| Sequence analysis alone suggests that point mutations in FOXE 1 , GLI 2 , JAG 2 , LHX 8 , MSX 1 , MSX 2 , SATB 2 , SKI , SPRY 2 , and TBX 10 may be rare causes of isolated cleft lip with or without cleft palate , and the linkage disequilibrium data support a larger , as yet unspecified , role for variants in or near MSX 2 , JAG 2 , and SKI . ^^^ |