responses to MCP 2 , MIP 1 alpha , MIP 1 beta , and RANTES were weaker , and no changes were obtained on stimulation with IL 8 or IP 10 . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Studies demonstrated that IL 10 dose dependently suppressed the expression and production of PMN derived macrophage inflammatory protein 1 alpha ( MIP 1 alpha ) , MIP 1 beta , IL 8 mRNA , and protein . ^^^ The t1 / 2 of MIP 1 alpha , MIP 1 beta , and IL 8 mRNA from PMNs treated for 4 h with LPS before actinomycin D ( Ac D ) addition were approximately 40 min , 1 . 7 h , and 2 h , respectively , whereas the t1 / 2 from PMNs stimulated for 8 h before Ac D were 2 , 2 , and > 9 h , respectively . ^^^ The t1 / 2 of MIP 1 alpha , MIP 1 beta , and IL 8 mRNA from PMNs treated with LPS plus IL 10 compared with LPS alone was reduced by 62 , 50 , and 40 % , respectively , at the 4 h time point and by 50 , 25 , and 70 % , respectively , at the 8 h time point . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Our laboratory has developed two sensitive and specific sandwich ELISAs for the detection of macrophage inflammatory protein 1 alpha and beta ( MIP 1 alpha and MIP 1 beta ) . ^^^ The lower threshold for detection of both MIP 1 alpha and MIP 1 beta was 100 pg / ml , and both of these ELISAs were efficacious for the detection of MIP 1 alpha and MIP 1 beta in conditioned media from pulmonary fibroblasts , monocytes , neutrophils , and a pulmonary epithelial cell line . ^^^ The development of these ELISAs will allow the measurement of MIP 1 alpha and MIP 1 beta from biologically relevant fluids and ascertain whether these two C C chemokines are present in disease . . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
MIP 1 consists of two highly homologous peptides , MIP 1 alpha and MIP 1 beta . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
This inhibition is not specific to MIP 1 alpha in that expression of MIP 1 beta , a related molecule that does not exhibit potent stem cell inhibitory properties , is inhibited in a similar manner . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The ability to inhibit collagen expression was also demonstrated by another member of the C 10 C branch of the platelet factor 4 superfamily , interleukin 8 ( IL 8 ) , but not by RANTES , MIP 1 alpha , or MIP 1 beta , which belong to the C C branch . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Additional experiments showed that the inhibitory effect of AcSDKP on primitive normal progenitor cycling in the LTC system could be overcome by the simultaneous addition of macrophage inflammatory protein 1 beta ( MIP 1 beta ) ; an antagonist of MIP 1 alpha . ^^^ The apparent differential effect of AcSDKP on primitive normal and CML progenitors may thus be a secondary consequence of the differential responsiveness of these cells to MIP 1 alpha for another molecule antagonized by MIP 1 beta ) , whose production or release by adherent marrow cells is inducible by AcSDKP . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Administration of anti HSV gD monoclonal antibody 1 day after infection was associated with reduced message for MIP 2 , MCP 1 , MIP 1 alpha , and MIP 1 beta . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
We report here the ability of the beta chemokines MIP 1 alpha , MIP 1 beta , RANTES , and MCP 1 to enhance some lymphocyte effector functions . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Here , we have characterised expression kinetics of the mRNAs for tumour necrosis factor alpha ( TNF alpha ) , interleukin 1 beta ( IL 1 beta ) , macrophage inflammatory protein 1 alpha ( MIP 1 alpha ) and macrophage inflammatory protein 1 beta ( MIP 1 beta ) in confluent cultures of the murine IC 21 macrophage line in response to LPS . ^^^ We conclude that the IC 21 cell line may represent a suitable model for studying the role of stimulated cytokine gene expression in inflammation and that the early events in the pulmonary inflammatory response to the inhalation of NO 2 do not involve stimulated release of TNF alpha , IL 1 beta or MIP 1 alpha / MIP 1 beta from macrophages . . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
RANTES , MIP 1 alpha , and MIP 1 beta induced significant transendothelial chemotaxis of CD4+ , CD8+ , and CD45R0+ T lymphocyte subsets . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Genomic cloning and promoter analysis of macrophage inflammatory protein ( MIP ) 2 , MIP 1 alpha , and MIP 1 beta , members of the chemokine superfamily of proinflammatory cytokines . ^^^ Macrophage inflammatory protein ( MIP ) 2 , MIP 1 alpha , and MIP 1 beta all belong to the newly recognized `` chemokine ' ' superfamily of structurally related , activation inducible cytokines with inflammatory and growth regulatory activities . ^^^ Proximal 5 ' promoter fragments cloned from both the MIP 1 alpha and MIP 1 beta genes unexpectedly conferred constitutive expression on the fused reporter gene sequences in macrophage like cells , but initial 5 ' deletion analysis did not link this responsiveness to known sequence motifs . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Fever and feeding : differential actions of macrophage inflammatory protein 1 ( MIP 1 ) , MIP 1 alpha and MIP 1 beta on rat hypothalamus . ^^^ Changes in body temperature ( Tb ) and feeding were characterized in unrestrained rats following the micro injection into the anterior hypothalamic preoptic area ( AH / POA ) of macrophage inflammatory protein 1 ( MIP 1 ) , MIP 1 alpha or MIP 1 beta . ^^^ MIP 1 alpha micro injected similarly evoked a biphasic fever , with the Tb declining transiently at the 30 min point > or = 0 . 4 degrees C lower than the congruent rises in Tb evoked by doublet MIP 1 or MIP 1 beta . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Induction of tax in JPX 9 with Cd2+ was accompanied by rapid induction of IL 8 , IP 10 , MIP 1alpha , MIP 1beta , 1309 and SCM 1 as determined by reverse transcription PCR . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Many of the known agonists for leukocytes including 13 chemokines ( IL 8 , NAP 2 , GRO alpha , ENA 78 , IP 10 , PF 4 , MCP 1 , 2 and 3 , RANTES , MIP 1 alpha , MIP 1 beta and I 309 ) , three neuropeptides ( neuropeptide Y , somatostatin and calcitonin ) , as well as C5a , did not activate HMC 1 cells , indicating that C3a is one of a few protein ligands for which this cell line expresses specific receptors . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Two chemokine ( chemoattractant cytokines ) beta peptides , macrophage inflammatory proteins 1 alpha and 1 beta ( MIP 1 alpha and MIP 1 beta ) , were induced in human monocyte cultures following infection with the human immunodeficiency virus type 1 ( HIV 1 ) . ^^^ Reverse transcription ( RT ) PCR and RT in situ PCR studies on brain tissue from patients with AIDS dementia demonstrated elevated MIP 1 alpha and MIP 1 beta mRNA expression relative to comparable samples from HIV 1 infected patients without dementia . ^^^ As MIP 1 alpha and MIP 1 beta are potent chemoattractants for both monocytes and specific subpopulations of lymphocytes , this dysregulation of beta chemokine expression may influence the trafficking of leukocytes during HIV infection . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
This relative resistance to HIV 1 infection did not extend to T cell line adapted strains , was restricted by the envelope glycoprotein , was not explained by the cell surface density of CD 4 molecules , but was associated with the activity of the C C chemokines RANTES , MIP 1alpha , and MIP 1beta . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The responses of cloned human NK cells ( ERNK 57 ) to seven CC chemokines ( monocyte chemotactic protein 1 ( MCP 1 ) , MCP 2 , MCP 3 , RANTES ( regulated on activation , normal T cell expressed and secreted ) , macrophage inflammatory protein 1 alpha ( MIP 1 alpha ) , MIP 1 beta , and 1309 ) and two CXC chemokines ( IL 8 and IP 10 ) were studied . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Because the chemokines macrophage inflammatory protein 1 alpha ( MIP 1 alpha ) and MIP 1 beta can activate adhesion and induce migration of T cells in vitro , we investigated their expression in human liver allografts to determine whether they might be involved in regulating the recruitment of T cells to allografts in vivo . ^^^ In situ hybridization with complementary ribonucleic acid probes showed no MIP 1 alpha or MIP 1 beta mRNA in normal liver but dramatic expression of both chemokines in infiltrating leukocytes and graft endothelium during rejection . ^^^ Increased MIP 1 alpha and MIP 1 beta mRNA expression was already found in biopsies taken at the end of the transplant operation , suggesting that early induction of chemokines , possibly in response to graft reperfusion , might promote the subsequent development of graft rejection . ^^^ These data demonstrate for the first time that MIP 1 alpha and MIP 1 beta are ( 1 ) expressed in human liver allografts , ( 2 ) produced by endothelial cells in vivo , and ( 3 ) induced early after transplantation . ^^^ They suggest that MIP 1 alpha and MIP 1 beta produced by graft infiltrating leukocytes and graft endothelium might play a crucial role in regulating T cell recruitment to liver allografts in vivo . . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Intragraft expression of 1 group of chemokine genes , including macrophage inflammatory protein 1alpha ( MIP 1alpha ) , MIP 1beta , JE , and KC was observed at peak levels 3 days posttransplant in each of the 3 different allograft models . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Sendai virus treatment of hPBL will also result in significant production of several chemokines and cytokines such as macrophage inflammatory protein 1alpha ( MIP 1alpha ) , MIP 1beta , RANTES , tumor necrosis factor alpha ( TNF alpha ) , interleukin 6 ( IL 6 ) , and IL 8 , in a time dependent way . ^^^ The amount of IFN alpha induced at 15 h after Sendai virus treatment is more than 16 fold higher than those of MIP 1alpha , MIP 1beta , and RANTES . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
CC CKR 3 also bound MCP 1 with lower affinity , but did not bind MIP 1 alpha or MIP 1 beta . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
We studied the effects of various chemokines including neutrophil activating peptide 2 ( NAP 2 ) , beta thromboglobulin ( beta TG ) , platelet factor 4 ( PF 4 ) , melanoma growth stimulating activity ( GRO ) , gamma interferon induced protein ( IP 10 ) , regulated on activation , normal T expressed and secreted ( RANTES ) , macrophage inflammatory protein 1 alpha ( MIP 1 alpha ) , MIP 1 beta , and monocyte chemotactic protein 1 ( MCP 1 ) on Immunoglobulin ( IgE ) and IgG 4 production by human B cells . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The principal cofactor for entry mediated by the envelope glycoproteins of primary macrophage tropic strains of HIV 1 is CC CKR 5 , a receptor for the beta chemokines RANTES , MIP 1alpha and MIP 1beta . . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
CC CKR 5 : a RANTES , MIP 1alpha , MIP 1beta receptor as a fusion cofactor for macrophage tropic HIV 1 . ^^^ The chemokines RANTES , MIP 1alpha , and MIP 1beta , which suppress infection by macrophage tropic isolates , selectively inhibited cell fusion mediated by the corresponding envelope glycoproteins ( Envs ) . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The rank order of CC chemokine competition for 125I labeled human RANTES ( regulated on activation , normal T cell expressed and secreted ) binding to human embryonic kidney ( HEK ) 293 cells stably transfected with the receptor cDNA was murine MIP 1alpha > > human MIP 1beta > human RANTES > murine RANTES > murine MIP 1beta > human MCP 2 > murine MCP 1 ( JE ) > human MIP 1alpha > human MCP 3 > human MCP 1 . ^^^ Of the chemokines tested , only murine MIP 1alpha , human and murine MIP 1beta and RANTES , human MCP 2 , and JE were able to induce mobilization of intracellular Ca2+ from fura 2 loaded HEK 293 cells expressing the receptor . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Molecular cloning and functional characterization of a novel human CC chemokine receptor ( CCR 5 ) for RANTES , MIP 1beta , and MIP 1alpha . ^^^ Transfected cells expressing the receptor bind RANTES ( regulated on activation normal T cell expressed ) , MIP 1beta , and MIP 1alpha with high affinity and generate inositol phosphates in response to these chemokines . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The beta chemokines RANTES , MIP 1 alpha , and MIP 1 beta have potent suppressive effects on HIV 1 infection resulting from an early postbinding block in virus fusion and entry . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
HIV 1 RNA and cytokine expression , including tumor necrosis factor alpha ( TNF ) , inducible nitric oxide synthetase ( iNOS ) , and macrophage inflammatory protein alpha ( MIP 1 alpha ) and MIP 1 beta mRNA were detected by reverse transcriptase ( RT ) in situ PCR . ^^^ TNF , iNOS , MIP 1 alpha and MIP 1 beta expression localized to tissues from AIDS dementia cases where HIV 1 infected cells were plentiful . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Macrophage inflammatory protein 1alpha ( MIP 1alpha ) , MIP 1beta , and RANTES were all potent agonists for CC CKR 5 ( EC 50 = 3 30 nM ) when calcium flux was measured in transfected HEK 293 cells , yet the apparent binding affinities of the corresponding iodinated chemokines to intact cells expressing the receptor were low ( IC 50 approximately 100 nM ) . ^^^ These data suggest that CC CKR 5 is a G ( 1 ) coupled receptor that may mediate monocyte responses to MIP 1alpha , MIP 1beta , and RANTES . . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
In cell lines expressing CXCR 4 and CD 4 , and in blood lymphocytes , SDF 1 is a powerful inhibitor of infection by lymphocyte tropic HIV 1 strains , whereas the CC chemokines RANTES , MIP 1 alpha and MIP 1 beta , which were shown previously to prevent infection with primary , monocyte tropic viruses , are inactive . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
TCA 3 , MIP 1 alpha , and MCP 1 ( but not MIP 1 beta ) treatment stimulates chemotaxis of vascular smooth muscle cells . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Migration of CD8+ T cells induced by culture supernatants from stimulated DETC 7 17 cells was strongly reduced in the presence of a neutralizing anti lymphotactin antiserum and to a lesser extent by neutralizing anti MIP 1 alpha , anti MIP 1 beta , or anti RANTES antiserum . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
All C C chemokines tested , including monocyte chemotactic protein ( MCP ) 1 , MCP 2 , MCP 3 , macrophage inflammatory protein 1 alpha ( MIP 1 alpha ) , MIP 1 beta , and RANTES , induced migration of DC enriched cells cultured with or without IL 4 with MCP 3 being the most potent chemoattractant . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Reversible association of the cytokines MIP 1 alpha and MIP 1 beta with the endothelia of the blood brain barrier . ^^^ We examined the ability of the monomer and polymer of MIP 1 alpha and the polymer of MIP 1 beta radioactively labeled with 125iodine ( 1 MIP 1 ) to cross the BBB . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
DESIGN / METHODS : Serum MIP 1 alpha , MIP 1 beta and RANTES levels were determined by enzyme linked immunosorbent assay using archived serum specimens obtained on two occasions at least 1 . 8 years apart . ^^^ Serum levels of MIP 1 alpha , MIP 1 beta and RANTES in specimens obtained either early or later in the course of HIV infection did not differ significantly between non progressing patients and AIDS patients . ^^^ Serum MIP 1 alpha and MIP 1 beta levels did not reach levels reported to suppress HIV proliferation in vitro . ^^^ When expressed as a quantity per peripheral blood CD8+ lymphocyte , AIDS patients exhibited significantly greater levels of MIP 1 alpha , MIP 1 beta and RANTES than non progressing HIV patients ( P < 0 . 05 ) . ^^^ CONCLUSIONS : Serum MIP 1 alpha , MIP 1 beta and RANTES levels do not distinguish patients with AIDS from patients with non progressing HIV infection . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Synthesis of the CC chemokines MIP 1alpha , MIP 1beta , and RANTES is associated with a type 1 immune response . ^^^ Interestingly , expression of three CC chemokines ( i . e . , MIP 1alpha , MIP 1beta , and RANTES ) correlated with the type 1 response induced by Y . enterocolitica Ag . ^^^ Chemokine secretion is not restricted to T lymphocytes ; therefore , synthesis of MIP 1alpha , MIP 1beta , and RANTES was also characterized in human T cell clones that display a cytokine pattern indicative of the Th 2 , Th 0 , or Th 1 phenotype . ^^^ In six analyzed IL 2 and IFN gamma secreting Th 1 clones and in two Th 0 clones , MIP 1alpha , MIP 1beta , and RANTES were detected , while none or only minimal secretion of these CC chemokines was observed in three IL 4 and IL 5 producing Th 2 cell clones . . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Chemokines RANTES , MIP 1 alpha and MIP 1 beta were expressed in biopsies , but were rarely detected in cell lines and absent from xenografts . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
RANTES , MIP 1 alpha and MIP 1 beta are not involved in the inhibition of HIV 1SF33 replication mediated by CD8+ T cell clones . ^^^ It has been suggested that such inhibition is mediated by three type cc chemokines : RANTES , MIP 1 alpha and MIP 1 beta . ^^^ To assess whether our T cell clones inhibited HIV replication through a similar mechanism , the clones ' ability to inhibit HIV 1SF33 replication was compared with their secretion of RANTES , MIP 1 alpha and MIP 1 beta . ^^^ We showed no correlation between the ability of these clones to secrete RANTES , MIP 1 alpha and MIP 1 beta and their ability to repress HIV 1SF33 replication . ^^^ CONCLUSION : The data indicate that CD8+ cells can inhibit HIV 1SF33 replication in vitro by mechanisms that do not involve either cytotoxicity or RANTES , MIP 1 alpha and MIP 1 beta . . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
CD8+ T cell mediated suppression of HIV 1 infection may not be due to chemokines RANTES , MIP 1 alpha and MIP 1 beta . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Furthermore , the murine CC chemokines , JE / MCP 1 , MCP 3 / MARC , MIP 1 alpha , MIP 1 beta , RANTES , TCA 3 , C10 / MRP 1 , MRP 2 , and eotaxin , are discussed more in detail . . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
This study demonstrates that the beta chemokines macrophage inflammatory proteins 1 alpha and 1 beta ( MIP 1 alpha and MIP 1 beta ) and , RANTES ( regulated on activation , normally T cell expressed and secreted ) inhibit human immunodeficiency virus ( HIV ) replication in anti CD 3 or recall antigen stimulated peripheral blood mononuclear cells ( PBMCs ) of asymptomatic HIV infected subjects . ^^^ Neutralization of endogenous MIP 1 alpha , MIP 1 beta , and RANTES did not rescue HIV replication in cultures to which greater than 10 % CD8+ T cells had been added , indicating that the HIV suppressor activity of CD8+ T cells can not be explained entirely by the beta chemokines . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Identification of RANTES , MIP 1 alpha , and MIP 1 beta as the major HIV suppressive factors produced by CD8+ T cells . ^^^ The chemokines RANTES , MIP 1 alpha , and MIP 1 beta were identified as the major HIV SF produced by CD8+ T cells . ^^^ RANTES , MIP 1 alpha , and MIP 1 beta were released by both immortalized and primary CD8+ T cells . ^^^ HIV SF activity produced by these cells was completely blocked by a combination of neutralizing antibodies against RANTES , MIP 1 alpha , and MIP 1 beta . ^^^ Recombinant human RANTES , MIP 1 alpha , and MIP 1 beta induced a dose dependent inhibition of different strains of HIV 1 , HIV 2 , and simian immunodeficiency virus ( SIV ) . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Alternatively , tissue macrophages may be recruited from the bone marrow pool through expression of other type 1 chemokines such as JE , RANTES , MIP 1 alpha , MIP 1 beta , IP 10 , and KC . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
CD8+ T cell derived soluble factor ( s ) , but not beta chemokines RANTES , MIP 1 alpha , and MIP 1 beta , suppress HIV 1 replication in monocyte / macrophages . ^^^ We demonstrate that : ( 1 ) CD8+ T cell supernatants did , but beta chemokines did not , suppress HIV replication in the M / M system ; ( 2 ) antibodies to regulated on activation normal T cell expressed and Secreted ( RANTES ) , macrophage inflammatory protein 1 alpha ( MIP 1 alpha ) and MIP 1 beta did not , whereas antibodies to interleukin 10 , interleukin 13 , interferon alpha , or interferon gamma modestly reduced anti HIV activity of the CD8+ T cell supernatants ; and ( 3 ) the CD8+ T cell supernatants did , but beta chemokines did not , suppress HIV 1 IIIB replication in peripheral blood mononuclear cells as well as HIV expression in U 1 cells . ^^^ These results suggest that HIV suppressor activity of CD8+ T cells is a multifactorial phenomenon , and that RANTES , MIP 1 alpha , and MIP 1 beta do not account for the entire scope of CD8+ T cell derived HIV suppressor factors . . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Primary infection with SIVmac 239 was characterized by a higher level of IL 4 , IL 10 , MIP 1alpha , MIP 1beta , MCP 1 , and RANTES gene expression and a lower level of IL 12 and granzyme B gene expression compared with infection with SIVmac 239 delta nef . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
A significant reduction of neutrophil chemotaxis was obtained by anti IL 8 and anti growth related gene product alpha Abs , and a reduction of mononuclear cell migration was achieved by a combination of anti monocyte chemotactic protein 1 , anti MIP 1 alpha , and anti MIP 1 beta Abs . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Primary HIV 1 isolates were evaluated for their sensitivity to inhibition by beta chemokines RANTES ( regulated upon activation , normal T cell expressed and secreted ) , macrophage inflammatory protein 1 alpha ( MIP 1 alpha ) , and MIP 1 beta . ^^^ More important to note , these data demonstrate that resistance to inhibition by beta chemokines RANTES , MIP 1 alpha , and MIP 1 beta is not restricted to T cell line adapted SI isolates but is also a consistent property among primary SI isolates . ^^^ Loss of virus sensitivity to inhibition by beta chemokines RANTES , MIP 1 alpha , and MIP 1 beta was furthermore associated with changes in the third variable ( V 3 ) region amino acid residues previously described to correlate with a shift of virus phenotype from NSI to SI . ^^^ In addition , we also identified viruses sensitive to RANTES , MIP 1 alpha , and MIP 1 beta of NSI phenotype that were isolated from individuals with AIDS manifestations , indicating that loss of sensitivity to beta chemokine inhibition and shift in viral phenotype are not necessarily prerequisites for the pathogenesis of HIV 1 infection . . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
In the acute infection system , where DCs from uninfected individuals are pulsed with HIV and cocultured with autologous CD4+ T cells , no inhibition of replication of monocytotropic or T cell tropic viral isolates by MIP 1 alpha , MIP 1 beta , and RANTES , alone or in combination , was observed . ^^^ Furthermore , no significant differences in secretion of MIP 1 alpha , MIP 1 beta , and RANTES by purified CD8+ T cells were noted in uninfected versus HIV infected donors , regardless of the stage of disease . ^^^ These results indicate that HIV suppression by CD8+ T cells derived from HIV infected donors is a multifactorial phenomenon and not limited to the action of MIP 1 alpha , MIP 1 beta , and RANTES . . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
In this study it was proved whether low molecular thymic peptides are able to increase the secretion of the chemokines monocyte chemotactic protein 1 ( MCP 1 ) , interleukin 8 ( IL 8 ) , macrophage inflammatory protein 1 alpha ( MIP 1 alpha ) and macrophage inflammatory protein 1 beta ( MIP 1 beta ) as well as the cytokine tumor necrosis factor alpha ( TNF alpha ) which is not related to chemokines using cell cultures of human whole blood . ^^^ The thymic peptides induced a significant ( p < 0 . 05 ) elevated secretion of MCP 1 and IL 8 whereas for MIP 1 alpha , MIP 1 beta and TNF alpha no significant chances were seen . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
DESIGN AND METHODS : We have compared changes in plasma HIV RNA levels and circulating levels of MIP 1 alpha , MIP 1 beta , RANTES , IL 16 and MCP 1 in 20 severely immunodeficient HIV infected individuals ( CD4+ T cells = 14 + / 3 cells 10 10 ( 6 ) / l ; plasma HIV RNA = 4 . 45 + / 0 . 27 log 10 copies / ml ) undergoing treatment with the HIV protease inhibitor indinavir that added to pre existing nucleoside based therapy . ^^^ Concomitantly , significant increases in MIP 1 alpha ( 19 % increase ) , MIP 1 beta ( 14 % increase ) , RANTES ( 15 % increase ) and IL 16 ( 1213 % increase ) levels occurred . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The C C chemokines RANTES , MIP 1 alpha and MIP 1 beta were recently identified as the major components of the HIV SF produced by both immortalized and primary patient CD 8 T cells . ^^^ Moreover , we show that RANTES , MIP 1 alpha and MIP 1 beta block the entry of HIV 1 into cells and that their antiviral activity is independent of pertussis toxin sensitive signal transduction pathways mediated by chemokine receptors . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Thus the prevention of the HIV 1 envelope glycoprotein mediated fusion by the chemokines RANTES , macrophage inflammatory protein 1 alpha ( MIP 1 alpha ) and MIP 1 beta , as well as by the recently identified fusin / CXCR 4 ligand , stromal cell derived factor 1 ( SDF 1 ) could be explained by disruption of that complex . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Macrophage tropic HIV 1 isolates are generally specific for CCR 5 , a receptor for the CC chemokines RANTES , MIP 1alpha , and MIP 1beta , while T cell line tropic viruses tend to use CXCR 4 ( also known as fusin , LESTR , or HUMSTR ) . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
These include MIP 1alpha , MIP 1beta , and RANTES , as well as a distinct factor ( s ) capable of inhibiting HIV 1 strains insensitive to these chemokines . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
ENA 78 , PF 4 , the CC chemokines MCP 1 , MCP 2 , MCP 3 , MCP 4 , MIP 1 alpha , MIP 1 beta . ^^^ The exclusive expression in activated T lymphocytes is of high interest since the receptors for chemokines which have been shown so far to attract lymphocytes , e . g . , MCP 1 , MCP 2 , MCP 3 , MIP 1 alpha , MIP 1 beta , and RANTES , are also found in monocytes and granulocytes . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The cell lines produced varying amounts of the cytokines IL 8 , IL 10 , TNF alpha , TNF beta , RANTES , MIP 1 alpha , and MIP 1 beta , but not IFN alpha . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
In third party CBA / Ca allografts on unsensitized and C57BL / 6 presensitized BALB / c mice , similar levels of IL 1beta , MIP 1alpha , and MIP 1beta expression were observed . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
After influenza A virus infection , only the mononuclear cell attracting CC chemokines macrophage inflammatory protein 1alpha ( MIP 1alpha ) , MIP 1beta , and RANTES were produced while the prototype neutrophil CXC chemoattractants IL 8 and GRO alpha were entirely suppressed . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Besides SCF , other chemotactic factors tested , such as interleukin 3 , nerve growth factor , transforming growth factor beta , RANTES ( regulated upon activation , normal Tcell expressed and secreted ) , monocyte chemotactic protein 1 ( MCP 1 ) , MCP 2 , MCP 3 , macrophage inflammatory protein 1alpha ( MIP 1alpha ) , and MIP 1beta , failed to stimulate migration of human mast cells . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
METHODS : The concentrations of RANTES , MIP 1 alpha and MIP 1 beta in a panel of CD8+ T lymphocyte derived supernatants were determined by enzyme linked immunosorbent assay . ^^^ RESULTS : The concentrations of RANTES , MIP 1 alpha and MIP 1 beta in a panel of CD8+ lymphocyte derived supernatants were found to correlate with their relative ability to suppress the LTR mediated gene expression ( r = 0 . 679 , 0 . 764 and 0 . 48 , respectively ) . ^^^ The CD 8 suppressive effect on HIV 1 LTR driven gene expression was not abrogated by a combination of antibodies of RANTES , MIP 1 alpha and MIP 1 beta . ^^^ CONCLUSIONS : RANTES , MIP 1 alpha and MIP 1 beta do not alter HIV 1 LTR directed gene expression at doses up to 100 ng / ml . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
In the present study , the potential roles of these CD8+ CTL in the generation of the inflammatory responses associated with MS have been investigated by measuring the capacity of these T cells to secrete the following proinflammatory chemokines : macrophage inflammatory protein 1alpha ( MIP 1alpha ) and MIP 1beta , lymphocyte chemoattractant factor ( IL 16 ) , IFN inducible protein 10 , as well as the proinflammatory enzymes of the matrix metalloproteinase family . ^^^ All of the 17 CD8+ CTL lines secreted detectable amounts of MIP 1alpha and MIP 1beta . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Depletion of C C chemokines ( RANTES , MIP 1 alpha , and MIP 1 beta ) neutralized the ability of LPS conditioned supernatants to inhibit HIV 1 replication in MDM . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Recently , three chemokines , MIP 1 alpha , MIP 1 beta , and RANTES , have been found to significantly decrease human immunodeficiency virus production from infected T cells . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Using in situ hybridization to mRNA , we examined expression of the chemokines MCP 1 , MIP 1 alpha , MIP 1 beta , and RANTES . ^^^ MCP 1 and MIP 1 alpha were expressed by significantly more cells than MIP 1 beta and RANTES ( P < 0 . 005 ) . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Each bound a distinct subset of other beta chemokines : the order of competition for 125I murine MIP 1alpha on D 6 was murine MIP 1alpha > human and murine MIP 1beta > human RANTES approximately JE > human MCP 3 > human MCP 1 . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
