| Interacting proteins: P09917 and P49137 |
Pubmed |
SVM Score :0.0 |
| Arachidonic acid promotes phosphorylation of 5 lipoxygenase at Ser 271 by MAPK activated protein kinase 2 ( MK 2 ) . ^^^ |
|
| Interacting proteins: P09917 and P49137 |
Pubmed |
SVM Score :0.0 |
| This model was used in conjunction with primary and secondary structural information to investigate putative nucleotide binding sites , a MAPKAP kinase 2 phosphorylation site , and a Src homology 3 binding site on the 5 lipoxygenase protein , further . ^^^ |
|
| Interacting proteins: P09917 and P49137 |
Pubmed |
SVM Score :0.0 |
| The activated MAPKAPK 2 phosphorylates its nuclear targets CREB / ATF1 , serum response factor , and E2A protein E 47 and its cytoplasmic targets HSP25 / 27 , LSP 1 , 5 lipoxygenase , glycogen synthase , and tyrosine hydroxylase . ^^^ |
|
| Interacting proteins: P09917 and P49137 |
Pubmed |
SVM Score :0.0 |
| Intriguingly , a significant difference in the potency of nonredox type inhibitors ( but not of BWA4C ) was determined between wild type 5 LO and the mutant S271A / S663A 5 LO ( lacking phosphorylation sites for ERK1 / 2 and MAPKAPK 2 ) in HeLa cells . ^^^ |
|
| Interacting proteins: P09917 and P49137 |
Pubmed |
SVM Score :0.0 |
| Recently , it has been shown that cellular 5 LO activity is regulated in a complex manner that can involve different signalling pathways . 5 LO can be activated by an increase in intracellular Ca2+ concentration , diacylglycerols , phosphorylation by MAPKAP kinase 2 and ERK . ^^^ |
|
| Interacting proteins: P09917 and P49137 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09917 and P49137 |
Pubmed |
SVM Score :0.0 |
| NA |
|