| Interacting proteins: P09619 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P40763 |
Pubmed |
SVM Score :0.0 |
| Ligand dependent activation of the platelet derived growth factor receptor ( PDGFR ) in fibroblasts in culture leads to the activation of the JAK family of protein tyrosine kinases and of the transcription factors Stat 1 and Stat 3 . ^^^ We conclude that the mechanisms of activation of Stat 1 and Stat 3 by PDGFR are distinct . ^^^ |
|
| Interacting proteins: P09619 and P40763 |
Pubmed |
SVM Score :0.0 |
| We have designed a targeted library of compounds from which we identified a novel molecule , GFB 204 , that binds PDGF and VEGF , blocks binding of PDGF and VEGF to their receptors ( 200 500 nM ) and subsequently inhibits PDGFR and Flk 1 tyrosine phosphorylation and stimulation of the protein kinases Erk 1 , Erk 2 and Akt and the signal transducer and activator of transcription STAT 3 . ^^^ |
|
| Interacting proteins: P09619 and P40763 |
Pubmed |
SVM Score :0.0 |
| The phosphorylation of FAK , mTOR , p70S6K , and PDK 1 were elevated in both breast cancer cell lines , whereas the phosphorylation of AKT , EGFR , ErbB2 / Her2 , PDGFR , Shc , and Stat 3 were elevated in only one breast cancer line compared to normal primary mammary epithelial cells and telomerase immortalised breast epithelial cells . ^^^ |
|
| Interacting proteins: P09619 and P40763 |
Pubmed |
SVM Score :0.0 |
| We found that BMS 354825 inhibited PDGF stimulated activation of PDGF receptor ( PDGFR ) , STAT 3 , Akt , and Erk 2 in rat A 10 VSMCs and in primary cultures of human aortic smooth muscle cells ( AoSMCs ) at low nanomolar concentrations . ^^^ |
|