| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| The focus of TGFbeta inhibition is observed to be directed in genes involved in chemotaxis ( IL 15 , CXCL 1 , CXCL 2 , CCL 3 , CCL 4 , CCL 5 , CCL 9 ) , chemokine receptors ( CCR 5 , CCR 9 ) , LIF receptor , and FPR 2 , and on genes mediating cell migration ( MMP 9 , MMP 13 , MacMARCKS , endothelin receptor B , Ena / VASP , Gas 7 ) , apoptosis ( FAS , TNF , TNF receptor , caspase 1 and 11 ) , and host response to infection ( toll like receptor 6 , Mx 1 , and MARCO ) . ^^^ |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| Lipopolysaccharide ( LPS ) mediated activation of TAMs resulted in defective expression of several proinflammatory cytokines ( eg , IL 1beta , IL 6 , TNF alpha ) and chemokines ( eg , CCL 3 ) , as opposed to a strong up regulation of immunosuppressive cytokines ( IL 10 , TGFbeta ) and IFN inducible chemokines ( CCL 5 , CXCL 9 , CXCL 10 , CXCL 16 ) . ^^^ |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| A number of well characterized cytokines have been implicated in the negative regulation of hematopoiesis : ferritin H subunit ( HF ) , lactoferrin ( Lf ) , prostaglandin E ( PGE ) , tumor necrosis factor ( TNF ) , interferon ( IFN ) , transforming growth factor beta ( TGF beta ) , acetyl N Ser Asp Lys Pro ( AcSDKP ) or thymosin beta 4 , pyroGlu Glu Asp Cys Lys ( pEEDCK ) , macrophage inflammatory protein 1 alpha ( MIP 1 alpha ) , inhibin , superoxide dismutase ( SOD ) , glutathione ( GSH ) and others not well known yet . ^^^ |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| Furthermore , tumor necrosis factor alpha ( TNF alpha ) and interferon gamma ( IFN gamma ) , but not macrophage inflammatory protein 1 alpha ( MIP 1 alpha ) , cooperated with TGF beta 1 to reverse the proliferative effects of multiple stimulatory cytokines , resulting in 76 % inhibition . ^^^ |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| Differential effects of the hematopoietic inhibitors MIP 1 alpha , TGF beta , and TNF alpha on cytokine induced proliferation of subpopulations of CD34+ cells purified from cord blood and fetal liver . ^^^ In the present study , we assessed the effects of the hematopoietic inhibitors , macrophage inflammatory protein 1 alpha ( MIP 1 alpha ) , transforming growth factor beta ( TGF beta ) , and tumor necrosis factor alpha ( TNF alpha ) , on the cytokine induced proliferation of three different CD34+ cell subpopulations derived from cord blood and on total CD34+ cells derived from fetal liver . ^^^ In a separate set of experiments , MIP 1 alpha , TGF beta , and TNF alpha were added to cultures of total CD34+ cells purified from fetal liver . ^^^ The results of the present study demonstrate that MIP 1 alpha , TGF beta , and TNF alpha have the capacity to modulate cytokine induced proliferation of cord blood and fetal liver progenitors . ^^^ |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| Studying the effect of tat and / or PMA + PHA on mRNA expression of 14 cytokines ( IL 1 alpha , IL 2 , IL 4 , IL 5 , IL 6 , IL 8 , IL 10 , IL 12 , TNF alpha , TNF beta , GM CSF , TGF beta , IFN gamma and MIP 1 alpha ) illustrated differential effects . ^^^ |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| Both transforming growth factor beta ( TGF beta ) and macrophage inflammatory protein 1 alpha ( MIP 1 alpha ) have been shown to be multifunctional regulators of hematopoiesis that can either inhibit or enhance the growth of hematopoietic progenitor cells ( HPC ) . ^^^ The effects of MIP 1 alpha and TGF beta on the growth of Lin progenitors were direct and correlate with colony formation in soft agar . ^^^ Separation of the Lin cells into Thy 1 and Thy 1lo subsets showed that the growth of Thy 1lo Lin cells is directly inhibited by MIP 1 alpha and TGF beta regardless of the cytokine used to stimulate growth ( IL 3 ) , GM CSF , or CSF 1 ) . ^^^ In contrast , two other stem cell populations ( 0 % to 15 % Hechst 33342 / Rhodamine 123 [ H / Rh123 ] and Lin Sca 1+ cells ) were markedly inhibited by TGF beta and unaffected by MIP 1 alpha . ^^^ Furthermore , MIP 1 alpha has no effect on high proliferative potential colony forming cells 1 or 2 ( HPP CFC / 1 or / 2 ) colony formation in vitro , whereas TGF beta inhibits both HPP CFC / 1 and HPP CFC / 2 . ^^^ |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| A number of inhibitory molecules may endeavour a physiological