| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| EGFR , PDGFR ) or cytoplasmic ( Src , Abl ) tyrosine kinases are found mutated in a variety of human tumors . ^^^ |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| The gene expression of PDGF , PDGFR and EGFR reached peaks on PBD 1 and the gene expression of EGF and TGF beta R 2 were highest on PBD 3 . ^^^ |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| These events may be direct or indirect via transactivation of tyrosine kinase receptors , including PDGFR , EGFR and IGFR . ^^^ |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| In contrast , AG 1295 and AG 1478 , specific inhibitors of PDGFR and EGFR , respectively , were unable to block the BMOV response . ^^^ |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| The growth factor tyrosine kinase receptors PDGFRB and EGFR were present in most cells of all investigated tumors . ^^^ |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| A bacterial fusion protein containing the precise SH 2 N domain , as defined by sequence homology , associated with both the activated beta platelet derived growth factor receptor and epidermal growth factor receptor , and p 62 in vitro . ^^^ |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| Four of these genes ( EGF R , IGFI R , CSF 1 R , and PDGF R beta ) were expressed in epithelial cells , whereas four ( erbB 2 , erbB 3 , NGF R , and met ) were not . ^^^ |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| We have studied , at the mRNA level , the influence of various defined growth conditions on the expression of TGF alpha , PDGF BB , EGF R , PDGF R alpha , and PDGF R beta in five different glioma cell lines ( D 37MG , D 54MG , D 263MG , GaMG , and U 251MG ) . ^^^ |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| Among 346 clones , we identified epidermal growth factor receptor ( EGF R ) , Tie 2 , platelet derived growth factor receptor ( PDGF R ) alpha , PDGF R beta , Flk 1 , Flt 4 , fibroblast growth factor receptor ( FGF R ) 1 , FGF R 3 , FGF R 4 , Met , and RYK / Nbtk 1 . ^^^ |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| Reverse transcriptase polymerase chain reaction ( RT PCR ) showed that all cell lines expressed mRNA for PDGF R alpha and / or PDGF R beta ; six cell lines expressed mRNA for the PDGF A chain , with one cell line coexpressing PDGF B chain mRNA ; seven cell lines expressed mRNA for TGF alpha whereas six cell lines expressed EGF R mRNA . ^^^ |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| Analysis of genomic organization and expression of platelet derived growth factor receptors ( PDGFR ) and epidermal growth factor receptor ( EGFR ) in human malignant gliomas showed amplification and overexpression of both receptors in distinct subsets of tumors . ^^^ Western blot analysis showed elevated expression of alpha PDGFR and EGFR proteins in 4 ( 24 % ) and 3 ( 18 % ) , respectively , of 17 tumor specimens analyzed . ^^^ Increased production of alpha PDGFR as well as EGFR proteins was observed in the presence or absence of gene amplification . ^^^ Our findings suggest that the amplification and / or overexpression either of EGFR or of the alpha PDGFR along with the coordinate overexpression of the beta PDGFR can contribute to the malignant phenotype of distinct subsets of human glioblastoma . . ^^^ |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| The CFTL 15 cells were transfected with growth factor receptors containing ligand inducible tyrosine kinase domains ( EGFR and PDGFR , and CSF IR ) or with the EPOR . ^^^ Stimulation of the EGFR and PDGFR transfectants with their respective ligands resulted in the production of IL 3 , IL 6 , and GM CSF . ^^^ |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| In situ distribution of oncogene products and growth factor receptors in breast carcinoma : c erbB 2 oncoprotein , EGFr , and PDGFr beta subunit . ^^^ The aims of the present study were to determine how three of these receptors , c erbB 2 protein , epidermal growth factor receptor ( EGFr ) and the beta subunit of platelet derived growth factor receptor ( PDGFr beta subunit ) , can effectively be demonstrated by immunohistochemical methods in breast tumors , how these receptors are distributed at the cellular level and how their expression correlates with well established prognostic indicators including hormone receptors and proliferative index . ^^^ We examined frozen tissue sections of 50 invasive human breast carcinomas , including 45 ductal , four lobular , and one mucinous tumours , by immunocytochemical methods to determine the in situ distributions of c erbB 2 , EGFr , and PDGFr beta subunit . ^^^ |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| We have examined the expression of mRNAs for epidermal growth factor ( EGF ) , transforming growth factor alpha ( TGF alpha ) , EGF receptor ( EGFR ) , PDGF A chain ( PDGFA ) , PDGF B chain ( PDGFB ) and PDGF receptor ( PDGFR ) genes in seven human colorectal carcinoma cell lines and 18 human colorectal carcinomas . ^^^ In surgically resected specimens of the 