| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| Two distinct receptors for the chemoattractant interleukin 8 ( designated IL 8RA and B ) have been cloned recently . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| Mutation of Leu 25 and Val 27 introduces CC chemokine activity into interleukin 8 . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| Pleural mesothelial cell expression of C C ( monocyte chemotactic peptide ) and C 10 C ( interleukin 8 ) chemokines . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| The genes encoding two receptors for Interleukin 8 ( IL8RA , IL8RB ) have been located on human chromosome 2 . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| CC chemokines are small inducible proteins that are related to interleukin 8 . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| Interleukin 8 and related chemotactic cytokines CXC and CC chemokines . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| Platelets also express mRNAs for interleukin 8 receptor A ( IL 8RA ) and a novel chemokine receptor K5 . 5 . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| The effects of interleukin 8 on neutrophils are mediated through two receptors , IL 8RA and IL 8RB . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| Two receptors for interleukin 8 ( IL 8 ) , IL 8rA and IL 8rB , have been cloned . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| Interleukin 8 ( IL 8 ) acts on human neutrophils via two receptors , CXCR 1 and CXCR 2 . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| Two G protein coupled receptor subtypes ( CXCR 1 and CXCR 2 ) mediate Interleukin 8 ( IL 8 ) action in cells . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| Distribution of the interleukin 8 receptors , CXCR 1 and CXCR 2 , in inflamed gut tissue . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| Expression of the interleukin 8 receptors CXCR 1 and CXCR 2 on cord blood derived cultured human mast cells . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| Interleukin 8 secreted by endothelial cells induces chemotaxis of melanoma cells through the chemokine receptor CXCR 1 . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| The cytokine interleukin 8 ( IL 8 ) binds with high affinity to the CXCR 1 and CXCR 2 receptors on neutrophils . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| Dimer dissociation is essential for interleukin 8 ( IL 8 ) binding to CXCR 1 receptor . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| Role of interleukin 8 in PiT 1 expression and CXCR 1 mediated inorganic phosphate uptake in chondrocytes . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| Expression of interleukin 8 receptors ( CXCR 1 and CXCR 2 ) in premenopausal women with recurrent urinary tract infections . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : To investigate the expression of interleukin 8 ( IL 8 ) receptors CXCR 1 and CXCR 2 in adenomyosis . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| Expression of interleukin 8 and its receptor IL 8RA in chronic hyperplastic candidosis . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| CXCR 1 is a receptor for cIL 8 ( 9E3 / cCAF ) and its N and C terminal peptides and is also activated by hIL 8 ( CXCL 8 ) . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| The interleukin 8 receptor type 1 ( IL8R1 ) binds IL 8 only , whereas the interleukin 8 receptor type 2 ( IL8R2 ) ( previously designated IL8RA ) also binds growth regulated gene ( GRO ) , and neutrophil activating protein 2 ( NAP 2 ) with high affinity . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| Human neutrophils at inflammatory sites may be an important source of the chemotactic cytokines macrophage inflammatory protein 1 alpha ( M1P 1 alpha ; a C C chemokine ) and interleukin 8 ( IL 8 ; a C 10 C chemokine ) . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| This quaternary structure is very different from that of the C 10 C chemokines such as interleukin 8 and melanoma growth stimulatory activity but similar to that found for the C C chemokine macrophage inflammatory factor 1 beta . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| This review discusses the potential role of chemokines in inflammation and focuses on the two best characterized chemokines , monocyte chemoattractant protein 1 ( MCP 1 ) , a CC chemokine , and interleukin 8 ( IL 8 ) , a member of the CXC chemokine sub family . . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| The human type A interleukin 8 receptor ( IL 8RA ) was modified to express an amino terminal epitope tag and stably overexpressed in a rat basophilic leukemia cell line ( RBL 2H3 ) . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| The CC chemokines , Macrophage inflammatory protein 1 alpha , RANTES , and monocyte chemotactic protein 1 were able to stimulate a Ca ( 2+ ) activated chloride channel in Xenopus laevis oocytes injected with K 5 5 cRNA , whereas no signal was detected in response to monocyte chemotactic protein 2 , macrophage inflammatory protein 1 beta , or the CXC chemokine , interleukin 8 . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| Human neutrophils are highly responsive to the chemokine interleukin 8 ( IL 8 ) owing to high levels of expression of two related receptors encoded by the single copy genes il8ra and il8rb located on chromosome 2q34 q 35 . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| In addition to the two human interleukin 8 ( IL 8 ) receptors that have been cloned , IL 8RA and IL 8RB , we recently described a binding protein in human erythrocytes that binds IL 8 and monocyte chemotactic peptide 1 ( MCP 1 ) , which we have termed the chemokine ( CK ) receptor . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| The ability to inhibit collagen expression was also demonstrated by another member of the C 10 C branch of the platelet factor 4 superfamily , interleukin 8 ( IL 8 ) , but not by RANTES , MIP 1 alpha , or MIP 1 beta , which belong to the C C branch . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| The high affinity interleukin 8 receptor gene ( IL8RA ) maps to the 2q33 q 36 region of the human genome : cloning of a pseudogene ( IL8RBP ) for the low affinity receptor . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| Human interleukin 8 receptors A ( IL 8RA ) and B ( IL 8RB ) are seven transmembrane domain ( TMD ) neutrophil chemokine receptors with similar sequences ( 77 % amino acid identity ) and similar G protein selectivity , but markedly different selectivity for CXC chemokines . