| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| Two distinct receptors for the chemoattractant interleukin 8 ( designated IL 8RA and B ) have been cloned recently . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| The genes encoding two receptors for Interleukin 8 ( IL8RA , IL8RB ) have been located on human chromosome 2 . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| Platelets also express mRNAs for interleukin 8 receptor A ( IL 8RA ) and a novel chemokine receptor K5 . 5 . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| The effects of interleukin 8 on neutrophils are mediated through two receptors , IL 8RA and IL 8RB . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| Two receptors for interleukin 8 ( IL 8 ) , IL 8rA and IL 8rB , have been cloned . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| Herein we describe interleukin 8 receptor B ( IL 8RB , also termed CXCR 2 ) immunoreactivity in the central nervous system . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| Interleukin 8 ( IL 8 ) acts on human neutrophils via two receptors , CXCR 1 and CXCR 2 . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| Two G protein coupled receptor subtypes ( CXCR 1 and CXCR 2 ) mediate Interleukin 8 ( IL 8 ) action in cells . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| The biologic role of interleukin 8 : functional analysis and expression of CXCR 1 and CXCR 2 on human eosinophils . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| Distribution of the interleukin 8 receptors , CXCR 1 and CXCR 2 , in inflamed gut tissue . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| Expression of the interleukin 8 receptors CXCR 1 and CXCR 2 on cord blood derived cultured human mast cells . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| The cytokine interleukin 8 ( IL 8 ) binds with high affinity to the CXCR 1 and CXCR 2 receptors on neutrophils . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| Interleukin 8 and its receptor CXCR 2 in atherosclerosis . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| Expression of interleukin 8 receptors ( CXCR 1 and CXCR 2 ) in premenopausal women with recurrent urinary tract infections . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : To investigate the expression of interleukin 8 ( IL 8 ) receptors CXCR 1 and CXCR 2 in adenomyosis . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| Expression of interleukin 8 and its receptor IL 8RA in chronic hyperplastic candidosis . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| The interleukin 8 receptor type 1 ( IL8R1 ) binds IL 8 only , whereas the interleukin 8 receptor type 2 ( IL8R2 ) ( previously designated IL8RA ) also binds growth regulated gene ( GRO ) , and neutrophil activating protein 2 ( NAP 2 ) with high affinity . ^^^ In the process of screening a genomic library with these cDNAs to obtain large clones for use in chromosomal localization studies , we isolated an interleukin 8 receptor pseudogene ( IL8RP ) that bears greatest similarity to IL8R2 . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| The human type A interleukin 8 receptor ( IL 8RA ) was modified to express an amino terminal epitope tag and stably overexpressed in a rat basophilic leukemia cell line ( RBL 2H3 ) . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| We have previously characterized the stably transfected , clonally selected human placental cell line , 3ASubE P 3 , which overexpresses the type B interleukin 8 receptor ( IL 8RB ) and responds to the chemokine melanoma growth stimulatory activity ( MGSA ) with enhanced phosphorylation of this receptor . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| Alanine scanning mutagenesis of the charged amino acids of melanoma growth stimulating activity ( MGSA ) was used to identify specific residues that are involved in binding to the human erythrocyte Duffy antigen / chemokine receptor ( DARC ) and to the type B interleukin 8 receptor ( IL 8RB ) on neutrophils . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| Human neutrophils are highly responsive to the chemokine interleukin 8 ( IL 8 ) owing to high levels of expression of two related receptors encoded by the single copy genes il8ra and il8rb located on chromosome 2q34 q 35 . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| In addition to the two human interleukin 8 ( IL 8 ) receptors that have been cloned , IL 8RA and IL 8RB , we recently described a binding protein in human erythrocytes that binds IL 8 and monocyte chemotactic peptide 1 ( MCP 1 ) , which we have termed the chemokine ( CK ) receptor . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| The high affinity interleukin 8 receptor gene ( IL8RA ) maps to the 2q33 q 36 region of the human genome : cloning of a pseudogene ( IL8RBP ) for the low affinity receptor . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| Human interleukin 8 receptors A ( IL 8RA ) and B ( IL 8RB ) are seven transmembrane domain ( TMD ) neutrophil chemokine receptors with similar sequences ( 77 % amino acid identity ) and similar G protein selectivity , but markedly different selectivity for CXC chemokines . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| To determine the regions of interleukin 8 ( IL 8 ) that allow high affinity and interleukin 8 receptor type 1 ( IL8R1 ) specific binding of chemokines , we produced chimeric proteins containing structural domains from IL 8 , which binds to both IL8R1 and interleukin 8 receptor type 2 ( IL8R2 ) with high affinity , and from GRO gamma , which does not bind to IL8R1 and binds to IL8R2 with reduced affinity . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| Two monoclonal antibodies , anti IL8R1 and anti IL8R2 , raised against both interleukin 8 receptors ( IL 8R ) of human neutrophils , IL 8R1 and IL 8R2 , were used to study individual receptor functions after stimulation with IL 8 , GRO alpha , or NAP 2 . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| To examine cross desensitization between receptors for lipid and peptide chemoattractants , cDNA encoding the PAF receptor ( PAFR ) was co expressed into RBL 2H3 cells with cDNAs encoding receptors for either formylated peptides ( FR ) , a product of the fifth component of complement ( C5aR ) or interleukin 8 A ( IL 8RA ) . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| In the present study , we sought to dissect these processes and to map important functional domains of the two CXC chemokine ( interleukin 8 ) receptors , CXCR 1 ( formally IL 8RA ) and CXCR 2 ( formally IL 8RB ) , using blocking monoclonal antibodies ( mAbs ) to the receptors and a series of chimeras between CXCR 1 and CXCR 2 . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| We have shown previously that chemokine receptors including the interleukin 8 receptor B ( CXCR 2 ) and the Duffy blood group antigen are expressed on subsets of neurons in various regions of the adult nervous system . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| Truncation of CXCR 2 by substitution of a stop codon for Ser 342 ( 342T ) or Ser 331 ( 331T ) results in total loss of melanoma growth stimulatory activity / growth related protein ( MGSA / GRO ) enhanced receptor phosphorylation , which can not be explained based upon altered ligand binding affinity or receptor number . 3ASubE cells expressing 342T or CXCR 2 with mutation of Ser 342 , 346 , 347 , and 348 to alanine ( 4A ) exhibit strong mobilization of Ca2+ in response to ligand ( interleukin 8 or MGSA / GRO ) , with a recovery phase significantly slower than that of cells expressing wild type ( WT ) CXCR 2 . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| This study was undertaken to define the regions of the human interleukin 8 type B receptor ( IL8RB ) which are critical for binding the ligands interleukin 8 , NAP 2 and GRO alpha . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| Two homologous high affinity receptors for the chemoattractant interleukin 8 , IL 8RA and IL 8RB , and one for the chemoattractant C5a ( C5aR ) have been cloned . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| We have recently observed that the interleukin 8 ( IL 8 ) receptor messages , IL 8RA and B ( CXCR 1 and CXCR 2 ) , also undergo changes in stability in response to the inflammatory stimulator lipopolysaccharide ( LPS ) . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| The CXC chemokine neutrophil activating peptide 2 induces two distinct optima of neutrophil chemotaxis by differential interaction with interleukin 8 receptors CXCR 1 and CXCR 2 . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| Identification of a potent , selective non peptide CXCR 2 antagonist that inhibits interleukin 8 induced neutrophil migration . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| The murine homolog of the interleukin 8 receptor CXCR 2 is essential for the occurrence of neutrophilic inflammation in the air pouch model of acute urate crystal induced gouty synovitis . ^^^ Urate crystals induce different classes of neutrophil chemotaxins , including certain chemokines ( e . g . , interleukin 8 [ IL 8 ] , growth related oncogene alpha [ GROalpha ] ) that share CXCR 2 as a receptor . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| Biochemical and interaction trap experiments suggest that the RGS 12 N terminus acts as a classical PDZ domain , binding selectively to C terminal ( A / S ) T 10 ( L / V ) motifs as found within both the interleukin 8 receptor B ( CXCR 2 ) and the alternative 3 ' exon form of RGS 12 . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| Neutrophils and transfected RBL 2H3 cells were used to investigate the mechanism of cross regulation of the human interleukin 8 ( IL 8 ) receptors CXCR 1 and CXCR 2 by chemoattractants . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| The interleukin 8 receptors ( CXCR 1 and CXCR 2 ) are specifically expressed at high levels in cells of the neutrophil lineage . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| Interleukin 8 ( IL 8 ) is an important mediator of neutrophil ( PMN ) function and the type A IL 8 receptor ( IL 8RA ) mediates these pro inflammatory signals . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| The neutrophil specific G protein coupled chemokine receptors , CXCR 1 and CXCR 2 , bind with high affinity to the potent chemoattractant interleukin 8 ( IL 8 ) . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| The effect of interleukin 8 ( IL 8 ) and growth related oncogene alpha ( GROalpha ) on [ 35S ] guanosine 5 ' O ( 3 thiotriphosphate ) ( [ 35S ] GTPgammaS ) binding , forskolin stimulated cyclic AMP accumulation and cytosolic calcium concentration were determined in recombinant CHO cells expressing HA tagged CXC chemokine receptors 1 and 2 ( CXCR 1 and CXCR 2 ) . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| CXCR 2 is a seven transmembrane receptor that transduces intracellular signals in response to the chemokines interleukin 8 , melanoma growth stimulatory activity / growth regulatory protein , and other ELR motif containing CXC chemokines by coupling to heterotrimeric GTP binding proteins . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| The functional role of neutrophils during acute inflammatory responses is regulated by two high affinity interleukin 8 receptors ( CXCR 1 and CXCR 2 ) that are rapidly desensitized and internalized upon binding their cognate chemokine ligands . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| Binding of a recombinant interleukin 8 ( rIL 8 ) molecule with a C terminal His tag to RBL 2H3 cells which stably express the IL 8 receptors CXCR 1 or CXCR 2 could also be demonstrated using the tag specific mAb . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| The number of cells expressing the inflammatory mediator serotonin and CXCR 2 , the shared interleukin 8 receptor , are upregulated with inflammation . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| In vitro studies have shown preferential loss of CXCR 2 expression and function after exposure to interleukin 8 , N formyl methionyl leucyl phenylalanine ( fMLP ) , C5a , and tumor necrosis factor alpha . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| To study CCR 1 cross regulation , RBL cells co expressing CCR 1 and receptors for interleukin 8 ( CXCR 1 , CXCR 2 , or a phosphorylation deficient mutant of CXCR 2 , 331T ) were produced . ^^^ Interleukin 8 stimulation of CXCR 1 or CXCR 2 cross phosphorylated CCR 1 and cross desensitized its ability to stimulate GTPase activity and Ca ( 2+ ) mobilization . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| One such receptor , CXCR 2 , binds multiple CXC chemokines , including interleukin 8 , GRO alpha , GRO beta , GRO gamma , and NAP 2 . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| Interleukin 6 receptor alpha ( IL 6R ) and interleukin 8 receptor ( IL 8RB ) are widely expressed in adult human and murine tissues . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| Interleukin 8 and its receptor CXCR 2 in atherosclerosis . ^^^ Although the C C chemokine monocyte chemoattractant protein 1 and its receptor , CCR 2 , have been implicated in atherosclerosis , the role of the classic C 10 C chemokine , interleukin 8 ( KC / growth related oncogene alpha in mice ) and its receptor CXCR 2 has not been studied in the pathogenesis of atherosclerosis . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : To search for single nucleotide polymorphisms in the interleukin 8 ( IL 8 ) and IL 8 receptor CXCR 1 and CXCR 2 genes , and to compare their distribution among patients with systemic sclerosis ( SSc ) with fibrosing alveolitis ( FASSc ) or without fibrosing alveolitis ( NFASSc ) , or patients with cryptogenic fibrosing alveolitis ( CFA ) , and normal healthy subjects . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : To evaluate the expression and clinical significance of interleukin 6 , soluble glycoprotein 130 ( sgp 130 ) , interleukin 8 and type A interleukin 8 receptor ( IL 8RA ) in acute promyelocytic leukemia ( APL ) patients during all trans retinoic acid ( ATRA ) treatment . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| Interleukin 8 , neutrophil activating peptide 2 and GRO alpha bind to and elicit cell activation via specific and different amino acid residues of CXCR 2 . ^^^ The objective of this investigation was to determine the amino acid residues of the human neutrophil CXC chemokine receptor 2 ( CXCR 2 ) that are critical for binding the ligands interleukin 8 ( IL 8 ) , neutrophil activating peptide 2 ( NAP 2 ) , and growth related protein alpha ( GROalpha ) and critical for receptor mediated signal transduction . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| PMNs were exposed to interleukin 8 ( IL 8 ) , growth regulated oncogene alpha ( GRO alpha ) , and platelet activating factor ( PAF ) to stimulate the CXCR 1 , CXCR 2 , and PAF receptors . [ Ca2+ ] 1 flux measurements were used to quantify receptor responses . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| Concomitantly , the expression of the angiogenic chemokines KC and MIP 2 , which are functionally related to interleukin 8 , were downregulated , whereas their shared receptor CXCR 2 was upregulated . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : To evaluate the expression of interleukin 8 ( IL 8 ) and its A , B type receptors ( IL 8RA , IL 8RB ) in acute leukemia ( AL ) . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| We studied the effects of killed S . aureus on the expression of interleukin 8 receptors , CXCR 1 and CXCR 2 , on polymorphonuclear leucocytes ( PMN ) , which are known to lack the expression of MHC 2 antigens . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| The chemokine interleukin 8 acutely reduces Ca ( 2+ ) currents in identified cholinergic septal neurons expressing CXCR 1 and CXCR 2 receptor mRNAs . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| Selective CXCR 2 antagonists may be useful to block the Gro alpha induced priming response whilst preserving neutrophil functions mediated by CXCR 1 , the alternative neutrophil receptor for interleukin 8 . . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| PURPOSE : In the present study , we examined the expression of a multifunctional cytokine , interleukin 8 ( IL 8 ) , and its receptors , CXCR 1 and CXCR 2 , in human colon carcinoma cells with different metastatic potentials and determined their role in modulating phenotypes associated with metastasis . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| As an example , the affinities and inhibition constants of fluorescently labeled interleukin 8 ( IL 8 ) and a low molecular weight antagonist toward the receptors CXCR 1 and CXCR 2 , which belong to the superfamily of G protein coupled receptors ( GPCRs ) , were determined . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| In vitro studies were performed on control subjects to determine changes in the surface expression of CXCR 1 , CXCR 2 , and CD11b on stimulation with interleukin 8 . ^^^ Correlations between interleukin 8 levels and CXCR 2 expression ( P < . 0001 ) and CD11b expression ( P < . 03 ) were demonstrated . ^^^ In addition , whereas interleukin 8 is an important determinant of both CXCR 1 and CXCR 2 expression in vitro , it only correlates with CXCR 2 and CD11b expression in vivo . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| Human embryonic kidney ( HEK ) 293 cells expressing recombinant G alpha ( 1 ) coupled , human CXC chemokine receptor 2 ( CXCR 2 ) were used to study the elevation of the intracellular [ Ca ( 2+ ) ] ( [ Ca ( 2+ ) ] ( 1 ) ) in response to interleukin 8 ( IL 8 ) following pre stimulation of endogenously expressed P2Y1 or P2Y2 nucleotide receptors . 2 . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| The selective CXCR 2 antagonist SB 272844 blocks interleukin 8 and growth related oncogene alpha mediated inhibition of spontaneous neutrophil apoptosis . ^^^ The aims of this study were to investigate the effects of Interleukin 8 ( IL 8 ) and Growth related oncogene alpha ( Gro alpha ) on neutrophil apoptosis and determine the potential for a selective CXCR 2 antagonist to inhibit these responses . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| Because the chemotactic responses of neutrophils are impaired after phagocytosis , we explored the effect of phagocytic stimuli on the expression of interleukin 8 ( IL 8 ) receptors , CXCR 1 and CXCR 2 , in human neutrophils . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| A self defence mechanism of astrocytes against Fas mediated death involving interleukin 8 and CXCR 2 . ^^^ Here , we show that survival of cultured astrocytes after Fas triggering is governed by the interaction of interleukin 8 with one of its receptors , CXCR 2 . ^^^ Furthermore , interleukin 8 secretion and CXCR 2 expression are both induced in human astrocytes after Fas stimulation , suggesting a new mechanism of self defence against Fas mediated death . . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| Special emphasis is placed on the interaction of the human immunodeficiency virus ( HIV ) Tat protein with endothelial , astroglial , microglial , and neuronal cells , resulting in altered expression of vascular endothelial growth factor , fibroblast growth factor , interleukin 8 , and regulation of calcium flux via CXCR 2 , which directly influences neuronal cell fitness . . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| Angiogenic effects of interleukin 8 ( CXCL 8 ) in human intestinal microvascular endothelial cells are mediated by CXCR 2 . ^^^ The chemokine interleukin 8 ( IL 8 ; CXCL 8 ) exerts potent angiogenic properties on endothelial cells through interaction with its cognate receptors CXCR 1 and CXCR 2 . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| In the present study , we examined the expression of chemokine receptors CXCR 1 and CXCR 2 ( receptors for interleukin 8 ) and CCR 5 ( receptor for RANTES [ regulated on activation , normal T cell expressed and secreted ] , macrophage inflammatory protein [ MIP ] 1alpha , and MIP 1beta ) in human endometrium . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| Characterization of the molecular interactions of interleukin 8 ( CXCL 8 ) , growth related oncogen alpha ( CXCL 1 ) and a non peptide antagonist ( SB 225002 ) with the human CXCR 2 . ^^^ Both receptors share two ligands , interleukin 8 ( CXCL 8 ) and GCP 2 ( CXCL 6 ) , whereas several chemokines , including growth related oncogen alpha ( CXCL 1 ) and a non peptide antagonist ( SB 225002 ) are specific for CXCR 2 . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| In this study , we addressed the question of whether expression of the interleukin 8 receptors IL 8RA ( CXCR 1 ) and IL 8RB ( CXCR 2 ) is upregulated in H . pylori infected human gastric biopsy samples . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| It is well known that chemokines and chemokine receptors , such as interleukin 8 and its receptors ( CXCR 1 and CXCR 2 ) , play important roles in the pathogenesis of psoriasis . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| The CXCR 2 is a GPCR that is activated , among the others , by the chemokines CXCL 8 ( interleukin 8 ) and CXCL 2 ( growth related gene product beta ) to induce cell chemotaxis . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| The putative Ins ( 1 , 4 , 5 ) P 3 receptor antagonist 2 aminoethoxydiphenyl borane reduced the response to CXCR 2 activation by interleukin 8 , as did sustained inhibition of phosphatidylinositol 4 kinase with wortmannin , suggesting the involvement of phosphoinositides in the potentiation . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| Expression of interleukin 8 receptors ( CXCR 1 , CXCR 2 ) and CD 14 of circulating neutrophils and monocytes was assessed by flow cytometry . ^^^ The expression of CXCR 2 but not CXCR 1 on neutrophils and monocytes correlated negatively with the levels of interleukin 8 and myeloperoxidase . ^^^ The negative correlation of CXCR 2 expression with interleukin 8 and myeloperoxidase indicates that myeloid cells were stimulated by CXC chemokines with Glu Leu Arg ( ELR ) motif and thereby contributed to tissue damage , leading to impairment of cardiovascular and respiratory function . . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| In comparison with the nonrespiratory surgical procedure and S COPD groups , neutrophilia and gene expression for epithelial derived neutrophil attractant 78 ( CXCL 5 ) , interleukin 8 ( CXCL 8 ) , CXCR 1 , and CXCR 2 were each upregulated in the E COPD group ( p < 0 . 01 ) ; compared with the S COPD group , by 97 , 6 , 6 , 3 , and 7 fold , respectively ( p < 0 . 01 ) . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| Expression of CXCR 1 and CXCR 2 receptors in malignant melanoma with different metastatic potential and their role in interleukin 8 ( CXCL 8 ) mediated modulation of metastatic phenotype . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : The human chemokine receptor CXCR 2 ( IL8RB ) is a high affinity receptor for interleukin 8 as well as other CXC chemokines , and is involved in the chemotaxis of immune cells . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| Based on high sequence similarity to the determined structures of the Nogo receptor ectodomain and the intermolecular complex of the Interleukin 8 ligand ( IL 8 ) and the N terminal peptide of the IL 8 receptor ( IL8RA ) , the hypothesis was developed that portions of the intramolecular components , Cysteine box 2 and Cysteine box 3 , of the GPHR ectodomain interact and localize at the interface between ectodomain and serpentine domain . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| Moreover , chemotaxis assays on rabbit CXCR 1 and CXCR 2 transfectants showed that NCP uses the same receptors as interleukin 8 ( IL 8 ) , a major rabbit CXC chemokine , but not rabbit GROalpha , which only recognized CXCR 2 . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| Important physiological activators of neutrophils are the cytokines interleukin 8 / CXC chemokine ligand 8 ( IL 8 / CXCL8 ) , which activates CXC chemokine receptor 1 and 2 ( CXCR 1 and CXCR 2 ) , and growth related oncogene ( GROalpha ) / CXCL1 , which stimulates only CXCR 2 . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| Therefore , we aimed to investigate the expression and localization of interleukin 8 ( IL 8 ) receptors CXCR 1 and CXCR 2 in eutopic and ectopic endometrial tissues of women with endometriosis , and in endometrium of women without endometriosis . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| Inhibition of interleukin 8 ( CXCL8 / IL 8 ) responses by repertaxin , a new inhibitor of the chemokine receptors CXCR 1 and CXCR 2 . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| Interleukin 8 ( IL 8 , CXCL 8 ) is a pro inflammatory chemokine which attracts neutrophils to sites of inflammation via an activation of the G protein coupled receptors , CXCR 1 and CXCR 2 . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| Interleukin 8 ( IL 8 ) , a member of the CXC subfamily of chemoattractant cytokines , induces a range of functional responses in human neutrophils via its interactions with two high affinity cell surface receptors , CXCR 1 and CXCR 2 . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| Interleukin 8 ( IL 8 ) , a ligand for the CXCR 1 and CXCR 2 receptors , is the most potent endogenous proinflammatory chemokine in sepsis . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| Neuroendocrine tumor cells expressed another type of interleukin 8 receptor , CXCR 2 , suggesting an autocrine mechanism by which interleukin 8 regulates the differentiation or function of the neuroendocrine cells . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| Nonapical and cytoplasmic expression of interleukin 8 , CXCR 1 , and CXCR 2 correlates with cell proliferation and microvessel density in prostate cancer . ^^^ PURPOSE : We characterized interleukin 8 ( IL 8 ) and IL 8 receptor expression ( CXCR 1 and CXCR 2 ) in prostate cancer to address their significance to this disease . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| These interactions were constitutive and unaffected by the presence of the agonist interleukin 8 and selective as no significant interactions were noted between either the CXCR 1 or CXCR 2 receptor and the alpha ( 1A ) adrenoreceptor . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| Cows with the CC or GC genotype at CXCR 2 +777 showed significantly lower neutrophil migration to recombinant human interleukin 8 ( rhIL 8 ) than cows with the GG genotype ( P < 0 . 05 ) . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| Interleukin 8 ( IL 8 / CXCL8 ) , a paracrine angiogenic factor , modulates multiple biologic functions in CXCR 1 and CXCR 2 expressing endothelial cells . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| A role for the autocrine or paracrine production of antiapoptotic interleukin 8 ( IL 8 ) expressed with A . phagocytophilum infection was excluded by the use of IL 8 , IL 8R1 ( CXCR 1 ) , and IL 8R2 ( CXCR 2 ) blocking antibodies . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| CONCLUSION : Various inflammatory responses that are of potential relevance in COPD pathophysiology do not affect transcription regulation and surface expression of the interleukin 8 receptors CXCR 1 and CXCR 2 on human bronchial epithelial cells . . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| Robust neutrophil chemorepulsion in microfluidic gradients of interleukin 8 ( IL 8 ; CXC chemokine ligand 8 ) was dependent on the absolute concentration of chemokine , CXC chemokine receptor 2 ( CXCR 2 ) , and was associated with polarization of cytoskeletal elements and signaling molecules involved in chemotaxis and leading edge formation . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| We examined the expression of CXCL 8 ( interleukin 8 ) , its receptors , CXCR 1 and CXCR 2 , and vessel density in human melanoma by immunohistochemical analysis of tumors from different Clark levels , depths , and thicknesses . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| Interleukin 8 ( IL 8 ) , a member of the chemokine superfamily , exists as both monomers and dimers , and mediates its function by binding to neutrophil CXCR 1 and CXCR 2 receptors that belong to the G protein coupled receptor class . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| Polymorphisms in interleukin 8 and its receptors ( IL 8 , IL8RA and IL8RB ) and association of common IL 8 receptor variants with peripheral blood eosinophil counts . ^^^ Interleukin 8 ( IL 8 ) is a potent proinflammatory cytokine that interacts with its receptors , IL8RA and IL8RB . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemistry showed that both CXCR 1 and CXCR 2 are expressed by macrophages and neutrophils in the rheumatoid and nonrheumatoid synovia , suggesting that both of these receptors are responsible for the CXCL 8 binding . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| CXCL 8 ( ( 3 73 ) ) K11R / G31P antagonizes ligand binding to the neutrophil CXCR 1 and CXCR 2 receptors and cellular responses to CXCL8 / IL 8 . ^^^ Furthermore , CXCL 8 ( ( 3 73 ) ) K11R / G31P competitively antagonized the binding of CXCR 1 and CXCR 2 specific antibodies to these receptors . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| Transendothelial migration of neutrophils in response to CXCL 7 or IL 8 ( CXCL 8 ) was subject to modulation by CTAP 3 , but not CXCL 4 , as seen by drastic desensitization of the migratory response of neutrophils pre exposed to CTAP 3 , which was paralleled by selective down modulation of CXCR 2 . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| We recently engineered a series of high affinity CXCL8 / IL 8 antagonists , one of which , CXCL 8 ( ( 3 73 ) ) K11R / G31P , binds very strongly to neutrophils via the CXCR 1 and CXCR 2 . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| Analysis of inter relationships between CXCR 1 and CXCR 2 during internalization indicated that the exposure of cells that expressed both CXCR 1 and CXCR 2 to CXCL 8 or CXCL 6 resulted in decreased levels of CXCR 1 internalization as compared to those in cells that expressed only CXCR 1 . ^^^ The presence of wortmannin during receptor recycling inhibited CXCR 1 and CXCR 2 re expression following CXCL 8 induced internalization , and resulted in a marked disruption of the proper organization of actin filaments . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| IL 8 ( or CXCL 8 ) activates the receptors CXCR 1 ( IL 8RA ) and CXCR 2 ( IL 8RB ) to induce chemotaxis in leukocytes , but only CXCR 1 mediates cytotoxic and cross regulatory signals . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| The CXC chemokines 1 and 8 ( CXCL 1 and CXCL 8 ) are ligands for the G protein coupled CXC chemokine receptor 2 ( CXCR 2 ) . ^^^ Here we describe that cocktails of melanocyte growth factors consisting of basic fibroblast growth factor ( bFGF ) , endothelin 1 ( ET 1 ) and alpha melanocyte stimulating hormone ( alpha MSH ) stimulated release of CXCL 1 and CXCL 8 , but did not influence expression of CXCR 2 in human melanocytes . ^^^ This study implicates that CXCL 1 , CXCL 8 and their receptor CXCR 2 are components of an autocrine mechanism in proliferating human melanocytes . . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| Recently , we have shown that CXCL 8 can acutely modulate ion channel activity in septal neurons expressing receptors CXCR 1 and / or CXCR 2 . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| Therefore , we analyzed the expression of CXC chemokine receptors ( CXCR 1 , CXCR 2 , CXCR 3 , CXCR 4 and CXCR 5 ) and ligands ( CXCL 8 , CXCL 10 , CXCL 12 and CXCL 13 ) both at molecular and protein levels , in human OCs grown on plastic or calcium phosphate coated slides at different stages of differentiation . ^^^ Real time PCR showed that CXCR 1 , CXCR 2 , CXCR 3 , CXCR 4 , CXCR 5 and CXCL 8 were expressed in undifferentiated cells and significantly decreased during OC differentiation . ^^^ Immunocytochemistry showed that OCs grown on plastic expressed CXCR 3 , CXCR 4 , CXCR 5 , CXCL 8 and CXCL 12 , while they were negative for CXCR 1 , CXCR 2 and CXCL 10 . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| The chemokine CXC ligand 8 ( CXCL 8 ) / IL 8 and related agonists recruit and activate polymorphonuclear cells by binding the CXC chemokine receptor 1 ( CXCR 1 ) and CXCR 2 . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| METHODS : The expression of CXCL 8 receptors CXCR 1 and CXCR 2 was assessed by RT PCR and FACS analysis in human Caco 2 and HT 29 cells . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| The present study demonstrated that the CXCR 2 ligands macrophage inflammatory protein 2 ( MIP 2 ) , CXCL 1 , and CXCL 8 , protected hippocampal neurons against beta amyloid ( 1 42 ) induced death . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| Human cytomegalovirus ( CMV ) ( Toledo strain ) produces a potent chemokine ( vCXCL 1 ) that specifically recognizes human ( Hu ) CXCR 2 , one of two human CXCL 8 ( IL 8 ) receptors found on peripheral blood neutrophils . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| Novel polymorphisms in IL 8 ( CXCL 8 ) and in one of its receptors , CXCR 2 gene , may have a role in enhanced IL 8 activity in BD . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| In CXCR 2 transfected NIH 3T3 cells and human microvascular endothelial cells ( HMEC ) , which express the CXCR 2 constitutively , STAT 3 is phosphorylated upon stimulation with IL 8 ( CXCL 8 ) . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| The IL 8 ( or CXCL 8 ) chemokine receptors , CXCR 1 and CXCR 2 , activate protein kinase C ( PKC ) to mediate leukocyte functions . ^^^ To investigate the roles of different PKC isoforms in CXCL 8 receptor activation and regulation , human mononuclear phagocytes were treated with CXCL 8 or CXCL 1 ( melanoma growth stimulating activity ) , which is specific for CXCR 2 . ^^^ CXCL 8 also failed to activate PKCepsilon in RBL 2H3 cells stably expressing CXCR 2 . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| Chemotaxis experiments were performed using the chemokine CXCL 8 under different flow rates with human HL 60 promyelocytic leukemia cells expressing a transfected CXCR 2 chemokine receptor . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| We also show that every Cys substitution in CXCR 2 , including those that still bind CXCL 8 , results in an impairment of receptor activity , analyzed as cell chemotaxis and intracellular signaling , suggesting that some structural requirement is likely fulfilled by Cys presence . . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| CXCL 8 activates PMNs by binding the seven transmembrane ( 7 TM ) G protein coupled receptors CXC chemokine receptor 1 ( CXCR 1 ) and CXC chemokine receptor 2 ( CXCR 2 ) . ( R ) Ketoprofen ( 1 ) was previously reported to be a potent and specific noncompetitive inhibitor of CXCL 8 induced human PMNs chemotaxis . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| The proangiogenic CXCR 2 ligands CXCL 1 , CXCL 3 , CXCL 5 , and CXCL 8 , as well as VEGF were elevated in the plasma of these patients and found to be expressed within the tumors . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| Enhanced chemotactic activity was suppressed by neutralizing mAb ( s ) to CXCL 1 , CXCL 5 , and CXCL 8 or to CXCR 2 but not to vascular endothelial growth factor A . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| CXCL 8 induced FAK phosphorylation via CXCR 1 and CXCR 2 : cytoskeleton and integrin related mechanisms converge with FAK regulatory pathways in a receptor specific manner . ^^^ The analysis intentionally dissociated between the CXCL 8 receptors CXCR 1 and CXCR 2 . ^^^ In both CXCR 1 and CXCR 2 expressing cells , actin and microtubules were required for CXCL 8 induced FAK phosphorylation , and CXCL 8 induced cell spreading was accompanied by concordant re localization of FAK with actin and beta tubulin . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| The chemokine receptors CXCR 1 and CXCR 2 present on polymorphonuclear neutrophils ( PMN ) , bind the chemokine CXC ligand 8 ( CXCL 8 ) / interleukin 8 ( IL 8 ) , and have a key role in PMN recruitment in inflammation . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| CXCL 8 , a ligand for the chemokine receptor CXCR 2 , was recently reported to be a transcriptional target of Ras signaling , but its role in Ras induced tumorigenesis has not been fully defined . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| During exacerbations , the inflammatory cellular pattern changes , with a further increase of eosinophils and / or neutrophils and various inflammatory mediators for example , cytokines ( tumor necrosis factor alpha , RANTES [ regulated upon activation normal T cell expressed and secreted ] , and eotaxin 1 ) , chemokines ( CXCL 5 [ ENA 78 ] , CXCL 8 ) , chemokine receptors ( CCR 3 , CXCR 1 , and CXCR 2 ) , adhesion molecules ( E selectin and ICAM 1 ) , and markers of oxidative stress ( H ( 2 ) O ( 2 ) and 8 isoprostane , glutathione depletion ) . ^^^ |
|
| Interacting proteins: P10145 and P25025 |
Pubmed |
SVM Score :0.0 |
| Cbl and Akt regulate CXCL 8 induced and CXCR 1 and CXCR 2 mediated chemotaxis . ^^^ Here , we found that CXCL 8 treatment of CXCR 1 and CXCR 2 over expressing L1 . 2 cells ( CXCR 1 L1 . 2 and CXCR 2 L1 . 2 , respectively ) induced the phosphorylation of Cbl and Akt . ^^^ Lastly , we have shown that pre treatment of L1 . 2 cells with the proteasome inhibitor Lactacystin blocks CXCL 8 induced internalization of the CXCR 1 and CXCR 2 receptors . ^^^ |
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