| Interacting proteins: P09619 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P20936 |
Pubmed |
SVM Score :0.54281204 |
| Association of PDGFR with PLC gamma 1 and RasGAP followed by their tyrosine phosphorylation failed , however , to activate PLC gamma 1 , protein kinase C ( PKC ) , and Ras . 0.54281204^^^ |
|
| Interacting proteins: P09619 and P20936 |
Pubmed |
SVM Score :0.0 |
| PDGF stimulated the association of PDGFR beta with p 85 , ras GTPase activating protein and PLC gamma . ^^^ |
|
| Interacting proteins: P09619 and P20936 |
Pubmed |
SVM Score :0.0 |
| This appears to involve for both the p145c kit and beta platelet derived growth factor receptor ( PDGF R ) cytoplasmic domains the formation of multiprotein signal transfer complexes , which include combinations of noncatalytic and enzymatically active subunits of phosphatidylinositol 3 ' kinase ( PI3 ' K ) , phospholipase C gamma ( PLC gamma ) , and guanosine trisphosphatase activating protein ( GAP ) . ^^^ |
|
| Interacting proteins: P09619 and P20936 |
Pubmed |
SVM Score :0.0 |
| However , the beta platelet derived growth factor receptor ( PDGFR ) was significantly more efficient at in vivo tyrosine phosphorylation of GTPase activating protein ( GAP ) . ^^^ |
|
| Interacting proteins: P09619 and P20936 |
Pubmed |
SVM Score :0.0 |
| In response to binding of platelet derived growth factor ( PDGF ) , the PDGF receptor ( PDGFR ) beta subunit is phosphorylated on tyrosine residues and associates with numerous signal transduction enzymes , including the GTPase activating protein of ras ( GAP ) and phosphatidylinositol 3 kinase ( PI3K ) . ^^^ In this study , the in vitro binding of GAP to the PDGFR was investigated . ^^^ Like PI3K , GAP associates only with receptors that have been permitted to autophosphorylate , and GAP itself does not require tyrosine phosphate in order to stably associate with the phosphorylated PDGFR . ^^^ To define which tyrosine residues are required for GAP binding , a panel of PDGFR phosphorylation site mutants was tested . ^^^ The in vitro and in vivo associations of GAP and PI3K activity to these PDGFR mutants were indistinguishable . ^^^ |
|
| Interacting proteins: P09619 and P20936 |
Pubmed |
SVM Score :0.0 |
| Whereas the PDGFr associated with PtdIns 3 ' kinase , ras GAP , GRB 2 , and phospholipase C gamma , only GRB 2 and PtdIns 3 ' kinase associated with IRS 1 . ^^^ |
|
| Interacting proteins: P09619 and P20936 |
Pubmed |
SVM Score :0.0 |
| In addition , the GTPase activating protein of Ras ( GAP ) and phosphatidylinositol 3 kinase were less stably associated with the wild type beta PDGFR than with the F 1009 receptor . ^^^ These findings are consistent with the in vitro experiments showign that Syp prefers to dephosphorylate sites on the beta PDGFR , that are important for binding phosphatidylinositol 3 kinase ( Tyr ( P ) 740 and Tyr ( P ) 751 ) and GAP ( Tyr ( P ) 771 ) . ^^^ |
|
| Interacting proteins: P09619 and P20936 |
Pubmed |
SVM Score :0.0 |
| Binding of platelet derived growth factor ( PDGF ) to the PDGF receptor ( PDGFR ) beta subunit triggers receptor tyrosine phosphorylation and the stable association of a number of signal transduction molecules , including phospholipase C gamma ( PLC gamma ) , the GTPase activating protein of ras ( GAP ) , and phosphatidylinositol 3 kinase ( PI3K ) . ^^^ Previous reports have identified three PDGFR tyrosine phosphorylation sites in the kinase insert domain that are important for stable association of GAP and PI3K . ^^^ |
|
| Interacting proteins: P09619 and P20936 |
Pubmed |
SVM Score :0.0 |
| Upon ligand induced tyrosine phosphorylation , the platelet derived growth factor ( PDGF ) receptor ( PDGFR ) beta subunit associates with PLC gamma 1 , RasGAP , P13K , and a 64 kd protein . ^^^ |