18 colorectal tumors , TGF alpha , EGFR , PDGFA , PDGFB and PDGFR mRNAs were detected at various levels in 15 ( 83 % ) , 9 ( 50 % ) , 18 ( 100 % ) , 8 ( 44 % ) and 12 ( 67 % ) , respectively . ^^^ |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| Some of the Shc associated phosphoproteins ( EGFR , PDGFR , erbB 2 , Met , bcr abl , H 4 ret ) bound both the Shc and Grb 2 SH2 domains in vitro ; others ( p 175 ; p 70 p80 ) only the Shc SH 2 domain and yet others ( p 140 ) only the Grb 2 SH3 domains . ^^^ |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| Transcripts coding for transcription factors ( RB , P 53 , FOS , MYC , MYB , ERBA , REL ) , growth factors ( FGF 1 , FGF 2 , INT 2 , TGFA , TGFB , PDGF , IGF 1 , IGF 2 ) , interleukins , ( IL 1 , IL 2 , IL 3 , IL 4 , IL 6 , TNF ) , growth factor receptors or cytosolic protein kinases ( RAF , PIM , FES , MET , SRC , ROS , TRK , KIT , CSFR , IGFR , PDGFR , EGFR , NEU ) were quantified in cultured human mammary fibroblasts from normal tissues , benign tumours , carcinomas and post radiation fibrosis lesions by slot blot autoradiography and image analysis . ^^^ |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| Several receptor cDNAs for the alpha and beta type platelet derived growth factor receptors [ alpha PDGFR and beta PDGFR ] , the epidermal growth factor receptor , and the colony stimulating factor 1 receptor ) were transfected into 32D cells constitutively expressing the E 5 protein to test for IL 3 independent growth . ^^^ The lack of cooperative interaction between E 5 and the epidermal growth factor receptor , the colony stimulating factor 1 receptor , and the highly related alpha PDGFR was paralleled by the inability of E 5 to bind to these receptors and failure to increase receptor tyrosine phosphorylation . ^^^ |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| The expression of mRNAs for epidermal growth factor ( EGF ) , transforming growth factor alpha ( TGF alpha ) , EGFR , platelet derived growth factor ( PDGF ) A and B chain , PDGF receptor ( PDGFR ) , transforming growth factor beta ( TGF beta ) , erbB 2 and estrogen receptor ( ER ) genes was first examined in 6 human esophageal carcinoma cell lines , 6 xenoplanted and 15 surgically resected esophageal carcinomas . ^^^ |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| The expression of both epidermal growth factor ( EGF ) and platelet derived growth factor ( PDGF ) , and of their receptors ( EGFR and PDGFR ) was immunohistochemically examined in 37 cases of osteosarcoma . ^^^ EGFR ( 81 % ) expressed more often than EGF ( 51 % ) and the expression of EGF and EGFR , and PDGF and PDGFR were recognized in 49 % and 38 % , respectively . ^^^ |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| The data revealed new potential Grb 2 binding sites at Tyr 1114 ( epidermal growth factor receptor ( EGFR ) C tail ) ; Tyr 743 ( platelet derived growth factor receptor ( PDGFR ) insert region ) , Tyr 1110 from the E helix of the catalytic domain of insulin receptor ( IR ) , and Tyr 47 , Tyr 939 , and Tyr 727 in IRS 1 . ^^^ Tyr 1068 and 1086 from the C tail of EGFR , Tyr 684 from the kinase insert region of PDGFR , and Tyr 895 from IRS 1 were confirmed as major binding sites for the Grb 2 SH2 domain . ^^^ With regard to Shc binding , the data revealed new potential binding sites at Tyr 703 and Tyr 789 from the catalytic domain of EGFR and at Tyr 557 in the juxtamembrane region of PDGFR . ^^^ The study confirmed the previous identification of Tyr 992 and Tyr 1173 in the C tail of EGFR and several phosphopeptides from the PDGFR as medium strength binding sites for the SH 2 domain of Shc . ^^^ |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| We also studied the expression of epidermal growth factor receptor ( EGFR ) and platelet derived growth factor receptors ( PDGFR ) because their ligands have been reported to promote angiogenesis . ^^^ The stromal cells expressed abundant EGFR and , in addition , some stromal cells expressed PDGFR alpha but not PDGFR beta . ^^^ |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| Against isolated epidermal growth factor receptor ( EGFr ) , platelet derived growth factor receptor ( PDGFr ) , and 5 src tyrosine kinases , compounds in this series displayed broad inhibitory activity with IC 50 = 0 . 9 to > 100 microM vs EGFr , 3 . 4 to > 50 microM vs PDGFr , and 0 . 4 6 . 7 microM vs 5 src . ^^^ In general , compounds derived from tryptophan displayed the greatest potency against EGFr and those from 2 halogeno 3 indolecarboxylic acids greater potency against PDGFr and 5 src . ^^^ A comparative study in the same cell line on the effects of the 2 , 2 ' diselenobis ( 1H indole ) derived from ( R ) tryptophan vs its disulfur congener on growth factor mediated tyrosine phosphorylation showed that this compound significantly inhibited EGFr and PDGFr ( in response to its ligand ) autophosphorylation with complete suppression at 25 and 5 microM , respectively . ^^^ |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| Compound 4b inhibited the PDGFr , FGFr , EGFr , and c src tyrosine kinases with IC 50 values of 1 . 