| Interacting proteins: O14745 and P09619 |
Pubmed |
SVM Score :0.51868862 |
| These findings reveal that NHERF can directly bind to the PDGFR and potentiate PDGFR activity , thus elucidating both a novel mechanism by which PDGFR activity can be regulated and a new cellular role for the PDZ domain containing adapter protein NHERF . . 0.51868862^^^ |
|
| Interacting proteins: O14745 and P09619 |
Pubmed |
SVM Score :0.0 |
| Expression of NHERF 1 , NHERF 2 , PDGFR alpha , and PDGFR beta in normal human kidneys and in renal transplant rejection . ^^^ Sodium hydrogen exchanger regulatory factor 1 and 2 ( NHERF 1 and NHERF 2 ) are adaptor proteins that regulate renal electrolyte transport and interact with the platelet derived growth factor receptors ( PDGFR ) . ^^^ |
|
| Interacting proteins: O14745 and P09619 |
Pubmed |
SVM Score :0.0 |
| The activation of the PI3K pathway after PDGFR stimulation was prolonged in NHERF 1 ( / ) mouse embryonic fibroblasts as compared to wild type cells , consistent with defective PTEN recruitment to PDGFR in the absence of NHERF 1 . ^^^ |
|
| Interacting proteins: O14745 and P09619 |
Pubmed |
SVM Score :0.0 |
| The NHERF PDZ 1 domain interacts specifically with the motifs DSLL , DSFL , and DTRL present at the carboxyl termini of the beta ( 2 ) adrenergic receptor ( beta ( 2 ) AR ) , the platelet derived growth factor receptor ( PDGFR ) , and the cystic fibrosis transmembrane conductance regulator ( CFTR ) , respectively , and plays a central role in the physiological regulation of these proteins . ^^^ This structure reveals the molecular mechanism of carboxyl terminal leucine recognition by class 1 PDZ domains , and provides insights into the specificity of NHERF interaction with the carboxyl termini of several membrane receptors and ion channels , including the beta ( 2 ) AR , PDGFR , and CFTR . . ^^^ |
|
| Interacting proteins: O14745 and P09619 |
Pubmed |
SVM Score :0.0 |
| NA |
|