| Interacting proteins: P15529 and P0C0L5 |
Pubmed |
SVM Score :0.0 |
| Human CD 46 ( membrane cofactor protein ) is a cell surface glycoprotein with cofactor activity for the factor 1 mediated cleavage of components C3b and C4b . ^^^ |
|
| Interacting proteins: P15529 and P0C0L5 |
Pubmed |
SVM Score :0.0 |
| Factor 1 dependent inactivation of human complement C4b of the classical pathway by C3b / C4b receptor ( CR 1 , CD 35 ) and membrane cofactor protein ( MCP , CD 46 ) . ^^^ A plasma protease factor 1 and membrane cofactors , C3b / C4b receptor ( CR 1 ) and membrane cofactor protein ( MCP ) , participate in the regulation of cell bound C4b although the physiological potency of these cofactors remains unknown . ^^^ |
|
| Interacting proteins: P15529 and P0C0L5 |
Pubmed |
SVM Score :0.0 |
| Membrane cofactor protein ( MCP ) regulates C activation by serving as a cofactor for the cleavage of C3b and C4b by the serine protease factor 1 . ^^^ |
|
| Interacting proteins: P15529 and P0C0L5 |
Pubmed |
SVM Score :0.0 |
| Membrane cofactor protein ( MCP ) is a cofactor for the factor 1 mediated inactivation of C3b and C4b . ^^^ |
|
| Interacting proteins: P15529 and P0C0L5 |
Pubmed |
SVM Score :0.0 |
| CD 46 ( membrane cofactor protein ) is a human cell surface glycoprotein with cofactor activity for factor 1 mediated cleavage of complement components C3b and C4b . ^^^ |
|
| Interacting proteins: P15529 and P0C0L5 |
Pubmed |
SVM Score :0.0 |
| Membrane cofactor protein ( MCP ) ( CD 46 ) of the C system binds to C3b and C4b , functions as a cofactor for their cleavage , and protects autologous cells from C mediated injury . ^^^ |
|
| Interacting proteins: P15529 and P0C0L5 |
Pubmed |
SVM Score :0.0 |
| These molecules are factor H , CR 1 ( C3b / C4b receptor ) , CR 2 ( C3d / EBV receptor ) , C4BP ( C4b binding protein ) , DAF ( decay accelerating factor ) , MCP ( membrane cofactor protein ; earlier designated p45 / 70 ) , CR 3 ( iC3b receptor or Mac 1 ) and CR 4 ( protein 150 / 95 ) . ^^^ |
|
| Interacting proteins: P15529 and P0C0L5 |
Pubmed |
SVM Score :0.0 |
| Membrane cofactor protein ( MCP ) , a regulatory molecular of the complement system with cofactor activity for the factor 1 mediated inactivation of C3b and C4b , is widely distributed , being present on leukocytes , platelets , endothelial cells , epithelial cells , and fibroblasts . ^^^ |
|
| Interacting proteins: P15529 and P0C0L5 |
Pubmed |
SVM Score :0.0 |
| Diversity of sites for measles virus binding and for inactivation of complement C3b and C4b on membrane cofactor protein CD 46 . ^^^ The complement system membrane cofactor protein ( MCP ) CD 46 serves as a C3b / C4b inactivating factor for the protection of host cells from autologous complement attack and as a receptor for measles virus ( MV ) . ^^^ |
|
| Interacting proteins: P15529 and P0C0L5 |
Pubmed |
SVM Score :0.0 |
| CD 46 ( membrane cofactor protein ; MCP ) is ubiquitously expressed on nucleated human cells ; it has a protective function , binding C3b and C4b , which are then cleaved by serum factor 1 . ^^^ |
|
| Interacting proteins: P15529 and P0C0L5 |
Pubmed |
SVM Score :0.0 |
| It regulates complement activation by proteolytic degradation of C3b or C4b in the presence of factor H , complement receptor type 1 , membrane cofactor protein or C4b binding protein as cofactor . ^^^ |
|
| Interacting proteins: P15529 and P0C0L5 |
Pubmed |
SVM Score :0.0 |
| Membrane cofactor protein ( MCP ) is a complement regulatory protein that acts as a cofactor for the cleavage of C3b and C4b by the serine protease factor 1 . ^^^ |
|
| Interacting proteins: P15529 and P0C0L5 |
Pubmed |
SVM Score :0.0 |
| Membrane cofactor protein ( MCP ; CD 46 ) is a widely distributed C3b / C4b binding glycoprotein that inhibits complement activation on host cells . ^^^ |
|
| Interacting proteins: P15529 and P0C0L5 |
Pubmed |
SVM Score :0.0 |