11 , 0 . 13 , 0 . 45 , and 0 . 22 microM , respectively . ^^^ Compound 4e inhibited the FGFr tyrosine kinase with an IC 50 of 0 . 060 microM , whereas IC50s for the inhibition of the PDGFr , FGFr , EGFr , c src , and InsR tyrosine kinases for this compound ( 4e ) were all greater than 50 microM . . ^^^ |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| This review covers the literature on significant studies of small molecule inhibitors of the epidermal growth factor receptor ( EGFR ) , platelet derived growth factor receptor ( PDGFR ) , fibroblast growth factor receptor ( FGFR ) , Flk 1 , and src family tyrosine kinases from 1996 through mid 1997 . ^^^ Potent and selective kinase inhibitors have also been described for PDGFR , but none of these compounds have appeared to advance in the developmental process as far as kinase inhibitors for the EGFR family . ^^^ |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| MATERIALS AND METHODS : We evaluated the potential role of Transforming growth factor alpha ( TGF alpha ) and Epidermal growth factor receptor ( EGF R ) , the Platelet derived growth factor A and B chain ( PDGF A and PDGF B ) and its receptors ( PDGFR alpha and PDGFR beta , and basic fibroblast growth factor ( bFGF ) in gliomas by analysing 86 of these tumours on the single cell level for the presence of immunoreactive growth factors and receptors . ^^^ |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| These alterations lead to changes in the expression of several genes ; protein 53 ( p 53 ) , retinoblastoma ( RB ) , interferon ( INF ) alpha / beta , cyclic AMP dependent kinase number 2 ( CDKN 2 ) , mutated in multiple advanced cancers 1 ( MMAC 1 ) , deleted in colon carcinoma ( DCC ) , epidermal growth factor receptor ( EGFR ) , platelet derived growth factor ( PDGF ) , platelet derived growth factor receptor ( PDGFR ) , MDM 2 , GL 1 , CDK 4 and SAS during the genesis and progression of human gliomas . ^^^ |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| Stimulation of PDGFR ' s and EGFR ' s induced tyrosine phosphorylation of the Shc adaptor protein and its association with Grb 2 , suggesting a mechanism by which Ras may be activated in human malignant astrocytoma cells . ^^^ |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| GBMs are characterized by overexpression of the Platelet Derived Growth Factor Receptors ( PDGFR ) and their ligands ( PDGF ) , as well as the Epidermal Growth Factor Receptor ( EGF R ) . ^^^ |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| Insulin like growth factor 1 receptor , platelet derived growth factor receptor ( PDGFR ) , TrkE , Axl , epidermal growth factor receptor , etc . , appear to be the most abundant receptor type PTKs in the thyroid ; many of which ( PDGFR , TrkE , Axl , etc . ) have never previously been demonstrated to be expressed in the thyroid . ^^^ |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| To understand the structural basis for the potency and specificity , a model for the binding mode of this class of inhibitors to the tyrosine kinase domains of c Src , PDGFr , FGFr , and EGFr tyrosine kinases was developed from structural information ( principally utilizing the catalytic domain of c AMP dependent protein kinase as template ) and structure activity relationship ( SAR ) information . ^^^ |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| The cross talk appears to be cell type specific : In L cells that lack EGFR , lysophosphatidic acid induced Shc and ERK activation is prevented completely by specific inhibition of PDGFR , whereas in COS 7 cells expressing only EGFR , the pathway via EGFR is chosen . ^^^ In Rat 1 cells , however , that express both EGFR and PDGFR , the EGFR pathway dominates . . ^^^ |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| Compounds of this series were competitive with ATP and displayed submicromolar to low nanomolar potency against a panel of TKs , including receptor ( platelet derived growth factor , PDGFr ; fibroblast growth factor , FGFr ; epidermal growth factor , EGFr ) and nonreceptor ( c Src ) classes . ^^^ One of the more thoroughly evaluated members was 63 with IC 50 values of 0 . 079 microM ( PDGFr ) , 0 . 043 microM ( bFGFr ) , 0 . 044 microM ( EGFr ) , and 0 . 009 microM ( c Src ) . ^^^ In in vivo studies against a panel of seven xenograft tumor models with known and / or inferred dependence on the EGFr , PDGFr , and c Src TKs , compound 63 produced a tumor growth delay of 10 . 