| Interacting proteins: P11717 and P10144 |
Pubmed |
SVM Score :0.0 |
| Inhibition of the granzyme B CI MPR interaction prevented granzyme B cell surface binding , uptake , and the induction of apoptosis . ^^^ |
|
| Interacting proteins: P11717 and P10144 |
Pubmed |
SVM Score :0.0 |
| The 280 kD cation independent mannose 6 phosphate receptor ( MPR ) has been shown to play a role in endocytic uptake of granzyme B , since target cells overexpressing MPR have an increased sensitivity to granzyme B mediated apoptosis . ^^^ |
|
| Interacting proteins: P11717 and P10144 |
Pubmed |
SVM Score :0.0 |
| Receptor mediated import of glycosylated GzmB and release from endosomes were suggested , but the role of the cation independent mannose 6 phosphate receptor was recently refuted . ^^^ |
|
| Interacting proteins: P11717 and P10144 |
Pubmed |
SVM Score :0.0 |
| In pulldown assays mediated by the cation independent mannose 6 phosphate receptor , granzyme B bound to the receptor more intensely in the presence of immobilized heparan sulfate . ^^^ |
|
| Interacting proteins: P11717 and P10144 |
Pubmed |
SVM Score :0.0 |
| Similarly , cells exposed to either monomeric granzyme B or granzyme B serglycin complexes readily internalize the granzyme and undergo apoptosis in the absence of Mpr 300 and Mpr 46 . ^^^ Further , no colocalization of granzyme B and Mpr 300 could be observed in target cells after internalization . ^^^ In conclusion , these results strongly argue against an Mpr 300 or Mpr 46 dependent pathway of granzyme mediated killing and provide new insight in the internalization of monomeric and complexed granzyme B . . ^^^ |
|
| Interacting proteins: P11717 and P10144 |
Pubmed |
SVM Score :0.0 |
| NA |
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