ZR 75 1 responded to MIP 1beta and GRO alpha , giving maximum migration indices of 3 . 7 and 5 . 3 , respectively , and exhibited a migratory response to MIP 1alpha , IL 8 and MCP 1 although to a lower degree . ^^^ The specificity of the chemotactic response of MCF 7 to MIP 1alpha and MIP 1beta was confirmed using chemokine specific neutralising antibodies and heat denaturation , and was demonstrated to involve G protein and cyclic AMP signalling pathways . ^^^ MIP 1beta and MIP 1alpha were shown to induce changes in the organisation of the actin cytoskeleton and the level of F actin in MCF 7 cells , as determined using flow cytometric analysis and confocal microscopy . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Expression of mRNA for IL 1beta , TNF alpha , and IFN gamma , known to enhance ICAM 1 expression , and MIP 1alpha , MIP 1beta , and MCP 1 , known to activate leukocyte integrins or to act as chemokines , were also induced in the glomeruli at a mRNA level in a profile similar to that of ICAM 1 expression . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
When spermine was added to cultures of human peripheral blood mononuclear cells stimulated with lipopolysaccharide ( LPS ) , it effectively inhibited the synthesis of the proinflammatory cytokines tumor necrosis factor ( TNF ) , interleukin 1 ( IL 1 ) , IL 6 , MIP 1alpha , and MIP 1beta . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Only ELC Flag , but not MCP 1 , MCP 2 , MCP 3 , eotaxin , MIP 1alpha , MIP 1beta , RANTES ( regulated on activation normal T cell expressed and secreted ) , thymus and activation regulated chemokine ( TARC ) , or liver and activation regulated chemokine ( LARC ) , competed with ELC SEAP for EBI 1 . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Control specimens from six patients without inflammatory muscle disease were analyzed for transcripts of interleukins 1 beta , 2 , 4 , 6 , 10 , and 15 , and interferon gamma , tumor necrosis factor alpha , transforming growth factor beta 1 , macrophage inflammatory proteins 1 alpha and 1 beta ( MIP 1 alpha , MIP 1 beta ) , and the chemokine `` regulated on activation , normally T expressed and secreted ' ' ( RANTES ) . ^^^ In contrast , MIP 1 alpha and MIP 1 beta were detected in 13 and 6 myositis biopsies , respectively , and RANTES , another beta ( CC ) chemokine , was detected in eight myositis biopsies . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Only LARC but not five other CC chemokines ( MCP 1 , RANTES , MIP 1alpha , MIP 1beta , and TARC ) competed with LARC SEAP for binding to GPR CY 4 . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Only TARC and not five other CC chemokines ( MCP 1 ( monocyte chemoattractant protein 1 ) , RANTES ( regulated upon activation , normal T cells expressed and secreted ) , MIP 1alpha ( macrophage inflammatory protein 1alpha ) , MIP 1beta , and LARC ( liver and activation regulated chemokine ) ) competed with TARC SEAP for binding to CCR 4 . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The other C C chemokines had no significant effect singly ( MIP 1 alpha PBM : 64 . 8 + / 21 . 9 % ; AM : 115 . 0 + / 2 . 4 % of control ; MIP 1 beta PBM : 68 + / 19 . 6 ; AM : 63 . 3 + / 26 . 2 % of control ) but modestly decreased HIV replication when incubated in addition to RANTES ( 24 . 5 + / 6 . 5 % of control ) . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
We exposed CD 4 + cytotoxic T lymphocytes specific for myelin basic protein , a putative target autoantigen in MS , to CsA in vitro , and determined the drug ' s effects on proliferation , expression of high affinity IL 2R , secretion of the proinflammatory cytokines IFN gamma and TNF alpha as well as on the secretion of the chemokines MIP 1 alpha and MIP 1 beta . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Desensitization experiments indicate that CKbeta 8 and MIP 1beta completely share receptors on monocytes and that the CKbeta 8 receptor , which appears to differ from the known ones , is also recognized by MCP 1 , MCP 2 , MCP 3 , MCP 4 , MIP 1alpha and RANTES . . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Binding assays using 125I labeled C C chemokines in mammalian cells indicated that CHEMR 1 did not bind MIP 1alpha , RANTES , or MIP 1beta , whereas CCR 1 binds MIP 1alpha and RANTES . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Ligation of CCR 5 by the CC chemokines RANTES , MIP 1alpha or MIP 1beta , and of CXCR 4 by the CXC chemokine SDF 1alpha , profoundly inhibits the replication of HIV strains that use these coreceptors for entry into CD 4 ( + ) T lymphocytes . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Identification of cell types producing RANTES , MIP 1 alpha and MIP 1 beta in rat experimental autoimmune encephalomyelitis by in situ hybridization . ^^^ To investigate the factors which regulate lymphocyte traffic in experimental autoimmune encephalomyelitis ( EAE ) , we studied , by in situ hybridization analysis , the kinetics of mRNA expression and the potent cellular sources of RANTES , MIP 1 alpha and MIP 1 beta in the central nervous system ( CNS ) during the course of EAE . ^^^ MIP 1 alpha and MIP 1 beta mRNA positive cells appeared around day 10 , increased further on days 12 13 and then gradually decreased . ^^^ Most of the MIP 1 alpha and MIP 1 beta positive mononuclear cells were located around blood vessels . ^^^ The kinetics of RANTES , MIP 1 alpha and MIP 1 beta expression paralleled those of the recruitment of infiltrating inflammatory cells and disease severity . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Sixty days after transplantation , intra allograft expression of chemokines in hearts from gallium nitrate treated recipients indicated low levels of MIP 1alpha , MIP 1beta , and KC but high levels of interferon gamma inducible protein and RANTES . . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
In the present study we investigated the expression of mRNAs for other CC chemokines , namely , MCP 3 , macrophage inflammatory protein 1alpha ( MIP 1alpha ) , MIP 1beta , RANTES and TCA 3 , all of which are chemotactic for monocytes , in the CGN model . ^^^ Moreover , induction of the gene expression of MIP 1alpha and MIP 1beta seemed to occur earlier than that of the others . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Several of them , including the CC chemokines RANTES , MIP 1 alpha , MIP 1 beta , MCP 1 , and the CXC chemokines IL 8 , GRO alpha , ENA 78 have been identified in rheumatoid synovium , implicating a potential role for these molecules in rheumatoid arthritis . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Suppression of HIV 1 transcription by beta chemokines RANTES , MIP 1 alpha , and MIP 1beta is not mediated by the NFAT 1 enhancer element . ^^^ We show here that the CD8+ derived beta chemokines , RANTES , MIP 1 alpha , and MIP 1beta , known suppressors of HIV 1 replication in human peripheral blood mononuclear cells , can suppress transcription from the HIV 1 LTR in transient transfection assays in cells of the Jurkat ( acute T leukemia ) line . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The beta chemokines monocyte chemotactic protein 1 ( MCP 1 ) , macrophage inflammatory protein 1 alpha ( MIP 1alpha ) , MIP 1beta and regulated on activation , normal T cells , expressed and secreted ( RANTES ) induced the in vitro migration of the monocytic cell line MonoMac 6 . ^^^ MCP 1 exhibits the most potent chemotactic effect on this cell line while MIP 1alpha , RANTES and to a lesser extent MIP 1beta were more moderate inducers of cell migration . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Progressors CTL responses are also defective and the production of the cytokines , specially the chemokines RANTES , MIP 1 alpha et MIP 1 beta which may have a role in inhibition of cellular infection by HIV , is impaired . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
We show by in situ hybridization that transcripts for the pro inflammatory cytokines TNF alpha and IL 1 as well as the chemokines MIP 1alpha and MIP 1beta are upregulated within the first hour following injury . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
RANTES and MIP 1 alpha are produced early in response to activation , followed by MIP 1 beta , ( alpha interferon , gamma interferon , alpha IFN , gamma IFN alpha and IFN alpha and gamma . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
However , stimulated RelB / fibroblasts exhibited dramatic persistent induction of seven chemokines ( RANTES , MIP 1 alpha , MIP 1 beta , MIP 2 , IP 10 , JE / MCP 1 , and KC / CINC ) . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
DC increased intracellular free calcium and migrated in response to the CC chemokines MCP 3 , MCP 4 , RANTES , MIP 1alpha , MIP 1beta , and MIP 5 / HCC2 and the CXC chemokine SDF 1 . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
IL 13 does not significantly inhibit the IL 2 induced T lymphocyte production of IFN gamma , RANTES , MIP 1 alpha or MIP 1 beta , nor that of perforin mRNA , as does IL 4 . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The CC chemokines RANTES , macrophage inflammatory protein 1alpha ( MIP 1alpha ) , MIP 1beta , eotaxin , and , to a lesser extent , monocyte chemoattractant protein 1 ( MCP 1 ) and MCP 4 blocked entry of M tropic virus into blood DC . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Of interest were the findings of high to normal levels of PHA induced synthesis of the chemokines MIP 1alpha , MIP 1beta , and RANTES in samples during the asymptomatic and early symptomatic period , which also dramatically decreased at late stages of the disease . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The CCR 5 ligands RANTES ( regulated on activation , normal T cell expressed and secreted ) , macrophage inflammatory protein 1alpha ( MIP 1alpha ) , and MIP 1beta are HIV 1 suppressive factors secreted by CD8+ cells that inhibit NSI viruses . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Physiological ligands of CCR 5 , namely the beta chemokines MIP 1alpha , MIP 1beta , and RANTES , were found to competitively inhibit the V 3 loop CCR 5 interaction . ^^^ We therefore hypothesized that the V 3 loop of gp 120 of macrophage tropic HIV 1 may share a binding site on CCR 5 with MIP 1alpha , MIP 1beta , and RANTES and that the V 3 loop therefore might have some homology with these beta chemokines . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
We demonstrate that the key region of CCR 5 involved in its specific interaction with MIP 1alpha , MIP 1beta , and RANTES , and its subsequent activation , lies within the second extracellular loop ( and possibly the adjacent transmembrane segments ) . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The CC chemokines RANTES and MIP 1alpha were poor competitors for MIP 1beta binding , with IC 50 values of 150 nM and 86 nM , respectively , but the K ( D ) for RANTES binding was still in the nanamolar range ( 4 . 8 nM ) . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
No substantial differences were observed in the in vitro production of chemokines including RANTES , MIP 1 alpha , MIP 1 beta , MCP 1 , and interleukin 8 ( IL 8 ) in supernatants of activated PBMCs or CD 8 depleted PBMCs of LTNPs , even when HIV isolation was simultaneously accomplished exclusively after removal of CD8+ cells . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Our investigations have demonstrated that HIV infection of macrophages stimulate considerably the synthesis of MIP 1 alpha , MIP 1 beta RANTES chemokines ( subgroup CC ) . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
This mAb was a genuine antagonist of CCR 5 , since it failed to stimulate an increase in intracellular calcium concentration in the CCR 5 transfectants , but blocked calcium responses elicited by RANTES , MIP 1alpha , or MIP 1beta . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Competition binding with chemokines demonstrated exactly the same rank order of potency for displacement of both ligands : MIP 1alpha approximately monocyte chemoattractant protein ( MCP ) 3 approximately RANTES > MIP 1beta > > MCP 1 > > > IL 8 . ^^^ MIP 1alpha , MIP 1beta and RANTES were unable to displace 125I MCP 1 . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The C C chemokines RANTES , MIP 1alpha , and MIP 1beta have been characterized as constituents of an HIV and SIV suppressive factor released by CD8+ cells . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Following the identification of the C C chemokines RANTES , MIP 1alpha and MIP 1beta as major human immunodeficiency virus ( HIV ) suppressive factors produced by CD8+ T cells , several chemokine receptors were found to serve as membrane co receptors for primate immunodeficiency lentiretroviruses . ^^^ Viral isolates obtained during the asymptomatic stages generally used only CCR 5 as a co receptor and were inhibited by RANTES , MIP 1alpha and MIP 1beta , but not by SDF 1 . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Neither unstimulated nor stem cell factor ( SCF ) stimulated lung MC expressed transcripts for interleukin 8 ( IL 8 ) , macrophage inflammatory protein 1alpha ( MIP 1alpha ) , MIP 1beta , or RANTES by Northern blotting . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
In these cell lines , IL 6 selectively induced MCP 1 and not other chemokines , including regulated upon activation normal T cells expressed and secreted ( RANTES ) , macrophage inflammatory protein 1alpha ( MIP 1alpha ) , MIP 1beta , and IL 8 . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
MIP 1 alpha and MIP 1 beta in a cohort of patients with primary HIV 1 infection ( PHI ) followed longitudinally . ^^^ The mean plasma concentration of RANTES , but not that of MIP 1 alpha or MIP 1 beta , was significantly higher in patients with PHI ( 192 . 3 ng / ml ) than in five HIV seronegative controls ( 8 . 0 ng / ml ) studied during the same time period . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
We have studied the breadth and potency of the inhibitory actions of the CC chemokines macrophage inhibitory protein 1alpha ( MIP 1alpha ) , MIP 1beta , and RANTES against macrophage tropic ( M tropic ) primary isolates of human immunodeficiency virus type 1 ( HIV 1 ) and of the CXC chemokine stromal cell derived factor 1alpha against T cell tropic ( T tropic ) isolates , using mitogen stimulated primary CD4+ T cells as targets . ^^^ Among the CC chemokines , the rank order for potency ( from most to least potent ) was RANTES , MIP 1beta , MIP 1alpha . ^^^ Thus , for CCR 5 , the rank order for down regulation was also RANTES , MIP 1beta , MIP 1alpha . . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
CD4+ clones from nonprogressors and CD8+ clones from AIDS patients secreted high levels of RANTES , MIP1alpha , and MIP 1beta . ^^^ Recent studies have demonstrated that the beta chemokines RANTES , MIP 1alpha , and MIP 1beta suppress human immunodeficiency virus type 1 ( HIV 1 ) replication in vitro and may play an important role in protecting exposed but uninfected individuals from HIV 1 infection . ^^^ In contrast , CD4+ clones from AIDS patients produced no RANTES and little or no MIP 1alpha or MIP 1beta . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Here , we show that the beta chemokines RANTES , MIP 1alpha and MIP 1beta enhance the uptake and cause intracellular destruction of Trypanosoma cruzi trypomastigotes by human macrophages obtained from healthy individuals . ^^^ Pretreatment of human macrophages with RANTES , MIP 1alpha and MIP 1beta induced strong tyrosine phosphorylation of several proteins , suggesting that signal transduction events are involved in enhanced trypanosome uptake and parasite killing . ^^^ Taken together these results suggest that the beta chemokines RANTES , MIP 1alpha and MIP 1beta , might play a beneficial role in parasite clearance and destruction in individuals infected with T . cruzi . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
In addition , incubation of acutely infected Mphi with a mixture of neutralizing antibodies to RANTES , MIP 1alpha , and MIP 1beta enhanced virus replication . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
HIV infected persons without AIDS had increased levels of MIP 1alpha , MIP 1beta , and RANTES ( P < . 01 ) compared with levels in controls . ^^^ Subjects with AIDS , compared with controls , had decreased production levels of MIP 1beta ( P < . 0001 ) and similar levels of MIP 1alpha and RANTES . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
RESULTS : Pretreatment of T cells with MIP 1alpha , MIP 1beta and RANTES affected T cell tropic strains , increased the replication of HIV 1beta and HIV 1RPdT strains dose dependently , as well as virus absorption and provirus DNA accumulation . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The C C chemokines monocyte chemoattractant protein ( MCP ) 1 , RANTES , macrophage inflammatory protein ( MIP ) 1alpha and MIP 1beta stimulated similar , dose dependent chemotaxis of purified gamma / delta T cells , whereas MCP 1 , RANTES , and MIP 1alpha produced greater chemotaxis of purified alpha / beta T cells than MIP 1beta . ^^^ Our data demonstrate that human peripheral blood alpha / beta and gamma / delta T cells can transmigrate to MCP 1 , RANTES , MIP 1alpha , and MIP 1beta , and suggest that both T lymphocyte subpopulations share the capacity to emigrate in response to C C chemokines during inflammation . . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
M . tuberculosis infected A 549 cells produced mRNAs and protein for monocyte chemotactic protein 1 ( MCP 1 ) and interleukin 8 ( IL 8 ) but not mRNAs for macrophage inflammatory protein 1alpha ( MIP 1alpha ) , MIP 1beta , and RANTES . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Inhibition of HIV type 1 BaL replication by MIP 1alpha , MIP 1beta , and RANTES in macrophages . ^^^ The beta chemokines RANTES , MIP 1alpha , and MIP 1beta have been shown to inhibit the infection of T cells by macrophage tropic HIV 1 strains by blocking env driven HIV 1 fusion through competition for the chemokine receptors or receptor downregulation . ^^^ The action of the beta chemokines MIP 1alpha , MIP 1beta , and RANTES was captured with that of the alpha chemokine interleukin 8 ( IL 8 ) and of interferon alpha ( IFN alpha ) , which is a well known broad range inhibitor of viral replication . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
In addition , RANTES , MIP 1alpha and MIP 1beta are secreted by CTL as a macromolecular complex containing sulphated proteoglycans . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
We showed that the neutralization of 89 . 6 in PBMC was not improved when CCR 5 was blocked by having RANTES , MIP 1alpha , and MIP 1beta in the culture medium , indicating that CCR 5 usage was not responsible for the decreased sensitivity to neutralization in PBMC . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Furthermore , neither the human beta chemokines RANTES , MIP 1alpha , MIP 1beta , and MCP 1 nor the alpha chemokine IL 8 had an effect on infection of either CrFK or Mya 1 cells with CrFK tropic virus . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
We found that IL 10 and IFN gamma independently inhibit HA induced expression of macrophage inflammatory protein 1alpha ( MIP 1alpha ) , MIP 1beta , and KC at both the mRNA and protein levels . ^^^ Whereas IL 10 inhibited most of the HA induced chemokines tested , IFN gamma selectively inhibited only MIP 1alpha , MIP 1beta , and KC . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Enzyme linked immunosorbent assay ( ELISA ) showed constitutive secretion of MIP 1alpha protein in only one and MIP 1beta in none of 7 cell lines tested . ^^^ In contrast , RT PCR analysis revealed that the majority of the tested tumor specimens of high grade . astrocytomas expressed both MIP 1alpha and MIP 1beta mRNAs . ^^^ ELISA detected MIP 1beta protein in 1 of 11 cerebrospinal fluid samples from patients with high grade astrocytoma and in 8 of 9 tumor cyst fluid samples , whereas MIP 1alpha was detected in only 1 cyst fluid somple . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
At day 3 , the concentrations of IL 1beta , IL 6 , and MIP 1beta were lower , whereas the levels of IL 10 , IL 12 , and MIP 1alpha remained similar , and the level of tumor necrosis factor alpha was now detectable . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Fibrocytes purified from wound chambers also were found to express mRNA for IL 1beta , IL 10 , TNF alpha , JE / MCP , MIP 1alpha , MIP 1beta , MIP 2 , PDGF A , TGF beta 1 , and M CSF . ^^^ The addition of IL 1beta ( 1 100 ng / ml ) , a critical mediator in wound healing , to fibrocytes isolated from human peripheral blood induced the secretion of chemokines ( MIP 1alpha , MIP 1beta , MCP 1 , IL 8 , and GRO alpha ) , hemopoietic growth factors ( IL 6 , IL 10 , and macrophage CSF ) , and the fibrogenic cytokine TNF alpha . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
We studied the expression of the beta chemokines : monocyte chemoattractant protein ( gene product JE ; MCP 1 / JE ) , macrophage inflammatory protein 1 alpha and beta ( MIP 1alpha and MIP 1beta ) , and the regulated upon activation normal T expressed and secreted chemokine ( RANTES ) as well as the alpha chemokines : interferon gamma inducible protein ( IP 10 ) and N51 / KC ( KC ; a murine homologue of MIP 2 ) . ^^^ MCP 1 and MIP 1alpha were elevated at 2 h and peaked 6 h , MIP 1beta peaked at 6 h , but declined more rapidly than MCP 1 or MIP 1alpha , and IP 10 peaked at 6 h and showed the most rapid decline . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Recombinant human RANTES , MIP 1alpha and MIP 1beta which bind to simian CCR 5 , suppressed SIV replication in a dose dependent manner , with RANTES being more effective than the other two chemokines . ^^^ The results suggest that immunization with SIV grown in human CD 4 ( + ) T cells induces CD 8 suppressor factor , RANTES , MIP 1alpha and MIP 1beta which may block CCR 5 receptors and prevent the virus from binding and fusion to CD 4 ( + ) cells . . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
A major advance in understanding human immunodeficiency virus ( HIV ) biology was the discovery that the beta chemokines MIP 1 alpha ( macrophage inflammatory protein 1 alpha ) , MIP 1 beta ( macrophage inflammatory protein 1 beta ) and RANTES ( regulated on activation , normal T cell expressed and secreted ) inhibit entry of HIV 1 into CD4+ cells by blocking the critical interaction between the CCR 5 coreceptor and the V 3 domain of the viral envelope glycoprotein gp 120 [ 1 , 2 ] . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Dextrin 2 sulphate accumulated in peritoneal macrophages and induced the release of MIP 1alpha and MIP 1beta from these cells in vitro . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The plasma levels of HIV 1 RNA , tumor necrosis factor alpha ( TNF alpha ) , soluble receptors type 2 of TNF alpha ( sTNF alpha RII ) , soluble receptors of interleukin 4 ( sR IL 4 ) , interleukin 6 ( IL 6 ) , soluble receptors of interleukin 6 ( sR IL 6 ) , granulocyte macrophage colony stimulating factor ( GM CSF ) , soluble receptors of GM CSF ( sR GM CSF ) , RANTES , MIP 1 alpha and MIP 1 beta were measured in 80 HIV infected patients . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
In chemotaxis assays using monocytic cells , RANTES ( 3 68 ) inhibited RANTES ( 1 68 ) , macrophage inflammatory protein 1alpha ( MIP 1alpha ) , MIP 1beta or monocyte chemotactic protein 3 ( MCP 3 ) , but not MCP 1 or MCP 2 induced chemotaxis . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Western blotting and ELISA indicated that the CC chemokines MIP 1alpha , MIP 1beta , and RANTES were present in these fractions . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The synthesis of mRNAs for interferon gamma ( IFN gamma ) , IL 12p35 , IL 12p40 , IL 4 , and for the C C chemokines RANTES , MIP 1alpha , and MIP 1beta was compared with that of lymph nodes from non infected individuals to define HIV specific events . ^^^ Only few cells expressing IFN gamma , RANTES , MIP 1alpha , and MIP 1beta mRNAs were detectable in the T dependent area of lymph nodes from HIV negatives . ^^^ In contrast , in FHLN from HIV+ patients a high number of IFN gamma , RANTES , MIP 1alpha , and MIP 1beta mRNA containing cells were detectable . ^^^ Thus , these results demonstrate that a high IFN gamma production is accompanied by a strong expression of MIP 1alpha , MIP 1beta , and RANTES in the lymph node after HIV infection . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Cytokine induction of MIP 1 alpha and MIP 1 beta in human fetal microglia . ^^^ As the expression of these chemoattractants may play an important role in the initiation and progression of neuroimmunologic diseases , we analyzed expression of the chemokines MIP 1 alpha , MIP 1 beta , MCP 1 , and RANTES in human fetal microglial cultures . ^^^ Unstimulated microglia expressed minimal levels of MIP 1 alpha , MIP 1 beta , and MCP 1 , while RANTES was undetectable . ^^^ In response to LPS , TNF alpha , or IL 1 beta , both MIP 1 alpha and MIP 1 beta were induced at the mRNA and protein levels in a dose and time dependent manner . ^^^ These results illustrate the ability of certain inflammatory stimuli to induce expression of MIP 1 alpha , MIP 1 beta , and MCP 1 by human fetal microglia . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
ATL cells produced high amounts of chemokines , macrophage inflammatory protein 1alpha ( MIP 1alpha ) , and MIP 1beta . ^^^ Adhesion of ATL cells to endothelial cells and the expression of activated form of LFA 1 were reduced by pretreatment with pertussis toxin , wortmannin , or anti MIP 1alpha and MIP 1beta antibodies or transfection with antisense of MIP 1alpha or MIP 1beta . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The CC chemokines MIP 1alpha , MIP 1beta , and RANTES suppress replication of certain HIV 1 strains in cultured PBMC and T cell lines by blocking interaction of gp 120 with CC chemokine receptor 5 ( CCR 5 ) . ^^^ Here we show that exogenous MIP 1alpha , MIP 1beta , and RANTES markedly suppressed replication of CCR 5 tropic HIV 1 strains in blocks of human lymphoid tissue infected ex vivo . ^^^ Moreover , endogenous MIP 1alpha , MIP 1beta , and RANTES were upregulated in tissues infected ex vivo with CXC chemokine receptor 4 tropic but not CCR 5 tropic HIV 1 . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
CD4+ lymphocytes from CCR5 / delta32 and CCR5 / CCR5 EU individuals were more sensitive to the HIV inhibitory effects of the recombinant beta chemokines RANTES , MIP 1alpha , and MIP 1beta than were CD4+ lymphocytes from CCR5 / CCR5 control individuals . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
This relative resistance to HIV 1 infection did not extend to T cell line adapted or syncytium inducing ( SI ) primary viral isolates , was restricted by the envelope glycoprotein , and was associated with an increased production of the C C chemokines RANTES , MIP 1alpha , and MIP 1beta . ^^^ The block to replication in CD4+ lymphocytes from two exposed uninfected subjects was at the point of entry , as was the block imposed by the recombinant C C chemokines RANTES , MIP 1alpha , and MIP 1beta . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
In contrast to the parental cell line , C / EBPepsilon expressing cell lines displayed lipopolysaccharide inducible expression of the interleukin 6 and monocyte chemoattractant protein 1 ( MCP 1 ) genes as well as elevated basal expression of the MIP 1alpha and MIP 1beta chemokine genes . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Furthermore , p 24 antigen stimulated beta chemokine production ( RANTES , MIP 1alpha , MIP 1beta ) was also augmented after immunization with the HIV 1 immunogen but not influenza vaccine . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The chemokines RANTES , MIP 1alpha , and MIP 1beta have been identified as HIV 1 suppressive factors produced by CD8+ T cells . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
U 12 functionally encoded a calcium mobilizing receptor for beta chemokines such as regulated upon activation , normal T expressed and secreted ( RANTES ) , macrophage inflammatory proteins 1alpha and 1beta ( MIP 1alpha and MIP 1beta ) and monocyte chemoattractant protein 1 but not for the alpha chemokine interleukin 8 , suggesting that the chemokine selectivity of the U 12 product was distinct from that of the known mammalian chemokine receptors . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
In experimental bacterial meningitis induced by Listeria monocytogeneses both CXC and CC chemokines namely MIP 1alpha , MIP 1beta and MIP 2 are produced intrathecally by meningeal macrophages and leukocytes which infiltrate into the CNS . ^^^ In patients with bacterial meningitis , IL 8 , GROalpha , MCP 1 , MIP 1alpha and MIP 1beta are detectable in the CSF . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
MIP 1alpha was expressed by astrocytes and macrophages within the plaque , while MIP 1beta was expressed by macrophages and microglia within the lesion , and by microglia in surrounding white matter . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The duodenal mucosa was infiltrated with cells expressing CD 56 and PEN 5 , two markers of NK cells , and there was a deregulation of local cytokine and chemokine production characterized by a decrease in IL 10 gene expression ( 25 % of controls ) and an increase in gene expression for IFN gamma ( 4 fold control ) , MIP 1alpha ( 8 fold control ) , and MIP 1beta ( 13 fold control ) . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NK cells produced significant amounts of RANTES , MIP 1alpha , and MIP 1beta constitutively , in response to stimulation with IL 2 alone and when they were performing their characteristic lytic activity ( K 562 killing ) . ^^^ In 50 % of patients tested , NK mediated HIV suppression could be abrogated by neutralizing antibodies to MIP 1alpha , MIP 1beta and RANTES ; in contrast , CD 8 ( + ) T cell mediated suppression was not significantly overcome upon neutralization of CC chemokines . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Large Kir 3 . 1 dependent currents generated in response to the corresponding chemokines ( SDF 1alpha for CXCR 4 and MIP 1alpha ; MIP 1beta and RANTES for CCR 5 ) were blocked by pertussis toxin , suggesting involvement of inhibitory guanine nucleotide binding proteins . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Production of RANTES , macrophage inhibitory protein 1alpha ( MIP 1alpha ) , or MIP 1beta from stimulated CD 8 ( + ) T cells of vaccinated animals was almost 10 fold higher than that from stimulated CD 8 ( + ) T cells of control animals . ^^^ Our results indicate that inhibition of SIV replication by CD 8 ( + ) T cells from animals immunized with live attenuated SIV strains involves both MHC restricted and unrestricted mechanisms and that MHC unrestricted inhibition of SIV replication is due principally to soluble factors other than RANTES , MIP 1alpha , and MIP 1beta . . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