6 days against the relatively refractory SK OV 3 ovarian xenograft and also displayed activity against the HT 29 tumor . ^^^ |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| Receptor tyrosine kinases ( RTKs ) , such as the epidermal growth factor receptor ( EGFR ) and the platelet derived growth factor receptor ( PDGFR ) , are critically involved in the transduction of mitogenic signals across the plasma membrane and therefore in the regulation of cell growth and proliferation . ^^^ EGFR and PDGFR are selectively inhibited by analogues of the marine natural product aeroplysinin . ^^^ |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| Tyrosine kinase activity was modulated by inhibitors of beta PDGFR autophosphorylation in cells , but not by specific inhibitors of EGFR or c Src tyrosine kinase . ^^^ |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| B 44 ( EGFR selective tyrphostin ) , AG 1295 ( platelet derived growth factor receptor [ PDGFR ] selective tyrphostin ) , and A 1 had no inhibitory effects on cells with or without E 2 treatments . ^^^ CONCLUSIONS : Of the agents tested , only EGFR selective tyrphostins blocked E 2 stimulated tumor cell proliferation , as opposed to the PDGFR selective tyrphostin , RTK noninhibitory agent , or the phytoestrogen , genistein , which did not exert such an effect . ^^^ |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| Whereas nontumorigenic lung cells expressed mRNA and protein for PDGF receptor ( PDGFR ) alpha , PDGFR beta , and EGF receptor ( EGFR ) , five of six neoplastic lines did not . ^^^ Consistent with our hypothesis , PDGFR alpha and EGFR contents , but not PDGFR beta contents , increased at stasis . ^^^ |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| In general , peptide growth factors signaling through cognate receptors with tyrosine kinase intracellular signaling domains such as FGFR , EGFR , IGFR , PDGFR and c met stimulate lung morphogenesis . ^^^ |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| Here , we studied the role of the epidermal growth factor receptor ( EGFR ) and platelet derived growth factor receptor ( PDGFR ) in Ang 2 induced ERK1 / 2 activation in human mesangial cells . ^^^ Ang 2 induced activation of ERK1 / 2 via the AT ( 1 ) receptor , and this response was blocked by the PDGFR selective tyrosine kinase inhibitor AG 1295 , but not by AG 1478 , an EGFR selective tyrosine kinase inhibitor , indicating participation of the PDGFR , but not of the EGFR in Ang 2 induced ERK1 / 2 activation . ^^^ In conclusion , our data show that Ang 2 induced activation of mitogenic signalling cascade in human mesangial cells involves ligand independent activation of the PDGFR , but not of the coexpressed EGFR . . ^^^ |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| FAK associates with activated PDGF and EGF receptor ( PDGFR and EGFR ) signalling complexes , and expression of the band 4 . 1 like domain at the FAK amino terminus is sufficient to mediate an interaction with activated EGFR . ^^^ |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| Recent experimental evidence suggests that growth factor receptors such as epidermal growth factor receptor ( EGFR ) and platelet derived growth factor receptor ( PDGFR ) play an important role in growth and development of pediatric renal tumors especially that of Wilms ' tumor . ^^^ METHODS : The authors studied the effect of genistein ( broad spectrum GFR TK inhibitor ) , AG 1478 ( EGFR specific GFR TK inhibitor ) , and AG 1295 ( PDGFR specific GFR TK inhibitor ) on proliferation and colonigenic growth of rhabdoid tumor of the kidney and Wilms ' tumor cell lines : G 401 and SK NEP 1 , respectively . ^^^ |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| The compounds were ATP competitive inhibitors of c Src kinase with IC ( 50 ) values < 10 nM and from 6 to > 100 fold selectivity for c Src tyrosine kinase relative to basic fibroblast growth factor receptor ( bFGFr ) tyrosine kinase , platelet derived growth factor receptor ( PDGFr ) tyrosine kinase , and epidermal growth factor receptor ( EGFr ) tyrosine kinase . ^^^ Autophosphorylation of EGFr tyrosine kinase or PDGFr tyrosine kinase was not inhibited by c Src inhibitors , thus showing the selective nature of the compounds in cells . ^^^ |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| It activated IRTK with an EC ( 50 ) of 300 nM and did not induce the activation of closely related receptors ( IGFIR , EGFR , and PDGFR ) at concentrations up to 30 000 nM . ^^^ |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| GPCR lack intrinsic kinase activity possessed by receptor tyrosine kinases ( RTK ) such as platelet derived growth factor receptor ( PDGFR ) or epidermal growth factor receptor ( EGFR ) . ^^^ |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| Our results demonstrated that expression of EGFR and PDGFR was greatly enhanced in vivo and in organotypic cultures of low grade cervical dysplastic tissues , but levels were decreased in high grade lesions . ^^^ When low grade dysplastic organotypic culture tissues were induced to differentiate more completely , EGFR expression , but not PDGFR expression , was relocalized to the basal layer as seen in normal tissues . ^^^ Differentiation also induced phosphorylation of EGFR but not PDGFR . ^^^ Our results suggest a role for EGFR and PDGFR during the early stages of cervical carcinogenesis , and demonstrate the facility of organotypic cultures to study the role of these growth factors in the development of cervical cancer . . ^^^ |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| In this paper we provide evidence that