| Interacting proteins: P18031 and P09619 |
Pubmed |
SVM Score :0.0 |
| We tested this hypothesis by determining whether recombinant Syp ( rSyp ) and a control PTP , recombinant PTP1B ( rPTP1B ) , were able to dephosphorylate the beta PDGFR . ^^^ |
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| Interacting proteins: P18031 and P09619 |
Pubmed |
SVM Score :0.0 |
| PTP1B also interacts with activated platelet derived growth factor receptor ( PDGFR ) but not with colony stimulating factor 1 receptor ( CSF 1R ) . ^^^ |
|
| Interacting proteins: P18031 and P09619 |
Pubmed |
SVM Score :0.0 |
| After growth factor treatment , cells lacking PTP1B exhibit increased and sustained phosphorylation of the epidermal growth factor receptor ( EGFR ) and the platelet derived growth factor receptor ( PDGFR ) . ^^^ Our results show that PTP1B does play a role in regulating EGFR and PDGFR phosphorylation but that other signaling mechanisms can largely compensate for PTP1B deficiency . ^^^ In gel phosphatase experiments suggest that other PTPs may help to regulate the EGFR and PDGFR in PTP1B ( / ) fibroblasts . ^^^ |
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