METHODS : In 192 patients , expression patterns of C 10 C chemokines ( IL 8 and growth regulated alpha ( GRO alpha ) ) and C C chemokines ( regulated on activation , normal T cell expressed and presumably secreted ( RANTES ) , monocyte chemotactic and activating factor ( MCAF ) , macrophage inflammatory protein 1 alpha ( MIP 1 alpha ) , and MIP 1 beta ) were examined using reverse transcription polymerase chain reaction ( RT PCR ) and enzyme linked immunosorbent assay ( ELISA ) . cagA gene was identified using PCR . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Immunohistochemistry for MIP 1beta , MIP 1alpha , RANTES , eotaxin , and MCP 3 ( ligands for CCR 5 and / or CCR 3 ) revealed the presence of MIP 1beta predominantly in a subpopulation of reactive astrocytes , which were more widespread in AD than control brains , and MIP 1alpha predominantly in neurons and weakly in some microglia in both AD and controls . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Supernates from TG cell cultures also contained detectable levels of C 10 , MCP 1 and eotaxin but little to no MIP 1alpha , MIP 1beta , or MIP 2 . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
An early increased secretion of prostaglandin F2alpha and chemokines ( RANTES > > MIP 1alpha > > MIP 1beta ) was observed , due to both microglia and astrocytes . ^^^ In contrast to persistent PGF2alpha production , an extinction of RANTES and MIP 1beta but not of MIP 1alpha secretion occurred during the 14 days of stimulation and was inversely correlated with the ability of glial cells to replicate HIV 1 . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Specifically , levels of pulmonary and hepatic macrophage inflammatory protein 1alpha ( MIP 1alpha ) , MIP 1beta , MIP 2 , and monocyte chemoattractant protein 1 ( MCP 1 ) mRNA , as well as hepatic IFN gamma inducible protein 10 and KC mRNA , were attenuated in MPL pretreated mice after CLP . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
With RT PCR , we detected induction of RNA message for the chemokines macrophage inflammatory protein ( MIP ) 2 , KC , MIP 1alpha , MIP 1beta , IFN gamma inducible protein 10 and RANTES in L . monocytogenes infected macrophages . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
This approach was used for the assessment of TNF alpha , IL 6 , IL 8 , IL 10 , IL 12 , GM CSF , MIP 1alpha , MIP 1beta and RANTES producing cells . ^^^ The incidence of chemokine producing cells ( IL 8 , RANTES , MIP 1alpha , MIP 1beta ) peaked 10 h after LPS stimulation in up to 60 % of the DC . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Only the C C chemokines , eotaxin and MIP 1 alpha , but not RANTES , MCP 1 , MCP 3 , MCP 4 , MIP 1 beta , KC and MIP 2 , effectively induced the recruitment of 111 In eosinophils in mouse skin . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
In this study , we examined the difference in susceptibility to anti HIV activity of the CC chemokines ( RANTES , MIP 1 alpha and MIP 1 beta ) among HIV 1 isolates and analysed its relation with phenotype ( syncytium inducibility ) and V 3 domain of gp 120 of the HIV 1 isolates . ^^^ Of 11 cases tested in endogenous assay , at a concentration of 200 ng / ml , RANTES , MIP 1 alpha , and MIP 1 beta showed more than 80 % suppression of HIV 1 replication in 10 , 8 , and 7 cases , respectively . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The CC or beta chemokines MIP 1alpha , MIP 1beta , and RANTES are the primary components of human immunodeficiency virus type 1 ( HIV 1 ) suppressive soluble factors in vitro . ^^^ We studied the relationship between the concentrations of MIP 1alpha , MIP 1beta , and RANTES in plasma and HIV viral load in HIV infected subjects . ^^^ The HIV positive patient group ( n = 140 ) had significantly lower concentrations of all three beta chemokines ( MIP 1alpha , P < 0 . 0005 ; MIP 1beta , P < 0 . 005 ; RANTES , P < 0 . 0005 ) than the control group ( n = 58 for MIP 1alpha , n = 27 for MIP 1beta , and n = 59 for RANTES ) . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
We found , in addition , the reading frames for homologues of cellular interleukin 6 , macrophage inflammatory proteins alpha and beta ( MIP 1 alpha and MIP 1 beta , respectively ) , an interferon responsive factor , and two inhibitors of apoptosis . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
In the immunohistochemical study reported here we have attempted to establish some understanding of the involvement of the beta chemokines RANTES , MCP 1 , MIP 1alpha and MIP 1beta in recruiting T cells to the intratubular site . ^^^ High concentrations of chemokines ( especially RANTES , MIP 1beta and / or MIP 1alpha ) were localised to the basolateral surface of tubular epithelial cells ( TEC ) . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
While both nave and memory CD 4 ( + ) subsets downregulated CCR 5 expression in response to CD 28 costimulation , only the memory cells produced high levels of the beta chemokines RANTES , MIP 1alpha , and MIP 1beta upon stimulation . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
METHODS : Using in situ hybridization ( ISH ) we analyzed the expression of mRNA for the C C chemokines monocyte chemoattractant protein 1 ( MCP 1 ) , macrophage inflammatory protein 1alpha and beta ( MIP 1alpha , MIP 1beta ) and RANTES in renal biopsy material from twenty patients with glomerulonephritis . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The cysteine cysteine family of chemokines RANTES , MIP 1alpha , and MIP 1beta induce trypanocidal activity in human macrophages via nitric oxide . ^^^ This paper describes a new role for the cysteine cysteine ( CC ) chemokines RANTES , MIP 1alpha , and MIP 1beta on human macrophage function , which is the induction of nitric oxide ( NO ) mediated trypanocidal activity . ^^^ In a previous report , we showed that RANTES , MIP 1alpha and MIP 1beta enhance Trypanosoma cruzi uptake and promote parasite killing by human macrophages ( M . ^^^ Here we study the mechanism by which RANTES , MIP 1alpha , and MIP 1beta activate human macrophages obtained from healthy individuals to kill T . cruzi . ^^^ Treatment of human macrophages with different concentrations of RANTES , MIP 1alpha , and MIP 1beta enhances T . cruzi trypomastigote phagocytosis in a dose peak response . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
In efforts to test the efficacy of such modified chemokines , our laboratory has cloned , sequenced , and prepared recombinant forms of wild type ( wt ) and amino terminus modified rhesus macaque chemokines MIP 1alpha , MIP 1beta , and RANTES . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
TILs produced high concentrations of MIP 1alpha and MIP 1beta and spontaneous polymerization of cytoskeletal F actin was observed in these cells . ^^^ Our results indicate that integrins on TILs are activated in an autocrine manner by MIP 1alpha and MIP 1beta , and that treatment with the chemokines increases the binding of TILs on osteoblasts and stromal cells via a mechanism involving intercellular adhesion molecule 1 and vascular cell adhesion molecule 1 as targets for the integrin . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
RESULTS : In cultures of peripheral monocytes , A beta 1 42 induced the secretion of proinflammatory cytokines TNF alpha , IL 6 , IL 1 beta , and IL 12 , as well as CC chemokines MCP 1 , MIP 1 alpha , and MIP 1 beta , and CXC chemokine IL 8 in a dose related fashion . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Biopsies from patients with SS showed that MIP 1beta was expressed by 51 % of infiltrating cells , while 41 % expressed MIP 1alpha , whereas 22 and 7 % expressed RANTES and IL 8 , respectively . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
We found that MCP 2 could bind to CCR 5 transfectants with high affinity and cross compete effectively with RANTES , MIP 1alpha , and MIP 1beta . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
We demonstrate that IFN gamma inhibits production of chemokines ( macrophage inflammatory proteins MIP 1alpha and MIP 1beta ) . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
This approach was used for the assessment of TNF alpha , IL 6 , IL 8 , IL 10 , IL 12 , GM CSF , MIP 1alpha , MIP 1beta and RANTES producing cells . ^^^ The incidence of chemokine producing cells ( IL 8 , RANTES , MIP 1alpha , MIP 1beta ) peaked 10 h after LPS stimulation in up to 60 % of the DC . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Mast cells accumulating in the nodes during DNFB sensitization were the predominant source of MIP 1 beta , whereas MIP 1 alpha was expressed by multiple cell types . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Tumour necrosis factor alpha ( TNF alpha ) induced MCP 1 , RANTES and MIP 1beta mRNA expression , and lipopolysaccharide ( LPS ) induced MCP 1 , MIP 1alpha and MIP 1beta mRNA expression in astrocytes . ^^^ LPS induced MCP 1 , MIP 1alpha and MIP 1beta mRNA expression by astrocytes was antagonized by transforming growth factor ( TGF ) beta 1 and interleukin ( IL ) 10 . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Although some concentrations of the chemokines , MIP 1alpha and MIP 1beta , were detected in supernatants obtained from the PMN suspensions cultured with plantar SC than in the control suspensions of PMN alone , their production by PMN was not influenced by the opsonization procedure . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
RT PCR verified by Southern blotting and sequencing of PCR products of four different C C chemokines , macrophage inflammatory protein 1alpha ( MIP 1alpha ) , monocyte chemotactic protein 1 ( MCP 1 ) , MIP 1beta , and RANTES , were performed on brain samples from EAE rats to evaluate mRNA transcription at different stages of disease . ^^^ MIP 1alpha , MCP 1 , and MIP 1beta mRNA transcription in EAE brains peaked at the onset of disease and declined during its remission , whereas RANTES transcription increased in EAE brains only following recovery . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Forty human immunodeficiency virus type 1 ( HIV 1 ) infected women participated in a cross sectional study of possible correlations between chemokine receptor ( CCR 5 and / or CCR2B ) genotype , HIV 1 RNA and DNA load , and beta chemokine levels ( RANTES , MIP 1alpha , MIP 1beta ) in blood and cervix . ^^^ In the blood , the proviral DNA load was significantly correlated with the MIP 1alpha concentration , whereas the DNA load in cervix was significantly associated with the MIP 1beta concentration . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Abundant expression of macrophage inflammatory protein ( MIP ) 1alpha and MIP 1beta mRNAs and proteins was observed in keratinocytes , and mast cell degranulation was significantly inhibited after administration of neutralizing antibodies to MIP 1alpha , but not MIP 1beta . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The C C chemokines MIP 1alpha , MIP 1beta , and RANTES have been identified as the major soluble macrophage tropic HIV 1 suppressive factors produced by CD8+ T cells , which exert their action at the level of viral entry . ^^^ Here , we demonstrate that monokine activated NK cells , isolated from both normal and HIV 1+ donors , produce similar amounts of MIP 1alpha , MIP 1beta , and RANTES protein , in vitro . ^^^ Importantly , the C C chemokines MIP 1alpha , MIP 1beta , and RANTES were responsible only for a fraction of the HIV 1 suppressive activity exhibited by NK cell supernatants against macrophage tropic HIV 1 . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Molecular cloning of feline CC chemokine cDNAs . cDNA clones of feline chemokines , MIP 1alpha , MIP 1beta and RANTES , were molecularly isolated with the purpose of using these sequences for future investigation of the inhibitory effects on lentivirus entry and their role in immunological functions . ^^^ The feline MIP 1alpha and MIP 1beta cDNA clones spanned their entire coding regions encoding 93 and 92 amino acids , respectively . ^^^ The amino acid sequences of feline MIP 1alpha and MIP 1beta compared to those of their human , mouse and rat counterparts showed similarities of 75 . 3 79 . 6 % and 73 . 9 88 . 0 % , respectively . ^^^ Feline MIP 1alpha and MIP 1beta had four conserved cysteines with a structure made up of the first two cysteines that are characteristic of the CC chemokine subfamily . ^^^ The amino terminal of these MIP 1alpha and MIP 1beta sequences was distinctly hydrophobic , suggesting that they may function as signal peptides . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
No significant difference in circulating plasma levels of MIP 1alpha and MIP 1beta were found between the resistant women and negative or HIV 1 infected controls . ^^^ In vitro cultures of media and PHA stimulated PBMCs indicated that the resistant women produced significantly less MIP 1alpha and MIP 1beta than did negative controls and no significant difference in RANTES levels were observed . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
To assess the role of MIP 1alpha and MIP 1beta in human inflammation , healthy subjects were studied during experimental endotoxemia with prior administration of ibuprofen , a cyclooxygenase inhibitor , or dimeric p 75 tumor necrosis factor ( TNF ) alpha receptor , a TNF antagonist ; septic patients were also studied . ^^^ In septic patients , elevated levels of MIP 1alpha and MIP 1beta were detected within 24 h of sepsis and fell in parallel with TNF alpha and interleukin 6 ( P < . 01 ) . ^^^ MIP 1alpha and MIP 1beta increase during acute inflammation but are not associated with fever in endotoxemic humans during cyclooxygenase blockade . . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The enhancing effects of RANTES are not mediated via CCR 5 or other known chemokine receptors and are not mimicked by MIP 1alpha or MIP 1beta . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Induction of the chemokine beta peptides , MIP 1 alpha and MIP 1 beta , by lipopolysaccharide is differentially regulated by immunomodulatory cytokines gamma IFN , IL 10 , IL 4 , and TGF beta . ^^^ Studies reported here demonstrate that , in contrast to the `` balanced ' ' MIP 1 alpha / MIP 1 beta chemokine responses of LPS stimulated macrophage cultures in vitro , circulating levels of MIP 1 beta are significantly higher than those of MIP 1 alpha following LPS administration in vivo . ^^^ Further studies have revealed that several immunomodulatory cytokines known to be up regulated in vivo as a consequence of exposure to an invasive stimulus ( gamma IFN , IL 10 , IL 4 , and transforming growth factor [ TGF ] beta ) down regulated the LPS induced release of MIP 1 alpha by macrophages in vitro , but spared the MIP 1 beta response . ^^^ This altered pattern of secretion may explain , at least in part , the high circulating levels of MIP 1 beta relative to MIP 1 alpha observed in vivo in response to LPS challenge . . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
This receptor may also mediate leukocyte and parenchymal responses to injury by virtue of its binding to locally released chemokines such as RANTES , MIP 1 alpha and MIP 1 beta during inflammation . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
THC decreased constitutive production of IL 8 , MIP 1alpha , MIP 1beta , and RANTES and phorbol ester stimulated production of TNF alpha , GM CSF and IFN gamma by NK cells . ^^^ It inhibited MIP 1beta in HTLV 1 positive B cells but tripled IL 8 , MIP 1alpha and MIP 1beta in B cells and MIP 1beta in eosinophilic cells but doubled IL 8 . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
PURPOSE : To investigate the presence of three C C chemokines ( monocyte chemotactic protein 1 [ MCP 1 ] , macrophage inflammatory protein 1alpha [ MIP 1alpha ] , and MIP 1beta ) in vitreous samples from eyes with proliferative vitreoretinopathy ( PVR ) , proliferative diabetic retinopathy ( PDR ) , or retinal detachment ( RD ) . ^^^ SUBJECTS AND METHODS : Vitreous samples were obtained and assayed by solid phase enzyme linked immunosorbent assay for the chemokines MCP 1 , MIP 1alpha , and MIP 1beta in a prospective study of 43 consecutive patients . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Recombinant radiolabeled RANTES , MIP 1alpha , and MIP 1beta , but not IL 8 , also bound to a 42 kDa protein on the membrane of MDMs as well as to the V3Cs interacting 42 kDa protein , and excess unlabeled V3Cs inhibited such binding . ^^^ This protein was also recognized by antibodies to CCR 5 , the RANTES / MIP 1alpha / MIP 1beta receptor . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The natural ligands for the chemokine receptors CCR 5 ( RANTES , MIP 1alpha , and MIP 1beta ) and CXCR 4 ( SDF 1 ) can act as potent inhibitors of infection by the human immunodeficiency virus type 1 ( HIV 1 ) at the level of viral entry . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Here , we used the CaN inhibitor FK 506 to probe for the contribution of CaN in MIP 1alpha , MIP 1beta , and RANTES production at the protein and mRNA levels in human T cells stimulated via CD3 / PMA or CD3 / CD28 . ^^^ With both modes of activation , FK 506 inhibited RANTES production only partially and late during a 3 day culture , whereas it suppressed both MIP 1alpha and MIP 1beta production throughout the culture . ^^^ However , FK 506 inhibition was more pronounced on MIP 1beta than MIP 1alpha , especially in CD3 / CD28 activated T cells . ^^^ Furthermore , comparison with IL 2 and TNF alpha revealed that both were more potently inhibited by the drug upon CD3 / PMA or CD3 / CD28 induction than either MIP 1alpha or MIP 1beta . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Infection by NSI viruses increased production of MIP 1alpha , MIP 1beta , and gamma interferon , whereas infection by SI viruses had no effect or decreased production of these cytokines . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
MPIF 1 binds specifically to sites , in particular CCR 1 , shared with macrophage inflammatory protein 1alpha ( MIP 1alpha ) on the surface of human monocytes and dendritic cells , as inferred by its ability to compete for [ 125I ] MIP 1alpha , but not for [ 125I ] MIP 1beta or [ 125I ] monocyte chemotactic protein 1 ( MCP 1 ) binding to intact cells . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The CC chemokines contained two major subfamilies : ( 1 ) the MIP subfamily ( including MIP 1alpha , MIP 1beta , and RANTES ) ; and ( 2 ) the MCP subfamily ( including MCP 1 , 2 , 3 , and 4 and eotaxin ) . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The Duffy Antigen Receptor for Chemokines ( DARC ) belongs to a family of erythrocyte chemokine receptors that bind C 10 C and C C chemokines such as interleukin 8 ( IL 8 ) , monocyte chemoattractant protein 1 ( MCP 1 ) and regulated on activation , normal T cell expressed and secreted ( RANTES ) , but not macrophage inflammatory protein 1 alpha ( MIP 1 alpha ) or MIP 1 beta . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Young mice with MAS showed an early up regulation of mRNA expression for MCP 1 , MIP 1beta and RANTES , while MIP 1alpha mRNA expression was not affected . ^^^ Adult mice with MAS showed a further up regulation of mRNA expression for MCP 1 , MIP 1beta and RANTES , and a remarkably strong up regulation for MIP 1alpha . ^^^ These observations implicate MCP 1 , MIP 1beta and RANTES as potential chemokines in induction of MAS , and MCP 1 , MIP 1beta , RANTES and prominently MIP 1alpha in progression and perturbation of MAS . . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Interleukin 8 ( IL 8 ) , monocyte chemoattractant protein 1 ( MCP 1 ) , macrophage inflammatory protein 1 alpha ( MIP 1 alpha ) , and MIP 1 beta were all detected in the parenchyma at sites of inflammation in alcoholic hepatitis , whereas in alcoholic cirrhosis , chemokines were restricted to inflammatory cells and endothelium in the fibrous septa and portal tracts . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Two rat CXC chemokines ( macrophage inflammatory protein ( MIP ) 2 and cytokine induced neutrophil chemoattractant ( CINC ) ) as well as three rat CC chemokines ( MIP 1alpha , MIP 1beta , and monocyte chemoattractant protein ( MCP ) 1 ) were investigated . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Increased sensitivity to hyperoxia was also observed , as demonstrated by increased abundance of mRNAs encoding Eotaxin , MIP 1 alpha , MIP 1 beta , MIP 2 , and interferon gamma inducible ( IP ) 10 after 68 hours of exposure , whereas WT mice were unaltered from controls . ^^^ Messenger RNAs encoding Eotaxin , MIP 1 alpha , MIP 1 beta , MIP 2 , IP 10 , and MCP 1 were increased identically . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Examination of proinflammatory cytokine , chemokine , and Mt mRNA in the lung revealed increases for messages encoding IL 1 alpha , IL 1 beta , IL 6 , IFN gamma , TNF alpha , Eotaxin , MIP 1 alpha , MIP 1 beta , MIP 2 , Mt , and IP 10 , while messages encoding IL 12 , IL 10 , IFN beta , Ltn , MCP 1 , TGF beta 1 + 2 , and RANTES were unchanged from those of sham exposed mice 2 h postexposure . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Monocytes treated with IFN gamma showed increased chemotaxis to the CCR 5 ligands macrophage inflammatory protein 1alpha ( MIP 1alpha ) and MIP 1beta , confirming the functional relevance of IFN gamma induced CCR 5 expression . ^^^ In addition , IFN gamma induced secretion of C C chemokines ( RANTES , MIP 1alpha , and MIP 1beta ) by mononuclear phagocytes may also suppress HIV entry into macrophages . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
These effects were more marked when the agent was given intratracheally , inducing a larger number of pulmonary macrophages , lymphocytes and neutrophils concomitant with increases in BAL tumor necrosis factor alpha ( TNF alpha ) , mouse inflammatory protein alpha ( MIP 1alpha ) , mouse inflammatory protein beta ( MIP 1beta ) , interleukin 1alpha ( IL 1alpha ) and interleukin 6 ( IL 6 ) , but not interleukin 2 ( IL 2 ) and interleukin 4 ( IL 4 ) . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Peptides from both conserved and variable domains were capable of inducing MIP 1alpha , MIP 1beta , and RANTES production . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Purified cultures of astrocytes and microglia were also induced by the same combination of cytokines , to produce all these mediators except MIP 1alpha and MIP 1beta , which were produced predominantly by astrocytes . ^^^ The inhibition of PG production by indomethacin led to a 37 60 % increase in RANTES , MIP 1alpha , and MIP 1beta but not in GROalpha and IL 8 secretion . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Here we report that superantigen stimulation of human peripheral blood monocytes results in a rapid , dose dependent , and specific down regulation of chemokine ( macrophage inflammatory protein 1alpha ( MIP 1alpha ) , monocyte chemotactic protein 1 and MIP 1beta ) binding sites ( e . g . , CCR 1 , CCR 2 , and CCR 5 ) , which correlates with a concomitant hyporesponsiveness of human monocytes to these CC chemokine ligands . ^^^ We further demonstrate that SAg induced down modulation of chemokine binding and monocyte hyporesponsiveness to the chemokines MIP 1alpha , monocyte chemotactic protein 1 , and MIP 1beta is mediated through cellular protein tyrosine kinases , and the down modulation can be mimicked by an MHC class 2 specific mAb . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Recently , it was shown that the natural CCR 5 ligands RANTES , macrophage inflammatory protein 1alpha ( MIP 1alpha ) , MIP 1beta , and amino terminal modifications of RANTES ( Met RANTES , AOP RANTES ) significantly differ in their abilities to induce sequestration of CCR 5 from cellular surfaces . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
RANTES , a polypeptide of 68 amino acid residues , is a member of the C C chemokine subfamily including other monocyte chemoattractants such as MIP 1alpha , MIP 1beta , MCP 1 , MCP 2 and MCP 3 . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Sulfated tyrosines contribute to the binding of CCR 5 to MIP 1 alpha , MIP 1 beta , and HIV 1 gp120 / CD4 complexes and to the ability of HIV 1 to enter cells expressing CCR 5 and CD 4 . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Analyses of the BAC clones containing the human PARC gene indicated that the gene is located most closely to MIP 1alpha ( HGMW approved symbol SCYA 3 ) and MIP 1beta ( HGMW approved symbol SCYA 4 ) on chromosome 17q11 . 2 . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
These observations are further supported by the finding that coinjection with ICAM 1 dramatically enhanced the level of interferon gamma ( IFN gamma ) and beta chemokines macrophage inflammatory protein 1alpha ( MIP 1alpha ) , MIP 1beta , and regulated on activation normal T cell expression and secreted ( RANTES ) produced by stimulated T cells . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
METHODS : The serum levels of beta chemokines , macrophage inflammatory protein 1alpha ( MIP 1alpha ) , MIP 1beta , RANTES , and monocyte chemoattractant protein 1 ( MCP 1 ) in patients with SLE were determined by ELISA . ^^^ RESULTS : There were significant differences between the patients with SLE and healthy controls in the serum concentrations of RANTES ( p < 0 . 001 ) and MCP 1 ( p < 0 . 01 ) , but not MIP 1alpha ( p = 0 . 07 ) and MIP 1beta ( p = 0 . 68 ) . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Compared to pre infection levels , we observed an increase in the levels of RANTES , MIP 1 alpha and MIP 1 beta production in the two groups of monkeys , by the time of peak viraemia . ^^^ Given the potential influence of beta chemokines on the immune response and virus replication , such results suggest that RANTES , MIP 1 alpha and MIP 1 beta could contribute to the singular features of the immune response elicited during infection of macaques with an attenuated SIV . . ^^^ Spontaneous MIP 1alpha , MIP 1beta and RANTES production was assessed by ELISA in supernatants of short term cultured BALMCs . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Increased expression of MCP 1 , MIP 1alpha , MIP 1beta and RANTES was also noted in the CNS of MAV 1 infected C57BL / 6 animals commencing around 72 h post infection . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Lipopolysaccharide from an Escherichia coli htrB msbB mutant induces high levels of MIP 1 alpha and MIP 1 beta secretion without inducing TNF alpha and IL 1 beta . ^^^ The capacity of these LPS preparations to induce tumor necrosis factor alpha ( TNF alpha ) , interleukin 1 beta ( IL 1 beta ) , and macrophage inflammatory proteins 1 alpha ( MIP 1 alpha ) and MIP 1 beta was assessed using a human peripheral blood mononuclear cell ( PBMC ) activation assay . ^^^ Nonetheless , mLPS retained a discrete agonist activity that induced MIP 1 alpha and MIP 1 beta secretion by PBMCs . ^^^ This latter agonist activity appears to be unique to mLPS , since two previously documented LPS antagonists , Rhodobacter sphaeroides diphosphoryl lipid A and synthetic lipid IVA , did not induce MIP 1 alpha and MIP 1 beta secretion . ^^^ Furthermore , synthetic lipid IVA was an antagonist of MIP 1 alpha and MIP 1 beta induction by mLPS . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The natural ligands for the CCR 5 chemokine receptor , macrophage inflammatory protein 1alpha ( MIP 1alpha ) , MIP 1beta , and RANTES ( regulated on T cell activation , normal T cell expressed and secreted ) , are known to inhibit human immunodeficiency virus ( HIV ) entry , and N terminally modified RANTES analogues are more potent than native RANTES in blocking infection . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The levels of RANTES , MIP 1alpha and MIP 1beta were measured by enzyme linked immunosorbent assay and correlated with different immunological and clinical parameters . ^^^ By contrast , the mean serum levels of MIP 1alpha and MIP 1beta did not differ significantly between the three study groups . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Antigen receptor engagement selectively induces macrophage inflammatory protein 1 alpha ( MIP 1 alpha ) and MIP 1 beta chemokine production in human B cells . ^^^ We show herein that B cell Ag receptor ( BCR ) triggering , but not stimulation by CD 40 mAb and / or IL 4 , rapidly induced the coordinated expression of two closely related T cell chemoattractants , macrophage inflammatory protein 1 beta ( MIP 1 beta ) and MIP 1 alpha , by human B cells . ^^^ This effect was partially blocked by anti MIP 1 beta and anti CC chemokine receptor 5 Ab , but not by anti MIP 1 alpha Ab suggesting that MIP 1 beta plays a major role in this chemoattraction . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Both mangabey and Rhesus macaque PBMC were found to secrete comparable levels of MIP 1alpha , MIP 1beta and RANTES after stimulation in vitro . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Indeed , there is evidence that targeted iliac lymph node ( TILN ) immunisation with SIVgp 120 and p 27 or xenoimmunisation with SIV grown in human T cells generates CD 8 SF , RANTES , MIP 1alpha and MIP 1beta which are significantly correlated with protection from SIV infection by the rectal mucosal or intravenous route , respectively . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