the transactivation of the EGF receptor ( EGFR ) by PDGFR is essential for PDGF to activate p 21 activated kinase ( PAK ) family kinases . ^^^ The activation of PAK was completely inhibited by either PDGFR specific inhibitor ( AG 1295 ) or EGFR specific inhibitor ( AG 1478 ) , suggesting that serum requires either the PDGF or EGF dependent pathway or the combination of both to activate PAK . ^^^ PDGF induced activation of PAK is completely inhibited by either AG 1295 or AG 1478 , indicating that PDGF requires both PDGFR and EGFR for PAK activation . ^^^ The platelet derived growth factor ( PDGF ) receptor ( PDGFR ) transactivates the epidermal growth factor ( EGF ) receptor ( ErbB 1 ) to stimulate the cell migration of fibroblasts through an unknown mechanism ( Li , J . , Kim , Y . ^^^ |
|
| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| One of the more thoroughly evaluated members , 32 , with IC 50 values of 0 . 21 microM ( PDGFr ) , 0 . 049 microM ( bFGFr ) , and 0 . 018 microM ( c Src ) , was evaluated in in vivo studies against a panel of five human tumor xenografts , with known and / or inferred dependence on the EGFr , PDGFr , and c Src TKs . ^^^ |
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| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| These events include activating mutations , amplification , and overexpression of various growth factor receptors ( e . g . epidermal growth factor receptor ( EGFR ) , platelet derived growth factor receptor ( PDGFR ) , c Met ) , signaling intermediates ( e . g . ^^^ |
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| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| METHOD : The expression of EGFR , PDGFR and IGF 1R was detected with immunohistochemical method using monoclonal antibodies . ^^^ RESULT : The expression of EGFR , PDGFR and IGF 1R showed higher positive rates in lung cancer cells than those in normal lung tissues , and the expression was increased as the disease was advanced . ^^^ CONCLUSION : The increased expression of EGFR , PDGFR and IGF 1R is related with the metastasis of lung cancer . . ^^^ |
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| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| With respect to several growth factor receptors such as EGFR , PDGFR , bFGFR and VEGFR , potent and specific inhibitors of receptor tyrosine kinases have been also examined as hopeful drug candidates . ^^^ |
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| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| Recent studies of border cell migration during Drosophila oogenesis demonstrate that the EGFR and PDGFR signaling pathways act in a partially redundant manner to guide this process . ^^^ |
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| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| Amplification of the EGFR , mdm 2 , CDK 4 and PDGFR A genes has been widely demonstrated in adult malignant gliomas , almost exclusively glioblastomas . ^^^ To determine the role of these mutational events in pediatric astrocytic gliomas we investigated the presence of EGFR , mdm 2 , CDK 4 and PDGFR A gene amplification in 38 childhood brain tumor biopsies , including 24 low grade astrocytomas and 14 malignant tumors . ^^^ |
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| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| After growth factor treatment , cells lacking PTP1B exhibit increased and sustained phosphorylation of the epidermal growth factor receptor ( EGFR ) and the platelet derived growth factor receptor ( PDGFR ) . ^^^ Our results show that PTP1B does play a role in regulating EGFR and PDGFR phosphorylation but that other signaling mechanisms can largely compensate for PTP1B deficiency . ^^^ In gel phosphatase experiments suggest that other PTPs may help to regulate the EGFR and PDGFR in PTP1B ( / ) fibroblasts . ^^^ |
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| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| These included absence of expression of CD 44 , E NCAM , A2B5 , epidermal growth factor receptor ( EGFR ) , and platelet derived growth factor receptor alpha ( PDGFR alpha ) , suggesting that negative selection using cell surface epitopes could be used to isolate stem cell populations from mixed cultures of cells . ^^^ |
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| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| In this review , we describe the effects of gangliosides on growth factor receptors , beginning with a list of known effects of gangliosides on growth factor receptors ; we then present three models based on fibroblast growth factor ( FGFR ) , platelet derived growth factor receptor ( PDGFR ) , and EGFR . ^^^ |
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| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| HIF 1 mediated gene expression may be directly or indirectly modulated by alterations in oncogenes / tumor suppressor genes that occur during astrocytoma development , including PTEN , TP 53 , p 16 ( CDKN2A ) , p14ARF , EGFR , and PDGFR . ^^^ |