role ( cytokines like TGF beta , TNF alpha , platelet factor 4 PF 4 , Interferons , MIP 1 alpha or peptides like p EEDCK , Ac SDKP . ^^^ |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| Comparison of the inhibitory effect of AcSDKP , TNF alpha , TGF beta , and MIP 1 alpha on marrow purified CD34+ progenitors . ^^^ The aim of this study was to compare the inhibitory effect of the tetrapeptide AcSDKP , tumor necrosis factor alpha ( TNF alpha ) , which contains the sequence of the peptide , transforming growth factor beta ( TGF beta ) , and macrophage inflammatory protein 1 alpha ( MIP 1 alpha ) on sorted CD34+ cells using both proliferation and clonogenic assays . ^^^ |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| The effects of epidermal growth factor ( EGF ) , transforming growth factor alpha ( TGF alpha ) , insulin like growth factor ( IGF ) 1 and 2 , acidic fibroblast growth factor ( FGF ) , tumour necrosis factor alpha ( TNF alpha ) , macrophage inhibitory protein 1 alpha ( MIP 1 alpha ) ( LD 78 ) , and TGF beta 1 on cell proliferation in the crypts of the small intestine of mice were investigated . ^^^ |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| Under these conditions , it was demonstrated that H ferritin , transforming growth factor beta 1 ( TGF beta 1 ) , and members of the chemokine family ( macrophage inflammatory protein 1 alpha [ MIP 1 alpha ] , MIP 2 beta , platelet factor 4 [ PF 4 ] , IL 8 , and macrophage chemotactic and activating factor [ MCAF ] ) had direct significant suppressive activities on single stem / progenitor cells from adult human BM in the presence or absence of serum . ^^^ |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| Recent studies suggest that the retention of primitive normal cells in a reversible G ( o ) state in this system is mediated by the cooperating action of limiting concentrations of at least two endogenously produced inhibitory factors ( transforming growth factor beta ( TGF beta ) and macrophage inflammatory protein 1 alpha ( MIP 1 alpha ) ) , either of which , however , if added exogenously at a sufficient concentration , can exert this action on its own . ^^^ |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| To test this hypothesis , we measured protein levels of transforming growth factor beta 1 ( TGF beta 1 ) and macrophage inflammatory protein 1 alpha ( MIP 1 alpha ) in the conditioned media of human umbilical cord and adult MNC using specific enzyme linked immunosorbent assays . ^^^ There was significantly less TGF beta 1 in culture supernatants of cord versus adult MNC after 24 , 72 , and 120 hours of stimulation ( P < . 05 ) , and significantly less MIP 1 alpha in cord versus adult supernatants after 72 hours and 120 hours of stimulation ( P < . 01 ) . ^^^ We then examined the mRNA expression of the negative regulators TGF beta 1 , MIP 1 alpha , and interleukin 8 ( IL 8 ) in cord and adult MNC using Northern blot hybridization followed by quantitative densitometry . ^^^ There were no significant differences in the transcription rates determined by nuclear run on assay of either the TGF beta 1 or MIP 1 alpha gene in cord versus adult MNC after 6 hours of stimulation , suggesting that the reduced TGF beta 1 and MIP 1 alpha mRNA in activated cord MNC may be secondary to alteration in posttranscriptional regulation . ^^^ |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| We have also documented heterogeneity in primitive CML cell responses to two factors that specifically and reversibly arrest the cycling of primitive normal hemopoietic cells ; i . e . , TGF beta and MIP 1 alpha , to which CML cells are normally responsive and abnormally unresponsive , respectively . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^ |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| Contrasting effects of rh MIP 1 alpha and TGF beta 1 on chronic myeloid leukemia progenitors in vitro . ^^^ For normal controls both macrophage inflammatory protein 1 alpha ( MIP 1 alpha ) and transforming growth factor beta 1 ( TGF beta 1 ) inhibited the proliferation of CFU A colonies when directly added to the assay . ^^^ In contrast , CML progenitors responded normally to TGF beta 1 , but showed no response to MIP 1 alpha . ^^^ In conclusion , the primitive progenitors from CML samples were inhibited normally by TGF beta 1 but showed no response to MIP 1 alpha . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^ |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| Transforming growth factor beta 1 ( TGF beta 1 ) and macrophage inflammatory protein 1 alpha ( MIP 1 alpha ) have recently been identified as potent inhibitors of hemopoietic stem cell proliferation . ^^^ We report here that both MIP 1 alpha and TGF beta are capable of inhibiting the same stem cell population ( colony forming unit [ CFU ] A / CFU S ) with similar potencies . ^^^ We further show that TGF beta potently inhibits MIP 1 alpha gene expression in bone marrow derived macrophages , the presumed source of MIP 1 alpha in the bone marrow . ^^^ The inhibition of MIP 1 alpha gene expression is also seen as a reduction in MIP 1 alpha protein production , which markedly decreases 24 h after treating RAW 264 . 7 cells , a murine macrophage cell line , with TGF beta . ^^^ These in vitro results suggest that in the presence of active TGF beta in vivo , and in the absence of upregulators of MIP 1 alpha transcription , very little MIP 1 alpha will be produced . ^^^ |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| Thus , we further determined the presence in the PBMNC conditioned medium ( CM ) of both inhibitory cytokines : macrophage inflammatory protein 1 alpha ( MIP 1 alpha ) , tumor necrosis factor alpha ( TNF alpha ) , transforming growth factor beta 2 ( TGF beta 2 ) , and interferon gamma ( IFN gamma ) , and stimulatory cytokines : interleukin 3 ( IL 3 ) and stem cell factor ( SCF ) . ^^^ |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| By RT PCR analysis , constitutive mRNA expression of c kit , G CSF , GM CSF , IL 1 beta , IL 6 , IL 7 , IL 8 , IL 11 , Kit ligand ( KL ) , LIF , M CSF , MIP 1 alpha , TGF beta , and TNF alpha was demonstrated in both cell lines , with L87 / 4 a more potent cytokine producer than L88 / 5 . ^^^ |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| Thus , we further determined the presence in the PBMNC conditioned medium ( CM ) of inhibitory cytokines ( macrophage inflammatory protein 1 alpha [ MIP 1 alpha ] , transforming growth factor beta 2 [ TGF beta 2 ] , interferon gamma [ IFN gamma ] , and tumor necrosis factor alpha [ TNF alpha ] ) and stimulatory cytokines ( granulocyte macrophage colony stimulatory factor [ GM CSF ] , interleukin 3 [ IL 3 ] , and stem cell factor [ SCF ] ) . ^^^ |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| Neutralization with antibodies against hematopoiesis inhibiting cytokines such as TGF beta 1 , IFN gamma , MIP 1 alpha and IL 4 which were detected in stromal cell CM , failed to abrogate the inhibitory effect of KM 102 CM on K 562 cells . ^^^ |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| TGF beta and macrophage inflammatory protein 1 alpha ( MIP 1 alpha ) appear to share a number of biologic properties . ^^^ Our earlier observations have indicated that TGF beta is a potent down regulator of MIP 1 alpha and MIP 1 beta expression in bone marrow macrophages and also of MIP 1 alpha receptor numbers on FDCPmix cells . ^^^ We now demonstrate that the interplay between TGF beta and MIP 1 alpha beta is relatively specific , in that only MIP 1 alpha and MIP 1 beta appear to be potently suppressed by TGF beta , and that this suppressive activity is restricted to the direct TGF beta isoforms . ^^^ We also demonstrate the existence of an endogenous TGF beta mediated block that acts to minimize MIP 1 alpha expression in TGF beta expressing macrophages . ^^^ This coupled with the observations that MIP 1 alpha can induce expression of TGF beta suggests to us that the complex interactions between MIP 1 alpha and MIP 1 beta and the direct TGF beta isoforms ( beta 1 , beta 2 , and beta 3 ) act to ensure minimized MIP 1 alpha beta expression and maximized TGF beta expression . ^^^ |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| Transforming growth factor beta ( TGF beta ) and macrophage inflammatory protein l alpha ( MIP 1 alpha ) are both well described inhibitors of committed and multipotential hematopoietic progenitors . ^^^ |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| We showed a time dependent variation of c jun mRNA expression with an early and transient dose dependent induction followed by a second increase at 24 and 48 h : a biphasic dose dependent variation of bcl 2 expression 30 min after irradiation with a reduction of mRNA level at 1 Gy , and a normalization at higher doses and