METHODS : OB were isolated from subchondral bone of rheumatoid arthritis ( RA ) , osteoarthritis ( OA ) and post traumatic ( PT ) patients , cultured in vitro in the presence or absence of interleukin 1beta ( IL 1beta ) and tumor necrosis factor alpha ( TNF alpha ) , and assessed for the production , immunolocalization , and mRNA expression of proinflammatory cytokines ( IL 1alpha , IL 1beta , TNF alpha ) and alpha and beta chemokines [ IL 8 , growth related gene product ( GRO alpha ) , monocyte chemoattractant protein 1 ( MCP 1 ) , RANTES , and macrophage inflammatory proteins MIP 1alpha , MIP 1beta ] . ^^^ RESULTS : Cultured OB from different patients did not release IL 1alpha , IL 1beta , or TNF alpha , and constitutively secreted IL 8 , GRO alpha , and MCP 1 , while RANTES , MIP 1alpha , MIP 1beta were undetectable or near the lower level of sensitivity of the immunoenzymatic assay . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
We analysed the spontaneous and cytokine stimulated production and expression in vitro of IL 8 , GROalpha , MCP 1 , RANTES , MIP 1alpha , MIP 1beta , by subchondral bone marrow stromal cells ( BMSC ) isolated from RA , OA , post traumatic ( PT ) patients and normal donors ( ND ) . ^^^ BMSC from different sources constitutively released MCP 1 , GROalpha and IL 8 , but not MIP 1alpha or MIP 1beta , while BMSC from ND constitutively released only IL 8 and MCP 1 . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
To facilitate further investigation of the human chemokines , we have constructed a novel multispecific competitor fragment containing primer binding sites for the CC chemokines MCP 1 , MCP 2 , MCP 3 , MIP 1alpha , MIP 1beta and RANTES , the CXC chemokines MIP 2alpha , MIP 2beta as well as for the housekeeping gene beta actin . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
We identified several genes up regulated by IL 12 , namely , MIP 1alpha , MIP 1beta , IL 1RA , and IFN regulatory factor 1 ( IRF 1 ) . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Similarly , up regulated expression of macrophage inflammatory protein 1 alpha ( MIP 1 alpha ) and MIP 1 beta gene transcripts was induced . ^^^ Exogenous TNF alpha alone also provided a potent stimulus of MIP 1 alpha and MIP 1 beta expression , and when neutralizing anti TNF alpha antiserum was included in cultures of parasite stimulated cells , expression of these CC family chemokines was partially blocked . ^^^ These results establish that T . gondii possesses the ability of driving neutrophil proinflammatory cytokine production , and they suggest that parasite induced MIP 1 alpha and MIP 1 beta partly results from autocrine stimulation through TNF alpha . . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
A comparison between intradermal , naso rectal i . m . and targeted iliac lymph node ( TILN ) routes showed that immunization by the TILN route elicited the most significant increase in CD 8 SF and the beta chemokines RANTES , MIP 1alpha and MIP 1beta . ^^^ Furthermore , CD 8 SF and the concentrations of RANTES , MIP 1alpha and MIP 1beta increased with secondary immunizations , suggesting that memory CD8+ cells are involved . ^^^ Treatment of CD8+ cell culture supernatant with antibodies to RANTES , MIP 1alpha and MIP 1beta neutralized the CD 8 SF activity , indicating that blocking the CCR 5 by these ligands played an important part in the CD 8 SF activity elicited by TILN immunization . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
In contrast to IP 10 , other chemotactic factors including the CC chemokines MCP 1 , MIP 1alpha , MIP 1beta and RANTES and the cytokines IL 15 and IL 16 were either not detected or increased in only less than 30 % of the patients . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The proinflammatory stimuli lipopolysaccharide and tumor necrosis factor alpha , which induced the release of monocyte chemotactic protein 1 , macrophage inflammatory protein 1alpha ( MIP 1alpha ) , MIP 1beta , and interleukin 8 , did not affect MPIF 1 release . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The mRNA levels of RANTES , MIP 1alpha , and MIP 1beta in BAL cells were significantly correlated with the lavaged lymphocyte proportion , and a significant inverse correlation was observed between the mRNA level of MIP 1beta and the CD4 / CD8 ratio of lavaged lymphocytes . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
We previously reported that the gene expression of six CC chemokines MCP 1 , MCP 3 , MIP 1alpha , MIP 1beta , RANTES , and TCA 3 was enhanced in a rat model of crescentic glomerulonephritis , the most severe form of glomerulonephritis . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
After stimulation with LPS , TNF alpha or CD 40 ligand , the inflammatory chemokines MIP 1alpha , MIP 1beta and IL 8 were produced rapidly and at high levels , but only for a few hours , while RANTES and MCP 1 were produced in a sustained fashion . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
CCR 5 , a receptor for chemokines MIP 1alpha ( LD78alpha ) , MIP 1beta , RANTES , and MCP 2 , is of particular importance in vivo as polymorphisms in this gene affect HIV infection and rate of progression to AIDS . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
In contrast , secretion of the chemokines RANTES , MIP 1alpha , and MIP 1beta was upregulated with LPS stimulation . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The deduced mature protein had the four conserved cysteine residues characteristic of CC chemokines and showed 44 % identity with MIP 1beta and 40 % identity with MIP 1alpha , RANTES , and MCP 4 . mRNA for this chemokine was expressed constitutively in human heart and liver and with lesser but detectable levels in skeletal muscle , kidney , and small intestine . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
However , when 8 week old infected SCID mice were immunologically reconstituted , signs of focal pulmonary inflammation were observed , and levels of RANTES , MCP 1 , lymphotactin , MIP 1alpha , MIP 1beta , and MIP 2 mRNAs were all significantly elevated . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Astrocyte derived monocyte chemoattractant protein 1 ( MCP 1 ) , RANTES , macrophage inflammatory protein 1alpha ( MIP 1alpha ) , and MIP 1beta mRNA were easily induced by lipopolysaccharide and / or the proinflammatory cytokines ( IFN gamma and / or TNF alpha ) , respectively . ^^^ Interestingly , ultraviolet light inactivated measles virus , but not cytomegalovirus , strongly induced expression of MCP 1 , RANTES , MIP 1alpha , and MIP 1beta mRNA in human embryonic astrocytes , especially MCP 1 and MIP 1beta . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
This study examined the expression and function of CXC ( human monokine induced by gamma interferon [ HuMig ] , interleukin 8 [ IL 8 ] , and interferon inducible protein 10 [ IP 10 ] ) and CC ( macrophage inflammatory protein 1alpha [ MIP 1alpha ] , MIP 1beta , regulated upon activation normal T lymphocyte expressed and secreted ( RANTES ) , and macrophage chemoattractant protein 1 [ MCP 1 ] ) chemokines and their respective receptors on lymphocytes infiltrating human liver tumors . ^^^ Tumor derived lymphocytes showed strong chemotactic responses to both CC and CXC chemokines in vitro and expressed high levels of CXCR 3 ( HuMig and IP 10 receptor ) and CCR 5 ( RANTES , MIP 1alpha , and MIP 1beta receptor ) . ^^^ The corresponding chemokines were detected on vascular endothelium ( HuMig , IL 8 , MIP 1alpha , and MIP 1beta ) and sinusoidal endothelium ( HuMig , MIP 1alpha , MIP 1beta ) in hepatocellular carcinoma . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Neither LPS induced MIP 1alpha , MIP 1beta , nor MIP 2 was significantly affected by PDTC or sodium salicylate , demonstrating that NF kappaB is dispensable for the transcriptional regulation of these genes by LPS . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Cerebrospinal fluid ( CSF ) samples from 73 HIV infected men were assayed for macrophage inflammatory protein 1 alpha ( MIP 1alpha ) , MIP 1beta , and regulated upon activation , normal T cell expressed and secreted ( RANTES ) . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
We also examined the local production of mononuclear cell attracting chemokines such as monocyte chemotactic protein 1 ( MCP 1 ) , regulated upon activation , normal T cell expressed and secreted ( RANTES ) , macrophage inflammatory protein 1alpha ( MIP 1alpha ) , MIP 1beta and IFN gamma inducible protein 10 ( IP 10 ) in the lungs using a reverse transcriptase polymerase chain reaction ( RT PCR ) method . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Augmented production of chemokines ( monocyte chemotactic protein 1 ( MCP 1 ) , macrophage inflammatory protein 1alpha ( MIP 1alpha ) and MIP 1beta ) in patients with systemic sclerosis : MCP 1 and MIP 1alpha may be involved in the development of pulmonary fibrosis . ^^^ To determine the role of chemokines in the pathogenesis of systemic sclerosis ( SSc ) , we examined serum levels , spontaneous production by peripheral blood mononuclear cells ( PBMC ) , and histological distribution in the affected skin , of MCP 1 , MIP 1alpha and MIP 1beta in SSc patients . ^^^ Serum levels and spontaneous production levels by PBMC of MCP 1 , MIP 1alpha , and MIP 1beta were significantly elevated in patients with SSc compared with normal controls . ^^^ Thus , MCP 1 , MIP 1alpha and MIP 1beta may be involved in the disease process , possibly by augmenting leucocyte migration into the affected tissues in SSc . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Studies have demonstrated that the beta chemokines RANTES , MIP 1alpha , and MIP 1beta suppress human immunodeficiency type 1 ( HIV 1 ) replication in vitro . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Both TSST 1 and SEB induced high levels ( ng / mL ) of MIP 1alpha , MIP 1beta , and MCP 1 . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
All CXC ( IFN gamma inducible protein ( IP 10 ) , macrophage inflammatory protein ( MIP ) 2 , and KC ) and CC ( JE / monocyte chemoattractant protein ( MCP ) 1 , MCP 5 , MIP 1alpha , MIP 1beta , and RANTES ) chemokine genes evaluated were sensitive to stimulation by LPS in vitro and in vivo . ^^^ While IL 10 suppressed the expression of all LPS induced chemokine genes evaluated in vitro , treatment with IFN gamma selectively induced IP 10 and MCP 5 mRNAs , but inhibited LPS induced MIP 2 , KC , JE / MCP 1 , MIP 1alpha , and MIP 1beta mRNA and / or protein . ^^^ Hepatic expression of MIP 1alpha , MIP 1beta , RANTES , and MCP 5 mRNAs were dramatically reduced in Kupffer cell depleted mice , while IP 10 , KC , MIP 2 , and MCP 1 were unaffected or enhanced . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
OBJECTIVES : To study the susceptibility to infection by different strains of HIV 1 viruses and the roles of chemokines ( macrophage inflammatory protein 1alpha [ MIP 1alpha ] , MIP 1beta , and regulated on activation T expressed and secreted [ RANTES ] ) in CD34+ stem cells maturing into dendritic cells ( DC ) . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
RANTES , MIP 1alpha and MIP 1beta have been suggested as the major human immunodeficiency virus suppressor factors produced by CD8+ T cells . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
IL 8 , GROalpha , MCP 1 , RANTES , MIP 1alpha and MIP 1beta expression was evaluated by flow cytometric analysis and RT PCR in chondrocytes isolated from cartilage specimens obtained from patients with osteoarthritis and rheumatoid arthritis and multiorgan donors as normal controls . ^^^ In osteoarthritis and rheumatoid arthritis patients , an enhancement of IL 8 , GROalpha , MIP 1alpha and MIP 1beta was observed . . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Both MIP 1alpha and MIP 1beta mRNA levels were reduced at a magnitude similar to the reduction in TNF alpha mRNA levels , whereas monocyte chemotactic protein ( MCP ) 1 mRNA levels were reduced at a magnitude similar to the reduction in MIP 2 mRNA levels following antioxidant treatment . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Our results show that mRNA expression of the macrophage chemoattractant factor ( MCP 1 ) and macrophage inflammatory peptides ( MIP 1alpha and MIP 1beta ) , but not RANTES , increases in Mycoplasma pulmonis infected mice . ^^^ As beta chemokines are chemotactic for lymphocytes and macrophages , these results suggest that MCP 1 , MIP 1alpha , and / or MIP 1beta , but not RANTES , contribute to mononuclear cell infiltration associated with murine mycoplasma respiratory disease . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Immature DC respond to many CC and CXC chemokines ( MIP 1alpha , MIP 1beta , MIP 5 , MCP 3 , MCP 4 , RANTES , TECK , and SDF 1 ) and in particular to MIP 3alpha / LARC , which acts through CCR 6 , a receptor mainly expressed in DC and lymphocytes . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
We conclude that the release of chemokines ( IL 8 , MIP 1alpha , MIP 1beta ) and granule enzymes ( MPO ) by RSV stimulated neutrophils may contribute to the pulmonary pathology in RSV bronchiolitis . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
In addition , in vitro infection with T . cruzi resulted in expression of beta chemokine MIP 1alpha , MIP 1beta , RANTES , and JE mRNA by macrophages . ^^^ The expression of the beta chemokine MIP 1alpha , MIP 1beta , RANTES , and JE proteins by murine macrophages cultured with trypomastigote forms of T . cruzi was confirmed by immunocytochemistry . ^^^ Further , the addition of the exogenous beta chemokines MIP 1alpha , MIP 1beta , RANTES , and JE / MCP 1 induced an increased T . cruzi uptake , leading to enhanced NO production and control of parasite replication in a dose dependent manner . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Sustained suppression of plasma HIV RNA is associated with an increase in the production of mitogen induced MIP 1alpha and MIP 1beta . ^^^ The chemokines that bind to this receptor ( MIP 1alpha , MIP 1beta , and RANTES ) are potent inhibitors of HIV replication and may play an important role in the pathophysiology of HIV disease . ^^^ We investigated the effect of potent antiretroviral therapy ( ritonavir and saquinavir ) on the production of MIP 1alpha , MIP 1beta , and RANTES in 19 HIV infected patients who had sustained decreases in plasma HIV RNA levels ( < 200 copies / ml ) . ^^^ MIP 1alpha , MIP 1beta , and RANTES levels in serum and plasma did not significantly change in the 48 week period . ^^^ In contrast , MIP 1alpha and MIP 1beta secreted by PHA stimulated PBMCs increased at 24 weeks , with this increase sustained at 48 weeks , whereas no significant change was observed in PHA induced RANTES production . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The CC chemokines RANTES , MIP 1alpha , MIP 1beta , and Eotaxin can suppress the replication of CCR 5 and CCR 3 dependent viruses , while SDF 1 alpha / beta suppresses that of CXCR 4 dependent strains . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
In order to gain further understanding of the role of chemokines in healthy oral mucosa , we analyzed mRNA expression of the alpha ( CXC ) family chemokines IL 8 and GROgamma as well as of the beta ( CC ) family chemokines MIP 1alpha , MIP 1beta and MCP 1 in twenty young and healthy subjects with good oral hygiene . ^^^ In healthy tissue , IL 8 and MCP 1 mRNA was constitutively expressed in all biopsies , whereas GROgamma , MIP 1alpha , and MIP 1beta were significantly lower . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
CCR 5 was first characterized as a receptor for MIP 1alpha , MIP 1beta , and RANTES , and was rapidly shown to be the main coreceptor for M tropic human immunodeficiency virus ( HIV ) 1 strains and simian immunodeficiency virus ( SIV ) . ^^^ We found that in addition to MIP 1beta , MIP 1alpha , and RANTES , five other CC chemokines could compete for [ ( 125 ) 1 ] MIP 1beta binding : MCP 2 , MCP 3 , MCP 4 , MCP 1 , and eotaxin binding was characterized by IC ( 50 ) values of 0 . 22 , 2 . 14 , 5 . 89 , 29 . 9 , and 21 . 7 nmol / L , respectively . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Low levels of MIP 1alpha , MIP 1beta , and IFN gamma inducible protein 10 were induced following treatment with higher doses of MIP 2 or KC . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
AM responded to RSV infection by the production of IL 8 , MIP 1alpha , MIP 1beta , and MCP 1 , while RANTES was derived solely from the RSV infected bronchial epithelial cell line BEAS 2B . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The importance of chemokine expression on HIV infection has been emphasized by the discovery that infection of CD 4 ( + ) T cells by M tropic strains of HIV 1 is antagonized by the chemokines RANTES , MIP 1alpha , and MIP 1beta , which are natural ligands of CCR 5 , a major coreceptor for macrophagetropic ( M tropic ) isolates of HIV 1 . ^^^ Chronic HIV 1 infection of U 937 monocytic cells increased the expression of RANTES , MIP 1alpha , MIP 1beta , and IL 8 chemokine genes , but strongly inhibited PMA / PHA and TNFalpha induced MCP 1 gene transcription . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Very little or no production of chemokines , including MCP 1 , RANTES , MIP 1alpha , MIP 1beta and IP 10 , was detected at the mRNA level using RT PCR as well as at a protein level in MCP 1 , RANTES and MIP 1alpha . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Examination of a large panel of chemokines indicates that in addition to RANTES , MIP 1alpha and MIP 1beta , the beta chemokine MCP 2 and , to a lesser extent , the gamma chemokine lymphotactin also show anti human immunodeficiency virus ( HIV ) activity in cell culture . ^^^ The amount of chemokine needed to suppress HIV replication by > or = 50 % was generally greater ( > or = 250 ng / ml ) than that required for inhibition of virus infection by RANTES , MIP 1alpha and MIP 1beta . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
IL 4 , IL 2 , and interferon gamma ( IFNgamma ) together with the beta chemokines MIP 1alpha and MIP 1beta correlated with protection against challenge infection with a chimeric virus ( simian immunodeficiency virus human immunodeficiency virus ) . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The study evaluated , with an immunoassay , the concentrations of monocyte chemotactic protein 1 ( MCP 1 ) , macrophage inflammatory protein 1alpha ( MIP 1alpha ) and macrophage inflammatory protein 1beta ( MIP 1beta ) , in the bronchoalveolar lavage fluid ( BALF ) of 12 smokers affected by chronic bronchitis and 14 smoking , 15 nonsmoking and six exsmoking healthy subjects . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
In contrast , no significant effect on IL 10 production was observed when 6Ckine , the other reported ligand for human CCR 7 , or other CC chemokines such as monocyte chemoattractant protein 1 , RANTES , MIP 1 alpha , and MIP 1 beta were added to LPS or PHA stimulated PBMCs . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Interaction of eosinophils or monocytes with RSV infected epithelial cells resulted in the production of additional beta chemokines MCP 1 and MIP 1beta , and increased levels of MIP 1alpha . ^^^ On the other hand , the levels of RANTES and the lack of eotaxin were not altered in the cocultures , RSV infected monocytes appeared to be the main source of MIP 1alpha and MIP 1beta , while MCP 1 was derived from monocytes as well as epithelial cells following coculture . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
In contrast to perforin and granzyme B gene expression , IL 2 administration did not increase the expression of macrophage inhibitory protein 1alpha ( MIP 1alpha ) , MIP 1beta , and regulated on activation normal T expressed and secreted ( RANTES ) genes . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
At enrolment , both spontaneous and lectin induced RANTES , macrophage inflammatory protein 1alpha ( MIP 1alpha ) and MIP 1beta production by PBMC were higher in HIV 1 infected individuals compared with normal controls , although differences for MIP 1beta were not statistically significant . ^^^ However , RANTES and MIP 1alpha production decreased during HAART at levels closer to that determined with normal controls , while MIP 1beta production was less consistently modified . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Transcripts for the chemokines MIP 1alpha , MIP 1beta , 1 309 , or lymphotactin could not be detected . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The level of susceptibility to HIV 1 correlated inversely with beta chemokine production , including RANTES ( regulated on activation , normally T cell expressed and secreted ) , macrophage inflammatory protein 1alpha ( MIP 1alpha ) , and MIP 1beta . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Although less well established , other chemokines such as RANTES , MIP 1alpha and MIP 1beta have also been implicated in atherosclerotic lesion formation as are a number of more recently discovered chemokines like MCP 4 , ELC and PARC . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
In a parallel manner , binding of labeled MIP 1alpha was first shown to be attenuated by unlabeled RANTES , both of which recognize CCR 1 and CCR 5 , and then separately antagonized by MCP 3 and MIP 1beta , which bind to CCR 1 and CCR 5 , respectively . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
MALP 2 induced the neutrophil attracting CXC chemokines interleukin 8 ( IL 8 ) and GRO alpha as well as the mononuclear leukocyte attracting CC chemokines MCP 1 , MIP 1alpha , and MIP 1beta . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Neutralization with specific Abs identified these factors as MIP 1alpha and MIP 1beta from most donors . ^^^ IL 4 , IL 10 , IFN gamma , and IL 18 primarily inhibited MIP 1beta secretion and also weakly suppressed MIP 1alpha secretion . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Adult T cell leukemia ( ATL ) cells spontaneously adhered to ICAM 1 , which depended on endogenous MIP 1alpha and MIP 1beta through activation of G protein sensitive PI 3 kinase . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Interestingly , administration of either MIP 1beta , an antagonist of both MIP 1alpha and MCP 1 or MCP 1 ( 9 76 ) , an antagonist of MCP 1 ( and MCP 2 and MCP 3 ) , into mice in which human marrow derived CFC had become quiescent , caused the rapid reactivation of these progenitors in vivo . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
CCR 5 is a functional receptor for MIP 1alpha , MIP 1beta , RANTES ( regulated on activation normal T cell expressed ) , MCP 2 , and MCP 4 and constitutes the main coreceptor for macrophage tropic human and simian immunodeficiency viruses . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
We have demonstrated that the factor ( s ) responsible for the suppression of HIV 1 LTR mediated gene expression are not the CC chemokines RANTES , MIP 1alpha , and MIP 1beta . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
During the development of nephrotoxic nephritis ( NTN ) in the mouse , we find that a variety of chemokines and chemokine receptors are induced : CCR 1 ( RANTES , MIP 1alpha ) , CCR 2 ( MCP 1 ) , CCR 5 ( RANTES , MIP 1alpha , MIP 1beta ) , CXCR 2 ( MIP 2 ) , and CXCR 3 ( IP 10 ) . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
A subset of chemokines , including regulated upon activation , normal T cell expressed and secreted ( RANTES ) , macrophage inflammatory protein 1alpha ( MIP 1alpha ) , and MIP 1beta , also suppress infection by HIV 1 . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
BACKGROUND : This study was designed to evaluate the role of the novel chemokine receptor antagonist amino oxypentane RANTES ( AOP RANTES ) , which blocks the binding of macrophage inflammatory protein 1alpha ( MIP 1alpha ) , MIP 1beta , and RANTES to the chemokine receptor 5 ( CCR 5 ) on the infiltration of monocytes in experimental glomerulonephritis . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
MIP 1alpha , RANTES , MCP 1 , C 10 , IP 10 , and MIP 1beta mRNA was specifically expressed in the central nervous system and not the periphery following Theiler ' s murine encephalomyelitis virus infection . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
We found that human CD 34 ( + ) cells and CD 34 ( + ) KIT ( + ) cells , which are enriched in myeloid progenitor cells , expressed and secreted the CCR 5 ligands RANTES , MIP 1alpha , and MIP 1beta and that IFN gamma stimulated expression of these chemokines . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
In this study we show that activation of Vdelta 2 ( + ) cells with the nonpeptidic antigen isopentenyl pyrophosphate ( IPP ) rapidly induces ( within 4 12 hours ) the C C chemokines MIP 1alpha , MIP 1beta , and lymphotactin but not MCP 1 . ^^^ IPP induction of MIP 1alpha and MIP 1beta was not affected by costimulation with interleukin 4 ( IL 4 ) , IL 10 , TGF beta , or interferon gamma ( INF gamma ) . ^^^ However , IL 12 significantly enhanced IPP induced expression and release of MIP 1alpha that was down regulated by TGF beta whereas the induction of MIP 1beta by IPP+IL 12 was refractory to cotreatment with TGFbeta indicating that these chemokines are differentially regulated by these cytokines . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Recently , several unique HIV 1 entry coreceptors ( e . g . , CCR 5 and CCR 3 ) and a trio of HIV 1 specific suppressor chemokines , namely , RANTES ( regulated upon activation T expressed and secreted ) , macrophage inflammatory protein 1alpha ( MIP 1alpha ) and MIP 1beta , were identified . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Three C C chemokines inhibit human immunodeficiency virus ( HIV ) entry into macrophages : macrophage inflammatory protein 1alpha ( MIP 1alpha ) , MIP 1beta , and regulated upon activation , normal T cell expressed and secreted ( RANTES ) . ^^^ Secretion of MIP 1alpha and MIP 1beta were similar in CBMC and ABMC . ^^^ Whereas MIP 1alpha and MIP 1beta secretion were comparable in monocytes and lymphocytes , RANTES was secreted primarily by lymphocytes . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Urine and serum levels of MCP 1 , MIP 1beta , and IP 10 , but not of MIP 1alpha were elevated in patients on admission , and decreased after initiation of antibiotic treatment . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
In contrast , astrocytes are resistant to Fas mediated cell death , however , ligation of Fas induces expression of the chemokines macrophage inflammatory protein 1beta ( MIP 1beta ) , MIP 1alpha , and MIP 2 . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
When IFNbeta was used as the stimulus , induction of MIP 1alpha , MIP 1beta , MCP 1 , and RANTES mRNA and protein was observed within 12 h of stimulation in microglia . ^^^ IFNbeta stimulation of blood monocytes resulted in upregulation of MIP 1alpha , MIP 1beta , and MCP 1 . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
A single round replication assay using a luciferase reporter HIV 1 strain pseudotyped with mutant envelopes confirmed that mutations in both V 2 and V 3 were necessary to confer the reduced sensitivity to MIP 1alpha , MIP 1beta , and RANTES . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
In the present study three sub lines derived from the parental MCF 7 cell line were selected for their ability to migrate in response to MIP 1alpha , MIP 1beta or RANTES across Transwell filters of 8 microm pore size . ^^^ Cells migrating to MIP 1beta were subjected to four further rounds of positive or negative selection , resulting in two sub lines , MCF 7L4 and MCF 7U4 which displayed an increased and decreased chemotactic response respectively to MIP 1alpha MIP 1beta and RANTES . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Such differential suppressive activity was not due to beta chemokines as evidenced by the lack of blocking activity of antibodies to RANTES , MIP 1beta , and MIP 1alpha on the antiviral activities of CD8+ T cells . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Limited expression of R 5 tropic HIV 1 in CCR 5 positive type 1 polarized T cells explained by their ability to produce RANTES , MIP 1alpha , and MIP 1beta . ^^^ In fact , an inverse correlation was observed between Th 1 polarized naive T cells and Th 1 like memory activated T cells in regards to p 24 Ag production and the release of the following CCR 5 binding chemokines : regulated on activation normal T expressed and secreted ( RANTES ) , macrophage inflammatory protein 1alpha ( MIP 1alpha ) , and MIP 1beta . ^^^ Moreover , infection with the HIV 1BaL strain of Th 1 polarized T cells in the presence of a mixture of anti RANTES , anti MIP 1alpha , and anti MIP 1beta neutralizing antibodies resulted in a significant increase of HIV 1 expression . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Coronary endothelia showed in vitro a strong chemotactic response to the CC chemokines RANTES , MIP 1alpha , and MIP 1beta . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Performing RNase protection assays , we detected the same pattern of chemokine ( RANTES , MCP 1 , IP 10 , MIP 1beta , MIP 1alpha and MIP 2 ) mRNA expression in brain and spinal cord during all three infections . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
We show here that ( 1 ) M 23 g3p was specifically recognized with anti CCR 5 mAb ; ( 2 ) M 23 g3p showed inhibitory activity on the infectivity of M tropic but not T tropic HIV 1 strains ; ( 3 ) M 23 g3p bound to MIP 1alpha , MIP 1beta , and RANTES but not MCP 1 . ^^^ These results suggested that the M 23 g3p might mimic the CCR 5 binding domain shared by beta chemokines , MIP 1alpha , MIP 1beta , and RANTES as well as the HIV 1 infection . . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
IFNbeta but not IFNgamma was effective in inducing the expression of beta chemokines MIP 1alpha and MIP 1beta in human microglia , with the levels of mRNA similar to those induced by IL 1beta or TNFalpha . ^^^ Neither MIP 1alpha nor MIP 1beta mRNAs were induced by any stimulation in human astrocytes . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Characterization of chemokines at RNA level revealed that unstimulated cells contain large amounts of IL 8 and monocyte chemotactic protein ( MCP ) 1 RNAs , and that stimulation with HGF or IL 1beta induced RNAs for regulated upon activation normal T expressed and secreted ( RANTES ) , macrophage inflammatory protein ( MIP ) 3alpha , interferon gamma inducible protein 10 ( IP 10 ) , and , to a lesser extent , MIP 1alpha and MIP 1beta . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Induction of both MIP 1 alpha and MIP 1 beta by PA was associated with transcriptional activation and mRNA stabilization , suggesting a dual molecular mechanism of control . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