|
| Interacting proteins: P09619 and P20936 |
Pubmed |
SVM Score :0.0 |
| The phosphorylated C terminal tail of the PDGFR bound PLC gamma 1 , but did not associate with phosphatidylinositol ( PI ) 3 ' kinase or GTPase activating protein ( GAP ) . ^^^ |
|
| Interacting proteins: P09619 and P20936 |
Pubmed |
SVM Score :0.0 |
| Our previous studies indicated that PI3K and PLC gamma were required for relay of the mitogenic signal of beta PDGFR , whereas GAP and Syp did not appear to be required for this response . ^^^ In this study , we further investigated the role of GAP and Syp in mitogenic signaling by beta PDGFR . ^^^ Focusing on the PLC gamma dependent branch of beta PDGFR signaling , we constructed a series of mutant beta PDGFRs that contained the binding sites for pairs of the receptor associated proteins : PLC gamma and PI3K , PLC gamma and GAP , or PLC gamma and Syp . ^^^ Thus , GAP functions to suppress signal relay by the beta PDGFR , and it does so by silencing PLC gamma . ^^^ |
|
| Interacting proteins: P09619 and P20936 |
Pubmed |
SVM Score :0.0 |
| Unlike the PDGFR beta subunit , the PDGF activated alpha subunit did not stably associate with the GTPase activating protein of ras ( rasGAP ) , nor did it mediate tyrosine phosphorylation of rasGAP . ^^^ We conclude that the PDGFR alpha subunit does not mediate tyrosine phosphorylation or associate with ras GAP , and that these events are not required for PDGF AA mediated activation of p21ras or DNA synthesis . . ^^^ |
|
| Interacting proteins: P09619 and P20936 |
Pubmed |
SVM Score :0.0 |
| Upon binding of platelet derived growth factor ( PDGF ) , the PDGF beta receptor ( PDGFR ) undergoes autophosphorylation on distinct tyrosine residues and binds several SH 2 domain containing signal relay enzymes , including phosphatidylinositol 3 kinase ( PI3K ) , phospholipase C gamma ( PLC gamma ) , the GTPase activating protein of Ras ( RasGAP ) , and the tyrosine phosphatase SHP 2 . ^^^ We constructed and characterized a series of PDGFR mutants which contain binding sites for PI3K as well as one additional protein , either RasGAP , SHP 2 , or PLC gamma . ^^^ |
|
| Interacting proteins: P09619 and P20936 |
Pubmed |
SVM Score :0.0 |
| We have found that the F 2 mutation has only a modest effect on ligand dependent activation of a chimeric PDGFR composed of the extracellular and transmembrane domains of the alphaPDGFR and the cytoplasmic domain of the betaPDGFR by three measures : ( 1 ) the ability to phosphorylate endogenous and exogenous protein substrates in vitro , ( 2 ) phosphorylation of tyrosine 857 , and ( 3 ) binding of the effector proteins PLCgamma , RasGAP , and SHP 2 . ^^^ |
|
| Interacting proteins: P09619 and P20936 |
Pubmed |
SVM Score :0.0 |
| Expression of a partially activated A Raf mutant resulted in decreased tyrosine phosphorylation of the PDGFR , specifically on Y 857 ( autophosphorylation site ) and Y 1021 ( phospholipase Cgamma 1 ( PLCgamma 1 ) binding site ) , but not the binding sites for other signalling proteins ( Nck , phosphatidylinositol 3 ' kinase ( PI3K ) , RasGAP , Grb 2 , SHP ) . ^^^ |
|
| Interacting proteins: P09619 and P20936 |
Pubmed |
SVM Score :0.0 |
| It was shown that Piwil 2 modulates expression of stem cell specific genes , including platelet derived growth factor receptor , beta polypeptide ( Pdgfrb ) , solute carrier family 2 member 1 ( Slc2a1 ) , gap junction membrane channel protein alpha 7 ( Gja 7 ) , and spermatogonial cell surface markers Thy 1 ( CD 90 ) , integrin alpha 6 ( Itga 6 ) , CD 9 , and spermatogonia specific markers heat shock protein 90 alpha ( Hsp90a ) , and stimulated by retinoic acid gene 8 ( Stra 8 ) . ^^^ |
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