stable levels of mRNA for c fos , c myc , G CSF , GM CSF , IL 6 , TNF alpha , TGF beta , and MIP 1 alpha genes . ^^^ |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| We have found that NK A , through NK 2 like receptors induces increased levels of macrophage inflammatory protein 1 alpha ( MIP 1 alpha ) and transforming growth factor beta ( TGF beta ) ( transcriptional and posttranscriptional ) in BM stroma . ^^^ |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| TGF beta and MIP 1 alpha exert their main inhibitory activity on very primitive CD34+2CD38 cells but show opposite effects on more mature CD34+CD38+ human hematopoietic progenitors . ^^^ We investigated the effects of transforming growth factor beta ( TGF beta ) and macrophage inflammatory protein 1 alpha ( MIP 1 alpha ) on very primitive CD34++CD38 and on more mature CD34++CD38+ human hematopoietic progenitor cells by means of a two stage pre colony forming cell ( pre CFC ) assay . ^^^ The first ( liquid ) stage of this assay allows evaluation of the effects of TGF beta and MIP 1 alpha on the `` primary ' ' proliferation of the progenitors under study and on the generation of `` secondary ' ' colony forming cells ( CFC , cells for which a second stage semisolid clonogenic assay was used as a read out ) . ^^^ Thus , TGF beta , and MIP 1 alpha both inhibit very primitive CD34+2 ) CD 38 cells , but they are not equally potent . ^^^ The effects of TGF beta and MIP 1 alpha on more mature progenitor cells are more complex . ^^^ |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| Control specimens from six patients without inflammatory muscle disease were analyzed for transcripts of interleukins 1 beta , 2 , 4 , 6 , 10 , and 15 , and interferon gamma , tumor necrosis factor alpha , transforming growth factor beta 1 , macrophage inflammatory proteins 1 alpha and 1 beta ( MIP 1 alpha , MIP 1 beta ) , and the chemokine `` regulated on activation , normally T expressed and secreted ' ' ( RANTES ) . ^^^ |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| The proliferative effects of SP correlate with the induction of positive hematopoietic growth factors such as IL 3 , IL 6 , GM CSF and c kit ligand and the inhibitory effects by NK A correlate with the induction of two negative hematopoietic regulators , MIP 1 alpha and TGF beta . ^^^ |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| We have compared the effects of AcSDKP , Thymosin beta 4 ( Tbeta 4 ) , MIP1alpha and TGFbeta on acute myeloid leukemia ( AML ) and B lineage acute lymphoid leukemia ( B ALL ) cells using liquid cultures in the presence of GM CSF , IL 3 and SCF for AML cells and IL 3 and IL 7 for ALL cells . ^^^ Whereas TGFbeta was found inhibitory in all the AML and B ALL cases studied , MIP1alpha was inhibitory in 6 / 12 AML cases and had no effect on B ALL cells . ^^^ Thus , our study not only confirms the effect of TGFbeta , MIP1alpha and AcSDKP on AML cells but also provides new data concerning their effect on B ALL and the possible inhibitory effect of AcSDKP at high doses . ^^^ |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| Interleukin 2 , 5 , 6 , 9 , 10 , MIP 1 alpha , RANTES and sCD 23 enhance the production of IgE whereas PAF , PGE 2 , IL 8 , 12 and 18 , IFN alpha and gamma , TGF beta , sIL 4R , IL 1Ra , and probably sIL 1R inhibit it . ^^^ |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| Prognostic value of MIP 1 alpha , TGF beta 2 , sELAM 1 , and sVCAM 1 in patients with gram positive sepsis . ^^^ The aim of the present study was to evaluate the potential prognostic value of MIP 1 alpha , TGF beta 2 , sELAM 1 , and sVCAM 1 in patients with gram positive sepsis . ^^^ |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| Induction of the chemokine beta peptides , MIP 1 alpha and MIP 1 beta , by lipopolysaccharide is differentially regulated by immunomodulatory cytokines gamma IFN , IL 10 , IL 4 , and TGF beta . ^^^ |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| Examination of proinflammatory cytokine , chemokine , and Mt mRNA in the lung revealed increases for messages encoding IL 1 alpha , IL 1 beta , IL 6 , IFN gamma , TNF alpha , Eotaxin , MIP 1 alpha , MIP 1 beta , MIP 2 , Mt , and IP 10 , while messages encoding IL 12 , IL 10 , IFN beta , Ltn , MCP 1 , TGF beta 1 + 2 , and RANTES were unchanged from those of sham exposed mice 2 h postexposure . ^^^ |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| IFN