LPS induced transient increases in serum MIP 1alpha , MIP 1beta , and MCP 1 . ^^^ Pretreatment with IL 10 inhibited LPS induced release of MIP 1alpha , MIP 1beta , and MCP 1 . ^^^ In whole blood in vitro , the IL 10 induced inhibition of MIP 1alpha and MIP 1beta release was equally potent in the presence or absence of an anti tumor necrosis factor ( TNF ) antibody . ^^^ Although isolated peripheral blood mononuclear cells produced more MIP 1alpha and MIP 1beta than neutrophils , the latter cells were more sensitive to the inhibiting effect of IL 10 . ^^^ IL 10 attenuates LPS induced production of CC chemokines in human endotoxemia , whereby in vitro experiments suggest that , in the case of MIP 1alpha and MIP 1beta release , this effect is independent from an inhibitory effect on TNF production . . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
OBJECTIVE : The purpose of this study is to determine the effects of alpha chemokines ( IL 8 and melanoma growth stimulating activator ) , beta chemokines ( monocyte chemotactic protein 1 , macrophage inflammatory protein 1alpha [ MIP 1alpha ] , MIP 1beta , and RANTES ) , and proinflammatory cytokines ( IL 1beta , TNF alpha , and IFN gamma ) on the expression of both ET 1 and endothelin converting enzyme 1 ( ECE 1 ) by human umbilical vein endothelial cells . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Decreases of MCP 1 and RANTES levels were found , but no durable changes of MIP 1 alpha and MIP 1 beta . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
METHODS : Sections from Banff graded transplant biopsies were examined for the presence of beta chemokines ( MCP 1 , MIP 1alpha , MIP 1beta , and RANTES ) by immunofluorescence and semiquantitative confocal laser scanning microscopy . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
In contrast , newborn and adult mice responded similarly at 2 h post endotoxin exposure , inducing messages encoding tumor necrosis factor ( TNF ) alpha , eotaxin , MIP 1alpha , MIP 1beta , MIP 2 , interferon inducible protein ( IP ) 10 , and monocyte chemoattractant protein ( MCP ) 1 . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Significantly higher immune responses , as well as CD8+ T cell generated anti SIV factors and the beta chemokines RANTES , MIP 1alpha , and MIP 1beta , were elicited by iliac as compared with axillary TLN immunization . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The discovery that RANTES ( regulated on activation , normal T cell expressed and secreted ) , MIP 1alpha , and MIP 1beta ( macrophage inflammatory protein 1 alpha and beta ) could inhibit HIV 1 replication by blocking viral entry processes led to the notion that these molecules are responsible for the CD 8 ( + ) cell suppressive activity . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
In contrast , the CCR 5 ligands ( macrophage inflammatory protein 1alpha [ MIP 1alpha ] , MIP 1beta , and RANTES ) did not activate calcium flux , MAPK and AKT phosphorylation or chemotaxis of CD 34 ( + ) KIT ( + ) cells or cells isolated from the BFU E colonies . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The CCR 5 ligands RANTES , MIP 1alpha and MIP 1beta suppress infection by R 5 HIV 1 particles via induction of CCR 5 internalization , and individuals whose peripheral blood lymphocytes produce high levels of these chemokines are relatively resistant to infection [ 7 ] [ 8 ] [ 9 ] . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
METHODS : Isogeneic and allogeneic skin grafts were transplanted to euthymic and athymic nude mice . mRNA expression and protein production of macrophage inflammatory protein 1alpha ( MIP 1alpha ) , MIP 1beta , and the murine homolog of Gro ( alpha ) , i . e . ^^^ RESULTS : Expression of KC , MIP 1alpha , and MIP 1beta mRNA was equivalent in C57BL / 6 allogeneic skin grafts and BALB / c isografts at day 2 posttransplant . ^^^ Analyses of allograft homogenates indicated increased levels of KC , MIP 1alpha , and MIP 1beta protein at day 4 posttransplant that were decreased in recipients depleted of NK cells . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Examination of the function of RANTES , MIP 1alpha , and MIP 1beta following interaction with heparin like glycosaminoglycans . ^^^ In this study , Chinese hamster ovary cells were transfected separately with the human chemokine receptors CCR 1 and CCR 5 , and these receptors were shown to induce an intracytoplasmic Ca ( 2+ ) flux and cellular chemotaxis following stimulation with the natural CC chemokine ligands ( MIP 1alpha , RANTES ( regulated on activation normal T cell expressed ) , and MIP 1beta ) . ^^^ In conclusion , it has been demonstrated clearly that GAG expression is not necessary for the biological activity of the chemokines MIP 1alpha , RANTES , or MIP 1beta . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The natural ligands for these receptors are SDF 1 and the beta chemokines ( MIP 1alpha , MIP 1beta , RANTES ) , respectively , and are the products of a variety of immune cells , including CD8+ T lymphocytes . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
MIP 1alpha and MIP 1beta were not detected in Sertoli cells , germ cells , peritubular cells , or Leydig cells . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
These findings represent a novel mechanism for inhibition of HIV 1 replication that differs from the previously described CD 8 anti HIV factors ( MIP 1alpha , MIP 1beta , RANTES , and CD 8 antiviral factor ) . . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The HIV suppressive CC chemokines RANTES , macrophage inflammatory protein 1alpha ( MIP 1alpha ) , and MIP 1beta were also determined in IL 2 stimulated PBMC cultures . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The most frequent cDNAs identified included the chemokines TCA 3 , macrophage inflammatory protein 1alpha ( MIP 1alpha ) , MIP 1beta , and lymphotactin ( LPTN ) , the cytokines interleukin 4 ( IL 4 ) and interferon gamma ( IFN gamma ) , and a granzyme . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The CTL clones expressed the CCR 5 receptor and localized among HIV infected cells expressing the ligands MIP 1alpha and MIP 1beta , CC chemokines produced at sites of virus replication . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The results suggest that RSV G and / or SH proteins inhibit early MIP 1alpha , MIP 1beta , MIP 2 , MCP 1 , and IP 10 mRNA expression . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
We previously reported that among six chemokines , the expression of mRNAs for MCP 1 , MCP 3 , TCA 3 , and MIP 1alpha , but not for MIP 1beta and RANTES , was markedly elevated in the renal cortex of rats with puromycin aminonucleoside induced nephrosis . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Mitogen induced production of MIP 1alpha , MIP 1beta , and RANTES by PBMCs was higher in HIV infected patients than in HIV seronegative controls . ^^^ The production of MIP 1alpha , MIP 1beta , RANTES , and IFN gamma was markedly reduced at 8 weeks and partially restored at 24 weeks after beginning protease inhibitor therapy . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Results of these studies show that the anti viral resistance induced by activation of CD4+ T cells with anti CD 3 + anti CD 28 is primarily conferred by the synthesis of tumor necrosis factor alpha ( TNF alpha ) , and highlight a unique regulatory role for TNF alpha in regulating synthesis of MIP 1alpha , MIP 1beta , and regulated on activation normal T expressed and secreted cells , which contributes to this state of antiviral resistance to R 5 tropic strains of HIV / SIV . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Whereas an elevated ratio of macrophage inflammatory protein 1alpha ( MIP 1alpha ) : MIP 1beta in the pancreas correlated with destructive insulitis and progression to diabetes in NOD mice , a decreased intrapancreatic MIP 1alpha : MIP 1beta ratio was observed in nonobese diabetes resistant ( NOR ) mice . ^^^ IL 4 treatment , which prevents diabetes in NOD mice by polarizing intraislet Th 2 responses , decreased CCR 5 expression in islets and potentiated a high ratio of MIP 1beta and monocyte chemotactic protein 1 ( MCP 1 ) : MIP 1alpha in the pancreas . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Exoenzyme S strongly induced transcription of proinflammatory cytokines and chemokines ( tumor necrosis factor alpha , interleukin 1alpha [ IL 1alpha ] , IL 1beta , IL 6 , IL 8 , MIP 1alpha , MIP 1beta , MCP 1 , RANTES , and 1 309 ) , modest transcription of immunoregulatory cytokines ( IL 10 and IL 12p40 ) , and weak transcription of Th 1 cytokines ( IL 2 and gamma interferon ) . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The C C chemokines MIP 1alpha , MIP 1beta and RANTES are specific and powerful inhibitors of HIV infectivity . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Specific inhibitors of RANTES induced activation , such as soluble glycosaminoglycans , MIP 1alpha and MIP 1beta , acted by preventing the binding of RANTES on the cell surface . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
We administered naked DNA vaccines encoding MIP 1 alpha , MCP 1 , MIP 1 beta , and RANTES to Lewis rats and confirmed that each of these vaccines induced immunological memory to the corresponding gene product . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
No difference was observed in TNF alpha , IL 1beta , IL 10 , IL 4 , MIP 1alpha , MIP 1beta , RANTES , CXCR 4 , and CCR 5 mRNA levels in PBMC , but IL 6 levels were higher in the HPS patient . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Lung mRNA expression of the C C chemokine MCP 1 was increased in OVA indomethacin mice , while there was no difference between the two groups in lung mRNA expression of eotaxin , MIP 1alpha , MIP 1beta , or MIP 2 . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Furthermore , we showed that the CXCR 4 and CCR 5 ligands ( stromal derived factor 1 and macrophage inflammatory protein 1alpha [ MIP 1alpha ] , MIP 1beta and RANTES , respectively ) inhibit HIV replication in both maturing Mo and Mk cells . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Using RNase protection assay , we demonstrate that CD14+CD16++ cell subset expresses a low ratio of IL 1beta / IL 1ra mRNA and expresses IL 6 , MIP 1alpha , MIP 1beta , MCP 1 , IL 8 , RANTES and 1 309 transcripts , similar to dendritic cells . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Interestingly , the maturation program induced by CT is unique since CT does not induce but rather inhibits cytokine ( IL 12p70 and TNF alpha ) and chemokine ( RANTES , MIP 1alpha and MIP 1beta ) secretion by lipopolysaccharide or CD 40 ligand activated DC . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
None of the other chemokines studied by RNase protection assay ( lymphotactin , RANTES , IP 10 , MIP 1alpha , MIP 1beta , IL 8 , and 1 309 ) were expressed after infection by live tachyzoites . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Progressive induction of chemokine gene expression was observed for IP 10 , MIP 2 , MIP 1alpha , MIP 1beta , MCP 1 , and RANTES peaking at 12 h with subsequent decrease . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Considering its mode of action and anti inflammatory properties , PMS 601 interferes with early and late steps of the HIV biological cycle and decreases the synthesis of PAF , TNF alpha , MIP 1 alpha , MIP 1 beta and RANTES . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Moreover , constitutive IFN beta production by DCs increases the synthesis of IL 12 and IFN gamma Th 1 type cytokines and of the beta chemokines MIP 1alpha , MIP 1beta , and RANTES . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
A29S displayed an unusual pharmacological profile , binding and responding to MCP 2 similarly to wtCCR 5 , but exhibiting severely impaired binding and functional responses to MIP 1alpha , MIP 1beta , and RANTES . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The potential CD26 / DPP 4 substrate macrophage inflammatory protein 1beta ( MIP 1beta ) and the related chemokine , LD78alpha ( ie , one of the MIP 1alpha isoforms ) , were not affected by this protease . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The chemokine mRNAs encoding JE , MIP 1alpha , MIP 1beta , KC , and MIP 2 were all mainly expressed at 15 and / or 30 days p . i . and diminished thereafter . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Chemokine receptors have been identified as coreceptors for viral entry into susceptible target cells , and several members of the beta chemokine subfamily of cytokines , MIP 1alpha , MIP 1beta , and RANTES , have been identified as the major human immunodeficiency virus ( HIV ) suppressive factors produced by activated CD8+ T lymphocytes . ^^^ In macrophages , HIV 1 infection itself was shown to upregulate the production of MIP 1alpha and MIP 1beta . ^^^ NOS inhibitors also decreased MIP 1alpha and MIP 1beta production by phytohemagglutinin stimulated monocyte depleted PBMC cultures . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Our data support the thesis that RANTES , MIP 1alpha , and MIP 1beta production is associated with decreased in vivo virus load . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
RANTES , macrophage inflammatory protein 1alpha ( MIP 1alpha ) , and MIP 1beta inhibited infection of intestinal lymphocytes by BaL , indicating that R 5 infection of the intestinal lymphocytes was mediated by CCR 5 . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Here , we analyzed the effect of extracellular Vpr as well as the virion associated Vpr on beta chemokines ( MIP 1alpha , MIP 1beta , and RANTES ) production in human macrophages and primary lymphocytes ( PBLs ) . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
We next evaluated the functionality of these chemokine receptors by calcium flux and chemotaxis assays , and by the ability of SDF 1 , MIP 1alpha , MIP 1beta and RANTES to influence the growth of the cells expressing CXCR 4 and / or CCR 5 . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Here we show that influenza A or Sendai virus infected human macrophages produce MIP 1alpha , MIP 1beta , RANTES , MCP 1 , MCP 3 , MIP 3alpha , IP 10 , and IL 8 , whereas no upregulation of MIP 3beta , eotaxin , or MDC production was detected . ^^^ Influenza A virus was a better inducer of MCP 1 and MCP 3 production than Sendai virus , whereas MIP 1alpha , MIP 1beta , RANTES , MIP 3alpha , and IL 8 were induced preferentially by Sendai virus . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
We report here that treating monocyte derived macrophages ( MDM ) with a trimeric soluble form of CD40L ( CD40LT ) induced them to secrete high levels of the beta chemokines RANTES , MIP 1alpha and MIP 1beta that are ligands for CCR 5 and able to inhibit HIV 1 entry . ^^^ The inhibitory activity appeared to be due to beta chemokines present in the supernatant , since pretreating them with a cocktail of antibodies to RANTES , MIP 1alpha and MIP 1beta neutralized the inhibitory activity of the supernatants . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
RNase protection analysis of RNA isolated from the BAL fluid of RacL 11 infected mice on day 3 postinfection revealed much higher levels of RNA specific for macrophage inflammatory protein 1alpha ( MIP 1alpha ) , MIP 1beta , and MIP 2 than were observed for KyA infected mice . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The mRNAs for MIP 1alpha and MIP 1beta were found to be upregulated with peak values at day 13 post immunization ( p . i . ) , preceding maximum disease severity . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Spinal cords from SJL mice primed with proteolipid protein peptide 139 151 ( pPLP ) expressed the chemokines RANTES , MCP 1 , MIP 2 , KC , MIP 1alpha , MIP 1beta , Mig , and fractalkine . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The chemokine ligands for CCR 5 , RANTES and MIP 1beta , also potently inhibited HIV 1 infection in microglia , but the third ligand MIP 1alpha failed to show inhibition . ^^^ Interestingly , when microglial cultures were treated with antibodies specific to each of these chemokines , HIV 1 infection was enhanced by anti RANTES and anti MIP 1beta , but not by anti MIP 1alpha . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Labeled MIP 1alpha binding was also antagonized by unlabeled MCP 3 , which is also recognized by CCR 1 , and MIP 1beta , which is a ligand for CCR 5 . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
In addition , low levels of MIP 1alpha and MIP 1beta were induced following treatment with MIP 2 or KC . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
To investigate the immunological features of human T lymphotropic virus type 2 ( HTLV 2 ) infection and specific mechanisms whereby HTLV 2 might influence the progression of HIV 1 disease in coinfected individuals , we have analyzed the production of the C C chemokines RANTES and macrophage inflammatory proteins 1alpha and 1alpha ( MIP 1alpha and MIP 1beta ) by PBMCs from HTLV 2 infected and HTLV II / HIV 1 coinfected individuals . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Donor and recipient cornea was examined by quantitative competitive reverse transcription polymerase chain reaction ( RT PCR ) for hypoxyanthine phosphoribosyltransferase ( HPRT ) , CD 3 , CD 25 , interleukin ( IL ) 1beta , IL 1RA , IL 2 , IL 6 , IL 10 , interferon gamma ( IFN gamma ) , tumor necrosis factor ( TNF ) , transforming growth factor ( TGF ) beta 1 , and macrophage inflammatory protein ( MIP ) 2 and by nonquantitative RT PCR for IL 4 , IL 5 , IL 12 p 40 , IL 13 , TGF beta 2 , monocyte chemotactic protein 1 ( MCP 1 ) , MIP 1alpha , MIP 1beta , and RANTES ( for regulated upon activation normal T cell expressed and secreted ) . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Since these cytokines induce expression of the chemokines , MIP 1alpha , MIP 1beta , RANTES , and SDF 1 , all of which inhibit viral infectivity , we were interested to determine if Product R also alters chemokine expression . ^^^ We have therefore utilized H 9 cells to test the effects of Product R on expression of mRNAs encoding the chemokine receptors , CD 4 , CXCR 4 and CCR 5 , as well as their ligands , IL 16 , SDF 1 , MIP 1alpha , MIP 1beta , and RANTES , by RT PCR . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Macrophage inflammatory protein 1alpha ( MIP 1alpha ) , MIP 1beta , and RANTES mRNA semiquantification and protein expression in active demyelinating multiple sclerosis ( MS ) lesions . ^^^ Since chemokines play a major role in the migration of monocytes and T cells , we here investigated the expression of the CC chemokines MIP 1alpha , MIP 1beta , and RANTES in brain tissue from MS patients using reverse transcriptase polymerase chain reaction techniques . ^^^ Immunohistochemistry revealed that , whereas RANTES was mainly localized in reactive astrocytes , MIP 1alpha and MIP 1beta immunoreactivity was predominantly found in perivascular and parenchymal macrophages , containing myelin degradation products . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
To test the hypothesis that beta chemokine levels may be relevant to the control of HIV in vivo , we compared RANTES , MIP 1alpha , and MIP 1beta production from purified CD 8 ( + ) T cells from 81 HIV infected subjects and from 28 uninfected donors . ^^^ Asymptomatic HIV ( + ) subjects produced significantly higher levels of MIP 1alpha and MIP 1beta , but not RANTES , than uninfected donors or patients that progressed to AIDS . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Peripheral blood lymphocytes and T cell clones produced nanogram quantities of the chemokines RANTES , MIP 1alpha , MIP 1beta , MCP 1 , IL 8 and GRO alpha as well as the motogenic cytokine HGF . ^^^ RANTES , MIP 1alpha , MIP 1beta , IL 8 , GRO alpha and lymphotactin did not augment the development of motile forms including the size and appearance of the pseudopodia activity of the T leukemia cell lines . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The amount of DC transmigrated through a monolayer of EC was increased of 2 3 fold by C C chemokines RANTES , MIP1alpha , and MIP 1beta . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
MIP 1alpha and MIP 1beta were present only at low levels , even after stimulation with IL 1beta and TNF alpha . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Using RNase protection assays , we determined that mast cells exposed in vitro to low passage number , but not high passage number , B . burgdorferi spirochetes show increased expression of additional mRNAs representing several chemokines , including macrophage inflammatory protein 1alpha ( MIP 1alpha ) , MIP 1beta , and TCA 3 , as well as the proinflammatory cytokine interleukin 6 . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
In this study we demonstrate that cross linking of LFA 1 using a monoclonal antibody results in the secretion of MIP 1alpha and MIP 1beta . ^^^ This contact was shown to be inhibited by the introduction of neutralizing antibodies to MIP 1alpha and MIP 1beta . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Gene expression and production of tumor necrosis factor alpha , interleukin 1beta ( IL 1beta ) , IL 8 , macrophage inflammatory protein 1alpha ( MIP 1alpha ) , MIP 1beta , and gamma interferon inducible protein 10 by human neutrophils stimulated with group B meningococcal outer membrane vesicles . ^^^ We found that PMN stimulated in vitro by OMV produce proinflammatory cytokines and chemokines including tumor necrosis factor alpha ( TNF alpha ) , interleukin 1beta ( IL 1beta ) , IL 8 , macrophage inflammatory protein 1alpha ( MIP 1alpha ) , and MIP 1beta . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
MIP 1alpha , MIP 1beta , IL 8 ) , proinflammatory cytokines ( TNF alpha , GM CSF and IL 6 ) and TGF beta by human enterocytic Caco 2 cells . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
In this study , we demonstrate that intranasal infection of BALB / c mice with RSV A results in inducible expression of lung chemokines belonging to the CXC ( MIP 2 and IP 10 ) , CC ( RANTES , eotaxin , MIP 1beta , MIP 1alpha , MCP 1 , TCA 3 ) and C ( lymphotactin ) families . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Recently we reported that the chemokines MIP 1alpha , MIP 1beta , and RANTES secreted by BM derived CD 34 ( + ) cells may compete with the macrophagotropic HIV ( R 5 HIV ) strain for the CCR 5 coreceptor . ^^^ In this study we extended our previous observations and examined various lympho hematopoietic CD 34 ( + ) cells isolated from thymus ( Th ) , cord blood ( CB ) , mobilized peripheral blood ( mPB ) , and BM for the expression of beta chemokines binding to CCR 5 , i . e . , MIP 1alpha , MIP 1beta , RANTES , MCP 2 , MCP 3 , and MCP 4 , and the alpha chemokine SDF 1 ( binding to CXCR 4 ) as these chemokines may compete with the R 5 and X 4 HIV strains , respectively , for entry into cells . ^^^ Using sensitive ELISA assays we found that although MIP 1alpha and MIP 1beta proteins were secreted by all the lympho hematopoietic CD 34 ( + ) cells tested , RANTES was detectable only in media conditioned by BM and CB derived CD 34 ( + ) cells and not Th derived cells . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Messenger RNA for lymphotactin , RANTES , MIP 1alpha , and MIP 1beta , but not IP 10 , monocyte chemotactic protein ( MCP ) 1 , IL 8 , or 1 309 was expressed in all 3 NK cell subsets . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
These studies have shown that immature DC respond to many CC and CXC chemokines ( MIP 1 alpha , MIP 1 beta , MIP 3 alpha , MIP 5 , MCP 3 , MCP 4 , RANTES , TECK and SDF 1 ) which are inducible upon inflammatory stimuli . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
In vitro studies demonstrate that macrophages exposed to CpG ODN up regulate expression of mRNA encoding the chemokines MIP 1alpha , MIP 1beta , MIP 2 , RANTES , JE / MCP 1 , and IP 10 . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
DESIGN : The CC chemokines RANTES , MIP 1alpha and MIP 1beta are ligands for CCR 5 , which has been identified as the principal co receptor for macrophage tropic strains of HIV 1 . ^^^ This study investigated whether the inducible levels of RANTES , MIP 1alpha and MIP 1beta produced by cultured whole blood samples related to different rates of progression of HIV infection and to the introduction of Nelfinavir based highly active anti retroviral therapy ( HAART ) . ^^^ MIP 1alpha , MIP 1beta and RANTES production was determined using commercial ELISA kits . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Cells susceptible to infection by these viruses can be protected by treatment with the CCR 5 ligands regulated on activation , normal T cell expressed and secreted ( RANTES ) , MIP 1alpha , and MIP 1beta . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Hyphal cells proved to be much less efficient than yeast cells in stimulating production of macrophage inflammatory protein 1alpha ( MIP 1alpha ) , MIP 1beta , interleukin 8 ( IL 8 ) , and particularly , monocyte chemotactic protein 1 ( MCP 1 ) by human monocyte . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Synovial tissue expression of the chemokines interleukin 8 ( IL 8 ) , monocyte chemotactic protein 1 ( MCP 1 ) , macrophage inflammatory protein 1alpha ( MIP 1alpha ) , MIP 1beta , Groalpha , and RANTES was also determined . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Endogenous levels of C C chemokines MIP 1alpha , MIP 1beta , and RANTES do not reflect the disease course in HIV seropositive individuals . ^^^ Instead , disease controls exhibited significantly more MIP 1alpha and MIP 1beta than normals or HIV patients . ^^^ In conclusion , endogenous levels of MIP 1alpha , MIP 1beta , and RANTES do not reflect the hypothesized protective effect on disease progression in HIV infection . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
RESULTS : Our main findings in CHF were : 1 ) markedly raised gene expression of macrophage inflammatory protein ( MIP ) 1alpha , MIP 1beta and interleukin ( IL ) 8 ; 2 ) enhanced gene expression of their corresponding receptors ; 3 ) modulation in a normal direction of this abnormal chemokine and chemokine receptor gene expression during IVIg , but not during placebo therapy ; 4 ) down regulation of MIP 1alpha , MIP 1beta and IL 8 during IVIg at the protein level in plasma ; and 5 ) a correlation between down regulation of MIP 1alpha gene expression and improved LVEF during IVIg therapy . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
RANTES induces rapid expression of transcripts for the CXC chemokines KC and macrophage inflammatory protein ( MIP ) 2 , the CC chemokines MIP 1beta and MIP 1alpha , and the cytokines TNF alpha and IL 6 . ^^^ Although DC demonstrated weak responses to eotaxin , DC failed to respond to other chemokines including KC , MIP 2 , stromal derived factor 1alpha , MIP 1beta , MIP 1alpha , monocyte chemoattractant protein 1 , T cell activation gene 3 , or thymus derived chemotactic agent 4 . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
BACKGROUND : MCP 1 , MIP 1 alpha and MIP 1 beta are CC chemokines , which act as chemoattractants for inflammatory cells like macrophages , lymphocytes and eosinophils . ^^^ The MCP 1 , MIP 1 alpha and MIP 1 beta levels were measured in induced sputum via ELISA method . ^^^ CONCLUSIONS : MIP 1 alpha maybe important for development of chronic bronchitis and MIP 1 beta for development of chronic obstructive pulmonary disease . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Our data showed that phagocytosis of apoptotic / necrotic tumor cells resulted in maturation of DCs with up regulated expression of proinflammatory cytokines [ interleukin ( IL ) 1beta , IL 6 , tumor necrosis factor alpha , interferon gamma and granulocyte macrophage colony stimulating factor ] , chemokines ( MIP 1alpha , MIP 1beta and MIP 2 ) , the CC chemokine receptor CCR 7 and the cell surface molecules ( MHC class 2 , CD11b , CD 40 and CD 86 ) , and down regulated expression of the CC chemokine receptors CCR 2 and CCR 5 . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The suppressive activity could be blocked by monensin and brefeldin A , was heat labile , and appeared in a pattern different from that of secretion of chemokines ( MDC , 1 309 , MIP 1alpha , MIP 1beta , and RANTES ) , cytokines ( gamma interferon , tumor necrosis factor alpha , and granulocyte macrophage colony stimulating factor ) , and interleukins ( interleukin 13 and interleukin 16 ) . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The family includes the inflammatory cytokines such as the interleukins and interferons , growth factors such as epidermal and hepatocyte growth factor and chemokines such as the macrophage inflammatory proteins , MIP 1alpha and MIP 1beta . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
In addition the beta chemokines RANTES ( regulated on activation T cell expressed and secreted ) , macrophage inflammatory protein 1 alpha ( MIP 1alpha ) , and MIP 1beta can block HIV 1 entry into cells by preventing the binding of the macrophage trophic HIV 1 strains to the coreceptor CCR 5 . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
