| Interacting proteins: P09917 and P62993 |
Pubmed |
SVM Score :0.0 |
| A short , proline rich region spanning residues 566 577 in human 5 lipoxygenase is a binding site for the Src homology 3 ( SH 3 ) domain of growth factor receptor bound protein 2 ( Grb 2 ) , an `` adaptor ' ' protein for tyrosine kinase mediated cell signaling . ^^^ Purified 5 lipoxygenase bound to glutathione S transferase fusion products of Grb 2 and a truncated version of Grb 2 containing its SH 3 domain . ^^^ |
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| Interacting proteins: P09917 and P62993 |
Pubmed |
SVM Score :0.0 |
| In order to examine molecular determinants of the proline motif : SH 3 interaction , an enzyme linked immunosorbent assay was developed to observe binding of 5 lipoxygenase to SH 3 domains of growth factor receptor binding protein 2 ( Grb 2 ) . ^^^ The interactions is specific for the Grb 2 portion of the fusion proteins , and 5 LO binds preferentially to Grb 2 fragments containing an SH 3 domain . ^^^ Results suggest that the specificity of the Grb 2 : 5 LO interaction is high . . ^^^ |
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| Interacting proteins: P09917 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
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