alpha , MIP 1 alpha and TGF beta stimulate production of membrane bound and soluble FL . ^^^ |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| TGF beta , GM CSF , c kit ligand , and IL 7 are produced constitutively and IL 1beta , IL 6 , IL 8 , TNF alpha , IFN gamma , and MIP 1 alpha are upregulated upon stimulation . ^^^ |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| Samples were assayed for IL 1beta , IL 6 , IL 4 , IL 8 , IL 10 , TGFbeta , TNFalpha , INFgamma , MIP1alpha , MIP1beta , RANTES , and TNFR 2 using enzyme linked immunosorbent assays . ^^^ |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| Induction of RYR 1 and / or RYR 2 mRNA was found after treatment with stromal cell derived factor 1 , macrophage inflammatory protein 1alpha ( MIP1alpha ) or TGF beta . ^^^ |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| Cytokines assumed to have a stimulatory effect on HPC stem cell factor ( SCF ) , fetal liver tyrosine kinase 3 ligand ( flt 3 ligand ) , thrombopoietin ( TPO ) , stromal cell derived factor 1 ( SDF 1 ) , oncostatin M ( OSM ) , a suppressive effect on HPC proliferation macrophage inflammatory protein 1alpha ( MIP 1alpha ) , transforming growth factor beta 1 ( TGFbeta 1 ) , tumour necrosis factor alpha ( TNFalpha ) and to be involved in migration of HPC ( SCF , flt 3 ligand , MIP1alpha , SDF 1 ) were examined at the level of mRNA expression by means of real time RT PCR . ^^^ |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| Time course of immunological markers in patients with the systemic inflammatory response syndrome : evaluation of sCD 14 , sVCAM 1 , sELAM 1 , MIP 1 alpha and TGF beta 2 . ^^^ Proinflammatory parameters such as sCD 14 , sVCAM 1 , sELAM 1 , MIP 1 alpha and anti inflammatory parameters such as TGF beta 2 were determined using enzyme linked immunosorbent assay ( ELISA ) . ^^^ |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| Many other cytokines are responsible for the growth , maturity , migration activation and apoptosis of all cells involved in allergic inflammation , among them are IL 2 , IL 5 , IL 6 , IL 9 , MIP 1 alpha , RANTES , IL 8 , IL 12 , IL 18 , IFN alpha 1 gamma , TGF beta , sIL 4 , IL 1Ra . ^^^ |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| These cytokines include at least transforming growth factor beta ( TGF beta ) , tumor necrosis factor alpha ( TNF alpha ) , platelet derived growth factor , fibroblast growth factors , ( TGF alpha ) , interleukin 1 , monocyte chemoattractant protein 1 and macrophage inflammatory protein 1 alpha . ^^^ |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| IL 1 , TNF alpha , transforming growth factor beta ( TGF beta ) , and macrophage inflammatory protein 1 alpha ( MIP 1alpha ) exert a chemoprotective effect on BM cells , while a putative role of IL 12 in this effect is still unknown . ^^^ |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| Expression of the chemokines monocyte chemoattractant protein 1 ( MCP 1 ) , macrophage inflammatory protein 1 alpha ( MIP 1alpha ) , RANTES ( regulated on activation normal T cell expressed and secreted ) , fractalkine , and thymocyte expressed chemokine ( TECK ) ; and the cytokines stem cell factor ( SCF ) and transforming growth factor beta 1 ( TGFbeta 1 ) , was constitutive and no alteration was detected following infection . ^^^ |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| Phasic upregulation of gene expression for chemokines T cell activation gene 3 ( TCA 3 ) / CCL1 , monocyte chemoattractant protein 1 ( MCP 1 ) / CCL2 , macrophage inflammatory protein 1 alpha ( MIP 1alpha ) / CCL3 , MIP 1beta / CCL4 , regulated on activation normal T cell expressed and secreted ( RANTES ) / CCL5 and MIP 2 / CXCL2 3 as well as cytokines tumour necrosis factor alpha ( TNF alpha ) , beta , LT beta , interferon gamma ( IFN gamma ) and transforming growth factor beta 1 ( TGF beta 1 ) in the CNS was observed during attacks of ChREAE . ^^^ |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| MATERIALS AND METHODS : The effect of inhibitory cytokines ( tumor necrosis factor alpha [ TNF alpha ] , interferon gamma [ IFN gamma ] , macrophage inflammatory protein 1 alpha [ MIP 1alpha ] , and transforming growth factor beta 1 [ TGF beta 1 ] ) was investigated , using clonogenic assays , competitive repopulation , and in vivo induction of proinflammatory cytokines by double stranded RNA . ^^^ |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| Compared with macrophage inflammatory protein alpha ( MIP 1alpha ) , Fc ( epsilon ) RI dependent Ltn and MIP 1alpha mRNA levels were up regulated by IL 4 , but not IFN gamma , although higher levels of IL 4 ( 100 and 1000 U / ml ) inhibited Ltn expression only ; and TGF beta preferentially enhanced Fc ( epsilon ) RI dependent Ltn mRNA levels , suggesting that Ltn and MIP 1alpha have shared and unique regulatory mechanisms . ^^^ |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| Infection and replication of human cytomegalovirus in bone marrow stromal cells : effects on the production of IL 6 , MIP 1alpha , and TGF beta 1 . ^^^ Thus , both the direct effect of HCMV on hematopoietic progenitors as well as altered cytokine production by bone marrow stromal cells ( including MIP 1alpha and TGF beta 1 , but not IL 6 ) could contribute to hematopoietic failure during HCMV infection . . ^^^ |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| In contrast , chemokines MIP 1alpha , C 10 , and RANTES were not induced , nor were TGF beta , IL 10 , IL 12 , or 1 NOS . ^^^ |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| Using ELISA and RIA , we studied , in the supernatant of cells from CDCL , the time course of interleukins 3 and 6 ( IL 3 , IL 6 ) , stem cell factor ( SCF ) , granulocyte macrophage , granulocyte and macrophage colony stimulating factors ( GM CSF , G CSF and M CSF ) , macrophage inflammatory protein 1alpha ( MIP 1alpha ) and transforming growth factor beta 1 ( TGF beta 1 ) . ^^^ |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| Enzyme linked immunosorbent assays ( ELISAs ) were employed to detect the concentrations of interleukin 4 ( IL 4 ) , IL 6 , IL 10 , interferon gamma ( IFN gamma ) , transforming growth factor beta 1 ( TGF beta 1 ) , and macrophage inflammatory protein 1alpha ( MIP 1alpha ) . ^^^ Fosfomycin could not suppress the HTLV 1 associated SP , but had the properties to decrease the levels of TGF beta 1 and MIP 1alpha . ^^^ |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| Proliferation of myeloid progenitors is inhibited by NK A , effects which correlate with the induction of two suppressive factors , TGF beta and MIP 1alpha . ^^^ |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| Fibrocytes purified from wound chambers also were found to express mRNA for IL 1beta , IL 10 , TNF alpha , JE / MCP , MIP 1alpha , MIP 1beta , MIP 2 , PDGF A , TGF beta 1 , and M CSF . ^^^ |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| Despite the lack of adherent stroma , CB cultures expressed mRNA for many growth factors ( G CSF , GM CSF , IL 1 , IL 6 , LIF , KL , FL , Tpo , TGF beta , TNF alpha , and MIP 1alpha ) that were also found in bone marrow ( BM ) cultures , with the exception of IL 11 ( found only in BM ) and IL 3 ( found in neither ) . ^^^ |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| Following an acute intraperitoneal injection of triethyltin ( TET ) sulfate ( 3 mg / kg ) to 17 day old CD 1 mice , significant increases in brain stem TNF alpha and IL 1alpha mRNA levels occurred at 6 and 24 h , respectively with elevations in TGF beta 1 and MIP 1alpha at 1 h . ^^^ In the cortex , responses were limited to elevations at 6 h in TNF alpha , TGF beta 1 and MIP 1alpha . ^^^ |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| Marrow stromal cells of patients treated by autologous bone marrow transplantation ( ABMT ) for malignancies have been assessed for their ability to secrete granulocyte colony stimulating factor ( G CSF ) , granulocyte macrophage colony stimulating factor ( GM CSF ) , stem cell factor ( SCF ) , leukemia inhibitory factor ( LIF ) , interleukin 6 ( IL 6 ) , transforming growth factor beta 1 ( TGFbeta 1 ) and macrophage inflammatory protein 1alpha . ( MIP 1alpha ) . ^^^ |