In a prospective study using flow cytometry , we examined percentages of blood mononuclear cells ( MNC ) expressing the chemokines RANTES , MCP 1 , MIP 1alpha , MIP 1beta , and IL 8 , the chemokine receptor CCR 5 , the T cell activation marker CD 25 , and the T cell chemoattractant IL 16 in patients with WAD and , for reference , in healthy controls . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Differential mRNA expression analysis and RNase protection assays revealed that macrophage inflammatory protein 1alpha ( MIP 1alpha ) , MIP 1beta , MIP 2 , and monocyte chemoattractant protein 1 are fibrinogen inducible in the RAW264 . 7 mouse macrophage like cell line , and ELISA confirmed that both RAW264 . 7 cells and primary murine thioglycolate elicited peritoneal macrophages up regulate the secretion of monocyte chemoattractant protein 1 > 100 fold upon exposure to fibrinogen . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Using filters coated with collagen ( 20 microg / mL ) , results showed that the chemokines differed in their ability to elicit cell movement according to the order MIP 1beta > RANTES MIP 1alpha . ^^^ Our results suggest that the migratory response to CCR 5 stimulation may vary quantitatively with both the CCR 5 ligand ( MIP 1alpha , MIP 1beta , and RANTES ) , as well as the nature and concentration of the ECM substrate involved . . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The influx of T cells , macrophages , and neutrophils was dramatically dampened as was the production of the inflammatory cytokines interferon gamma and tumor necrosis factor alpha and the chemokines monocyte chemotactic protein 1 , macrophage inflammatory protein 1alpha ( MIP 1alpha ) , MIP 1beta , and lymphotactin , normally upregulated in the lung during IPS . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
MIP 1 alpha and MIP 1 beta induction by dengue virus . ^^^ Two cellular factors , MIP 1 alpha and MIP 1 beta , have been found to be induced by infection with DV . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Enhanced production of CC chemokines ( RANTES , MCP 1 , MIP 1alpha , MIP 1beta , and eotaxin ) in patients with atopic dermatitis . ^^^ Spontaneous production of RANTES , MCP 1 , MIP 1alpha and MIP 1beta by PBMC was augmented in AD patients ( n = 39 ) and in patients with severe AD ( n = 14 ) compared with normal controls ( n = 20 ) . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
CpG ODN rapidly up regulated their production of IL 1beta , IL 6 , IL 12 , TNFalpha , MIP 1alpha and / or MIP 1beta . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Most of these genes encoded proteins involved in cell migration and homing , including the chemokines interleukin ( IL ) 8 , osteopontin , monocyte chemotactic protein 1 ( MCP 1 ) , macrophage inflammatory protein 1alpha ( MIP 1alpha ) , regulated on activation , normal , T cell expressed and secreted ( RANTES ) , MIP 1beta , MIP 3alpha , myeloid progenitor inhibitory factor 1 ( MPIF 1 ) , pulmonary and activation regulated chemokine ( PARC ) , growth regulated gene beta ( GRO beta ) , GRO gamma , MCP 2 , 1 309 , and the T helper 2 ( Th 2 ) and eosinophil attracting chemokine , eotaxin . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Several potential mechanisms for expansion of HIV 1 in situ were found , including augmentation in expression of tumor necrosis factor ( TNF ) alpha and the HIV 1 noninhibitory beta chemokine ( MCP 1 ) , low presence of HIV 1 inhibitory beta chemokines ( MIP 1 alpha , MIP 1 beta , and RANTES [ regulated on activation , normal T expressed and secreted ] ) , and upregulation in expression of the HIV 1 coreceptor , CCR 5 , by pleural fluid mononuclear cells . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Coincidentally , both macrophage inflammatory protein 1alpha ( MIP 1alpha ) and MIP 1beta mRNA expression increased in the lungs after immunization with Ag plus CT , while only MIP 1beta expression increased when mice were given influenza Ag alone . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Viral entry can be inhibited by the natural ligands for CXCR 4 , the CXC chemokine SDF 1 and CCR 5 , the CC chemokines RANTES , MIP 1alpha and MIP 1beta . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Then the mRNA expression of the following cytokines was measured by RT PCR method in the GSM 06 cells : proinflammatory cytokine IL 1 beta , and chemokine RANTES , eotaxin , MCP 1 , MIP 1 alpha and MIP 1 beta . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Blood samples from animals showing high levels of cytokines were also tested for the chemokines : MCP 1 , IL 1beta , MIP 1alpha , MIP 1beta , IP 10 , and RANTES . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
These studies revealed that Mig ( monokine induced by gamma interferon ) , cytokine responsive gene 2 / 10 kDa interferon inducible protein , RANTES , lymphotactin , macrophage inflammatory protein 1beta ( MIP 1beta ) , JE / monocyte chemoattractant protein 1 , and MIP 2 are associated with type 1 egg induced responses and that thymus derived chemotactic agent 3 ( TCA 3 ) , eotaxin , MIP 1alpha , and MIP 1gamma are associated with type 2 egg induced responses . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Our novel findings indicate that independently of their coreceptor phenotype and independently of virus replication , exposure to certain R 5 and X 4 HIV 1 species induced secretion of high levels of macrophage inflammatory protein 1alpha ( MIP 1alpha ) , MIP 1beta , RANTES , and tumor necrosis factor alpha . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
We then examined HIV infection , HIV receptor ( CD 4 , CCR 5 ) expression , and beta chemokine [ macrophage inflammatory protein 1alpha and 1beta ( MIP 1alpha , MIP 1beta ) ] production by placental cord monocyte derived dendritic cells ( MDDC ) as compared to that of autologous cord monocyte derived macrophages ( MDM ) . ^^^ This limited susceptibility of cord MDDC to M tropic HIV infection may be due to lower expression of CD 4 and CCR 5 on the cell membrane and higher production of MIP 1alpha and MIP 1beta . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Cultured neurons constitutively produced interleukin 1 ( IL 1 ) , IL 6 , macrophage inflammatory protein 1alpha ( MIP 1alpha ) , and MIP 1beta but not transforming growth factor beta 1 ( TGF beta 1 ) , IL 10 , and granulocyte macrophage colony stimulating factor . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
These cells decreased gradually after BMT TNF alpha mRNA and mRNA of C C chemokine families , including MCP 1 , IP 10 , MIP 1alpha , MIP 1beta , and RANTES , were upregulated in the twi / twi CNS but downregulated gradually following BMT . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
RNase protection studies , however , revealed that the production of most chemokines , including MIP 2 , MIP 1alpha , MIP 1beta , and eotaxin , tended to decline with age . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Apoptosis of Mac 1 ( high ) peritoneal macrophages was observed within 0 . 5 h of mFasL VP injection and correlated with the detection of increased macrophage inflammatory protein ( MIP ) 2 levels in peritoneal lavage fluid as well as induced RNA expression of IL 1beta , MIP 2 , MIP 1alpha , and MIP 1beta . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Of the chemokines tested ( MIP 1alpha , MIP 1beta , MCP 1 , MCP 3 , RANTES , SDF 1 , IL 8 , IP 10 ) , only MIP 1alpha , detected specifically on microglia , was expressed both constitutively and consistently . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
MCP 1 , MIP 1alpha and MIP 1beta were constitutively expressed in 1 day cultured monocytes , and their secretion increased with time in culture despite any change in mRNA accumulation . ^^^ In contrast , MIP 1alpha and MIP 1beta secretion was up regulated by IFN beta only in MDM . ^^^ Although MCP 1 , MIP 1alpha and MIP 1beta mRNA expression was up regulated by IFN beta in both 1 day cultured monocytes and MDM , no correlation was found between mRNA level and protein secretion . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
MIP 1alpha preferentially mediates chemotaxis of CD 8 rather than CD 4 lymphocytes , whereas the reverse is true for MIP 1beta . ^^^ We measured the concentrations of MIP 1alpha and MIP 1beta in bronchoalveolar lavage fluid ( BALF ) of 30 subjects affected by different stages of pulmonary sarcoidosis and 18 healthy normal subjects . ^^^ The MIP 1beta concentrations correlated with the number of total ( r = 0 . 65 , p = 0 . 0001 ) and both CD 4 ( r = 0 . 64 , p = 0 . 0001 ) and CD 8 ( r = 0 . 62 , p = 0 . 0001 ) lymphocytes ; on the contrary , the MIP 1alpha concentrations correlated only with CD 8 lymphocytes ( r = 0 . 45 , p = 0 . 002 ) . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Increased levels of interferon ( IFN ) alpha , IFN beta , interleukin ( IL ) 6 , IL 18 , MIP 1alpha , and MIP 1beta were observed in all EBOV infected monkeys , indicating the occurrence of a strong proinflammatory response . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
An increased production of both spontaneous and lectin induced RANTES , MIP 1alpha , and MIP 1beta was found at baseline in HIV infected individuals . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The presence of chemokine receptor ( CCR 5 , CXCR 3 , CCR 3 ) positive cells and chemokine ( MCP 1 , MIP 1alpha , MIP 1beta , IP 10 ) positive cells in human periapical granulomas . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
CD40L induced the activation of mitogen activated protein kinases ERK1 / ERK2 and stimulated MDMs to secrete RANTES ( regulated on activation , normal T cell expressed and secreted ) , macrophage inflammatory protein 1alpha ( MIP 1alpha ) , MIP 1beta , interleukin 6 ( IL 6 ) , IL 1beta , and tumor necrosis factor alpha . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
HIV 1 infected subjects had higher percentages of MIP 1alpha and MIP 1beta positive CD 4 ( + ) and CD 8 ( + ) T cells ( p < 0 . 02 ) and of RANTES positive CD 8 ( + ) T cells ( p = 0 . 054 ) than uninfected controls . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
This strategy was tested in peptides ranging from 28 to 70 amino acid residues , including analogues of somatostatins and two CC chemokines MIP 1alpha and MIP 1beta . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Expression of RANTES , eotaxin , MIP 1 alpha , MIP 1 beta , IP 10 , and MCP 1 was upregulated by day 7 after infection . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
METHODS : In 98 patients infected with Helicobacter pylori , mucosal mRNA expression rates of cytokines ( IL 1 beta , IL 6 , and IL 10 ) , C C chemokines ( macrophage inflammatory protein 1 alpha ( MIP 1 alpha ) , and macrophage inflammatory protein 1 beta ( MIP 1 beta ) , monocyte chemotactic and activating factor ( MCAF ) , regulated on activation , normal T cell expressed and presumably secreted ( RANTES ) ) and C 10 C chemokines ( IL 8 and growth regulated a ( GRO alpha ) ) were examined using reverse transcription polymerase chain reaction ( RT PCR ) . ^^^ After eradication of H . pylori , expressions of mRNA for three cytokines ( IL 1 beta , IL 6 and IL 10 ) , four C C chemokines ( MIP 1 alpha , MIP 1 beta , MCAF and RANTES ) and two C 10 C chemokines ( IL 8 and GRO alpha ) were significantly decreased . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
We investigated the effects of a number of naturally occurring chemokines ( MIP 1alpha , MIP 1beta , RANTES , MCP 2 , MCP 3 , MCP 4 ) on different processes linked to the chemokine receptor CCR 5 in recombinant CHO cells expressing the receptor at different levels . 2 . ^^^ Internalization of CCR 5 following chemokine treatment was studied and MIP 1alpha , MIP 1beta and RANTES ( 50 nM ) were able to induce internalization ( similar 50 % ) of the receptor . ^^^ Phosphorylation of CCR 5 following chemokine treatment was studied and MIP 1alpha , MIP 1beta and RANTES ( 50 nM ) were able to induce phosphorylation of CCR 5 whereas the other chemokines did not induce CCR 5 phosphorylation . 4 . ^^^ MIP 1alpha , MIP 1beta , RANTES and MCP 2 were able to stimulate [ ( 35 ) S ] GTPgammaS binding , an index of receptor / G protein activation , whereas MCP 3 and MCP 4 had no effect in this assay . ^^^ MCP 2 was a partial agonist ( similar 80 % ) compared to MIP 1alpha , MIP 1beta and RANTES , which gave similar maximal stimulations in this assay . 5 . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The chemokines monocyte chemotatic protein 1 ( MCP 1 ) , MCP 3 , macrophage inflammatory protein 1alpha ( MIP 1alpha ) , MIP 1beta , MIP 1gamma , regulated upon activation normal T cell expressed and secreted , eotaxin , interferon inducible protein of 10 kDa , growth regulated oncogene , lymphotactin , and fractalkine were all expressed in the PMSG primed rat ovary 6 h post human CG . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Furthermore , using neutralizing antibodies we could show that inhibition by the beta chemokines MIP 1alpha , MIP 1beta , and RANTES and the inhibitory effect of CD8+ lymphocytes on nef mutant SIVmac viruses are harbored on different levels . . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
RANTES , macrophage inflammatory protein 1 alpha ( MIP 1 alpha ) , and MIP 1 beta were the major beta CK produced in response to M . tuberculosis infection . ^^^ Virulent M . tuberculosis ( H37Rv ) induced significantly less MIP 1 alpha than did the avirulent strain ( H37Ra ) , while MIP 1 beta and RANTES production was comparable for both strains . ^^^ MIP 1 alpha and MIP 1 beta were induced by the membrane , but not cytosolic , fraction of M . tuberculosis . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
LPS stimulated cultures produced 3 to 10 times higher levels of MIP 1alpha , MIP 1beta and RANTES than unstimulated cultures . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The functional consequence of rNef treatment of immature DCs is a decrease in their endocytic and phagocytic activities and an increase in cytokine ( IL 1beta , IL 12 , IL 15 , TNF alpha ) and chemokine ( MIP 1alpha , MIP 1beta , IL 8 ) production as well as in their stimulatory capacity . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Constitutive induction of IL 8 , MIP 1alpha , MIP 1beta , MCP 1 and regulated on activation , normal T cell expressed , and secreted ( Rantes ) was detected in cryostat sections of embryonic forebrains in an age dependent manner . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
In this study we demonstrate that treatment of BALB / c mice with perflubron intranasally 6 hours after RSV infection significantly inhibited lung cellular inflammation as well as the expression of the chemokines RANTES , MIP 1 alpha , MIP 1 beta , and MIP 2 , compared with phosphate buffered saline treated control mice . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Using primary monocyte derived macrophages and primary adult astrocytes as a model , amyloid beta ( Abeta ) ( 1 42 ) was able to stimulate the production , as measured by RT PCR , of MIP 1alpha and MIP 1beta mRNA in macrophages and MCP 1 in astrocytes . ^^^ Cocultures showed in unstimulated as well as in Abeta stimulated cells an increase in MIP 1alpha , MIP 1beta and MCP 1 mRNA . ^^^ ELISAs of supernatant samples of stimulated macrophages and astrocytes also showed an increase in MIP 1alpha and MIP 1beta in macrophages and MCP 1 in astrocytes . ^^^ Stimulated cocultures showed an increase in MIP 1alpha , MIP 1beta and MCP 1 protein levels in contrast to unstimulated cocultures . . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Binding of UV inactivated HIV 1 elevates MCP 1 , RANTES , MIP 1alpha , MIP 1beta , and IL 8 expression , but fails to alter the production of IP 10 , suggesting that the induction of IP 10 is dependent on downstream events following viral internalization . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
There was no significant difference in the mRNA expression of the lymphokines IL 2 , 4 , 5 , 8 , 9 , 10 , 14 , 15 , or chemokines MIP 1alpha , MIP 1beta , MCP 1 , and Ltn . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Bovine immunodeficiency virus expression in vitro is reduced in the presence of beta chemokines , MIP 1alpha , MIP 1beta and RANTES . ^^^ The inhibition of HIV expression in vitro by a cocktail of the beta chemokines MIP 1alpha , MIP 1beta and RANTES provided the initial evidence that HIV utilizes chemokine receptors as co receptors for infection of cells . ^^^ The purpose of this study was to determine whether MIP 1alpha , MIP 1beta and RANTES affect BIV expression in vitro , as a prelude to identifying the cellular receptors utilized by this virus . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
In contrast , the expression of CCR 5 in spleens and MIP 1alpha / MIP 1beta in tumor masses was marginally induced before and even after IL 12 treatment in the Meth A model in which T cell migration is not observed . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The beta chemokines , RANTES , MIP 1alpha and MIP 1beta , have been implicated as being some of the protective factors in the immune response against human immunodeficiency virus ( HIV ) infection . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Normal unstimulated human microglia expressed constitutively mRNA transcripts for interleukin 1beta ( IL 1beta ) 6 , 8 , 10 , 12 , 15 , tumor necrosis factor alpha ( TNF alpha ) , macrophage inflammatory protein 1alpha ( MIP 1alpha ) , MIP 1beta , and monocyte chemoattractant protein 1 ( MCP 1 ) , while treatment with lipopolysaccharide ( LPS ) or amyloid beta peptides ( Abeta ) led to increased expression of mRNA levels of IL 8 , IL 10 , IL 12 , TNF alpha , MIP 1alpha , MIP 1beta , and MCP 1 . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
We found that stimulation with GM CSF or M CSF induced macrophage inflammatory proteins ( MIP 1alpha and MIP 1beta ) and augmented RANTES expression , after HIV 1 infection of microglia . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Stimulation of astrocytes with 1 nM RANTES or 3 10 nM of the structurally related chemokines ( eotaxin , macrophage inflammatory protein 1alpha and beta [ MIP 1alpha , MIP 1beta ] ) induced transcripts for KC , monocyte chemoattractant protein 1 ( MCP 1 ) , tumor necrosis factor alpha ( TNF alpha ) , MIP 1alpha , MIP 2 , and RANTES in a chemokine and cell specific fashion . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Administration of neutralizing antibody to IL 1alpha significantly reduced ear swelling and suppressed the levels of MIP 2 , MIP 1alpha , MIP 1beta , and RANTES . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Using synthetic RNA standards , we quantified mRNAs of IL 2 , IL 4 , IL 6 , IL 10 , IL 12 p 40 , interferon gamma ( IFN gamma ) , tumor necrosis factor alpha ( TNF alpha ) , RANTES , macrophage inflammatory protein 1 alpha ( MIP 1 alpha ) , and MIP 1 beta in unstimulated peripheral blood mononuclear cells ( PBMCs ) and lymph nodes from macaques chronically infected with SIV or SHIV . ^^^ In addition , MIP 1 alpha , MIP 1 beta , and RANTES mRNA expression increased in viremic monkeys with decreased CD 4 ( + ) T cell counts ; gene expression was inversely correlated with CD 4 ( + ) T cell counts , but not viral load . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Migration of CD 8 T cells in response to MIP 1alpha , MIP 1beta , and RANTES was significantly reduced in HCV infected patients ( P < . 05 ) . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Indeed , in addition to specific immunity , including significant SIgA antibody secreting cells in the iliac lymph nodes , CD 8 suppressor factor and the 3beta chemokines ( RANTES , MIP 1alpha and MIP 1beta ) are significantly associated with protection against rectal mucosal SIV infection . . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
In contrast , other investigated chemokines ( growth related oncogene alpha , interleukin 8 , epithelial derived neutrophil attractant 78 , 1 309 , MIP 1 alpha , and MIP 1 beta ) were minimally expressed or absent . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The higher RANTES production by MS gamma delta T cell lines , together with a lower expression of CCR 5 , may reflect an autoregulatory loop , caused by an increased production of its ligands ( RANTES , MIP 1 alpha , and MIP 1 beta ) or due to other pro inflammatory cytokines . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The capacity of CD8+ and CD4+ T cells and CD14+ monocytes to generate the CC chemokines , RANTES , MIP 1alpha and MIP 1beta , and SIV suppressor factors were studied using cells separated from PBMC of macaques immunized with the 70 kDa heat shock protein ( HSP 70 ) . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Secretion of MIP 1alpha and MIP 1beta correlated well with the ability of myeloma cells to enhance osteoclastic bone resorption both in vitro and in vivo as well as in MM patients . ^^^ In osteoclastogenic cultures of rabbit bone cells , cocultures with myeloma cells as well as addition of myeloma cell conditioned media enhanced both formation of osteoclastlike cells and resorption pits to an extent comparable to the effect of recombinant MIP 1alpha and MIP 1beta . ^^^ Importantly , these effects were mostly reversed by neutralizing antibodies against MIP 1alpha and MIP 1beta , or their cognate receptor , CCR 5 , suggesting critical roles of these chemokines . ^^^ We also demonstrated that stromal cells express CCR 5 and that recombinant MIP 1alpha and MIP 1beta induce expression of receptor activator of nuclear factor kappaB ( RANK ) ligand by stromal cells , thereby stimulating osteoclast differentiation of preosteoclastic cells . ^^^ These results suggest that MIP 1alpha and MIP 1beta may be major osteoclast activating factors produced by MM cells . . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The production of MIP 1alpha , MIP 1beta , and RANTES proteins encompassing the induction of their mRNAs was confirmed by specific ELISA . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Elevated levels of secreted RANTES , MIP 1alpha , and MIP 1beta , but not IL 8 or ENA 78 , were observed following infection of KU 812 or HMC 1 human mast cell basophil lines . ^^^ Neither antibody enhanced dengue virus infection of the highly permissive U 937 monocytic cell line nor adenovirus infection of mast cells induced a RANTES , MIP 1alpha , or MIP 1beta response , demonstrating a selective mast cell response to dengue virus . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
MIP 1alpha and MIP 1beta levels were considerably elevated in a subgroup of patients with newly diagnosed diabetes . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Morphine sulfate induces the formation and expression of both forms of CCR 5 whereas RANTES , MIP 1alpha or MIP 1beta inhibits them . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Bell shaped dose responses for PACAP mediated release of chemokines into the culture medium were observed with EC ( 50 ) ' s of 3 10 10 ( 15 ) M ( RANTES : regulated upon activation normal T cell expressed and secreted ) , 3 10 10 ( 11 ) M ( MIP 1 beta ) and 10 ( 7 ) M ( MIP 1 alpha ) . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Role of the autocrine chemokines MIP 1alpha and MIP 1beta in the metastatic behavior of murine T cell lymphoma . ^^^ Here , we demonstrate that ESb MP cells are already responsive to the chemotactic activity of macrophage inflammatory protein 1alpha ( MIP 1alpha ) and MIP 1beta from 1 ng / ml onward . ^^^ Indeed , the major autocrine chemoattractants , isolated from ESb MP cells , were intact MIP 1alpha and MIP 1beta . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
We used radioligand binding and [ 35S ] GTPgammaS exchange assays in membranes from a cell line transfected to express CCR 1 ( Ba / F3 hCCR 1 ) to characterize a panel of chemokines ( HCC 1 , MIP 1alpha , MIP 1beta , MIP 1delta , MPIF 1 , MCP 2 , MCP 3 , and RANTES ) as CCR 1 ligands . ^^^ MPIF 1 was the more efficacious ( MPIF 1 > RANTES=MIP 1alpha > > MIP 1beta ) . 125I MIP 1beta binding in Ba / F3 hCCR 1 and HL 60 ( Rx ) membranes was competitively displaced by MIP 1alpha , MPIF 1 and MIP 1beta . ^^^ Lastly , MIP 1beta antagonized [ 35S ] GTPgammaS exchange , Ca2+ flux and chemotaxis in HL 60 ( Rx ) cells in response to robust agonists such as MIP 1alpha , RANTES and MPIF 1 . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The effects of these two preparations on the capacity of staphylococcal toxic shock syndrome toxin 1 ( TSST 1 ) to stimulate the production of cytokines ( IL 1beta , IL 6 , TNF alpha , IFN gamma ) and chemokines ( MIP 1alpha , MIP 1beta and MCP 1 ) by peripheral blood mononuclear cell ( PBMC ) was tested . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The effect of IL 10 in the culture supernatant of these cells was then evaluated by determining changes in the production of tumor necrosis factor alpha ( TNFalpha ) , macrophage inflammatory protein 1alpha ( MIP 1alpha ) , and MIP 1beta by macrophages . ^^^ The culture supernatant of these cells exerted the biologic activity of IL 10 , showing inhibition of TNFalpha , MIP 1alpha , and MIP 1beta production by macrophages . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Concentration of macrophage inflammatory proteins MIP 1 alpha and MIP 1 beta and interleukin 8 in erythema migrants ] . ^^^ The aim of present study was to evaluate concentrations of chemokines : interleukin 8 ( IL 8 ) and macrophage inflammatory protein 1 alpha and 1 beta ( MIP 1 alpha and MIP 1 beta ) in serum of patients with early clinical manifestation of Lyme borreliosis erythema migrans ( EM ) . ^^^ Mean serum concentrations of IL 8 , MIP 1 alpha and MIP 1 beta in examination 1 and of MIP 1 alpha and MIP 1 beta in examination 2 were significantly higher in comparison with control group . ^^^ These results show expression of IL 8 , MIP 1 alpha and MIP 1 beta in the course of EM and suggest their role in the inflammatory response to Borrelia burgdorferi infection . . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
However , the mRNA expressions of macrophage inflammatory protein 1alpha ( MIP 1alpha ) , MIP 1beta , interferon inducible protein 10 ( IP 10 ) , RANTES , lymphotactin and 1 309 were either very weak or undetectable . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
A number of inflammatory CC chemokines , including MIP 1 alpha , MIP 1 beta , RANTES , MCP 2 , and HCC 1 [ 9 74 ] act as CCR 5 agonists , while MCP 3 is a natural antagonist of the receptor . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The reduction of HIV 1 RNA plasma levels in late stage patients receiving protease inhibitors has been associated with increased concentrations of MIP 1alpha , MIP 1beta , RANTES and IL 16 and a decrease in levels of MCP 1 . ^^^ We determined plasma levels of MCP 1 , MIP 1alpha , MIP 1beta , RANTES and IL 16 during the first 16 weeks of highly active antiretroviral therapy ( HAART ) in chronic HIV 1 infected patients . ^^^ A significant increase was observed in the levels of MIP 1alpha and MIP 1beta in the NNRTI cohort ( P = 0 . 0010 and P = 0 . 0012 , respectively ) . ^^^ A significant decrease in levels of MIP 1alpha and MIP 1beta ( P = 0 . 0015 and P = 0 . 0299 , respectively ) was observed over the 16 weeks in the PI cohort . ^^^ A significant difference was seen when the levels of MIP 1alpha and MIP 1beta were compared between the NNRTI and the PI cohorts at week 16 ( P = 0 . 04 and P = 0 . 05 , respectively ) . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
MIP 1alpha and MIP 1beta differentially mediate mucosal and systemic adaptive immunity . ^^^ Macrophage inflammatory protein 1alpha ( MIP 1alpha ) and MIP 1beta are distinct but highly homologous CC chemokines produced by a variety of host cells in response to various external stimuli and share affinity for CCR 5 . ^^^ To better elucidate the role of these CC chemokines in adaptive immunity , we have characterized the affects of MIP 1alpha and MIP 1beta on cellular and humoral immune responses . ^^^ MIP 1alpha stimulated strong antigen ( Ag ) specific serum immunoglobulin G ( IgG ) and IgM responses , while MIP 1beta promoted lower IgG and IgM but higher serum IgA and IgE antibody ( Ab ) responses . ^^^ MIP 1alpha elevated Ag specific IgG 1 and IgG2b followed by IgG2a and IgG 3 subclass responses , while MIP 1beta only stimulated IgG 1 and IgG2b subclasses . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
At later time points , the expression of MIP 1alpha and MIP 1beta , but not of Ltn , was restored despite the inhibition of calcineurin activity . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Since both human MIP 1alpha subtypes ( LD78alpha and LD78beta ) and MIP 1beta signal through CCR 5 , the major co receptor for M tropic HIV 1 strains , these chemokines are capable of inhibiting HIV 1 infection in susceptible cells . ^^^ Macrophage inflammatory protein 1alpha ( MIP 1alpha ) and MIP 1beta are highly related members of the CC chemokine subfamily . ^^^ Despite their structural similarities , MIP 1alpha and MIP 1beta show diverging signaling capacities . ^^^ In this review , different aspects of human and mouse MIP 1alpha and MIP 1beta are discussed , including their protein and gene structures , their regulated production , their receptor usage and biological activities and their role in several pathologies including HIV 1 infection . . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Finally , KgI / gE / 75 and RacL 11 elicited the production of the proinflammatory chemokines MIP 1alpha , MIP 1beta , and MIP 2 in the lungs of infected mice , while KyA did not , suggesting that gI and / or gI and gE contribute to the up regulation of these mediators of inflammation . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Increases in MIP 1 alpha and MIP 1 beta were also observed in the supernatants of hPBMCs exposed to AMB . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
OBJECTIVE : To study glomerular expression of C C chemokines , monocyte chemoattractant protein 1 ( MCP 1 ) , macrophage inflammatory protein 1alpha and beta ( MIP 1alpha , MIP 1beta ) and the effect of steroid and cyclophosphamide ( CTX ) intermittent intravenous pulse therapy on expression in patients with crescentic glomerulonephritis ( CGN ) to further investigate the underlying mechanism of the treatment . ^^^ Expression of MCP 1 , MIP 1alpha , MIP 1beta , and CD 68 in glomeruli with cellular and fibrocellular crescents were examined by immunohistochemical analysis in serial sections of renal biopsies . ^^^ It was found that steroid and CTX intermittent intravenous pulse therapy reduced the expression of CD 68 , MCP 1 , and MIP 1alpha , but had no effect on MIP 1beta in glomeruli with cellular crescents of patients with LN CGN . ^^^ In patients with 5 CGN , the therapy also reduced the expression of CD 68 , but had no effect on MCP 1 , MIP 1alpha , and MIP 1beta in glomeruli with cellular crescents . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