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| Specifically , in vitro studies indicate that C 10 C chemokines [ interleukin 8 ( IL 8 ) and macrophage inflammatory protein 2 ( MIP 2 ) and the C C chemokine macrophage inflammatory protein 1 alpha ( MIP 1 alpha ) augment the ability of polymorphonuclear leukocytes ( PMNs ) and alveolar macrophages , respectively , to phagocytose and kill Escherichia coli . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| The structure is similar to that already determined for the CC chemokine macrophage inflammatory protein 1 beta , and it has a completely different dimer interface to that of the CXC chemokine interleukin 8 ( IL 8 ) . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| C C chemokines , but not the C 10 C chemokines interleukin 8 and interferon gamma inducible protein 10 , stimulate transendothelial chemotaxis of T lymphocytes . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| To determine the regions of interleukin 8 ( IL 8 ) that allow high affinity and interleukin 8 receptor type 1 ( IL8R1 ) specific binding of chemokines , we produced chimeric proteins containing structural domains from IL 8 , which binds to both IL8R1 and interleukin 8 receptor type 2 ( IL8R2 ) with high affinity , and from GRO gamma , which does not bind to IL8R1 and binds to IL8R2 with reduced affinity . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| Two monoclonal antibodies , anti IL8R1 and anti IL8R2 , raised against both interleukin 8 receptors ( IL 8R ) of human neutrophils , IL 8R1 and IL 8R2 , were used to study individual receptor functions after stimulation with IL 8 , GRO alpha , or NAP 2 . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| To examine cross desensitization between receptors for lipid and peptide chemoattractants , cDNA encoding the PAF receptor ( PAFR ) was co expressed into RBL 2H3 cells with cDNAs encoding receptors for either formylated peptides ( FR ) , a product of the fifth component of complement ( C5aR ) or interleukin 8 A ( IL 8RA ) . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| The resultant antibodies stained positively 293 cells transfected with CCR 1 cDNA but neither parental cells nor cells transfected with CXCR 1 [ interleukin 8 ( IL 8 ) receptor type A ] cDNA , confirming its specificity . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| The CXC chemokines ( including interleukin 8 ) predominantly attract neutrophils , whereas CC chemokines induce migration of monocytes , as well as other leukocyte cell types . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| In the present study , we sought to dissect these processes and to map important functional domains of the two CXC chemokine ( interleukin 8 ) receptors , CXCR 1 ( formally IL 8RA ) and CXCR 2 ( formally IL 8RB ) , using blocking monoclonal antibodies ( mAbs ) to the receptors and a series of chimeras between CXCR 1 and CXCR 2 . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| Interleukin 8 and monocyte chemotactic protein 1 are the best characterized members of the C 10 C and C C chemokine subfamilies , respectively . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| Two homologous high affinity receptors for the chemoattractant interleukin 8 , IL 8RA and IL 8RB , and one for the chemoattractant C5a ( C5aR ) have been cloned . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| CCR 8 is unusual for its selectivity for a single chemokine , previously shown only for CXCR 1 and CXCR 4 , which bind interleukin 8 and stromal cell derived factor 1 , respectively . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| As reported herein , a proinflammatory cytokine gene program that includes C 10 C and C C chemokines [ interleukin 8 ( IL 8 ) , growth related ( GRO ) alpha , GRO beta , GRO gamma , epithelial neutrophil activating peptide 78 ( ENA 78 ) , and RANTES ] and the cytokines tumor necrosis factor alpha ( TNF alpha ) and macrophage colony stimulating factor was upregulated in human hepatocytes after stimulation with IL 1 alpha or TNF alpha or bacterial invasion . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| The release of the CXC chemokines interleukin 8 ( IL 8 ) and GRO alpha and the CC chemokines MIP 1alpha , MCP 1 , and RANTES was determined by specific enzyme linked immunosorbent assays , and the corresponding gene expression patterns were determined by Northern blot analysis . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| We have recently observed that the interleukin 8 ( IL 8 ) receptor messages , IL 8RA and B ( CXCR 1 and CXCR 2 ) , also undergo changes in stability in response to the inflammatory stimulator lipopolysaccharide ( LPS ) . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| The CXC chemokine neutrophil activating peptide 2 induces two distinct optima of neutrophil chemotaxis by differential interaction with interleukin 8 receptors CXCR 1 and CXCR 2 . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| Members of the different chemokine families are defined by the orientation of specific critical cysteine residues , and are designated as C 10 C ( e . g . interleukin 8 ) , C C ( e . g . regulated upon activation normally T cell expressed and secreted , RANTES ) , or C ( lymphotactin ) . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| Here we examined the kinetics of mesangial cell chemokine expression with focus on the C C or beta chemokines monocyte chemoattractant protein 1 ( MCP 1 ) , regulated upon activation , normal T cell expressed and secreted ( RANTES ) , macrophage inflammatory protein 1 alpha ( MIP 1 alpha ) , and the C 10 C or alpha chemokine interleukin 8 ( IL 8 ) in response to lymphocyte or monocyte derived cytokines and mesangial cell growth factors . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| Interleukin 8 ( IL 8 ) receptor A ( CXCR 1 ) couples to a pertussis toxin sensitive G protein to mediate phospholipase Cbeta ( PLCbeta ) activation and cellular responses . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| Since the discovery of interleukin 8 ( IL 8 ) , a prototype of CXC chemokines , in 1987 and monocyte chemotactic and activating factor / monocyte chemoattractant protein 1 ( MCAF / MCP 1 ) , a prototype of chemotactic cytokines ( CC ) chemokines , in 1989 , more than 30 members of chemokines have been identified so far . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| Neutrophils and transfected RBL 2H3 cells were used to investigate the mechanism of cross regulation of the human interleukin 8 ( IL 8 ) receptors CXCR 1 and CXCR 2 by chemoattractants . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| Using in situ hybridization and immunohistochemistry , the expression and localization of the lymphocyte and / or monocyte / macrophage attractant CC chemokines macrophage chemoattractant protein 1 ( MCP 1 ) , regulated on activation , normal T cell expressed , and secreted ( RANTES ) , macrophage inflammatory protein 1alpha and 1alpha ( MIP 1alpha / beta ) , 1 309 and the CXC chemokines monokine induced by interferon gamma ( MIG ) , interferon gamma inducible protein 10 ( IP 10 ) , interleukin 8 ( IL 8 ) , epithelial derived neutrophil attractant 78 , and growth related oncogene alpha were investigated . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| The interleukin 8 receptors ( CXCR 1 and CXCR 2 ) are specifically expressed at high levels in cells of the neutrophil lineage . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| The biologic role of interleukin 8 : functional analysis and expression of CXCR 1 and CXCR 2 on human eosinophils . ^^^ Whereas CXC chemokines such as interleukin 8 ( IL 8 ) activate predominantly neutrophils , CC chemokines such as RANTES and eotaxin activate predominantly eosinophils . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| HEK 293 cells were stably cotransfected with the Gi coupled receptor for interleukin 8 , CXCR 1 , and with a chimeric Galpha , Galphaqz 5 , which resembles Galphai in susceptibility to activation by Gi coupled receptors but can not regulate the Galphai effector , adenylyl cyclase . ^^^ These cells , unlike cells expressing CXCR 1 alone , migrated toward interleukin 8 even after treatment with pertussis toxin , which prevents activation of endogenous Galphai but not that of Galphaqz 5 . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| The Duffy Antigen Receptor for Chemokines ( DARC ) belongs to a family of erythrocyte chemokine receptors that bind C 10 C and C C chemokines such as interleukin 8 ( IL 8 ) , monocyte chemoattractant protein 1 ( MCP 1 ) and regulated on activation , normal T cell expressed and secreted ( RANTES ) , but not macrophage inflammatory protein 1 alpha ( MIP 1 alpha ) or MIP 1 beta . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| Interleukin 8 ( IL 8 ) is an important mediator of neutrophil ( PMN ) function and the type A IL 8 receptor ( IL 8RA ) mediates these pro inflammatory signals . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| The neutrophil specific G protein coupled chemokine receptors , CXCR 1 and CXCR 2 , bind with high affinity to the potent chemoattractant interleukin 8 ( IL 8 ) . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| The effect of interleukin 8 ( IL 8 ) and growth related oncogene alpha ( GROalpha ) on [ 35S ] guanosine 5 ' O ( 3 thiotriphosphate ) ( [ 35S ] GTPgammaS ) binding , forskolin stimulated cyclic AMP accumulation and cytosolic calcium concentration were determined in recombinant CHO cells expressing HA tagged CXC chemokine receptors 1 and 2 ( CXCR 1 and CXCR 2 ) . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemistry was used to localize the C 10 C ( alpha ) chemokine interleukin 8 ( IL 8 ) and the C C ( beta ) chemokines monocyte chemoattractant protein 1 ( MCP 1 ) and macrophage inflammatory protein 1beta ( MIP 1beta ) in 30 needle biopsies of human kidney transplants taken for diagnosis of renal dysfunction . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| The functional role of neutrophils during acute inflammatory responses is regulated by two high affinity interleukin 8 receptors ( CXCR 1 and CXCR 2 ) that are rapidly desensitized and internalized upon binding their cognate chemokine ligands . ^^^ While interleukin 8 stimulation promoted CXCR 1 sequestration in RBL 2H3 cells , receptor internalization in HEK 293 cells required co expression of G protein coupled receptor kinase 2 and beta arrestin proteins . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| This study examined the expression and function of CXC ( human monokine induced by gamma interferon [ HuMig ] , interleukin 8 [ IL 8 ] , and interferon inducible protein 10 [ IP 10 ] ) and CC ( macrophage inflammatory protein 1alpha [ MIP 1alpha ] , MIP 1beta , regulated upon activation normal T lymphocyte expressed and secreted ( RANTES ) , and macrophage chemoattractant protein 1 [ MCP 1 ] ) chemokines and their respective receptors on lymphocytes infiltrating human liver tumors . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| Binding of a recombinant interleukin 8 ( rIL 8 ) molecule with a C terminal His tag to RBL 2H3 cells which stably express the IL 8 receptors CXCR 1 or CXCR 2 could also be demonstrated using the tag specific mAb . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| PURPOSE : To determine the roles of the murine interleukin 8 receptor homolog ( mIL 8Rh , neutrophil chemokine CXC receptor 2 ) and macrophage inflammatory protein 1alpha ( MIP 1alpha , a CC chemokine ) in two eye inflammation models : endotoxin induced uveitis ( EIU ) and immune complex induced uveitis ( reverse passive Arthus reaction ( RPAR ) uveitis ) . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : To evaluate the role of chondrocytes in producing CXC chemokines [ interleukin 8 ( IL 8 ) , growth related gene product ( GRO alpha ) ] and CC chemokines [ monocyte chemoattractant protein ( MCP 1 ) , macrophage inflammatory protein ( MIP 1alpha ) , RANTES ] in patients with rheumatoid arthritis ( RA ) and osteoarthritis ( OA ) and subjects after traumatic injury ( PT ) . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| MALP 2 induced the neutrophil attracting CXC chemokines interleukin 8 ( IL 8 ) and GRO alpha as well as the mononuclear leukocyte attracting CC chemokines MCP 1 , MIP 1alpha , and MIP 1beta . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| Stimulation of the CXCR 1 / 2 receptors by human interleukin 8 ( IL 8 ) rapidly activated the p44 / 42 mitogen activated protein ( extracellular signal regulated kinase ( Erk1 / 2 ) ) kinase pathway . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| K 60 exhibits a similar degree of sequence identity to human interleukin 8 and other related CXC chemokines ( about 50 % ) , rendering straight forward predictions of its biological properties difficult . cDNA K 203 codes for a novel CC chemokine of 89 amino acids including a putative N terminal signal peptide of 21 residues . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| To study CCR 1 cross regulation , RBL cells co expressing CCR 1 and receptors for interleukin 8 ( CXCR 1 , CXCR 2 , or a phosphorylation deficient mutant of CXCR 2 , 331T ) were produced . ^^^ Interleukin 8 stimulation of CXCR 1 or CXCR 2 cross phosphorylated CCR 1 and cross desensitized its ability to stimulate GTPase activity and Ca ( 2+ ) mobilization . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| Although the C C chemokine monocyte chemoattractant protein 1 and its receptor , CCR 2 , have been implicated in atherosclerosis , the role of the classic C 10 C chemokine , interleukin 8 ( KC / growth related oncogene alpha in mice ) and its receptor CXCR 2 has not been studied in the pathogenesis of atherosclerosis . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| The M 3 protein bound the CC chemokines human regulated upon activation of normal T cell expressed and secreted ( RANTES ) , murine macrophage inflammatory protein 1alpha ( MIP 1alpha ) , and murine monocyte chemoattractant protein 1 ( MCP 1 ) , as well as the human CXC chemokine interleukin 8 , the murine C chemokine lymphotactin , and the murine CX ( 3 ) C chemokine fractalkine with high affinity ( K ( d ) = 1 . 6 to 18 . 7 nM ) . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : To search for single nucleotide polymorphisms in the interleukin 8 ( IL 8 ) and IL 8 receptor CXCR 1 and CXCR 2 genes , and to compare their distribution among patients with systemic sclerosis ( SSc ) with fibrosing alveolitis ( FASSc ) or without fibrosing alveolitis ( NFASSc ) , or patients with cryptogenic fibrosing alveolitis ( CFA ) , and normal healthy subjects . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : To evaluate the expression and clinical significance of interleukin 6 , soluble glycoprotein 130 ( sgp 130 ) , interleukin 8 and type A interleukin 8 receptor ( IL 8RA ) in acute promyelocytic leukemia ( APL ) patients during all trans retinoic acid ( ATRA ) treatment . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| PMNs were exposed to interleukin 8 ( IL 8 ) , growth regulated oncogene alpha ( GRO alpha ) , and platelet activating factor ( PAF ) to stimulate the CXCR 1 , CXCR 2 , and PAF receptors . [ Ca2+ ] 1 flux measurements were used to quantify receptor responses . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| In this study , we investigated whether keratinocytes possess autocrine and paracrine mechanisms for CC chemokine secretion and receptor expression as reported for the expression of interleukin 8 and its receptors . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : To evaluate the expression of interleukin 8 ( IL 8 ) and its A , B type receptors ( IL 8RA , IL 8RB ) in acute leukemia ( AL ) . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| We studied the effects of killed S . aureus on the expression of interleukin 8 receptors , CXCR 1 and CXCR 2 , on polymorphonuclear leucocytes ( PMN ) , which are known to lack the expression of MHC 2 antigens . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| In A 549 cells , membrane based cDNA macroarrays and high density oligonucleotide probe based microarrays identified inducible expression of CC ( 1 309 , Exodus 1 , TARC , RANTES , MCP 1 , MDC , and MIP 1 alpha and 1 beta ) , CXC ( GRO alpha , beta , and gamma , ENA 78 , interleukin 8 [ IL 8 ] , and 1 TAC ) , and CX ( 3 ) C ( Fractalkine ) chemokines . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| The chemokine interleukin 8 acutely reduces Ca ( 2+ ) currents in identified cholinergic septal neurons expressing CXCR 1 and CXCR 2 receptor mRNAs . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| Selective CXCR 2 antagonists may be useful to block the Gro alpha induced priming response whilst preserving neutrophil functions mediated by CXCR 1 , the alternative neutrophil receptor for interleukin 8 . . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| PURPOSE : In the present study , we examined the expression of a multifunctional cytokine , interleukin 8 ( IL 8 ) , and its receptors , CXCR 1 and CXCR 2 , in human colon carcinoma cells with different metastatic potentials and determined their role in modulating phenotypes associated with metastasis . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| As an example , the affinities and inhibition constants of fluorescently labeled interleukin 8 ( IL 8 ) and a low molecular weight antagonist toward the receptors CXCR 1 and CXCR 2 , which belong to the superfamily of G protein coupled receptors ( GPCRs ) , were determined . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| In vitro studies were performed on control subjects to determine changes in the surface expression of CXCR 1 , CXCR 2 , and CD11b on stimulation with interleukin 8 . ^^^ In addition , whereas interleukin 8 is an important determinant of both CXCR 1 and CXCR 2 expression in vitro , it only correlates with CXCR 2 and CD11b expression in vivo . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| RESULTS : The messenger RNA expression of C 10 C ( interleukin 8 , growth related alpha [ GROalpha ] , GRObeta , GROgamma , epithelial cell derived neutrophil activator 78 , and interferon gamma inducible protein 10 ) and C C ( monocyte chemotactic protein 1 , macrophage inflammatory protein 1beta , and RANTES [ regulated on activation , normal T cell expressed and secreted ] ) but not C ( lymphotactin ) chemokines was significantly higher in the affected mucosa of UC patients than in the unaffected mucosa of UC patients or in the normal mucosa of normal controls . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| Here we discuss the mechanisms of neutrophil mediated , chemokine receptor ( CXCR 1 ) dependent clearance , and the defect in interleukin 8 receptor homolog knock out ( IL 8Rh KO ) mice and describe the data linking low CXCR 1 expression to recurrent pyelonephritis in man , as well as the information on the genetic basis for low CXCR 1 expression in affected patients . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| We , therefore , investigated the in vitro effects of DCA on human monocyte and neutrophil responses to classic chemoattractants [ fMet Leu Phe ( fMLP ) , complement fraction 5a ( C5a ) ] , CC chemokine [ monocyte chemoattractant protein 1 ( MCP 1 / CCL2 ) ] , and / or CXC chemokines [ stromal cell derived factor 1 ( SDF 1alpha / CXCL12 ) , interleukin 8 ( IL 8 / CXCL8 ) ] . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| The recently discovered CC chemokine , regakine 1 , is constitutively present in bovine serum and synergizes with the CXC chemokine interleukin 8 ( IL 8 ) to chemoattract neutrophils . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| On the other hand , cells expressing all single , double , or triple histidine substituted CXCR 1 demonstrated high affinity binding to interleukin 8 in the presence and absence of metal ions . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| Because the chemotactic responses of neutrophils are impaired after phagocytosis , we explored the effect of phagocytic stimuli on the expression of interleukin 8 ( IL 8 ) receptors , CXCR 1 and CXCR 2 , in human neutrophils . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| The chemokine interleukin 8 ( IL 8 ; CXCL 8 ) exerts potent angiogenic properties on endothelial cells through interaction with its cognate receptors CXCR 1 and CXCR 2 . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| To investigate the effects of chemokine receptor cross regulation in HIV 1 infection , monocytes and MAGIC 5 and rat basophilic leukemia ( RBL 2H3 ) cell lines co expressing the interleukin 8 ( IL 8 or CXCL 8 ) receptor CXCR 1 and either CCR 5 ( ACCR 5 ) or CXCR 4 ( ACXCR 4 ) were generated . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| In the present study , we examined the expression of chemokine receptors CXCR 1 and CXCR 2 ( receptors for interleukin 8 ) and CCR 5 ( receptor for RANTES [ regulated on activation , normal T cell expressed and secreted ] , macrophage inflammatory protein [ MIP ] 1alpha , and MIP 1beta ) in human endometrium . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| The interleukin 8 ( IL 8 / CXCL8 ) receptor CXCR 1 was expressed in 12 / 12 patients , the CXCR 4 in 6 / 12 patients ( four CD3+ve and two CD 3 ve ) and the CXCR 3 in 3 / 12 patients ( one CD3+ve and two CD 3 ve ) . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| Our studies showed that LD infection caused the upregulation of three beta chemokines ( macrophage inflammatory protein 1 alpha ( MIP 1alpha ) , MIP 1beta and RANTES ( regulated on activation normal T cell expressed and secreted ) ) , one alpha chemokine ( interleukin 8 ( IL 8 ) ) and the CC chemokine receptor 5 ( CCR 5 ) but not CCR 1 , as evident from reverse transcriptase polymerase chain reaction ( RT PCR ) analysis . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| RESULTS : The genotype frequency of interleukin 8 T 251 A was 52 . 2 % for TT , 39 . 5 % for TA , and 8 . 3 % for AA , and that of interleukin 10 T 819C was 49 . 5 % for TT , 39 . 9 % for TC and 10 . 6 % for CC . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| In this study , we addressed the question of whether expression of the interleukin 8 receptors IL 8RA ( CXCR 1 ) and IL 8RB ( CXCR 2 ) is upregulated in H . pylori infected human gastric biopsy samples . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| METHODS : In situ hybridization of the CXC chemokines growth related oncogene alpha ( Gro alpha ) ( CXCL 1 ) , interleukin 8 ( CXCL 8 ) , macrophage interferon gamma inducible gene ( CXCL 9 ) , and interferon gamma inducible protein 10 ( CXCL 10 ) and of the CC chemokines macrophage chemoattractant protein 1 ( MCP 1 ) ( CCL 2 ) , macrophage inflammatory protein 1alpha ( CCL 3 ) , and regulated on activation , normal T cell expressed and secreted ( CCL 5 ) was performed to localize chemokine messenger RNA . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| A CXC chemokine , interleukin 8 , and six CC chemokines including macrophage inflammatory protein 1alpha ( MIP 1alpha ) , MIP 1beta , monocyte chemotactic protein 1 ( MCP 1 ) , MCP 3 , eotaxin , and regulated on activation , normal T cell expressed and secreted ( RANTES ) concentrations in their sera were analyzed using enzyme linked immunosorbent assay . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| It is well known that chemokines and chemokine receptors , such as interleukin 8 and its receptors ( CXCR 1 and CXCR 2 ) , play important roles in the pathogenesis of psoriasis . ^^^ |
|
| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| Expression of interleukin 8 receptors ( CXCR 1 , CXCR 2 ) and CD 14 of circulating neutrophils and monocytes was assessed by flow cytometry . ^^^ The expression of CXCR 2 but not CXCR 1 on neutrophils and monocytes correlated negatively with the levels of interleukin 8 and myeloperoxidase . ^^^ |
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| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| In comparison with the nonrespiratory surgical procedure and S COPD groups , neutrophilia and gene expression for epithelial derived neutrophil attractant 78 ( CXCL 5 ) , interleukin 8 ( CXCL 8 ) , CXCR 1 , and CXCR 2 were each upregulated in the E COPD group ( p < 0 . 01 ) ; compared with the S COPD group , by 97 , 6 , 6 , 3 , and 7 fold , respectively ( p < 0 . 01 ) . ^^^ |
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| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| Expression of CXCR 1 and CXCR 2 receptors in malignant melanoma with different metastatic potential and their role in interleukin 8 ( CXCL 8 ) mediated modulation of metastatic phenotype . ^^^ |
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| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| Mechanical ventilation alone resulted in minimal cytokine expression in the lung but did enhance LPS induced expression of tumor necrosis factor alpha , the CXC chemokines interleukin 8 and growth related protein alpha , and the CC chemokine monocyte chemoattractant protein 1 . ^^^ |
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| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| Based on high sequence similarity to the determined structures of the Nogo receptor ectodomain and the intermolecular complex of the Interleukin 8 ligand ( IL 8 ) and the N terminal peptide of the IL 8 receptor ( IL8RA ) , the hypothesis was developed that portions of the intramolecular components , Cysteine box 2 and Cysteine box 3 , of the GPHR ectodomain interact and localize at the interface between ectodomain and serpentine domain . ^^^ |
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| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| The effect of the V2b splice variant is specific , as it does not affect the surface expression of the G protein coupled interleukin 8 receptor ( CXCR 1 ) . ^^^ |
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| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| Putative candidate genes for the disease include ABH blood groups , interleukin 8 receptor ( CXCR 1 ) , the human leucocyte antigen locus , toll like receptors , tumour necrosis factor , and Tamm Horsfall protein . . ^^^ |
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| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| Moreover , chemotaxis assays on rabbit CXCR 1 and CXCR 2 transfectants showed that NCP uses the same receptors as interleukin 8 ( IL 8 ) , a major rabbit CXC chemokine , but not rabbit GROalpha , which only recognized CXCR 2 . ^^^ |
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| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| Important physiological activators of neutrophils are the cytokines interleukin 8 / CXC chemokine ligand 8 ( IL 8 / CXCL8 ) , which activates CXC chemokine receptor 1 and 2 ( CXCR 1 and CXCR 2 ) , and growth related oncogene ( GROalpha ) / CXCL1 , which stimulates only CXCR 2 . ^^^ |