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| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| MCP 1 , not MIP 1alpha , is the endogenous chemokine that cooperates with TGF beta to inhibit the cycling of primitive normal but not leukemic ( CML ) progenitors in long term human marrow cultures . ^^^ |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| ELISA and RT PCR experiments showed that contact did not induce changes in the levels of several known growth factors , including GM CSF , IL 1beta , IL 3 , IL 6 , IL 11 , LIF , KL , FL , Tpo , TGF beta , and MIP 1alpha . ^^^ |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| RESULTS : Arthritic paws exhibited mRNA levels of interleukin 1beta ( IL 1beta ) , IL 2 , macrophage inflammatory protein 2 ( MIP 2 ) , IL 6 , IL 1 receptor antagonist , RANTES , tumor necrosis factor alpha ( TNFalpha ) , TNFbeta , MIP 1alpha , IL 11 , transforming growth factor beta 1 ( TGFbeta 1 ) , TGFbeta 2 , and TGFbeta 3 that were increased above mRNA levels in paws of normal , unimmunized mice and that exhibited distinct temporal patterns of mRNA expression . ^^^ |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| To investigate this hypothesis the in situ release by BAL cells of the following cytokines was measured and correlated with the chest 10 ray findings of 43 patients with pulmonary tuberculosis : interleukin ( IL ) 8 , macrophage inflammatory protein 1alpha ( MIP 1alpha ) , IL 6 , tumor necrosis factor alpha ( TNF alpha ) , transforming growth factor beta ( TGF beta ) , interferon gamma ( IFN gamma ) , IL 2 , IL 4 and IL 5 . ^^^ |
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| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| In this paper we show that apoptotic cell uptake by mouse J 774 macrophages also inhibits the synthesis and secretion of the chemokines , macrophage inflammatory protein 2 ( Mip 2 ) , KC , and Mip 1alpha ( but not that of monocyte chemoattractant protein 1 ( MCP 1 ) / JE ) , and increases TGF beta formation . ^^^ Apoptotic cell ingestion or TGF beta also inhibited Mip 2 and Mip 1alpha gene expression in LPS treated J 774 cells , whereas TNF alpha mRNA levels were unaffected . ^^^ |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| Nonobese diabetic / severe combined immunodeficient ( NOD / SCID ) mice transplanted with human cord blood or adult marrow cells and injected 6 weeks posttransplant with 2 daily doses of transforming growth factor beta ( 1 ) ( TGF beta ( 1 ) ) , monocyte chemoattractant protein 1 ( MCP 1 ) , or a nonaggregating form of macrophage inflammatory protein 1alpha ( MIP 1alpha ) showed unique patterns of inhibition of human progenitor proliferation 1 day later . ^^^ |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| IPP induction of MIP 1alpha and MIP 1beta was not affected by costimulation with interleukin 4 ( IL 4 ) , IL 10 , TGF beta , or interferon gamma ( INF gamma ) . ^^^ However , IL 12 significantly enhanced IPP induced expression and release of MIP 1alpha that was down regulated by TGF beta whereas the induction of MIP 1beta by IPP+IL 12 was refractory to cotreatment with TGFbeta indicating that these chemokines are differentially regulated by these cytokines . ^^^ |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| We demonstrate that the level of plasma interleukin 8 ( IL 8 ) was 4 fold higher during the follicular phase than the luteal phase ( p = 0 . 004 ) , whereas plasma IL 1beta , IL 4 , IL 6 , IL 10 , interferon gamma ( IFN gamma ) , transforming growth factor beta ( TGF beta ) , tumor necrosis factor alpha ( TNF alpha ) , macrophage inflammatory protein 1alpha ( MIP 1alpha ) , and TNF receptor 2 ( TNFR 2 ) were not altered during the ovulatory cycle . ^^^ |
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| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| MIP 1alpha and TGF beta production in CD34+ progenitor stromal cell coculture systems : effects of progenitor isolation method and cell cell contact . ^^^ Both MIP 1alpha and TGF beta have been found to influence cell cycle status and proliferation status of early hematopoietic progenitors , and both have potential effects on accessory cell function . ^^^ |
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| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| MIP 1alpha , MIP 1beta , IL 8 ) , proinflammatory cytokines ( TNF alpha , GM CSF and IL 6 ) and TGF beta by human enterocytic Caco 2 cells . ^^^ |
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| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| Cultured neurons constitutively produced interleukin 1 ( IL 1 ) , IL 6 , macrophage inflammatory protein 1alpha ( MIP 1alpha ) , and MIP 1beta but not transforming growth factor beta 1 ( TGF beta 1 ) , IL 10 , and granulocyte macrophage colony stimulating factor . ^^^ |
