| Interacting proteins: P10070 and Q9NRP7 |
Pubmed |
SVM Score :0.0 |
| In cultured cells , mSu ( fu ) overexpression inhibited transcriptional activation mediated by Sonic hedgehog ( Shh ) , Gli 1 and Gli 2 . ^^^ Co immunoprecipitation of epitope tagged proteins indicated that mSu ( fu ) interacts with Gli 1 , Gli 2 , and Gli 3 , and that the inhibitory effects of mSu ( fu ) on Gli 1 ' s transcriptional activity were mediated through interactions with both amino and carboxy terminal regions of Gli 1 . ^^^ |
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| Interacting proteins: P10070 and Q9NRP7 |
Pubmed |
SVM Score :0.0 |
| HSu ( fu ) was found to repress activity of the zinc finger transcription factor Gli , which mediates Hedgehog signaling in vertebrates , and to physically interact with Gli , Gli 2 and Gli 3 as well as with Slimb , an F box containing protein which , in the fly , suppresses the Hedgehog response , in part by stimulating the degradation of the fly Gli homologue . ^^^ |
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| Interacting proteins: P10070 and Q9NRP7 |
Pubmed |
SVM Score :0.0 |
| This long FU and a much shorter isoform were compared for the ability to regulate GLI 1 and GLI 2 . ^^^ None of the FU isoforms showed any effects on GLI 1 induced transcription but the long form can enhance GLI 2 activity . ^^^ Furthermore , FU is able to enhance the activity of GLI 2 but not of GLI 1 , implicating FU in some aspects of Hedgehog signaling . . ^^^ |
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| Interacting proteins: P10070 and Q9NRP7 |
Pubmed |
SVM Score :0.0 |
| Human SHH , IHH , DHH ( Hedgehog homologs ) , HHAT ( Hedgehog acyltransferase ) , HHIP ( Hedgehog interacting protein ) , DISP 1 , DISP 2 , DISP 3 ( Dispatched homologs ) , PTCH 1 , PTCH 2 ( Patched homologs ) , SMO ( Smoothened homolog ) , KIF 27 , KIF 7 ( Costal 2 homologs ) , STK 36 ( Fused homolog ) , SUFU ( SuFu homolog ) , DZIP 1 ( Iguana homolog ) , GLI 1 , GLI 2 and GLI 3 ( Cubitus interruptus homologs ) are implicated in the Hedgehog signaling . ^^^ |
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| Interacting proteins: P10070 and Q9NRP7 |
Pubmed |
SVM Score :0.0 |
| We demonstrate here that Su ( fu ) prevents the nuclear accumulation of Gli 1 and Gli 2 through multiple mechanisms . ^^^ In contrast , CRM 1 mediated export is not required for Su ( fu ) to sequester Gli 2 . ^^^ Together , these observations reveal that Su ( fu ) regulates the activity of Gli 1 and Gli 2 through distinct cytoplasmic and nuclear mechanisms . . ^^^ |
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| Interacting proteins: P10070 and Q9NRP7 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P10070 and Q9NRP7 |
Pubmed |
SVM Score :0.0 |
| NA |
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