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| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| Other tyrphostins discussed are AG 1478 and RG 13022 , which are both epidermal growth factor receptor kinase inhibitors ; AG 490 , a Jak 2 kinase inhibitor ; AG 1296 , a PDGFR kinase inhibitor ; and STI 571 ( imatinib , Glivec / Gleevec ; Novartis Pharma AG , Basel , Switzerland ) . ^^^ |
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| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| The expression pattern of phosphorylated ERK1 / 2 in the trophoblasts was compared with that of various growth factor receptors , such as c met , IGF 1R , flt 1 , EGFR , PDGFR , Bek , and flg . ^^^ |
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| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| GBMs commonly overexpress the oncogenes EGFR and PDGFR , and contain mutations and deletions of tumor suppressor genes PTEN and TP 53 . ^^^ We describe strategies to : 1 ) target EGFR , its ligand independent variant EGFRvIII , and PDGFR on the cell surface , 2 ) inhibit constitutively activate RAS / MAPK and PI3K / Akt signaling pathways , 3 ) target TP 53 mutant tumors , and 4 ) block GBM angiogenesis and invasion . ^^^ |
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| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| This review describes the preclinical and clinical status of low molecular weight drugs targeted against different tyrosine kinases ( e . g . , epidermal growth factor receptor [ EGFR ] , vascular endothelial growth factor receptor [ VEGFR ] , platelet derived growth factor receptor [ PDGFR ] , Kit , Fms like tyrosine kinase [ Flt ] 3 ) , briefly describes new targets , and provides a critical analysis of the current situation in the area of tyrosine kinase inhibitors . . ^^^ |
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| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| We report here that HNE delivered to cells by oxidized LDL reacts with cellular proteins , for instance with tyrosine kinase receptors ( RTK ) such as EGFR and PDGFR . ^^^ In intact living cells , oxidized LDL ( and pure HNE ) trigger HNE adduct formation and activation of PDGFR and EGFR , through an antioxidant insensitive and reactive oxygen species independent mechanism . ^^^ |
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| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| We researched the highly potent and selective inhibitors on the basis of both PDGFr and epidermal growth factor receptor ( EGFr ) inhibitory activity . ^^^ First , we found a compound , Ki 6783 ( 1 ) , which inhibited PDGFr autophosphorylation at 0 . 13 microM , but it did not inhibit EGFr autophosphorylation at 100 microM . ^^^ |
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| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| Consistent with its reported effects on VEGFR 2 [ IC ( 50 ) < 2 nM ] , ZM 323881 inhibited activation of VEGFR 2 , but not of VEGFR 1 , epidermal growth factor receptor ( EGFR ) , platelet derived growth factor receptor ( PDGFR ) , or hepatocyte growth factor ( HGF ) receptor . ^^^ |
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| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| We investigated this crosstalk under different conditions and found that both Akt and ERK activation induced by S1P , but not lysophosphatidic acid ( LPA ) , in HEY ovarian cancer cells required PDGFR but not epidermal growth factor receptor ( EGFR ) or insulin like growth factor 1 receptor ( IGFR ) . ^^^ |
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| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| For example , platelet derived growth factor receptor ( PDGFR ) is very similar to EGFR in terms of both signaling and trafficking ; however , little is known about the endosomal signaling of PDGFR . ^^^ In this research , we applied the same approaches from our recent studies regarding EGFR endosomal signaling to investigate the endosomal signaling of PDGFR . ^^^ |
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| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| AG 1478 , an EGFR kinase inhibitor , prevented the CaR mediated increases of pERK and PTHrP release , while AG 1296 , a PDGFR kinase inhibitor , had no effect . ^^^ |
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| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| Because the CaR is a G protein coupled receptor ( GPCR ) , it is likely to transactivate the epidermal growth factor receptor ( EGFR ) or the platelet derived growth factor receptor ( PDGFR ) . ^^^ In this study , we hypothesized that activation of the CaR transactivates the EGFR or PDGFR , and examined whether transactivation affects PTHrP secretion in PC 3 human prostate cancer cells . ^^^ Taken together , these findings indicate that activation of the CaR transactivates the EGFR , but not the PDGFR , leading to phosphorylation of ERK1 / 2 and resultant PTHrP secretion , although CaR EGFR ERK might not be the only signaling pathway for PTHrP secretion . ^^^ |
