| Interacting proteins: P10124 and P10144 |
Pubmed |
SVM Score :0.0 |
| To learn how the interaction of granzyme B ( GrB ) with serglycin might influence the apoptotic potential of this proteases , we have evaluated a model system where desalted CS is combined with isolated human granzyme . ^^^ |
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| Interacting proteins: P10124 and P10144 |
Pubmed |
SVM Score :0.0 |
| Cytotoxic cell granule mediated apoptosis : perforin delivers granzyme B serglycin complexes into target cells without plasma membrane pore formation . ^^^ Granzyme B ( GrB ) and perforin were found to coexist as multimeric complexes with the proteoglycan serglycin ( SG ) in cytotoxic granules , and cytotoxic cells were observed to secrete exclusively macromolecular GrB SG . ^^^ |
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| Interacting proteins: P10124 and P10144 |
Pubmed |
SVM Score :0.0 |
| Characterization of the macromolecular complex of granzyme B with serglycin . ^^^ We now report our biophysical studies establishing the nature of granzyme B serglycin ( GrB . ^^^ |
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| Interacting proteins: P10124 and P10144 |
Pubmed |
SVM Score :0.0 |
| A novel mechanism for protein delivery : granzyme B undergoes electrostatic exchange from serglycin to target cells . ^^^ The molecular interaction of secreted granzyme B serglycin complexes with target cells remains undefined . ^^^ Targets exposed to double labeled granzyme B serglycin complexes show solely the uptake of granzyme B . ^^^ A mechanism of delivery is proposed entailing electrostatic transfer of granzyme B from serglycin to cell surface proteins . . ^^^ |
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| Interacting proteins: P10124 and P10144 |
Pubmed |
SVM Score :0.0 |
| Serglycin deficient cytotoxic T lymphocytes display defective secretory granule maturation and granzyme B storage . ^^^ The serglycin deficiency did not affect the mRNA expression for granzyme A , granzyme B , or perforin . ^^^ However , the storage of granzyme B , but not granzyme A , Fas ligand , or perforin , was severely defective in serglycin deficient cells . ^^^ Taken together , these results point to a key role for serglycin in the storage of granzyme B and for secretory granule maturation but argue against a major role for serglycin in the apoptosis mediated by cytotoxic T lymphocytes . . ^^^ |
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| Interacting proteins: P10124 and P10144 |
Pubmed |
SVM Score :0.0 |
| Here granzyme B was delivered as a purified monomer , or in complex with either glycosaminoglycans or serglycin , and killing was evaluated . ^^^ We therefore propose the model that under physiological conditions serglycin bound granzyme B is critically endocytosed by a mannose 6 phosphate receptor , and receptor binding is enhanced by cell surface heparan sulfate . . ^^^ |
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| Interacting proteins: P10124 and P10144 |
Pubmed |
SVM Score :0.0 |
| NA |
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