| Interacting proteins: P09619 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P19174 |
Pubmed |
SVM Score :0.97957226 |
| Association of PDGFR with PLC gamma 1 and RasGAP followed by their tyrosine phosphorylation failed , however , to activate PLC gamma 1 , protein kinase C ( PKC ) , and Ras . 0.97957226^^^ |
|
| Interacting proteins: P09619 and P19174 |
Pubmed |
SVM Score :0.0 |
| Identification of residues in the beta platelet derived growth factor receptor that confer specificity for binding to phospholipase C gamma 1 . ^^^ To identify the phosphotyrosine involved in association of phospholipase C ( PLC ) gamma 1 with the beta platelet derived growth factor receptor ( PDGFR ) , and to investigate which contiguous residues confer specificity for PLC gamma 1 , phosphotyrosine containing glutathione S transferase ( GST ) fusion proteins possessing different regions of the beta PDGFR were incubated with lysates of Rat 2 cells that overexpress PLC gamma 1 . ^^^ |
|
| Interacting proteins: P09619 and P19174 |
Pubmed |
SVM Score :0.0 |
| While the C terminal SH 2 domain of phospholipase C gamma 1 ( PLCC SH 2 ) interacts with eight residues of a pTyr containing peptide from its high affinity binding site on the beta platelet derived growth factor receptor , it can still bind tightly to a phosphopeptide containing only three residues . ^^^ |
|
| Interacting proteins: P09619 and P19174 |
Pubmed |
SVM Score :0.0 |
| Electrostatic interactions in a complex of the phospholipase C gamma 1 C terminal SH 2 domain with a high affinity binding phosphopeptide representing the sequence around Tyr 1021 of the beta platelet derived growth factor receptor were studied by pKa determination of various titratable groups over the pH range of 5 to 8 . ^^^ |
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| Interacting proteins: P09619 and P19174 |
Pubmed |
SVM Score :0.0 |
| The signal transduction protein phospholipase C gamma 1 ( PLC gamma 1 ) is activated when its C terminal SH 2 domain ( PLCC ) binds the phosphorylated Tyr 1021 site ( pTyr 1021 ) in the beta platelet derived growth factor receptor ( PDGFR ) . ^^^ |
|
| Interacting proteins: P09619 and P19174 |
Pubmed |
SVM Score :0.0 |
| Upon ligand induced tyrosine phosphorylation , the platelet derived growth factor ( PDGF ) receptor ( PDGFR ) beta subunit associates with PLC gamma 1 , RasGAP , P13K , and a 64 kd protein . ^^^ F 5 PDGFR failed to activate PLC gamma 1 , P13K , or Ras and was unable to trigger DNA synthesis . ^^^ Permitting association of F 5 PDGFR with either PLC gamma 1 or P13K restored Ras activation and a mitogenic response . ^^^ |
|
| Interacting proteins: P09619 and P19174 |
Pubmed |
SVM Score :0.0 |
| The PDGF stimulated release of G6PD was partially restored in PDGFR mutants in which either phosphatidylinositol 3 kinase or phospholipase C gamma 1 could associate with the PDGFR . ^^^ |
|
| Interacting proteins: P09619 and P19174 |
Pubmed |
SVM Score :0.0 |
| PDGF receptor ( PDGFR ) , protein kinase C alpha ( PKC alpha ) , phospholipase C gamma 1 ( PLC gamma 1 ) , and PLD 1 were examined by Western blot analysis . ^^^ The protein levels of PKC alpha and PLC gamma 1 were unchanged , but those of PLD 1 and PDGFR were reduced with age . ^^^ |
|
| Interacting proteins: P09619 and P19174 |
Pubmed |
SVM Score :0.0 |
| Here we show that functional phospholipase C gamma 1 ( PLC gamma 1 ) is required for c Abl activation by PDGFR . ^^^ |
|
| Interacting proteins: P09619 and P19174 |
Pubmed |
SVM Score :0.0 |
| By using this system , we showed that endosomal activation of PDGFR recruits various signaling proteins including Grb 2 , SHC , phospholipase C gamma 1 , and the p85alpha subunit of phosphatidylinositol 3 kinase into endosomes and forms signaling complexes with PDGFR . ^^^ |
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| Interacting proteins: P09619 and P19174 |
Pubmed |
SVM Score :0.0 |
| These data show that , although both kinases are activated and form complexes with proteins in the PDGFR signaling pathway , only c Abl functions downstream of PLC gamma 1 to mediate chemotaxis . . ^^^ |
|
| Interacting proteins: P09619 and P19174 |
Pubmed |
SVM Score :0.0 |
| Expression of a partially activated A Raf mutant resulted in decreased tyrosine phosphorylation of the PDGFR , specifically on Y 857 ( autophosphorylation site ) and Y 1021 ( phospholipase Cgamma 1 ( PLCgamma 1 ) binding site ) , but not the binding sites for other signalling proteins ( Nck , phosphatidylinositol 3 ' kinase ( PI3K ) , RasGAP , Grb 2 , SHP ) . ^^^ Thus , A Raf can regulate PLCgamma 1 signalling via a PDGFR dependent mechanism and may also regulate PI3K signalling via a PDGFR independent mechanism . . ^^^ |
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