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| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| PDGFR , not FAK or EGFR , appears to be the upstream protein tyrosine kinase responsible for the detachment induced Src activation in the lung tumor cells . ^^^ |
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| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| Here we evaluated the possible involvement of growth factor receptors , such as the platelet derived growth factor receptor ( PDGFR ) , insulin like growth factor 1 receptor ( IGF IR ) , and epidermal growth factor receptor ( EGFR ) on periodontal ligament cells and their ligands during periodontal ligament cells differentiation in vitro . ^^^ The mineralized nodule formation was strongly inhibited by a PDGFR kinase blocker ( AG 1295 and AG 1296 ) , partially inhibited by an IGF IR kinase blocker ( 1 Ome AG 538 and AG 1024 ) , and not inhibited by an EGFR kinase blocker ( AG 99 ) . ^^^ |
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| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemical analysis was performed using antibodies against c kit and platelet derived growth factor receptor ( PDGFR ) alpha and beta and EGFR tyrosine kinase . . ^^^ |
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| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| Herein , we will review the current state of the art using agents that target as prototypes Bcr Abl , platelet derived growth factor receptor ( PDGFR ) , KIT ( stem cell factor receptor ) , and epidermal growth factor receptor ( EGFR ) . ^^^ |
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| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| They were immunohistochemically ( IHC ) examined using antibodies for EGFR , platelet derived growth factor receptor ( PDGFR ) alpha , PDGFRbeta , parathyroid hormone ( PTH ) receptor , Ki 67 , cyclinD 1 , p 53 , and vimentin . ^^^ |
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| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| The deficits in Akt and ERK activation in cells deficient in both PS 1 and PS 2 ( PS / ) are evident after serum withdrawal and stimulation with fetal bovine serum or ligands of select receptor tyrosine kinases , platelet derived growth factor receptor beta ( PDGFR beta ) and PDGFR alpha , but not insulin like growth factor 1R and epidermal growth factor receptor . ^^^ |
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| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| The Raf / MEK / ERK pathway is an important downstream convergence point for signaling through VEGFR , platelet derived growth factor receptor ( PDGFR ) , and EGFR ( all have receptor tyrosine kinase activity ) and also has important antiapoptotic effects , thereby providing an attractive target for intervention . ^^^ |
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| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| Because epidermal growth factor receptor ( EGFR ) , vascular endothelial growth factor receptor ( VEGFR ) , and platelet derived growth factor receptor ( PDGFR ) modulate tumor progression , we hypothesized that inhibition of phosphorylation of all three on tumor cells , tumor associated endothelial cells , and stroma cells would improve the treatment efficacy of gemcitabine in an orthotopic pancreatic tumor model in nude mice and prolong survival . ^^^ We found that tumor associated endothelial cells in this model highly expressed phosphorylated EGFR , VEGFR , and PDGFR . ^^^ Thus , inhibiting phosphorylation of EGFR , VEGFR , and PDGFR in combination with gemcitabine enhanced the efficacy of gemcitabine , resulting in inhibition of experimental human pancreatic cancer growth and significant prolongation of survival . . ^^^ |
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| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| The phosphorylation of FAK , mTOR , p70S6K , and PDK 1 were elevated in both breast cancer cell lines , whereas the phosphorylation of AKT , EGFR , ErbB2 / Her2 , PDGFR , Shc , and Stat 3 were elevated in only one breast cancer line compared to normal primary mammary epithelial cells and telomerase immortalised breast epithelial cells . ^^^ |
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| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| An immunocytochemical study on subconfluent BM fibroblast cultures from 13 healthy patients , 16 LCP , and 8 BCP was performed , using as primary antibodies , anti type 1 of IL 1 R ( IL 1R 1 ) , anti alpha , beta chains of PDGF R ( PDGFR alpha , PDGFR beta ) , anti type 1 of FGF R ( FGFR 1 ) , anti type 1 , 2 , and 3 of TGF beta R ( TGF betaR 1 , TGF betaR 2 , and TGF betaR 3 ) , anti EGF R , anti c Fos , and anti c Myc . ^^^ A diminished percentage of subconfluent fibroblasts expressing PDGFR alpha , TGFbetaR 1 , 2 , 3 , EGFR , and FGFR 1 was found in LCP and BCP compared to healthy patients . ^^^ |