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| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| Therefore , we aimed to investigate the expression and localization of interleukin 8 ( IL 8 ) receptors CXCR 1 and CXCR 2 in eutopic and ectopic endometrial tissues of women with endometriosis , and in endometrium of women without endometriosis . ^^^ |
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| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| Inhibition of interleukin 8 ( CXCL8 / IL 8 ) responses by repertaxin , a new inhibitor of the chemokine receptors CXCR 1 and CXCR 2 . ^^^ |
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| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| Interleukin 8 ( 0 . 25 ng ) was injected subcutaneously to the scalp as a preparation of the recipient site 24 hours before the fat injection and was added to the fat graft itself ( 25 ng per 1 cc of injected fat ) . ^^^ |
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| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| Interleukin 8 ( IL 8 , CXCL 8 ) is a pro inflammatory chemokine which attracts neutrophils to sites of inflammation via an activation of the G protein coupled receptors , CXCR 1 and CXCR 2 . ^^^ |
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| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| Interleukin 8 ( IL 8 ) , a member of the CXC subfamily of chemoattractant cytokines , induces a range of functional responses in human neutrophils via its interactions with two high affinity cell surface receptors , CXCR 1 and CXCR 2 . ^^^ |
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| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| Two major groups of chemokines can be distinguished : C 10 C chemokines like Interleukin 8 attract mainly neutrophils , C C chemokines ( e . g . ^^^ |
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| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| Interleukin 8 ( IL 8 ) , a ligand for the CXCR 1 and CXCR 2 receptors , is the most potent endogenous proinflammatory chemokine in sepsis . ^^^ |
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| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| Expression of the interleukin 8 receptor CXCR 1 was negative or low in benign prostatic tissue and was frequently increased in malignant cells of high grade prostatic intraepithelial neoplasia and prostate cancer ; however , CXCR 1 was not detected in the neuroendocrine tumor cells , suggesting a paracrine mechanism by which interleukin 8 produced by neuroendocrine tumor cells stimulates androgen independent proliferation of prostate cancer . ^^^ |
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| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| Nonapical and cytoplasmic expression of interleukin 8 , CXCR 1 , and CXCR 2 correlates with cell proliferation and microvessel density in prostate cancer . ^^^ PURPOSE : We characterized interleukin 8 ( IL 8 ) and IL 8 receptor expression ( CXCR 1 and CXCR 2 ) in prostate cancer to address their significance to this disease . ^^^ |
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| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| These interactions were constitutive and unaffected by the presence of the agonist interleukin 8 and selective as no significant interactions were noted between either the CXCR 1 or CXCR 2 receptor and the alpha ( 1A ) adrenoreceptor . ^^^ |
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| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| Here , using live cell fluorescence resonance energy transfer imaging to detect the proximity between CXCR 1 cyan fluorescent protein ( CFP ) and fluorescence probes that label lipid raft or non lipid raft microdomains and using fluorescence recovery after photobleaching analysis to measure the lateral diffusion of CXCR 1 CFP , we found that interleukin 8 induces association between the receptors and lipid raft microenvironments . ^^^ |
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| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| RESULTS : Macrophage derived chemokine ( MDC ) , hemofiltrate CC chemokine 1 ( HCC 1 ) , monocyte chemoattractant protein 3 ( MCP 3 ) , interleukin 8 ( IL 8 ) and eotaxin were strongly produced by epithelial glands , comparable to levels in premenstrual phase endometrium . ^^^ |
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| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| We investigated changes in interleukin 8 ( IL 8 ) mediated neutrophil migration and associated changes in receptor expression , of the IL 8 receptors CXCR 1 , the integrins CD11b / CD18 and platelet endothelial cell adhesion molecule 1 ( PECAM 1 ) in patients sustaining major trauma . ^^^ |
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| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| Cows with the CC or GC genotype at CXCR 2 +777 showed significantly lower neutrophil migration to recombinant human interleukin 8 ( rhIL 8 ) than cows with the GG genotype ( P < 0 . 05 ) . ^^^ |
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| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| Interleukin 8 ( IL 8 / CXCL8 ) , a paracrine angiogenic factor , modulates multiple biologic functions in CXCR 1 and CXCR 2 expressing endothelial cells . ^^^ |
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| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| We have used trimethylamine N oxide ( TMAO ) , a protecting osmolyte , to dissect the complex thermodynamic linkages involved in the interaction between the chemokine interleukin 8 ( IL 8 ) and the N domain of its receptor CXCR 1 . ^^^ |
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| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| Neutrophils are highly responsive to the chemokine , interleukin 8 ( IL 8 ) due to the abundant distribution of CXCR 1 , one of the IL 8 receptors on the neutrophil cell surface . ^^^ |
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| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| A role for the autocrine or paracrine production of antiapoptotic interleukin 8 ( IL 8 ) expressed with A . phagocytophilum infection was excluded by the use of IL 8 , IL 8R1 ( CXCR 1 ) , and IL 8R2 ( CXCR 2 ) blocking antibodies . ^^^ |
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| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| CONCLUSION : Various inflammatory responses that are of potential relevance in COPD pathophysiology do not affect transcription regulation and surface expression of the interleukin 8 receptors CXCR 1 and CXCR 2 on human bronchial epithelial cells . . ^^^ |
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| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| We examined the expression of CXCL 8 ( interleukin 8 ) , its receptors , CXCR 1 and CXCR 2 , and vessel density in human melanoma by immunohistochemical analysis of tumors from different Clark levels , depths , and thicknesses . ^^^ |