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| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| Gene expression of adhesion molecules , interleukin 1alpha ( IL 1alpha ) , IL 1beta , monocyte chemoattractant protein 1 , macrophage inflammatory protein 1alpha ( MIP 1alpha ) , MIP 2 , transforming growth factor beta 1 ( TGF beta 1 ) connective tissue growth factor ( CTGF ) , vascular endothelial growth factor ( VEGF ) , Flt 1 , and Flk 1 was enhanced at the wound site . ^^^ |
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| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| The combination of apoptotic cells and TLR ligands enhanced early secretion of TNF alpha , MIP 1alpha , and MIP 2 and increased late TGF beta 1 secretion , while suppressing late TNF alpha , IL 10 , and Il 12 by mechanisms which could nevertheless be overridden by IFN gamma . ^^^ |
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| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| The results showed : ( 1 ) six cytokines , MIP 1alpha , MIP 2 , TGF beta , TNF alpha , IFN gamma and Tbeta ( 4 ) , inhibited the growth of CFU GM when murine WEHI 3 conditioned medium was added to the culture system as a source of colony stimulation . ( 2 ) The original endothelial cell conditioned medium ( E CM ) did not affect the production of CFU GM , but the > 10 kD component of E CM increased its production , and the < 10 kD component decreased it . ^^^ All three components of macrophage conditioned medium ( M CM ) inhibited the growth of CFU GM . ( 3 ) Expression of four of the mRNAs , namely MIP 2 , TNF alpha , INF gamma and Tbeta ( 4 ) , was seen in all three types of stromal cells , while TGF beta mRNA was only seen in endothelial cells and macrophages , and MIP 1alpha mRNA in endothelial cells and fibroblasts . ^^^ The inhibitors TGF beta , MIP 1alpha , and Tbeta ( 4 ) have an inhibitory effect on the growth of CFU GM , but TNF alpha , INF gamma and MIP 2 do not . . ^^^ |
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| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| Thus , chemotherapy for ALL induces functional deregulation within bone marrow stromal cells with an increase in the growth inhibiting factor TGF beta 1 , together with a decrease in MIP 1alpha , which might contribute to hematopoietic toxicity . . ^^^ |
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| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| A / J mice challenged with B . anthracis ( Sterne ) showed increased gene expression for Fas , FasL , Bax , IL 1 beta , TNF alpha , TGF beta , MIP 1alpha , KC and RANTES . ^^^ |
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| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| In Jurkat cells , the expression of IL 3 , GM CSF , TNF alpha , TGF beta 1 , IL 2 , lymphotactin , MIP 1alpha , and MIP 1beta was inhibited to different extents . ^^^ In THP 1 cells , inhibition of the expression of M CSF , G CSF , stem cell factor , IFN gamma , TNF alpha , TGF beta 1 , lymphotoxin beta 1 , MIP 1alpha , MIP 1beta , and IL 8 was observed . ^^^ |
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| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| Hematopoietic suppression mediated by NK A could be partly explained through the production of TGF beta 1 and MIP 1alpha . ^^^ |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| CSF levels of 5 growth factors ( HGF , GDNF , VEGF , BDNF , FGF 2 ) and 3 cytokines / chemokines ( TNF alpha , TGF beta 1 , MIP 1alpha ) did not significantly differentiate between the studied groups . ^^^ |
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| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| Animals with fibrotic alterations showed an induction of pancreatic pro collagen 1 gene expression , and the infiltration of immune cells was accompanied by the expression of the inflammatory mediators MIP 1alpha , IL 1beta , and TGF beta in 33 % ( 4 / 12 ) of the animals . ^^^ |
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| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| Cycloheximide , actinomycin D , and antibodies against MIP 1alpha and monocyte chemoattractant protein 1 ( MCP 1 ) abolished the stimulation of cell migration by TGF beta 1 . ^^^ These findings suggest that migration of these cells is regulated directly and indirectly via the expression of chemokines such as MIP 1alpha and MCP 1 mediated by RhoA in response to TGF beta 1 . ^^^ |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P01137 |
Pubmed |
SVM Score :0.0 |
| NA |
|