| Interacting proteins: P09619 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and Q06124 |
Pubmed |
SVM Score :0.0 |
| Binding competition results with these and other PDGFR , IRP , and IRS 1 peptides suggested some general rules for sequence recognition by the SH 2 domains of SH PTP 2 . ^^^ |
|
| Interacting proteins: P09619 and Q06124 |
Pubmed |
SVM Score :0.0 |
| We present data indicating that the 64 kDa protein that associates with the activated PDGFR is Syp ( also called SH PTP 2 , PTP 1D , or SH PTP 3 ) , the ubiquitously expressed 64 kDa SH 2 containing protein tyrosine phosphatase . ^^^ |
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| Interacting proteins: P09619 and Q06124 |
Pubmed |
SVM Score :0.0 |
| Upon binding of platelet derived growth factor ( PDGF ) , the PDGF beta receptor ( PDGFR ) undergoes autophosphorylation on distinct tyrosine residues and binds several SH 2 domain containing signal relay enzymes , including phosphatidylinositol 3 kinase ( PI3K ) , phospholipase C gamma ( PLC gamma ) , the GTPase activating protein of Ras ( RasGAP ) , and the tyrosine phosphatase SHP 2 . ^^^ We constructed and characterized a series of PDGFR mutants which contain binding sites for PI3K as well as one additional protein , either RasGAP , SHP 2 , or PLC gamma . ^^^ |
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| Interacting proteins: P09619 and Q06124 |
Pubmed |
SVM Score :0.0 |
| Predominant expression of the src homology 2 containing tyrosine phosphatase protein SHP 2 in vascular smooth muscle cells . src homology 2 ( SH 2 ) containing protein tyrosine phosphatase SHP 2 is known to transduce positive signals from activated receptor protein tyrosine kinases such as platelet derived growth factor receptor ( PDGFR ) beta and insulin receptor . ^^^ The functional associations of SHP 2 with PDGFR beta , which transduces major growth signals in vascular SMC , identify a crucial function of SHP 2 in blood vessels in consert with PDGFR beta . . ^^^ |
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| Interacting proteins: P09619 and Q06124 |
Pubmed |
SVM Score :0.0 |
| Furthermore , we show transient oxidation of the SH 2 domain containing PTP , SHP 2 , in response to PDGF that requires association with the PDGFR . ^^^ Our results indicate that SHP 2 inhibits PDGFR signaling and suggest a mechanism by which autophosphorylation of the PDGFR occurs despite its association with SHP 2 . ^^^ |
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| Interacting proteins: P09619 and Q06124 |
Pubmed |
SVM Score :0.0 |
| The protein tyrosine phosphatase SHP 2 , which dephosphorylates Tyr 751 on the PDGFR , was more active in cells treated with PDGF plus PE than in cells treated with either agent alone . ^^^ |
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| Interacting proteins: P09619 and Q06124 |
Pubmed |
SVM Score :0.0 |
| Significantly , cell death induced by 1O2 was enhanced by inhibition of PI 3 K , suggesting that activation of Akt by 1O2 may contribute to fibroblast survival under this form of oxidative stress . 1O2 treatment did not induce phosphorylation of platelet derived growth factor receptor ( PDGFR ) or activate SH PTP 2 , a substrate of growth factor receptors , suggesting that PDGFR was not activated . ^^^ |
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