In parallel with disease activity and the number of postinfection ( p . i . ) leukocytes , C57BL / 6 mice induced CRG 2 / IP 10 , MuMIG , RANTES , MCP 1 , MIP 1alpha , and MIP 1beta earlier and reached increased levels , as compared with BALB / c mice . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Viral entry can be inhibited by the natural ligands for CXCR 4 , the CXC chemokine SDF 1 and CCR 5 , the CC chemokines RANTES , MIP 1alpha and MIP 1beta , respectively . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Natural ligands for CCR 5 , MIP 1alpha , MIP 1beta and RANTES , have been shown to inhibit HIV replication in CD4+ T cells . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The presence of chemokine ( MCP 1 , MIP 1alpha , MIP 1beta , IP 10 , RANTES ) positive cells and chemokine receptor ( CCR 5 , CXCR 3 ) positive cells in inflamed human gingival tissues . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Most primary HIV strains use CCR 5 as a coreceptor and thereby are sensitive to inhibition by the CCR 5 ligand chemokines , RANTES , MIP 1alpha and MIP 1beta . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Finally , experiments performed with actinomycin D suggest that H ( 2 ) O ( 2 ) mediated MIP 1beta mRNA up regulation results from transcriptional control , whereas that of MIP 1alpha , MIP 2 , and monocyte chemoattractant protein 1 is due to both gene transcription activation and mRNA posttranscriptional stabilization . . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The antiviral activity of their natural ligands ( stromal cell derived factor 1 [ SDF 1 ] , regulated on activation normal T cell expressed and secreted , ( RANTES ) and macrophage inflammatory proteins 1alpha and 1beta , MIP 1alpha and MIP 1beta ) and the finding that individuals deficient in CCR 5 are relatively resistant to HIV infection led to the concept that chemokine receptor antagonists can play an important role in anti HIV therapy . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Trabecular bone biopsies were tested by immunohistochemistry to identify interleukin ( IL ) 8 , GRO alpha , MCP 1 , RANTES , MIP 1alpha and MIP 1beta expression . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
To analyse the role of CC chemokines in the pathogenesis of FHF , this study examined serum levels and intrahepatic expression of MCP 1 , MIP 1alpha , MIP 1beta , and RANTES in the livers and sera of patients with FHF and controls by ELISA , immunohistochemistry , and competitive RT PCR . ^^^ The functional relationship between intrahepatic chemokine release and infiltration was confirmed in chemotaxis assays by inhibiting chemotaxis induced by homogenates of liver tissue obtained from FHF patients with neutralizing MCP 1 , MIP 1alpha , MIP 1beta , and RANTES antibodies . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Xenograft rejection was associated with early intragraft transcript expression for monocyte chemotactic protein 1 ( MCP 1 ) ( 3 to 5 days ) , IP 10 ( 3 to 4 days ) and macrophage inflammatory protein 1alpha ( MIP 1alpha ) ( 3 to 5 days ) and subsequent expression of eotaxin ( days 4 to 10 ) , MIP 1beta ( days 4 and 5 ) and regulated on activation , normal T cell expressed and secreted ( RANTES ) ( days 4 to 6 ) mRNA . ^^^ This pattern was consistent with the early recruitment of macrophages ( MCP 1 , MIP 1alpha ) , the influx of CD 4 T cells ( MCP 1 , MIP 1alpha , MIP 1beta , IP 10 and RANTES ) and the characteristic infiltrate of eosinophils ( eotaxin and RANTES ) associated with islet xenograft rejection . ^^^ Inhibition of beta chemokine signaling in CCR 2 / mice ( which lack the major co receptor for MCP 1 ) resulted in retarded macrophage and CD 4 T cell recruitment , enhanced eosinophil influx and a minor delay in rejection , compared with wildtype mice ; there was little effect on leukocyte infiltration in xenografts harvested from CCR 5 / mice ( lacking the co receptor for MIP 1alpha , MIP 1beta and RANTES ) . ^^^ The impeded migration of leukocytes into xenografts in CCR 2 / hosts was associated with delayed intragraft expression of MCP 1 and RANTES mRNA ; absence of MCP 1 / CCR2 mediated signaling led to enhanced intragraft expression of MCP 1 , MIP 1alpha and MIP 1beta mRNA . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Monocyte chemoattractant protein 1 ( MCP 1 ) , macrophage inflammatory protein 1alpha ( MIP 1alpha ) and macrophage inflammatory protein 1beta ( MIP 1beta ) concentrations were measured daily over 2 weeks after study inclusion by ELISA in sera and lesser sac aspirates . ^^^ Compared with systemic concentrations , local lesser sac aspirates revealed significantly higher levels of MCP 1 , whereas MIP 1alpha and MIP 1beta were not different . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
We report herein that human neuronal cells ( NT 2 N ) produce macrophage inflammatory protein 1alpha and 1beta ( MIP 1alpha and MIP 1beta ) , which could be enhanced by interleukin ( IL ) 1beta at both mRNA and protein levels . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Induction of MIP 1beta , MIP 1alpha , MIP 2 , IP 10 , and MCP 1 mRNAs was attenuated in the TNFRI ( / ) mice , in comparison to WT mice , particularly at 28 days after exposure . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
After periodontal therapy no changes were seen with regard to MDC , MIP 1 alpha , MIP 1 beta and RANTES , whereas the MCP 1 levels decreased ( P < 0 . 05 ) and the IL 12p70 levels strongly increased ( P < 0 . 01 ) . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Single cell analysis of the murine chemokines MIP 1alpha , MIP 1beta , RANTES and ATAC / lymphotactin by flow cytometry . ^^^ We have established the intracellular flow cytometric detection of the murine chemokines macrophage inflammatory protein 1alpha ( MIP 1alpha ) , MIP 1beta , regulated on activation normal T cell expressed and secreted ( RANTES ) and activation induced , T cell derived and chemokine related cytokine ( ATAC ) / lymphotactin . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The beta chemokines RANTES ( regulated on activation , normal T cell expressed and secreted ) , macrophage inflammatory protein 1alpha ( MIP 1alpha ) , and MIP 1beta are the natural ligands of the HIV 1 coreceptor CCR 5 and compete with the virus for receptor binding . ^^^ The observed antiviral effect likely was due to the increased levels of beta chemokines RANTES , MIP 1alpha , and MIP 1beta because ( 1 ) supernatants greatly inhibited the replication of HIV 1 BaL , whereas they affected HIV 1 IIIb replication only slightly ; ( 2 ) neutralizing antibodies against the chemokines abrogated the antiviral effect of the supernatants ; and ( 3 ) the hydroxyurea concentrations shown to up regulate chemokine levels were not sufficient to inhibit virus replication by depletion of intracellular nucleotide pools . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Altered intracellular expression of the chemokines MIP 1alpha , MIP 1beta and IL 8 by peripheral blood CD4+ and CD8+ T cells in mild allergic asthma . ^^^ Following in vitro stimulation of peripheral venous blood with phorbol 12 myristate acetate ( PMA ) and ionomycin , flow cytometry was used to estimate the percentage of CD4+ and CD8+ T cells producing a number of chemokines , including macrophage inflammatory proteins MIP 1alpha and MIP 1beta , RANTES ( regulated on activation , T cell expressed and secreted ) , monocytic chemotactic protein 1 ( MCP ) 1 , and interleukin ( IL ) 8 , or the cytokines interferon ( IFN ) gamma and IL 4 . ^^^ Serum levels of MIP 1alpha , MIP 1beta , RANTES , MCP 1 , IL 8 , IFN gamma and IL 4 were also assessed by quantitative ELISA . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Our studies showed that LD infection caused the upregulation of three beta chemokines ( macrophage inflammatory protein 1 alpha ( MIP 1alpha ) , MIP 1beta and RANTES ( regulated on activation normal T cell expressed and secreted ) ) , one alpha chemokine ( interleukin 8 ( IL 8 ) ) and the CC chemokine receptor 5 ( CCR 5 ) but not CCR 1 , as evident from reverse transcriptase polymerase chain reaction ( RT PCR ) analysis . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
In contrast , MIP 1alpha , MIP 1beta , and MIP 1gamma were not detected . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
LPS induced MIP 1alpha , MIP 1beta , IL 8 , IL 1beta , and IL 1Ra mRNA production , which was delayed by 1 hr and reduced twofold by IC 14 treatment . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Studying a panel of human B cell lines derived from patients with Burkitt ' s lymphoma ( BL ) and AIDS associated Burkitt ' s lymphoma ( AIDS BL ) we had described constitutive expression and secretion of large amounts of Interleukin 16 ( IL 16 ) , Macrophage Inflammatory Protein 1alpha ( MIP 1alpha ) , Macrophage Inflammatory Protein 1beta ( MIP 1beta ) , Interleukin 12 ( IL 12 ) , Interleukin 10 ( IL 10 ) , and Interleukin 7 ( IL 7 ) . ^^^ Some of these cytokines like IL 16 , MIP 1beta , MIP 1alpha and Regulated upon activation normal T expressed and secreted ( RANTES ) are shown to have inhibitory effect on HIV replication . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
A CXC chemokine , interleukin 8 , and six CC chemokines including macrophage inflammatory protein 1alpha ( MIP 1alpha ) , MIP 1beta , monocyte chemotactic protein 1 ( MCP 1 ) , MCP 3 , eotaxin , and regulated on activation , normal T cell expressed and secreted ( RANTES ) concentrations in their sera were analyzed using enzyme linked immunosorbent assay . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
CCR 5 is a G protein coupled receptor for RANTES , MIP 1alpha , MIP 1beta , and MCP 2 that functions as the front line coreceptor for human immunodeficiency virus type 1 infection . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Levels of macrophage inflammatory protein 1 alpha ( MIP 1 alpha ) and MIP 1 beta in intervillous blood plasma samples from women with placental malaria and human immunodeficiency virus infection . ^^^ Macrophage inflammatory protein 1 alpha ( MIP 1 alpha ) and MIP 1 beta play an important role in modulating immune responses . ^^^ The IVB plasma levels of MIP 1 alpha and MIP 1 beta positively correlated with the cord blood plasma levels of these chemokines . ^^^ MIP 1 beta and MIP 1 alpha levels in PM positive women were positively associated with parasite density and malaria pigment levels . ^^^ Macrophage inflammatory protein 1 alpha ( MIP 1 alpha ) and MIP 1 beta play an important role in modulating immune responses . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
RT PCR and RNase Protection Assay were used to measure mRNA expression for the following chemokines : IP 10 , MIP 1alpha , MIP 1beta , MCP 1 , and RANTES . ^^^ There was no detectable gene expression for MIP 1alpha , MIP 1beta , or RANTES from MIN 6 or Bm . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
In addition , the concentrations of chemokines ( interleukin 8 ( IL 8 ) , macrophage inflammatory protein 1 alpha ( MIP 1 alpha ) , and MIP 1 beta ) were measured by enzyme linked immunosorbent assay . ^^^ Helicobacter pylori water extracts also stimulated neutrophil IL 8 production , although MIP 1beta production was only stimulated weakly , and MIP 1alpha was not stimulated at all . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
RESULTS : Expression of MCP 1 , RANTES , MIP 1 alpha , MIP 1 beta , IP 10 and Mig was demonstrated in all Hashimoto ' s and most Graves ' thyroid specimens but very little expression was detected in the nonautoimmune goitre samples . ^^^ CONCLUSION : We postulate that TFC may play a role in the pathogenesis of autoimmune thyroid disease as they are able to express the chemokines MIP 1 alpha , MIP 1 beta , MCP 1 , RANTES , IP 10 and Mig that would promote the infiltration of immune cells into the thyroid gland . . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Following treatment with influenza A virus , the induction of gene expression , which occurred in a dose and time dependent manner , was strong for macrophage inflammatory protein 1 alpha ( MIP 1 alpha ) and MIP 1 beta ; moderate for tumor necrosis factor alpha ( TNF alpha ) , interleukin 6 ( IL 6 ) , and IL 8 ; and weak for IL 1 beta and monocyte chemotactic peptide 1 ( MCP 1 ) . ^^^ In contrast , infection of HMEE cells with S . pneumoniae alone induced low levels of mRNA expression of MIP 1 alpha and MIP 1 beta and did not significantly induce the transcription of the other cytokines and chemokines examined . ^^^ However , both S . pneumoniae opacity variants increased mRNA expression of MIP 1 alpha , MIP 1 beta , IL 6 , and MCP 1 in HMEE cells activated by a prior influenza A virus infection compared to levels in cells treated with either agent alone . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
We detected an upregulation or de novo synthesis of interleukin 1 alpha ( IL 1 alpha ) , IL 1 beta , IL 8 , macrophage inflammatory protein 1 alpha ( MIP 1 alpha ) , MIP 1 beta , GRO alpha , transforming growth factor beta , MCP 1 , IL 2 receptor gamma ( IL 2R gamma ) , IL 10R alpha , and IL 6R . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Neutralizing antibodies against human RANTES , MIP 1alpha , MIP 1beta , alpha interferon ( IFN alpha ) , IFN beta , IFN gamma , interleukin 4 ( IL 4 ) , IL 10 , IL 13 , IL 16 , MCP 1 , MCP 3 , tumor necrosis factor alpha ( TNF alpha ) , or TNF beta failed to reverse the HIV 1 suppressive activity . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
METHODS : Lung biopsies from 4 patients that had classical features of WG were examined for protein expression of CCR 5 , RANTES , MIP 1alpha and MIP 1beta using immunohistochemistry . ^^^ Enhanced protein concentrations of RANTES , MIP 1alpha , and MIP 1beta were present in WG lung lesions , indicating redundancy of ligands for CCR 5 in affected tissue . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
METHODS : RANTES , MIP 1alpha and MIP 1beta synthesis was measured by the presence of protein secretion in the cell culture supernatant as determined by enzyme linked immunosorbent assay . ^^^ RESULTS : Infection of human monocytes with M . bovis BCG induced RANTES , MIP 1alpha and MIP 1beta secretion in a dose dependent manner . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Recent evidence has revealed that MCP 1 , MIP 1alpha and MIP 1beta are potent chemoattractants for glial cell populations . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Serum and cerebrospinal fluid concentration of inflammatory proteins MIP 1 alpha and MIP 1 beta and of interleukin 8 in the course of borreliosis ] . ^^^ The aim of this study was to investigate serum and cerebrospinal fluid ( CSF ) concentrations of the following chemokines : interleukin 8 ( Il 8 ) and macrophage inflammatory protein 1 alpha and 1 beta ( MIP 1 alpha and MIP 1 beta ) in patients with neuroborreliosis . ^^^ Mean serum concentrations of chemokine were elevated in neuroborreliosis patients at baseline ( Il 8 mean + / SD = 668 . 25 + / 661 . 51 pg / ml , MIP 1 alpha 124 . 90 + / 89 . 37 pg / ml , MIP 1 beta 233 . 40 + / 298 . 40 pg / ml ) as compared to these in the control group ( Il 8 23 . 72 + / 7 . 68 pg / ml , MIP 1 alpha 36 . 81 + / 4 . 74 pg / ml , MIP 1 beta 70 . 41 + / 16 . 41 pg / ml ) . ^^^ Post treatment mean concentrations of Il 8 ( 197 . 70 + / 285 . 56 pg / ml ) and MIP 1 beta ( 102 . 70 + / 42 . 56 pg / ml ) remained significantly elevated , while the mean concentration of MIP 1 alpha ( 53 . 65 + / 38 . 50 pg / ml ) was insignificantly higher than that in the control group . ^^^ MIP 1 alpha and MIP 1 beta CSF concentrations were significantly lower than their concentrations in serum . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
C C chemokines , monocyte chemoattractant protein 1 ( MCP 1 ) and macrophage inflammatory protein 1alpha and beta ( MIP 1alpha and MIP 1beta ) , are major chemoattractants for macrophages . ^^^ METHODS : The expression of MCP 1 , MIP 1alpha , MIP 1beta and CD 68 was detected in glomeruli with different forms of crescents ( cellular , fibrocellular and fibrous crescents ) by immunohistochemistry in serial sections of renal biopsies taken from 32 patients with biopsy proven CGN including eight patients with anti glomerular basement membrane ( GBM ) disease ( type 1 CGN ) , 12 patients with immune complex mediated CGN ( type 2 CGN ) and another 12 patients with pauci immune CGN ( type 3 CGN ) enrolled in this study . ^^^ RESULTS : MCP 1 , MIP 1alpha , MIP 1beta and CD 68 were undetectable in glomeruli of normal kidney . ^^^ In crescentic biopsies , MCP 1 , MIP 1alpha , MIP 1beta and CD 68 were detected in fibrocellular crescents and were even more prominent in cellular crescents , but were undetectable in fibrous crescents . ^^^ Using consecutive sections for staining , it was demonstrated that a high proportion of infiltrating CD 68 positive macrophages , mainly localized to the area of the expression of chemokines , were MCP 1 , MIP 1alpha and MIP 1beta positive in crescents . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
RESULTS : Our data demonstrated that AdVFlt3L transfection up regulated the expression of cytokine IL 1beta and chemokines MIP 1alpha , MIP 1beta , IP 10 , MCP 1 and MIP 2 , and stimulated DC ( Flt3L ) cell proliferation in vitro and migration toward regional lymph nodes in vivo . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Gene transcripts encoding RANTES , GRO alpha , MIP 1alpha , MIP 1beta , and others were found at high levels of signal intensity and confirmed literature data . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Furthermore , the chemokines MIP 1alpha and MIP 1beta belonging to the RANTES family are potent osteoclastogenic factors produced by myeloma cells and participate in myeloma associated bone disease . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
CT also enhanced the expression of CD 80 , CD 86 , and OX 40 ( CD 134 ) on DC and induced the secretion of the chemokine , macrophage inflammatory protein 2 ( MIP 2 ) , but inhibited LPS driven induction of CD 40 and ICAM 1 expression and production of the inflammatory cytokines / chemokines IL 12 , TNF alpha , MIP 1alpha , MIP 1beta , and monocyte chemoattractant protein 1 . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
RESULTS : Ischemia reperfusion induced expression of MCP 1 , MIP 1alpha , and MIP 1beta mRNA in the retinal vessels 3 hours after reperfusion . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Ribonuclease protection assay was used to determine gene expression for cell markers F4 / 80 ( macrophages ) , CD 8 ( type 1 T cells ) , CD 4 ( type 2 T cells ) , and CD 19 ( natural killer cells ) , and for chemokines IP 10 , MIP 1alpha , MIP 1beta , MCP 1 , and RANTES . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The beta chemokines MIP 1alpha , MIP 1beta , and RANTES inhibit HIV 1 infection of CD4+ T cells by inhibiting interactions between the virus and CCR 5 receptors . ^^^ In lymphocytes , exposure to RANTES significantly increases the pool of inhibitory beta chemokines through intracellular signals that result in increased production of MIP 1alpha and MIP 1beta , thereby amplifying the antiviral effects of RANTES . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
We show for the first time that rough brucellae induce higher amounts than smooth brucellae of several CXC ( GRO alpha , IL 8 ) and CC ( MIP 1alpha , MIP 1beta , MCP 1 , RANTES ) chemokines , as well as pro ( IL 6 , TNF alpha ) and anti inflammatory ( IL 10 ) cytokines released by challenged monocytes . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
In the same cases , RPA demonstrated the presence of mRNAs for MCP 1 , RANTES , IP 10 , MIP 1alpha , and MIP 1beta . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Hsp70L1 shares common receptors on DCs with Hsp 70 and can interact with DCs , promoting DC maturation and stimulating secretion of the proinflammatory cytokines interleukin 12p70 ( IL 12p70 ) , IL 1beta , tumor necrosis factor alpha ( TNF alpha ) , and the chemokines IP 10 , macrophage inflammatory protein 1alpha ( MIP 1alpha ) , MIP 1beta , and normal T cell expressed and secreted ( RANTES ) . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Using reverse transcriptase analysis of stomachs from normal and gastritic mice we found no difference in expression of CCR 5 and its chemokine ligands MIP 1alpha , MIP 1beta , and RANTES . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Two mechanisms induced by IFN tau treatment in macrophages may account for this inhibition : ( 1 ) the synthesis of the cellular antiviral factors such as 2 ' , 5 ' oligoadenylate synthetase / RNase L and MxA protein and ( 2 ) an increased production of MIP 1alpha , MIP 1beta , and RANTES , which are natural ligands of CCR 5 , the principal coreceptor of HIV on macrophages . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Serum samples ( n= 100 ; 25 active , 75 inactive ) were obtained from 50 patients with RV , and levels of the chemokines MIP 1alpha , macrophage inflammatory protein 1beta ( MIP 1beta ) and monocyte chemoattractant protein 1 ( MCP 1 ) were measured by ELISA . ^^^ Serum levels of the chemokines MIP 1beta and MIP 1alpha , but not MCP 1 were raised in patients with retinal vasculitis . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
METHODOLOGY : The concentrations of MIP 1alpha and MIP 1beta in BAL fluid ( BALF ) obtained from patients with BOOP ( n = 13 ) and control patients ( CP , n= 18 ) were measured by enzyme linked immunosorbent assay . ^^^ The concentration of MIP 1alpha significantly correlated with the percentage of lymphocytes in BALF , and the concentration of MIP 1beta significantly correlated with the numbers of lymphocytes , neutrophils and eosinophils in BALF . ^^^ Both MIP 1alpha and MIP 1beta in BALF were decreased after corticosteroid therapy and this was accompanied by decreased lymphocytes in BALF . ^^^ CONCLUSION : This study suggests that MIP 1alpha and MIP 1beta may play important roles in the recruitment of immuno inflammatory cells into the lungs , and may contribute to the pathogenesis of BOOP . . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
T cell receptor ( TCR ) / coreceptor stimulation up regulates MIP 1alpha , MIP 1beta , and Ltn , and down regulates IP 10 and RANTES expression in CD4+ T cells . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Antigen receptor cross linking induced secretion of the chemokines macrophage inflammatory protein 1 alpha ( MIP 1 alpha ) and MIP 1 beta in adult and cord blood B cells , and secretion was enhanced by IL 2 or IL 4 . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Treatment of monocytes with gram negative bacterial lipopolysaccharide ( LPS ) also led to enhanced production of IL 6 , MIP 1alpha , and MIP 1beta . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Intragastric administration of a single dose of CpG ODN significantly increased local production of the CC chemokines macrophage inflammatory protein 1alpha ( MIP 1alpha ) , MIP 1beta , and RANTES and the CXC chemokine gamma interferon inducible protein 10 in the stomach and / or the small intestine . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
IC 14 attenuated the LPS induced release of MIP 1beta , but not of MIP 1alpha . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Tracheal aspirate concentrations of monocyte chemoattractant proteins 1 , 2 , 3 ( MCP 1 , 2 , 3 ) and macrophage inflammatory proteins 1alpha and 1beta ( MIP 1alpha , MIP 1beta ) were determined by enzyme linked immunosorbent assay ( ELISA ) . ^^^ Tracheal aspirate concentrations of MCP 1 , MCP 2 , MCP 3 , and MIP 1beta increased during the first week of life in infants with RDS , whereas MIP 1alpha concentrations did not increase appreciably . ^^^ Maximal TA concentrations of MCP 1 , MCP 2 , MCP 3 , MIP 1alpha , and MIP 1beta were significantly higher in infants who were oxygen dependent at 28 postnatal days compared to infant who were not . ^^^ Similarly , maximal TA MCP 1 , MCP 2 , and MCP 3 but not MIP 1alpha and MIP 1beta concentrations were significantly higher in infants who were oxygen dependent at 36 weeks of postconceptional age ( PCA ) than those who were not oxygen dependent at 36 weeks PCA . ^^^ Histologic chorioamnionitis and isolation of Ureaplasma urealyticum from the airways were associated with higher maximal TA concentrations of MIP 1alpha and MIP 1beta . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Hypoxia inhibitory effects were selective for MCP 1 because the chemokines macrophage inflammatory protein 1beta ( MIP 1beta ) , RANTES , IFN gamma inducible protein 10 , and MIP 2 were not affected , and MIP 1alpha was induced . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Chemokine receptor 5 ( CCR 5 ) binds macrophage inflammatory protein 1alpha ( MIP 1alpha ) , MIP 1beta , RANTES , and members of the monocyte chemotactic protein family and is also a receptor for human immunodeficiency virus ( HIV ) . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
However , of the remaining of proinflammatory mediators measured in CSF at baseline , only a few children had detectable concentrations : tumor necrosis factor alpha , n = 1 ; RANTES , n = 5 ; MMP 9 , n = 9 ; MIP 1 alpha and MIP 1 beta , n = 0 . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Instead , similar to the MHV JHM infection , reduced survival following S4R22 infection was observed in the presence of elevated MIP 1alpha and MIP 1beta mRNA accumulation and enhanced macrophage numbers within infected brains . ^^^ These observations suggest that the S protein of MHV JHM influences neurovirulence through the induction of MIP 1alpha and MIP 1beta driven macrophage immunopathology . . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
EBV latency 3 regulated gene products mediate cell migration ( EBI 2 , CCR 7 , RGS 1 , RANTES , MIP 1 alpha , MIP 1 beta , CXCR 5 , and RGS 13 ) , antigen presentation ( major histocompatibility complex proteins and JAW 1 ) , mitogen activated protein kinase pathway ( DUSP 5 and p62Dok ) , and interferon ( IFN ) signaling ( IFN gamma R alpha , IRF 4 , and STAT 1 ) . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
We now added MLIF to resting and PMA stimulated cells of a human monocyte cell line and measured the effect upon mRNA and protein expression of pro inflammatory chemokines ( RANTES , IP 10 , MIP 1alpha , MIP 1beta , MCP 1 , IL 8 , 1 309 and lymphotactin ) and the shared CC receptor repertoire . ^^^ The constitutive expression of these chemokines and the CC receptors was unaffected , whereas induced expression of MIP 1alpha , MIP 1beta , and 1 309 , and that of the CCR 1 receptor all involved in monocyte chemotaxis was significantly inhibited by MLIF . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
AGEs significantly stimulated secretion of both MIP 1alpha and MIP 1beta from trophoblasts in a time and dose dependent manner . ^^^ Increased secretions of MIP 1alpha and MIP 1beta by AGEs were significantly suppressed by inhibitors of nitric oxide synthase ( NOS ) or nafamostat mesilate , a synthetic serine protease inhibitor and a suppressor of transcription factor , NF kappaB activation . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Dendrimer glucosamine inhibited Toll like receptor 4 mediated lipopolysaccharide induced synthesis of pro inflammatory chemokines ( MIP 1 alpha , MIP 1 beta , IL 8 ) and cytokines ( TNF alpha , IL 1 beta , IL 6 ) from human dendritic cells and macrophages but allowed upregulation of the costimulatory molecules CD 25 , CD 80 , CD 83 and CD 86 . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
With the goal of reducing CCR 5 and protecting CCR5+ cells from R 5 tropic HIV , we used Tag deleted SV 40 derived vectors to deliver several anti CCR 5 transgenes : 2C7 , a single chain Fv ( SFv ) antibody ; VCKA 1 , a hammerhead ribozyme ; and two natural CCR 5 ligands , MIP 1alpha and MIP 1beta , modified to direct these chemokines , and hence their receptor to the endoplasmic reticulum . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
In the present investigation it is observed that 10microg / ml of rF 1 antigen activated murine peritoneal macrophages in vitro . rF 1 induced the production of TNF alpha , IL 1 , IL 6 , and NO . rF 1 treatment also induced increased transcription of IFN gamma and its related chemokines KC , IP 10 , MIP 1alpha , MIP 1beta , MCP 1 , RANTES in macrophages . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
BACKGROUND : Ligands of chemokine receptor CCR 5 , including MIP 1 alpha , MIP 1 beta , and RANTES , have been implicated in rheumatoid arthritis . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
This study examined CC ( RANTES / CCL5 , MIP 1 alpha / CCL3 , MIP 1 beta / CCL4 ) and CXC ( IP 10 / CXCL10 , B lymphocyte chemoattractant ( BLC / CXCL13 ) , and B cell and monocyte activating chemokine ( BMAC / CXCL14 ) ) chemokine expression during lethal NY strain and non lethal Eg 101 strain infection in mice . ^^^ We found that the mRNA of the CC chemokines , RANTES , MIP 1 alpha , MIP 1 beta , and IP 10 was highly up regulated in the brain of NY strain infected mice . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Both WT B 6 and IRF 1 / profiles showed 13 genes upregulated ( IFN gamma , MCP 2 , MIP 1alpha , MIP 1beta , CCR 5 , MIG , IP 10 and others ) and one gene downregulated ( SDF 2 ) among the 76 genes detectable on the array . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Monocyte chemoattractant protein 1 , macrophage inflammatory protein 1alpha ( MIP 1alpha ) , MIP 1beta , MIP 3alpha , regulated on activation , normal T expressed and secreted ( RANTES ) , MIP 2 , and interferon inducible protein 10 ( IP 10 ) mRNA expression was up regulated between days 5 and 15 after infection , consistent with a role for these chemokines in leukocyte recruitment to the lung . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Taken together , these observations suggest that CCR 5 ligands , and in particular MIP 1alpha and MIP 1beta , released in the course of memory responses may play a role in protecting CD 4 ( + ) memory T cells from infection . . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
In addition , transcription and stability assays performed in presence of actinomycin D showed that MSU crystal mediated MIP 1beta mRNA up regulation resulted solely from transcriptional control , whereas that of MIP 1alpha , MIP 2 , and MCP 1 was due to both gene transcription activation and mRNA posttranscriptional stabilization . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