| CD 46 , membrane cofactor protein ( MCP ) , is a membrane regulatory glycoprotein of the complement system , and acts as a cofactor of factor 1 , which inactivates C3b and C4b bound on autologous cell membrane . ^^^ |
|
| Interacting proteins: P15529 and P0C0L5 |
Pubmed |
SVM Score :0.0 |
| Human CD 46 ( membrane cofactor protein ) is a type 1 glycoprotein that functions to protect autologous cells from complement mediated damage by binding C3b and C4b for their factor 1 mediated cleavage . ^^^ |
|
| Interacting proteins: P15529 and P0C0L5 |
Pubmed |
SVM Score :0.0 |
| Membrane cofactor protein ( CD 46 ) is one such regulator that protects cells by acting as a cofactor for the factor 1 mediated cleavage of C3b and C4b . ^^^ |
|
| Interacting proteins: P15529 and P0C0L5 |
Pubmed |
SVM Score :0.0 |
| Membrane cofactor protein ( MCP ; CD 46 ) , a widely distributed regulator of complement activation , is a cofactor for the factor 1 mediated degradation of C3b and C4b deposited on host cells . ^^^ |
|
| Interacting proteins: P15529 and P0C0L5 |
Pubmed |
SVM Score :0.0 |
| Role of membrane cofactor protein ( CD 46 ) in regulation of C4b and C3b deposited on cells . ^^^ Membrane cofactor protein ( MCP ; CD 46 ) , factor H , and C4b binding protein mediate this reaction , known as cofactor activity , that also requires the plasma serine protease factor 1 . ^^^ |
|
| Interacting proteins: P15529 and P0C0L5 |
Pubmed |
SVM Score :0.0 |
| Membrane cofactor protein ( MCP ; CD 46 ) regulates the complement cascade by inhibiting C3b and C4b deposited on self tissue . ^^^ |
|
| Interacting proteins: P15529 and P0C0L5 |
Pubmed |
SVM Score :0.0 |
| It circulates in an active form and has very restricted specificity , cleaving only C3b or C4b in the presence of a cofactor such as factor H ( fH ) , complement receptor type 1 , membrane cofactor protein , or C 4 binding protein . ^^^ |
|
| Interacting proteins: P15529 and P0C0L5 |
Pubmed |
SVM Score :0.0 |
| A chimeric fusion protein encompassing the CD 46 ectodomain linked to the C terminal part of the C4b binding protein ( C4bp ) alpha chain ( sCD 46 C4bpalpha ) was produced in eukaryotic cells . ^^^ |
|
| Interacting proteins: P15529 and P0C0L5 |
Pubmed |
SVM Score :0.0 |
| CD 46 is a ubiquitous human cell surface receptor for the complement components C3b and C4b and for measles virus and human herpesvirus 6 . ^^^ |
|
| Interacting proteins: P15529 and P0C0L5 |
Pubmed |
SVM Score :0.0 |
| CD 46 belongs to a family of proteins that contain structurally related short consensus repeat ( SCR ) domains and regulate the activation of the complement components C3b and / or C4b . ^^^ Homology based molecular modeling of CD 46 SCRs 3 and 4 revealed a cluster of positively charged residues between the interface of these SCR domains similar to the verified M protein binding sites on the plasma complement regulators factor H and C4b binding protein . ^^^ |
|
| Interacting proteins: P15529 and P0C0L5 |
Pubmed |
SVM Score :0.0 |
| CD 46 is a widely expressed transmembrane protein that was initially identified as binding and inactivating C3b and C4b complement products . ^^^ |
|
| Interacting proteins: P15529 and P0C0L5 |
Pubmed |
SVM Score :0.0 |
| CD 46 is a ubiquitous human cell surface receptor for the complement components C3b and C4b and for various pathogens , including the measles virus and human herpes virus 6 . ^^^ |
|
| Interacting proteins: P15529 and P0C0L5 |
Pubmed |
SVM Score :0.0 |
| Its role as an inactivator of C3b and C4b deposited on self tissue is highlighted by the observation that partial deficiency of CD 46 is a predisposing factor to hemolytic uremic syndrome . ^^^ |
|
| Interacting proteins: P15529 and P0C0L5 |
Pubmed |
SVM Score :0.0 |
| CD 46 is a ubiquitously expressed receptor that serves as a cofactor for the inactivation of the complement components C3b and C4b , and it also serves as a receptor for diverse microbial pathogens . ^^^ |
