| Interacting proteins: P10144 and P09874 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10144 and P09874 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10144 and P09874 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10144 and P09874 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10144 and P09874 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10144 and P09874 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10144 and P09874 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10144 and P09874 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10144 and P09874 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10144 and P09874 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10144 and P09874 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10144 and P09874 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10144 and P09874 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10144 and P09874 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10144 and P09874 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10144 and P09874 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10144 and P09874 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10144 and P09874 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10144 and P09874 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10144 and P09874 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10144 and P09874 |
Pubmed |
SVM Score :0.0 |
| Zn CCP phosphorescence decay increases from 8 . 3 to 9 . 1 ms upon addition of poly ( L lysine ) used to mimic cyt c . ^^^ |
|
| Interacting proteins: P10144 and P09874 |
Pubmed |
SVM Score :0.0 |
| Here we show that granzyme B cleaves and activates CPP 32 , the precursor of the protease responsible for cleavage of poly ( ADP ribose ) polymerase . . ^^^ |
|
| Interacting proteins: P10144 and P09874 |
Pubmed |
SVM Score :0.0 |
| However , processing by granzyme B leads directly to the activation of Yama , which is now able to bind inhibitors and cleave the substrate poly ( ADP ribose ) polymerase whose proteolysis is a marker of apoptosis initiated by several other stimuli . ^^^ |
|
| Interacting proteins: P10144 and P09874 |
Pubmed |
SVM Score :0.0 |
| In ICE / B cells or HeLa cells transfected with mutant inactive ICE or Ich 1S that exhibit resistance to granzyme B , CPP 32 is processed to p 17 and poly ( ADP ribose ) polymerase is cleaved indicating that this protease although activated was not associated with an apoptotic nuclear phenotype . ^^^ |
|
| Interacting proteins: P10144 and P09874 |
Pubmed |
SVM Score :0.0 |
| Granzyme B / perforin mediated apoptosis of Jurkat cells results in cleavage of poly ( ADP ribose ) polymerase to the 89 kDa apoptotic fragment and less abundant 64 kDa fragment . ^^^ We show here that exposure of Jurkat cells to granzyme B and perforin results in cleavage of poly ( ADP ribose ) polymerase to an apoptotic 89 kDa fragment and to lesser amounts of a 64 kDa fragment . ^^^ Establishing the intracellular function of GrB in the apoptotic response , these results indicate that granzyme B enters perforin treated targets activating the ICE / Ced 3 family proteases which then cleave poly ( ADP ribose ) polymerase to its apoptotic fragment . ^^^ Intracellular granzyme B appears to be translocated to the nucleus where the protease directly cleaves poly ( ADP ribose ) polymerase . . ^^^ |
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| Interacting proteins: P10144 and P09874 |
Pubmed |
SVM Score :0.0 |
| Necrotic death of HL 60 cells and apoptotic death of Jurkat cells mediated by granzyme B and perforin were accompanied by distinct additional fragments , suggesting cleavage of PARP at other sites by caspases or other death proteases . ^^^ |
|
| Interacting proteins: P10144 and P09874 |
Pubmed |
SVM Score :0.0 |
| The caspase substrate poly ( ADP ) ribose polymerase is cleaved by granzyme B in a cell free assay at two sites that resemble the granzyme B specificity determined by the combinatorial methods . ^^^ |
|
| Interacting proteins: P10144 and P09874 |
Pubmed |
SVM Score :0.0 |
| Treatment of mice with poly 1 : C upregulated IFN alpha and granzyme B , but not perforin , in the spleen . ^^^ Administration of EtOH before poly 1 : C prevented the upregulation of IFN alpha and granzyme B and decreased perforin levels . ^^^ |
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| Interacting proteins: P10144 and P09874 |
Pubmed |
SVM Score :0.0 |
| Granzyme B is characterised by its being a cysteine protease with substrates such as prointerleukin 1 beta , TR receptor and poly ( ADP ribose ) polymerase . ^^^ |
|
| Interacting proteins: P10144 and P09874 |
Pubmed |
SVM Score :0.0 |
| Abbreviations used in this paper are : CTL , cytotoxic T lymphocytes ; ER , endoplasmic reticulum ; GluR 3 , subunit 3 of the glutamate receptor ; GrB , granzyme B ; M3R , type 3 muscarinic receptor ; NK cells , natural killer cells ; PARP , poly ( ADP ribose ) polymerase ; SS , Sjgren ' s syndrome ; SLE , systemic lupus erythematosus ; and UV , ultraviolet . . ^^^ |
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| Interacting proteins: P10144 and P09874 |
Pubmed |
SVM Score :0.0 |
| Treatment with poly 1 : C also induced expression of NKG2D , granzyme B , perforin , Fas L , TRAIL , and IFN gamma on liver lymphocytes , which were delayed or reduced in ethanol treated mice compared with pair fed mice . ^^^ |
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