In this study , we investigated the differential expression of genes encoding the inflammatory chemokines Mip 1alpha , Mip 1beta and Rantes , and the secretion of these chemokines , among splenic DC subsets . ^^^ Whilst the pDC were the highest producers of Mip 1alpha and Mip 1beta in response to some TLR stimuli , the DN and CD4+ cDC subsets were the superior producers of Rantes . ^^^ Thus , we report a new functional difference between the murine splenic cDC subsets , with the CD4+ cDC demonstrating the most efficient production of the inflammatory chemokines Mip 1alpha , Mip 1beta and Rantes . . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
In Jurkat cells , the expression of IL 3 , GM CSF , TNF alpha , TGF beta 1 , IL 2 , lymphotactin , MIP 1alpha , and MIP 1beta was inhibited to different extents . ^^^ In THP 1 cells , inhibition of the expression of M CSF , G CSF , stem cell factor , IFN gamma , TNF alpha , TGF beta 1 , lymphotoxin beta 1 , MIP 1alpha , MIP 1beta , and IL 8 was observed . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Peak transcript expression was identified at day 4 ( IP 10 , MCP 1 ) , day 5 ( eotaxin ) , day 6 ( MIP 1alpha , MIP 1beta ) , and day 14 ( RANTES ) . ^^^ These findings suggest that IP 10 regulates the initial influx of T cells into proislet allografts , MCP 1 / CCR2 signaling controls initial macrophage entry , and the MIP 1alpha , MIP 1beta , and RANTES / CCR5 pathway contributes to the rejection response by subsequently amplifying the recruitment of T cell subpopulations required for graft destruction . . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The markers of SOX autoantibodies to oxidized LDL ( OxLDL Ab ) ; total peroxides ; and the major antioxidant enzyme Cu / Zn superoxide dismutase ( Cu / Zn SOD ) ; as well as tumor necrosis factor alpha ( TNF alpha ) ; regulated upon activation , normal T cell expressed and secreted ( RANTES ) ; and macrophage inflammatory protein 1alpha ( MIP 1alpha ) and beta ( MIP 1beta ) levels were measured in the plasma of uraemic patients with hepatitis in comparison to subjects without hepatitis and to healthy volunteers . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
In contrast , MIP 1 alpha and MIP 1 beta supernatant levels were significantly lower in HIV patients than in controls . ^^^ Prolonged ( > 3 years ) administration of HAART in HIV patients normalized the intracellular levels of MIP 1 beta and RANTES and restored the decreased supernatant levels of MIP 1 alpha and MIP 1 beta to levels observed among controls . ^^^ These data indicate that lymphocytes of HIV patients display a disrupted capacity to secrete the beta chemokines MIP 1 alpha and MIP 1 beta , which may constitute a mechanism of immune dysfunction in progressive HIV infection . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Concentrations of macrophage inflammatory proteins MIP 1alpha and MIP 1beta and interleukin 8 ( il 8 ) in lyme borreliosis . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
RNase protection analyses revealed increased expression of numerous cytokines and chemokines , including interleukin 1beta ( IL 1beta ) , IL 6 , tumor necrosis factor alpha , macrophage inflammatory protein 1alpha ( MIP 1alpha ) , MIP 1beta , MIP 2 , interferon gamma inducible protein , monocyte chemotactic protein 1 , and T cell activation gene 3 at 12 h postinfection with KyARgp2F . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Compared to wild type , LPS stimulated peritoneal macrophages from MCP 1 ( / ) mice showed a significant increase in the expression of RANTES , MIP 1beta , MIP 1alpha and MIP 2 mRNA . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The natural ligands of CCR 5 , the beta chemokines macrophage inflammatory protein 1alpha ( MIP 1alpha ) , MIP 1beta , and RANTES , interfere with HIV 1 binding to CCR 5 receptors and decrease the amount of virions entering cells . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
A cytokine macroarray analysis of transcripts derived from macrophage like THP 1 cells treated with Stx 1 , lipopolysaccharides ( LPS ) , or both demonstrated a consistent up regulation of TNF alpha , IL 1beta , and four genes encoding the chemokines interleukin 8 ( IL 8 ) , macrophage inflammatory protein 1alpha ( MIP 1alpha ) , MIP 1beta , and growth related oncogene beta ( GRO beta ) . ^^^ Finally , enzyme linked immunosorbent assay data for Stx 1 plus LPS treated cells demonstrated a poor correlation between IL 8 , MIP 1alpha , MIP 1beta , and GRO beta mRNA levels and protein production , indicating a posttranscriptional regulatory effect . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
RANTES , IL 8 , MIP 1alpha , MIP 1beta , IL 1beta , IL 10 , IL 12 p 35 , IL 18 , IFN gamma and IL 1Ra were the cytokine transcripts expressed in elevated levels from RNA of peripheral blood mononuclear cells of LGL leukemia patients . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Transcripts of myeloid cell recruitment factors such as MIP 1alpha , MIP 1beta , and MCP 1 , as well as IL1alpha and TNFalpha were upregulated > 10 fold between 30 and 40 days , well before prion protein ( PrP ) abnormalities that begin only after 80 days . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Chemokine expression ( MIP 1alpha , MIP 1beta , MIP 2 and KC ) , Akt , MAPK ( p44 / p42 ) , and RSK expressions were also measured in liver tissue by enzyme linked immunosorbent assay ( ELISA ) and Western blot analysis , respectively . ^^^ This selectin inhibition modulated the expression of Akt , MAPK ( p44 / 42 ) , and RSK , as well as MIP 1alpha , MIP 1beta , MIP 2 , and KC chemokines . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
GM CSF KO mice do not express normal levels of the inflammatory cytokine tumor necrosis factor alpha ( TNF alpha ) nor the chemokines , regulated on activation , normal T expressed and secreted ( RANTES ) , macrophage inflammatory protein 1beta ( MIP 1beta ) , MIP 1alpha , and lymphotactin , which are required for recruitment of lymphocytes and expression of a T helper cell type 1 ( TH 1 ) response within the lungs . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The recruitment of major histocompatibility complex ( MHC ) class 2 ( + ) LC was significantly suppressed in CCR 5 ( / ) mice and blockade of RANTES and MIP 1beta , but not in CCR 1 ( / ) , CCR 2 ( / ) / MIP 1alpha ( / ) , or MIP 1alpha ( / ) mice . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
APL cells prepared from two APL patients showed gene expression of chemokines , such as IL 8 , MCP 1 , MIP 1alpha , and MIP 1beta when stimulated with ATRA in vitro . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Competitive chemotaxis in peripheral blood mononuclear cells demonstrated that Met RANTES inhibited MIP 1alpha and MIP 1beta at 50 % inhibition concentrations of 5 nM and 2 nM , respectively . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Here we demonstrate that local neuroinflammation promotes the selective activation of chemokines , such as stromal cell derived factor 1 ( SDF 1 ) , macrophage inflammatory protein 1 alpha ( MIP 1alpha ) , and MIP 1beta , which chemoattract genetically modified BMCs into the CNS . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The third clone ( AB 187 ) had highest homology to chicken MIP 1beta ( 36 % amino acid identity ) and showed closer relation to a number of chemokines belonging to monocyte chemoattractant proteins and MIP 1alpha chemokines . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
OBJECTIVE : We hypothesized that the chemokine receptor 5 ( CCR 5 ) ligands , MIP 1alpha , MIP 1beta and RANTES , are virulence correlates in M . tuberculosis infection and are indispensable to granuloma formation . ^^^ RESULTS : In vivo , lung mRNA and protein measurements of MIP 1alpha , MIP 1beta and RANTES indicate significantly higher ( p < 0 . 05 ) values ( days 14 28 ) in the H37Rv infected than the H37Ra infected mice . ^^^ CONCLUSIONS : The production of the CCR 5 ligands , MIP 1alpha , MIP 1beta , and RANTES , does not clearly correlate with virulence of M . tuberculosis . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
By mixing commercially available reagents and newly developed ones , a combination has been created that allows for the detection of 20 NHP chemokines and cytokines in a single sample , including G CSF , GM CSF , IFN gamma , IL 1beta , IL 1Ra , IL 2 , IL 4 , IL 5 , IL 6 , IL 8 , IL 10 , IL 12 ( p 40 ) , IL 17 , IL 18 , MCP 1 , MIP 1alpha , MIP 1beta , RANTES , TNF alpha , and TNF beta . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
We hypothesized the possible roles of beta chemokines [ monocyte chemoattractant protein 1 ( MCP 1 ) , macrophage inflammatory proteins ( MIP 1alpha , MIP 1beta ) and regulated upon activation , normal T cell expressed and secreted ( RANTES ) ] as regulators of the metabolism of the vascular extracellular matrix in conditions of increased SOX in hemodialysis ( HD ) patients . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
We describe here that Fas ligation induced DCs to rapidly produce both CXC and CC chemokines , including macrophage inflammatory protein 2 ( MIP 2 ) , MIP 1alpha , MIP 1beta , monocyte chemoattractant protein 1 ( MCP 1 ) , RANTES ( regulated on activation normal T cell expressed and secreted ) , and TARC ( thymus and activation regulated chemokine ) , resulting in enhanced chemoattraction of neutrophils and T cells by Fas ligated DCs in vivo or by its supernatant in vitro . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Real time polymerase chain reaction revealed a plaque progression dependent increase in mRNA levels of MCP 1 , MCP 5 , MIP 1alpha , and MIP 1beta . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Since the role of chemokines in regulating host immunity in children with Plasmodium falciparum malaria has not previously been reported , circulating levels of beta chemokines ( MIP 1alpha , MIP 1beta , and RANTES ) and their respective transcriptional profiles in ex vivo peripheral blood mononuclear cells ( PBMCs ) were investigated . ^^^ Peripheral blood MIP 1alpha and MIP 1beta levels were significantly elevated in mild and severe malaria , while RANTES levels decreased with increasing disease severity . ^^^ Baseline MIP 1alpha and MIP 1beta did not significantly differ between children with prior severe malaria and those with mild malaria . ^^^ Taken together , the results presented here demonstrate that children with severe malaria have a distinct profile of beta chemokines characterized by increased circulating levels of MIP 1alpha and MIP 1beta and decreased RANTES . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Gingival crevicular fluid EMAP 2 , MIP 1alpha and MIP 1beta levels of patients with periodontal disease . ^^^ The aim of this study was to examine gingival crevicular fluid ( GCF ) levels of EMAP 2 , MIP 1alpha and MIP 1beta in patients with different periodontal diseases ( EMAP 2 , endothelial monocyte activating polypeptide ; MIP 1alpha , macrophage inflammatory protein 1alpha ; MIP 1beta , macrophage inflammatory protein 1beta ) . ^^^ GCF EMAP 2 , MIP 1alpha and MIP 1beta levels were quantified by enzyme immunoassay . ^^^ G AgP , CP , gingivitis and healthy groups had comparable GCF MIP 1alpha and MIP 1beta levels . ^^^ At this point , MIP 1alpha and MIP 1beta levels in GCF do not seem to play a discriminatory role in periodontitis . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
In competition binding assays , binding of radiolabeled mouse JE to rabbit CCR 2 is differentially competed by human MCP 1 , 2 , 3 and 4 , but not by RANTES , MIP 1alpha or MIP 1beta . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
However , the transcription of chemokines like MCP 1 , MIP 1alpha , MIP 1beta , and RANTES were inhibited by rLcrV and rYopB . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The expression of MCP 1 , MCP 3 , MIP 1alpha , MIP 1beta , and RANTES transcripts were noted at P 8 and reached a peak at P 12 . ^^^ The chemokines MCP 1 , MCP 3 , MIP 1alpha , MIP 1beta , and RANTES are involved in activation and recruitment of the microglia to the degenerating photoreceptor cell layer . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The expression of interleukin 8 , MIP 1alpha , and MIP 1beta was not different in the three experimental groups . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
DEN2V infection of HepG 2 and primary dendritic cells induced the production of interleukin 8 ( IL 8 ) , RANTES , MIP 1alpha , and MIP 1beta , whereas only IL 8 and RANTES were induced following dengue virus infection of HEK 293 cells . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Chemokines involved in T cell and monocyte trafficking were also significantly up regulated in the HCV MC vasculitis patients ( mean + / SEM fold increase 27 . 4 + / 8 . 3 for macrophage inflammatory protein 1alpha [ MIP 1alpha ] , 19 . 9 + / 5 . 7 for MIP 1beta , and 7 . 2 + / 1 . 5 for CXCR 3 ) . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
By day 6 after transplantation , still well before graft rejection , significantly higher levels of RANTES , eotaxin , MIP 1alpha , MIP 1beta , MIP 2 , and MCP 1 were detected in HR eyes . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
In particular , levels of some SEB induced cytokines ( tumor necrosis factor alpha , gamma interferon ) and chemokines ( monocyte chemoattractant protein 1 , macrophage inflammatory protein 1 alpha [ MIP 1alpha ] , MIP 1beta ) were significantly diminished or even nonexistent , depending upon the timing of edema toxin administration . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
In addition , they produce the chemokines MIP 1alpha , MIP 1beta and SDF 1alpha , which also increase osteoclast activity . ^^^ Preclinical studies provided strong evidence that the suppression of the osteoclast activity using bisphosphonates , RANKL blockade or inhibition of MIP 1alpha or MIP 1beta is effective both in reducing myeloma bone disease and tumor growth and therefore may offer an important treatment strategy in multiple myeloma . . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Compared with uninfected controls , an altered cytokine and chemokine production by BM cells has been observed before treatment , characterised by decreased IL 2 and elevated TNF alpha , MIP 1alpha , MIP 1beta , and RANTES levels , along with a defective BM clonogenic activity . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
In addition , they produce the chemokines MIP 1alpha , MIP 1beta , and SDF 1alpha , which also increase osteoclast activity . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Compared to HIV IFA alone , immunization with HIV IFA and HYB 2055 combination elicited strong production of HIV and p 24 specific IFNgamma , RANTES , MIP 1alpha , and MIP 1beta , as well as high titers of HIV and p 24 specific antibodies . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Immunohistochemistry was used for evaluation of GFAP , CNPase , and NF expression in pup brains at postnatal day 7 ( P 7 ) and reverse transcriptase PCR ( RT PCR ) to analyze macrophage inflammatory protein 1 alpha mRNA ( MIP 1 alpha mRNA ) , macrophage inflammatory protein 1 beta mRNA ( MIP 1beta mRNA ) , the regulated upon activation normal T expressed and secreted chemokine mRNA ( RANTES mRNA ) and Eotaxin mRNA expression in pup brains at P 1 , P 3 and P 7 . ^^^ The expression of MIP 1 alpha mRNA and MIP 1 beta mRNA in brain of the E . coli treated pup rat were higher than the control at P 1 , but the expression of MIP 1 alpha mRNA and MIP 1 beta mRNA in brain of the pup rat at P 3 and P 7 had no significant difference between two groups . ^^^ Moreover , the transient increase in expression of chemokine such as MIP 1 alpha , MIP 1 beta in neonatal brain after intrauterine infection indicated that MIP 1 alpha , MIP 1 beta may be a mechanism mediating between the neonatal white matter damage and the intrauterine infection . . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
In LPS stimulated human neutrophils , engagement of the adenosine A2A receptor selectively prevented the expression and release of TNF alpha , MIP 1alpha / CCL3 , MIP 1beta / CCL4 , MIP 2alpha / CXCL2 , and MIP 3alpha / CCL20 . ^^^ In mice lacking the A2A receptor , granulocytes that migrated into the air pouch 4 h after LPS injection expressed higher mRNA levels of TNF alpha , MIP 1alpha , and MIP 1beta than PMNs from wild type mice . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
We show that MIP 1 alpha and MIP 1 beta neutralizing antibodies can partially inhibit the ability of BeSO ( 4 ) to stimulate cell migration of PBMC / DCs in vitro . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Two of the identified proteins , macrophage inflammatory protein 1beta ( MIP 1beta ) and macrophage inflammatory protein 1alpha ( MIP 1alpha ) are known secreted proteins . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The RNA level of TNF alpha , MIP 1alpha , MIP 1beta , MIP 3alpha , and IL 8 was not affected by the presence of cycloheximide , an inhibitor of the translation process , suggesting that they are the direct targets of PG 101 . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
CD3+ T cells , infiltrating the retina , also expressed the chemokine receptor CCR 5 , and CCR 5 ligands , macrophage inflammatory protein 1alpha ( MIP 1alpha ) , MIP 1beta , and regulated on activation , normal T expressed and secreted ( RANTES ) , were strongly expressed in the retina at peak EAU . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
To better understand the interaction of the host with HIV 1 during active tuberculosis , we investigated in vivo expression of the HIV 1 coreceptors , CCR 5 and CXCR 4 , and circulating levels of the inhibitory beta chemokines , macrophage inflammatory protein 1 alpha ( MIP 1alpha ) , macrophage inflammatory protein 1 beta ( MIP 1beta ) , and regulated upon activation T cell expressed and secreted ( RANTES ) , in HIV positive individuals with and without active pulmonary tuberculosis . ^^^ Higher amounts of MIP 1alpha , MIP 1beta , and RANTES were detected in plasma of HIV 1 positive individuals , particularly those with dual infection , although the increase was not found to be statistically significant . . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
We measured MIP 1alpha , MIP 1beta , RANTES , and SDF 1 in month 1 breastmilk specimens from HIV 1 infected women in Nairobi and HIV 1 viral load was calculated in maternal plasma and breastmilk at delivery and 1 month postpartum . ^^^ MIP 1alpha , MIP 1beta , RANTES , and SDF 1 were all positively correlated with breastmilk HIV 1 RNA ( P < 0 . 0005 ) . ^^^ Women with clinical mastitis had 50 % higher MIP 1alpha and MIP 1beta levels ( P < 0 . 001 and P=0 . 006 , respectively ) and women with subclinical mastitis ( breastmilk Na ( + ) / K ( + ) > 1 ) had approximately 70 % higher MIP 1alpha , MIP 1beta and RANTES ( P < 0 . 002 for all ) compared to women without mastitis . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
TAK 652 inhibited the binding of RANTES ( regulated on activation , normal T cell expressed and secreted ) , macrophage inflammatory protein 1alpha ( MIP 1alpha ) , and MIP 1beta to CCR 5 expressing cells at nanomolar concentrations . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The mechanism of this unexpected finding was explained by an HMGB 1 mediated increased release of chemokines ( RANTES , MIP 1alpha , and MIP 1beta ) that are known to inhibit HIV 1 replication . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Here we demonstrate that triptolide significantly impairs DC mediated chemoattraction of neutrophils and T cells both in vitro and in vivo by suppressing DC production of CC and CXC chemokines including MIP 1alpha , MIP 1beta , MCP 1 , RANTES , TARC , and IP 10 in response to LPS . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
A biochemical evaluation for a battery of cytokines was undertaken ( IL 1beta , IL 1ra , IL 2 , IL 2R , IL 4 , IL 5 , IL 6 , IL 7 , IL 8 , IL 10 , IL 12p40 , IL 13 , IL 15 , IL 17 , TNF alpha , IFN alpha , IFN gamma , GM CSF , MIP 1alpha , MIP 1beta , IP 10 , MIG , Eotaxin , RANTES , and MCP 1 , and neuropeptides ) using high resolution multiplex bead immunoassays and enzyme linked immunosorbent assay ( ELISA ) . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
In a dose dependent manner , gammadelta T cells up regulated production of cytokines ( TNF alpha , IL 6 , IL 10 ) and chemokines ( MIP 1alpha , MIP 1beta ) by Listeria elicited macrophages . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Levels of MIP 1beta , but not of MIP 1alpha or RANTES , in the supernatants of PHA activated PBMC , were higher in the EUs than in the UCs ( p = 0 . 007 ) . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The aim of this study was to investigate the effect of the hepatitis C envelope protein E 2 on LFA 1 stimulated T cell migration and macrophage inflammatory protein ( MIP 1alpha , MIP 1beta ) secretion . ^^^ MIP 1alpha and MIP 1beta levels were detected by enzyme linked immunosorbent assay . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
LPS significantly ( P < 0 . 0001 ) increased plasma concentrations of TNFalpha , IL 1 beta , IL 6 , IL 15 , IL 9 , IL 2 , IL 1 alpha , IL 1 beta , Rantes , MIP 1 alpha , MIP 1 beta , MCP 1 , KC , GM CSF , G CSF , Eotaxin , IL 13 , and IL 12 in both wild type and Otc ( spf ash ) mice . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Following the cross linking of CCR 5 , monocytes synthesized high levels of M CSF , RANTES , MIP 1 alpha , and MIP 1 beta associated with a readily detectable down modulation of CD 14 , CD 4 , CCR 5 , and CXCR 4 expression . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Certain CC chemokines , including RANTES , MIP 1alpha , and MIP 1beta , might facilitate the development of such microbicides since they potently suppress HIV 1 infection by binding to CCR 5 , the viral coreceptor used by most sexually transmitted strains of HIV 1 to enter host cells . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
LLDT 8 decreased CC chemokine receptor 5 ( CCR 5 ) and their ligands macrophage inflammatory protein 1 alpha ( MIP 1alpha ) and beta ( MIP 1beta ) mRNA expressions in allografts . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
This structure of V 3 ( MN ) was found to have conformation and sequence similarities to beta hairpins in CD 8 and CCR 5 ligands MIP 1alpha , MIP 1beta , and RANTES and differed from the beta hairpin of a V 3 ( IIIB ) peptide bound to the strain specific murine anti gp 120 ( IIIB ) antibody 0 . 5beta . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Hosts injected with wild type Tc 1 effectors had more T cells within the tumor at day 4 , had higher levels of MCP 1 , IFN gamma inducible protein 10 , MIP 1alpha , and MIP 1beta mRNA transcripts , had greater numbers of CD11b+ and Gr 1+ cells within the tumor , and had massive regions of tumor cell apoptosis as compared with IFN gamma knockout Tc 1 cell treated hosts . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
RESULTS : Significantly increased levels of macrophage inflammatory protein 1alpha ( MIP 1alpha ) , MIP 1beta and interleukin 8 ( IL 8 ) were detected . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The CC chemokines , Macrophage inflammatory protein 1 alpha , RANTES , and monocyte chemotactic protein 1 were able to stimulate a Ca ( 2+ ) activated chloride channel in Xenopus laevis oocytes injected with K 5 5 cRNA , whereas no signal was detected in response to monocyte chemotactic protein 2 , macrophage inflammatory protein 1 beta , or the CXC chemokine , interleukin 8 . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
In this study we show that the human mast cell leukemia line HMC 1 is a source of multiple chemokines , including 1 309 , monocyte chemoattractant protein 1 , macrophage inflammatory protein 1 alpha , macrophage inflammatory protein 1 beta , RANTES , and interleukin 8 . 1 309 and MCP 1 transcripts are expressed at low levels in unstimulated HMC 1 . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The chemokines ( macrophage inflammatory protein 1 alpha , macrophage inflammatory protein 1 beta , RANTES , and IFN inducible protein 10 ) have recently been reported to be chemotactic for T cells . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
In functional calcium signalling assays , the CCR 5 endogenous ligands MIP 1alpha , MIP 1beta and RANTES evoked a robust response in the dog recombinant CCR 5 cells . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Furthermore , monocytes from these individuals were less capable of producing interleukin 8 ( IL 8 ) , Exodus 2 , MIP 1alpha , MIP 1beta , and IL 1alpha and preferentially expressed genes involved in apoptosis and adhesion compared with monocytes from uninfected donors . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The levels of IL 8 , MCP 1 , MIP 1alpha , MIP 1beta , and RANTES in the vitreous fluid were measured using cytometric bead array method . ^^^ MIP 1alpha , MIP 1beta , and RANTES levels in Groups 2 and 3 were almost the same as those in Group 1 . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Innate immune factors [ cathepsin D , lactoferrin ( Lf ) , myeloid related protein ( MRP ) 8 , MRP 8 / 14 , secretory leukocyte protease inhibitor , and gp 340 ] , cytokines ( IL 1beta and TNF alpha ) , and chemokines ( MIP 1alpha , MIP 1beta , RANTES , and SDF 1alpha ) were quantified by ELISA . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
MDC and TARC competed for binding to CCR 4 , while no binding competition was observed for six other chemokines ( MCP 1 , MCP 3 , MCP 4 , RANTES ( regulated on activation normal T cell expressed and secreted ) , macrophage inflammatory protein 1 alpha , macrophage inflammatory protein 1 beta ) . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Equilibrium binding analyses using 125I labeled RANTES indicated the presence of a receptor for RANTES on these cells , which has a Kd of 0 . 1 nM , is expressed at approximately 600 sites per cell , and a binding specificity that was not comparable with that of any of the known chemokine receptors , since 125I labeled RANTES was displaced by macrophage inflammatory protein 1 beta ( but not macrophage inflammatory protein 1 alpha ) , monocyte chemotactic protein 1 ( MCP 1 ) , MCP 3 , MCP 4 , and eotaxin . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
By contrast , the most highly regulated genes in B cells were the CC chemokines macrophage inflammatory protein 1 alpha and macrophage inflammatory protein 1 beta . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
RANTES secretion from osteoblast is inhibited by differentiation promoting hormones , e . g . 1 , 25 ( OH ) 2D3 and dexamethasone , whereas macrophage inflammatory protein 1 alpha ( but not macrophage inflammatory protein 1 beta ) and elevated calcium induce it . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
From these results , the order and the orientation of CC chemokine genes on chromosome 17 were determined as follows : centromere neurofibromatosis 1 ( MCP 3 , MCP 1 , NCC 1 , 1 309 ) Y 1741 breakpoint RANTES ( LD78gamma , AT744 . 2 , LD78beta ) ( NCC 3 , NCC 2 , AT744 . 1 , LD78alpha ) NCC 4 retinoic acid receptor alpha telomere . . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Chemokines tested to date ( GRO a , MCP 1 , MCP 3 , MIP 1a , MIP 1b , C5a , RANTES , and LTB 4 ) have failed to elicit any reproducible response . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
These include the complete TS gene and a dihydrofolate reductase ( DHFR ) gene , four novel cytokine genes ( encoding viral interleukin 6 , viral MIP 1A , viral MIP 1B , and BCK ) that have not previously been found to be encoded by a virus , and a bcl 2 homolog . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Chemokines suppress in vitro virus replication in cells from HIV infected people by making CD8+ T cells secrete three immune signalling molecules , RANTES , MIP 1alpha and MIP 1B . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
We report that VIP and PACAP inhibit the expression of the macrophage derived CXC chemokines MIP 2 and KC ( IL 8 ) , and of the CC chemokines MIP 1a , MIP 1b , MCP 1 and RANTES in vivo and in vitro . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
We measured serum levels of CC chemokines , including monocyte chemoattractant protein 1 ( MCP 1 ) and macrophage inflammatory protein 1a and 1b ( MIP 1a and MIP 1b ) in 32 women with chronic autoimmune thyroiditis in comparison with 2 control groups ( 33 apparently healthy women and 43 women with benign cold thyroid nodules ) by enzyme linked immunosorbent assay ( ELISA ) . ^^^ There was no difference in either serum MIP 1a ( P = . 69 ) or MIP 1b ( P = . 81 ) levels between women with chronic autoimmune thyroiditis and controls . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
The recent discovery that the chemokines RANTES ( regulated upon activation , normal T cell expressed and secreted ) , macrophage inflammatory protein 1alpha ( MIP 1a ) , and macrophage inflammatory protein 1beta ( MIP 1b ) are important modulators of HIV 1 infection and the subsequent identification of the essential role that chemokine receptors play as co receptors for HIV 1 infection have provided new insight into the pathogenesis of HIV 1 . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
RESULTS : As expected , TNFA , IL 8 , CD 83 , MIP1A , and MIP1B were among the genes up regulated . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
These chemokine genes are arranged in the same orientation , and their sizes are relatively long , 3 . 1 ( HCC 1 ) 8 . 8 kb ( RANTES ) when compared with other CC chemokine genes , such as MIP 1alpha / LD78alpha ( SCYA 3 ) ( 1 . 9 kb ) and MCP 1 ( SCYA 2 ) ( 1 . 5 kb ) . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
Similarly , cDNA sequence polymorphisms in Nos 2 , Scya 3 , Scya 4 , Scya 5 , Scya 6 , Scya 7 , Scya 9 , Scya 10 , and Scya 11 were excluded as candidates for eae 7 . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
At 72 h the upregulated genes were IL1RA , IL2RG , CXCR 4 , SCYA 1 , SCYA 3 , SCYA 4 , SCYA 5 , SCYA 22 , ANX 2 , CD 83 and UPAR . cDNA array results were confirmed on randomly selected genes using quantitative real time polymerase chain reaction for three upregulated ( CXCR 4 , IL1B and CD 14 ) and three downregulated ( DEK , AF 4 and FLI 1 ) genes . ^^^
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P10147	Pubmed	SVM Score :0.0
NA