|
| Interacting proteins: P15529 and P0C0L5 |
Pubmed |
SVM Score :0.0 |
| MCP is a widely distributed regulatory glycoprotein of the complement system which binds C3b and C4b and has factor 1 dependent co factor activity . ^^^ |
|
| Interacting proteins: P15529 and P0C0L5 |
Pubmed |
SVM Score :0.0 |
| This amino acid sequence is identical to that of the NH 2 terminal of the recently cloned membrane co factor protein ( MCP ) , a membrane protein that binds the C3b and C4b fragments of complement and acts as a co factor for 1 protein mediated decay of the complement convertases . ^^^ |
|
| Interacting proteins: P15529 and P0C0L5 |
Pubmed |
SVM Score :0.0 |
| These are complementary in function : MCP acts as a cofactor in factor 1 mediated C3b and C4b inactivation , thus preventing the assembly of C 3 convertases , whereas DAF accelerates spontaneous decay of the assembled C 3 convertase . ^^^ |
|
| Interacting proteins: P15529 and P0C0L5 |
Pubmed |
SVM Score :0.0 |
| As it is not known why the strictly controlled C system starts to react against autologous heart tissue , we have analyzed the expression of various membrane regulators of C ( CR 1 , DAF , MCP , CD 59 , C 8 binding protein ) and the pattern of deposition of C components and plasma C regulators ( C4b binding protein and vitronectin ) in normal ( n = 7 ) and infarcted ( n = 13 ) human myocardium . ^^^ |
|
| Interacting proteins: P15529 and P0C0L5 |
Pubmed |
SVM Score :0.0 |
| MCP binds C3b and C4b deposited on autologous cells and then serves as a cofactor for their inactivation by limited proteolytic cleavage . ^^^ |
|
| Interacting proteins: P15529 and P0C0L5 |
Pubmed |
SVM Score :0.0 |
| In addition , the rate and magnitude of cell surface cleavage of C4b to C4c and C4d by MCP and factor 1 correlated with cytoprotection . ^^^ |
|
| Interacting proteins: P15529 and P0C0L5 |
Pubmed |
SVM Score :0.0 |
| The ethylene analogues [ MCp ( 2 ) ( C ( 2 ) H ( 4 ) ) ] react with perfluoro tert butyl iodide to yield the products MCp ( 2 ) [ ( CH ( 2 ) CH ( 2 ) C ( CF ( 3 ) ) ( 3 ) ] 1 ( 25 , M = Mo ; 26 , M = W ) resulting from fluoroalkylation at the ethylene ligand . ^^^ |
|
| Interacting proteins: P15529 and P0C0L5 |
Pubmed |
SVM Score :0.0 |
| Reaction of trans [ ( MCp ) ( 2 ) ( mu CH ( 2 ) ) ( 2 ) Cl ( 2 ) ] ( M = Rh , Ir ; Cp = eta ( 5 ) C ( 5 ) Me ( 5 ) ) with Li ( 2 ) S ( 2 ) afforded the disulfido complexes [ ( MCp ) ( 2 ) ( mu CH ( 2 ) ) ( 2 ) ( mu S ( 2 ) S : S ' ) ] which were easily oxidized by O ( 2 ) to give the oxygenated complexes [ ( MCp ) ( 2 ) ( mu CH ( 2 ) ) ( 2 ) ( mu SSO ( 2 ) S : S ' ) ] . ^^^ |
|
| Interacting proteins: P15529 and P0C0L5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15529 and P0C0L5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15529 and P0C0L5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15529 and P0C0L5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15529 and P0C0L5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15529 and P0C0L5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15529 and P0C0L5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15529 and P0C0L5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15529 and P0C0L5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15529 and P0C0L5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15529 and P0C0L5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15529 and P0C0L5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15529 and P0C0L5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15529 and P0C0L5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15529 and P0C0L5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15529 and P0C0L5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15529 and P0C0L5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15529 and P0C0L5 |
Pubmed |
SVM Score :0.0 |
| NA |
|