| Interacting proteins: P09619 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P62993 |
Pubmed |
SVM Score :0.0 |
| Whereas the PDGFr associated with PtdIns 3 ' kinase , ras GAP , GRB 2 , and phospholipase C gamma , only GRB 2 and PtdIns 3 ' kinase associated with IRS 1 . ^^^ |
|
| Interacting proteins: P09619 and P62993 |
Pubmed |
SVM Score :0.0 |
| In a panel of mutant PDGF beta receptors , in which Tyr 716 and the previously known autophosphorylation sites were individually mutated , only PDGFR beta Y716F failed to bind GRB 2 . ^^^ |
|
| Interacting proteins: P09619 and P62993 |
Pubmed |
SVM Score :0.0 |
| Moreover , a mutant PDGFR lacking its SHPTP 2 binding site displays markedly reduced Grb 2 binding . ^^^ These data indicate that phosphorylation of SHPTP 2 couples Grb 2 to PDGFR in vivo , providing a mechanism for Ras activation by PDGFR and for positive signaling via SHPTP 2 and Csw . . ^^^ |
|
| Interacting proteins: P09619 and P62993 |
Pubmed |
SVM Score :0.0 |
| The data revealed new potential Grb 2 binding sites at Tyr 1114 ( epidermal growth factor receptor ( EGFR ) C tail ) ; Tyr 743 ( platelet derived growth factor receptor ( PDGFR ) insert region ) , Tyr 1110 from the E helix of the catalytic domain of insulin receptor ( IR ) , and Tyr 47 , Tyr 939 , and Tyr 727 in IRS 1 . ^^^ Tyr 1068 and 1086 from the C tail of EGFR , Tyr 684 from the kinase insert region of PDGFR , and Tyr 895 from IRS 1 were confirmed as major binding sites for the Grb 2 SH2 domain . ^^^ |
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| Interacting proteins: P09619 and P62993 |
Pubmed |
SVM Score :0.0 |
| Stimulation of PDGFR ' s and EGFR ' s induced tyrosine phosphorylation of the Shc adaptor protein and its association with Grb 2 , suggesting a mechanism by which Ras may be activated in human malignant astrocytoma cells . ^^^ |
|
| Interacting proteins: P09619 and P62993 |
Pubmed |
SVM Score :0.0 |
| When GRB 2 , an adapter protein , was immunoprecipitated from treated VSMCs followed by Western blot analysis with anti phosphotyrosine , PDGFR alpha , and GRB 2 antibodies , respectively , phosphotyrosine positive staining was observed on PDGFR alpha bands of the same blot in stretch stressed VSMCs , supporting the mechanical stress induced activation of PDGFR alpha . ^^^ |
|
| Interacting proteins: P09619 and P62993 |
Pubmed |
SVM Score :0.0 |
| In conclusion , our results demonstrate that Gi enables the PDGFR to signal more efficiently to p42 / p44 MAPK , and this appears to be achieved through the regulation of c Src and Grb 2 / PI3K , which are intermediates in the p42 / p44 MAPK cascade . . ^^^ |
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| Interacting proteins: P09619 and P62993 |
Pubmed |
SVM Score :0.0 |
| By using this system , we showed that endosomal activation of PDGFR recruits various signaling proteins including Grb 2 , SHC , phospholipase C gamma 1 , and the p85alpha subunit of phosphatidylinositol 3 kinase into endosomes and forms signaling complexes with PDGFR . ^^^ |
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| Interacting proteins: P09619 and P62993 |
Pubmed |
SVM Score :0.0 |
| Expression of a partially activated A Raf mutant resulted in decreased tyrosine phosphorylation of the PDGFR , specifically on Y 857 ( autophosphorylation site ) and Y 1021 ( phospholipase Cgamma 1 ( PLCgamma 1 ) binding site ) , but not the binding sites for other signalling proteins ( Nck , phosphatidylinositol 3 ' kinase ( PI3K ) , RasGAP , Grb 2 , SHP ) . ^^^ |
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