| Interacting proteins: P09619 and P29353 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P29353 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P29353 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P29353 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P29353 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P29353 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P29353 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P29353 |
Pubmed |
SVM Score :0.0 |
| In agreement with this assumption , Ang 2 caused tyrosine phosphorylation of the PDGFR and the adapter protein Shc in an AG 1295 sensitive fashion . ^^^ |
|
| Interacting proteins: P09619 and P29353 |
Pubmed |
SVM Score :0.0 |
| In one glioblastoma cell line , a Shc associated p 190 was identified as the activated PDGFR . ^^^ Some of the Shc associated phosphoproteins ( EGFR , PDGFR , erbB 2 , Met , bcr abl , H 4 ret ) bound both the Shc and Grb 2 SH2 domains in vitro ; others ( p 175 ; p 70 p80 ) only the Shc SH 2 domain and yet others ( p 140 ) only the Grb 2 SH3 domains . ^^^ |
|
| Interacting proteins: P09619 and P29353 |
Pubmed |
SVM Score :0.0 |
| With regard to Shc binding , the data revealed new potential binding sites at Tyr 703 and Tyr 789 from the catalytic domain of EGFR and at Tyr 557 in the juxtamembrane region of PDGFR . ^^^ The study confirmed the previous identification of Tyr 992 and Tyr 1173 in the C tail of EGFR and several phosphopeptides from the PDGFR as medium strength binding sites for the SH 2 domain of Shc . ^^^ |
|
| Interacting proteins: P09619 and P29353 |
Pubmed |
SVM Score :0.0 |
| Stimulation of PDGFR ' s and EGFR ' s induced tyrosine phosphorylation of the Shc adaptor protein and its association with Grb 2 , suggesting a mechanism by which Ras may be activated in human malignant astrocytoma cells . ^^^ |
|
| Interacting proteins: P09619 and P29353 |
Pubmed |
SVM Score :0.0 |
| The cross talk appears to be cell type specific : In L cells that lack EGFR , lysophosphatidic acid induced Shc and ERK activation is prevented completely by specific inhibition of PDGFR , whereas in COS 7 cells expressing only EGFR , the pathway via EGFR is chosen . ^^^ |
|
| Interacting proteins: P09619 and P29353 |
Pubmed |
SVM Score :0.0 |
| Autophosphorylation of beta PDGFR and tyrosine phosphorylation of PLC gamma , PI3Kp85 and Shc were detected only in PDGF BB stimulated cells that express beta PDGFR . ^^^ |
|
| Interacting proteins: P09619 and P29353 |
Pubmed |
SVM Score :0.0 |
| By using this system , we showed that endosomal activation of PDGFR recruits various signaling proteins including Grb 2 , SHC , phospholipase C gamma 1 , and the p85alpha subunit of phosphatidylinositol 3 kinase into endosomes and forms signaling complexes with PDGFR . ^^^ |
|
| Interacting proteins: P09619 and P29353 |
Pubmed |
SVM Score :0.0 |
| The phosphorylation of FAK , mTOR , p70S6K , and PDK 1 were elevated in both breast cancer cell lines , whereas the phosphorylation of AKT , EGFR , ErbB2 / Her2 , PDGFR , Shc , and Stat 3 were elevated in only one breast cancer line compared to normal primary mammary epithelial cells and telomerase immortalised breast epithelial cells . ^^^ |
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