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| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| Interleukin 8 ( IL 8 ) , a member of the chemokine superfamily , exists as both monomers and dimers , and mediates its function by binding to neutrophil CXCR 1 and CXCR 2 receptors that belong to the G protein coupled receptor class . ^^^ |
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| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| Polymorphisms in interleukin 8 and its receptors ( IL 8 , IL8RA and IL8RB ) and association of common IL 8 receptor variants with peripheral blood eosinophil counts . ^^^ Interleukin 8 ( IL 8 ) is a potent proinflammatory cytokine that interacts with its receptors , IL8RA and IL8RB . ^^^ |
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| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemistry showed that both CXCR 1 and CXCR 2 are expressed by macrophages and neutrophils in the rheumatoid and nonrheumatoid synovia , suggesting that both of these receptors are responsible for the CXCL 8 binding . ^^^ |
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| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| CXCL 8 ( ( 3 73 ) ) K11R / G31P antagonizes ligand binding to the neutrophil CXCR 1 and CXCR 2 receptors and cellular responses to CXCL8 / IL 8 . ^^^ Furthermore , CXCL 8 ( ( 3 73 ) ) K11R / G31P competitively antagonized the binding of CXCR 1 and CXCR 2 specific antibodies to these receptors . ^^^ |
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| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| We recently engineered a series of high affinity CXCL8 / IL 8 antagonists , one of which , CXCL 8 ( ( 3 73 ) ) K11R / G31P , binds very strongly to neutrophils via the CXCR 1 and CXCR 2 . ^^^ |
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| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| Analysis of inter relationships between CXCR 1 and CXCR 2 during internalization indicated that the exposure of cells that expressed both CXCR 1 and CXCR 2 to CXCL 8 or CXCL 6 resulted in decreased levels of CXCR 1 internalization as compared to those in cells that expressed only CXCR 1 . ^^^ The presence of wortmannin during receptor recycling inhibited CXCR 1 and CXCR 2 re expression following CXCL 8 induced internalization , and resulted in a marked disruption of the proper organization of actin filaments . ^^^ |
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| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| IL 8 ( or CXCL 8 ) activates the receptors CXCR 1 ( IL 8RA ) and CXCR 2 ( IL 8RB ) to induce chemotaxis in leukocytes , but only CXCR 1 mediates cytotoxic and cross regulatory signals . ^^^ |
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| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| The mutants generated showed that : ( a ) for CXCL 8 binding , the N terminus of CXCR 1 and the second extra cellular loop of CXCR 2 are determinant , the N terminus of CXCR 2 is not sufficient and the transmembrane domain seven is probably involved ; ( b ) for CXCL 1 , the N terminus of CXCR 2 is necessary but not sufficient for binding . ^^^ |
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| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| Recently , we have shown that CXCL 8 can acutely modulate ion channel activity in septal neurons expressing receptors CXCR 1 and / or CXCR 2 . ^^^ |
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| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| Therefore , we analyzed the expression of CXC chemokine receptors ( CXCR 1 , CXCR 2 , CXCR 3 , CXCR 4 and CXCR 5 ) and ligands ( CXCL 8 , CXCL 10 , CXCL 12 and CXCL 13 ) both at molecular and protein levels , in human OCs grown on plastic or calcium phosphate coated slides at different stages of differentiation . ^^^ Real time PCR showed that CXCR 1 , CXCR 2 , CXCR 3 , CXCR 4 , CXCR 5 and CXCL 8 were expressed in undifferentiated cells and significantly decreased during OC differentiation . ^^^ Immunocytochemistry showed that OCs grown on plastic expressed CXCR 3 , CXCR 4 , CXCR 5 , CXCL 8 and CXCL 12 , while they were negative for CXCR 1 , CXCR 2 and CXCL 10 . ^^^ |
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| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| In this study , expression of the CXC chemokines CXCL 8 [ interleukin ( IL ) 8 ] , CXCL 1 [ growth related oncogene alpha ( Gro alpha ) ] , CXCL 9 [ monokine induced by interferon ( IFN ) gamma ] and CXCL 10 [ IFN gamma inducible protein 10 ( IP 10 ) ] and the corresponding chemokine receptors CXCR 1 3 was investigated by immunohistochemistry in intestinal and diffuse type gastric carcinoma . ^^^ |
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| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| Exposure to kpOmpA increased ICAM 1 mRNA and cell surface expression , as well as the secretion of IL 6 , CXC chemokine ligand ( CXCL ) 1 , CXCL 8 , C C chemokine ligand 2 , CXCL 10 by BEAS 2B cells , and BEC primary cultures ( p < 0 . 005 ) . ^^^ |
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| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| The chemokine CXC ligand 8 ( CXCL 8 ) / IL 8 and related agonists recruit and activate polymorphonuclear cells by binding the CXC chemokine receptor 1 ( CXCR 1 ) and CXCR 2 . ^^^ |
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| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| This study investigated effects of dexamethasone , PGE ( 2 ) and T ( h ) 2 cytokines , all potential down regulatory mediators , on control of S . aureus induced C 10 C ( CXCL 8 , CXCL 10 ) and C C ( CCL 5 , CCL 2 ) chemokine gene expression and secretion from human osteoblastic MG 63 cells and primary NHOst cells . ^^^ |
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| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| CXCL 8 modulates human intestinal epithelial cells through a CXCR 1 dependent pathway . ^^^ METHODS : The expression of CXCL 8 receptors CXCR 1 and CXCR 2 was assessed by RT PCR and FACS analysis in human Caco 2 and HT 29 cells . ^^^ Enhancement of intestinal epithelial cell migration by CXCL 8 was partially CXCR 1 dependent and TGFbeta independent . ^^^ |
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| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| CXCL 8 secretion , and partly the secretion of VEGF , were up regulated in monocytic cells , but not in breast tumor cells , by the CC chemokines CCL 5 and CCL 2 . ^^^ |