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| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| They were evaluated for morphological differences using H & E staining for the platelet derived growth factor receptor ( PDGFR ) , epidermal growth factor receptor ( EGFR ) , TGFbeta receptorIII ( TGFbetaRIII ) , transforming growth factor beta 1 and 3 ( TGFbeta 1 and TGFbeta 3 ) and von Willebrand factor ( vWF ) expression using immunohistochemistry . ^^^ |
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| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| In vascular smooth muscle cells ( VSMCs ) , through its G protein coupled AngII Type 1 receptor ( AT ( 1 ) ) , AngII activates various intracellular protein kinases , such as receptor or non receptor tyrosine kinases , which includes epidermal growth factor receptor ( EGFR ) , platelet derived growth factor receptor ( PDGFR ) , c Src , PYK 2 , FAK , JAK 2 . ^^^ |
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| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| New therapies , such as inhibitors of the tyrosine kinase receptor family c kit , platelet derived growth factor receptors ( PDGFR ) alpha and beta and epidermal growth factor receptor ( EGFR ) have shown promising results in other malignancies and might be of value in malignant lung carcinoids . ^^^ |
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| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| The objective of this study was to evaluate the expression of epidermal growth factor ( EGFR ) , platelet derived growth factor ( PDGFR ) , and p 53 in ULMS specimens , their prognostic relevance , and the expression of these molecular markers when compared to benign LMA specimens . ^^^ Immunohistochemical ( IHC ) staining was performed for EGFR , PDGFR , and p 53 . ^^^ |
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| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| EGFR and other members of the receptor tyrosine kinases ( RTKs ) family , such as VEGFR , PDGFR , and IGFR , et cetera , are often overexpressed in most of malignant gliomas and share common downstream signaling pathways . ^^^ |
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| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : Receptor tyrosine kinases ( RTKs ) such as epidermal growth factor receptor ( EGFR ) and platelet derived growth factor receptor ( PDGFR ) are capable of eliciting kinase activity after ligand binding . ^^^ |
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| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| Specific molecular targeted therapeutic agents for hormone refractory prostate cancer ( HRPC ) include endothelin A receptor antagonist , EGF receptor ( EGFR ) inhibitor , platelet derived growth factor receptor ( PDGFR ) inhibitor , nuclear factor of kappaB ( NF kappaB ) inhibitor , cyclooxygenase 2 ( COX 2 ) inhibitor , and active form of Vitamin D . ^^^ |
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| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| New evidence indicates that Galpha ( 13 ) , the alpha subunit of the G protein G ( 13 ) , breaks away from this traditional exclusive signaling alliance with GPCRs to transmit signals from receptor tyrosine kinases ( RTKs ) , such as platelet derived growth factor receptor ( PDGFR ) , epidermal growth factor receptor ( EGFR ) , and vascular endothelial growth factor receptor ( VEGFR ) . ^^^ |
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| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| Two major families of receptor tyrosine kinases , the epidermal growth factor receptor ( EGFR ) and platelet derived growth factor receptor ( PDGFR ) families , have received a great deal of attention as potential therapeutic targets for pulmonary diseases , as these receptors have been shown to play key roles in chronic tissue remodeling in asthma , bronchitis , and pulmonary fibrosis . ^^^ The variety of EGFR and PDGFR ligands produced by the airway epithelium or adjacent mesenchymal cells allows for intimate epithelial mesenchymal cell communication . ^^^ |
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| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| We studied the expression of the following TKs in head and neck squamous cell carcinoma ( HNSCC ) : platelet derived growth factor receptor ( PDGFR ) , c kit , epidermal growth factor receptor ( EGFR ) , and a serine threonine kinase , Akt . ^^^ All 4 kinases in the tumor samples were expressed highly ( PDGFR , 95 % 100 % ; EGFR , 38 % 43 % ; c kit , 50 % 86 % ; p Akt , 57 % 81 % ) , with EGFR , c kit , and p Akt significantly higher than in benign samples . ^^^ |
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| Interacting proteins: P09619 and P00533 |
Pubmed |
SVM Score :0.0 |
| The lesion was resected , and the tissue was subjected to immunostaining for gene products associated with pregnancy , including estrogen receptor ( ER ) , progesterone receptor ( PR ) , platelet derived growth factor receptor B ( PDGFRB ) , fibroblastic growth factor receptor 2 ( FGFR 2 ) , epidermal growth factor receptor ( EGFR ) and human placental lactogen ( hPL ) . ^^^ |
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