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| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| The huMDM released large amounts of CXC chemokine ligand 8 ( CXCL 8 ) and CC chemokine ligand 2 when incubated with live or killed LVS organisms , and live bacteria also elicited production of interleukin 1beta ( IL 1beta ) . ^^^ |
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| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| The IL 8 ( or CXCL 8 ) chemokine receptors , CXCR 1 and CXCR 2 , activate protein kinase C ( PKC ) to mediate leukocyte functions . ^^^ |
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| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| METHODS : This study quantified CXC ( CXCL 1 , CXCL 3 , CXCL 5 , CXCL 8 , CXCL 9 , and CXCL 10 ) and CC ( CCL 2 , CCL 4 , and CCL 5 ) chemokines in sequential urine samples obtained from 50 patients with febrile urinary tract infections during 24 hours after diagnosis . ^^^ |
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| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| Arylpropionic CXC chemokine receptor 1 ( CXCR 1 ) ligands as novel noncompetitive CXCL 8 inhibitors . ^^^ CXCL 8 activates PMNs by binding the seven transmembrane ( 7 TM ) G protein coupled receptors CXC chemokine receptor 1 ( CXCR 1 ) and CXC chemokine receptor 2 ( CXCR 2 ) . ( R ) Ketoprofen ( 1 ) was previously reported to be a potent and specific noncompetitive inhibitor of CXCL 8 induced human PMNs chemotaxis . ^^^ |
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| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| CXCL 8 induced FAK phosphorylation via CXCR 1 and CXCR 2 : cytoskeleton and integrin related mechanisms converge with FAK regulatory pathways in a receptor specific manner . ^^^ The analysis intentionally dissociated between the CXCL 8 receptors CXCR 1 and CXCR 2 . ^^^ In both CXCR 1 and CXCR 2 expressing cells , actin and microtubules were required for CXCL 8 induced FAK phosphorylation , and CXCL 8 induced cell spreading was accompanied by concordant re localization of FAK with actin and beta tubulin . ^^^ Of note , even in the absence of integrin stimulation , the CXCL 8 induced phosphorylation of FAK in CXCR 1 expressing cells required cytoskeletal elements . ^^^ CXCL 8 induced migration in both cell types was highly reliant on actin filaments , but only the migration of CXCR 1 expressing cells was fully dependent on microtubules . ^^^ |
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| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| IL 21 pretreatment also dramatically reduced LPS stimulated production of tumor necrosis factor alpha , IL 12 , CC chemokine ligand 5 ( CCL 5 ) , and CXC chemokine ligand 10 ( CXCL 10 ) but not that of CXCL 8 . ^^^ |
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| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| The chemokine receptors CXCR 1 and CXCR 2 present on polymorphonuclear neutrophils ( PMN ) , bind the chemokine CXC ligand 8 ( CXCL 8 ) / interleukin 8 ( IL 8 ) , and have a key role in PMN recruitment in inflammation . ^^^ |
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| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| During exacerbations , the inflammatory cellular pattern changes , with a further increase of eosinophils and / or neutrophils and various inflammatory mediators for example , cytokines ( tumor necrosis factor alpha , RANTES [ regulated upon activation normal T cell expressed and secreted ] , and eotaxin 1 ) , chemokines ( CXCL 5 [ ENA 78 ] , CXCL 8 ) , chemokine receptors ( CCR 3 , CXCR 1 , and CXCR 2 ) , adhesion molecules ( E selectin and ICAM 1 ) , and markers of oxidative stress ( H ( 2 ) O ( 2 ) and 8 isoprostane , glutathione depletion ) . ^^^ |
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| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| Cbl and Akt regulate CXCL 8 induced and CXCR 1 and CXCR 2 mediated chemotaxis . ^^^ Here , we found that CXCL 8 treatment of CXCR 1 and CXCR 2 over expressing L1 . 2 cells ( CXCR 1 L1 . 2 and CXCR 2 L1 . 2 , respectively ) induced the phosphorylation of Cbl and Akt . ^^^ Lastly , we have shown that pre treatment of L1 . 2 cells with the proteasome inhibitor Lactacystin blocks CXCL 8 induced internalization of the CXCR 1 and CXCR 2 receptors . ^^^ |
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| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| In RBL 2H3 cells coexpressing the PAFRs along with CXCR 1 , IL 8 ( CXCL 8 ) cross desensitized Ca2+ mobilization to PAF by all the receptors but only PAFR G alpha ( i 3 ) activation cross inhibited the response of CXCR 1 to CXCL 8 . ^^^ |
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| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| Likewise , treatment with 10 ( 6 ) M of the antiestrogens tamoxifen ( Tam ) , nafoxidine ( Naf ) , or clomiphene citrate ( CC ) also enhanced FSH stimulated aromatase activity . ^^^ Increasing concentrations ( 3 10 10 ( 8 ) 10 ( 6 ) M ) of the antiestrogens augmented the stimulatory effect of FSH ( 10 ng / ml ) on estrogen production in a dose related manner ( CC greater than Tam greater than Naf ) . ^^^ Similar doses of these antiestrogens inhibited the stimulatory effect of FSH ( 300 ng / ml ) on progesterone and 20 alpha OH P production ( Tam greater than CC greater than Naf ) . ^^^ Furthermore , the antiestrogens inhibited the binding of [ 3H ] estradiol to ovarian estrogen receptors with binding affinity constants of 364 , 437 , and 2144 nM for CC , Tam , and Naf , respectively . ^^^ Like estrogens , CC , Tam , and Naf enhance FSH stimulated aromatase activity with potencies comparable with their abilities to interact with ovarian estrogen receptors . ^^^ |
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| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| The aim of this investigation was to determine whether sublethal concentrations of chlorhexidine ( Cx ) , hexetidine ( Hx ) , cetylpyridinium chloride ( Cc ) , sodium dodecyl sulfate ( SDS ) , sanguinarine ( Sg ) , sodium fluoride ( NaF ) , and ammonium fluoride ( NH4F ) could affect hydrophobicity and adhesion of Streptococcus sanguis and Streptococcus mutans to saliva coated hydroxyapatite ( S HA ) . ^^^ Growth in the presence of sub MIC concentrations of Cx , SDS , Cc , NaF , or NH4F did not change significantly the hydrophobicity of S . sanguis cells when compared to the control which lacked any agent . ^^^ |
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| Interacting proteins: P10145 and P25024 |
Pubmed |
SVM Score :0.0 |
| The AC activity upon stimulants acting on beta AR ( isoprenaline ) , G protein ( GTP , NaF ) and AC ( forskolin ) was decreased in CC liver . ^^^ |
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